CN104448027B - 从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 - Google Patents
从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 Download PDFInfo
- Publication number
- CN104448027B CN104448027B CN201410855043.8A CN201410855043A CN104448027B CN 104448027 B CN104448027 B CN 104448027B CN 201410855043 A CN201410855043 A CN 201410855043A CN 104448027 B CN104448027 B CN 104448027B
- Authority
- CN
- China
- Prior art keywords
- thallus
- fucoxanthine
- fucoidan
- extraction
- thallus laminariae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229920000855 Fucoidan Polymers 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 68
- 238000000605 extraction Methods 0.000 claims abstract description 29
- 239000000284 extract Substances 0.000 claims abstract description 20
- 239000000706 filtrate Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000006228 supernatant Substances 0.000 claims abstract description 10
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 9
- 238000001556 precipitation Methods 0.000 claims abstract description 9
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 9
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 9
- 239000002244 precipitate Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 13
- 229910021641 deionized water Inorganic materials 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 11
- 239000001913 cellulose Substances 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 8
- 150000002148 esters Chemical class 0.000 claims description 8
- 241000195493 Cryptophyta Species 0.000 claims description 3
- 239000011435 rock Substances 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 9
- 238000003912 environmental pollution Methods 0.000 abstract description 3
- 238000001291 vacuum drying Methods 0.000 abstract description 2
- 238000004140 cleaning Methods 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 description 6
- 239000012043 crude product Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 238000003809 water extraction Methods 0.000 description 3
- 241001466453 Laminaria Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 238000003811 acetone extraction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- SJWWTRQNNRNTPU-ABBNZJFMSA-N fucoxanthin Chemical compound C[C@@]1(O)C[C@@H](OC(=O)C)CC(C)(C)C1=C=C\C(C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)C(=O)C[C@]1(C(C[C@H](O)C2)(C)C)[C@]2(C)O1 SJWWTRQNNRNTPU-ABBNZJFMSA-N 0.000 description 1
- AQLRNQCFQNNMJA-UHFFFAOYSA-N fucoxanthin Natural products CC(=O)OC1CC(C)(C)C(=C=CC(=CC=CC(=CC=CC=C(/C)C=CC=C(/C)C(=O)CC23OC2(C)CC(O)CC3(C)C)C)CO)C(C)(O)C1 AQLRNQCFQNNMJA-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 235000013675 iodine Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- -1 yield is 1.15% Polymers 0.000 description 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410855043.8A CN104448027B (zh) | 2014-12-31 | 2014-12-31 | 从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410855043.8A CN104448027B (zh) | 2014-12-31 | 2014-12-31 | 从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104448027A CN104448027A (zh) | 2015-03-25 |
CN104448027B true CN104448027B (zh) | 2016-08-24 |
Family
ID=52894827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410855043.8A Active CN104448027B (zh) | 2014-12-31 | 2014-12-31 | 从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104448027B (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106832022A (zh) * | 2015-12-04 | 2017-06-13 | 威海市宇王集团有限公司 | 一种提取岩藻聚糖硫酸酯的方法 |
CN108420834B (zh) * | 2018-06-07 | 2021-04-23 | 艾苛密(上海)健康科技股份有限公司 | 软骨修复用海藻提取物及其制备方法 |
CN112679450A (zh) * | 2020-12-30 | 2021-04-20 | 上海珈凯生物科技有限公司 | 一种从墨角藻中综合提取岩藻黄质和海藻多糖的方法 |
CN115417934B (zh) * | 2022-09-02 | 2023-09-26 | 威海迪普森生物科技有限公司 | 一种高含量岩藻低聚糖海带提取物的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102321052A (zh) * | 2011-05-26 | 2012-01-18 | 天津市尖峰天然产物研究开发有限公司 | 综合利用海带提取纯化岩藻黄质和岩藻聚糖硫酸酯的方法 |
CN102898539A (zh) * | 2012-09-21 | 2013-01-30 | 南京泽朗农业发展有限公司 | 一种利用亚临界水提取灵芝多糖的方法 |
JP5140304B2 (ja) * | 2007-04-05 | 2013-02-06 | 金秀バイオ株式会社 | フコキサンチンとフコイダンの同時製造方法 |
CN103232552A (zh) * | 2013-04-24 | 2013-08-07 | 集美大学 | 一种酶法制备褐藻岩藻聚糖与岩藻黄素的方法 |
CN103880972A (zh) * | 2014-03-12 | 2014-06-25 | 江苏大学 | 一种亚临界水同步萃取多糖和蛋白质的方法 |
CN104093746A (zh) * | 2011-10-24 | 2014-10-08 | 华盛顿州立大学研究基金会 | 分步水热法从富油生物质中提取生物油和其他生物产品 |
-
2014
- 2014-12-31 CN CN201410855043.8A patent/CN104448027B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5140304B2 (ja) * | 2007-04-05 | 2013-02-06 | 金秀バイオ株式会社 | フコキサンチンとフコイダンの同時製造方法 |
CN102321052A (zh) * | 2011-05-26 | 2012-01-18 | 天津市尖峰天然产物研究开发有限公司 | 综合利用海带提取纯化岩藻黄质和岩藻聚糖硫酸酯的方法 |
CN104093746A (zh) * | 2011-10-24 | 2014-10-08 | 华盛顿州立大学研究基金会 | 分步水热法从富油生物质中提取生物油和其他生物产品 |
CN102898539A (zh) * | 2012-09-21 | 2013-01-30 | 南京泽朗农业发展有限公司 | 一种利用亚临界水提取灵芝多糖的方法 |
CN103232552A (zh) * | 2013-04-24 | 2013-08-07 | 集美大学 | 一种酶法制备褐藻岩藻聚糖与岩藻黄素的方法 |
CN103880972A (zh) * | 2014-03-12 | 2014-06-25 | 江苏大学 | 一种亚临界水同步萃取多糖和蛋白质的方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104448027A (zh) | 2015-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104448027B (zh) | 从海带中提取岩藻聚糖硫酸酯和岩藻黄质的方法 | |
CN104592410A (zh) | 一种高效提取枸杞叶多糖的方法 | |
CN104292352B (zh) | 一种杜仲精粉、杜仲多糖及杜仲胶联产提取分离方法 | |
CN103720599B (zh) | 一种从山药皮渣中制备保湿剂的方法 | |
CN104231281A (zh) | 一种提取分离杜仲胶的方法 | |
CN105032282A (zh) | 一种高纯度皂荚天然表面活性剂的制备方法 | |
CN102807511B (zh) | 一种从贻贝中提取牛磺酸的方法 | |
CN103467617A (zh) | 一种连续逆流超声提取高***芪多糖的方法 | |
CN105535153A (zh) | 一种低温提取覆盆子活性成分的方法 | |
CN102389149A (zh) | 从槟榔嫩果中提取纯化多酚的方法 | |
CN105769737A (zh) | 一种具有修复皮肤紫外损伤作用的鲟鱼软骨胶原肽复配物及其制备方法 | |
CN103304532A (zh) | 一种从莲房中提取原花青素的方法 | |
CN104961839A (zh) | 一种特异性茯苓多糖配方颗粒的制备方法 | |
CN104592412A (zh) | 一种提取板栗多糖的方法 | |
CN103446339A (zh) | 一种黑果枸杞提取物的制备方法 | |
CN106496363A (zh) | 一种肝素钠的高效制备工艺 | |
CN103980730A (zh) | 一种高纯度火龙果色素的制备方法 | |
CN102784193A (zh) | 采用耦合技术制备红芪提取物的方法 | |
CN102731674B (zh) | 一种从丹参醇提残渣中提取丹参多糖的方法 | |
CN104844707A (zh) | 从螺旋藻中提取藻蓝色素的提取方法 | |
CN105566507A (zh) | 一种茶叶多糖的制备方法 | |
CN104788515B (zh) | 一种减压超声辅助提取制备高纯度水溶性橄榄苦甙的方法 | |
CN103554295A (zh) | 一种从海洋褐藻中提取制备低分子岩藻多糖的方法 | |
CN103665922A (zh) | 一种花青素≥25%的蓝莓提取物的生产工艺 | |
CN103804522A (zh) | 一种提高肝素钠纯度的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 264200 No. 20 Yong Jiang Street, Zhang Town, Huancui District, Shandong, Weihai Applicant after: Weihai Rensheng Group Co.,Ltd. Address before: 264200, Shandong, Weihai province Huancui District Zhang Village Road West Tianmu Applicant before: WEIHAI ZHIEN PHARMACEUTICAL Co.,Ltd. |
|
COR | Change of bibliographic data | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: 264200 No. 20 Yong Jiang Street, Zhang Town, Huancui District, Shandong, Weihai Patentee after: WEIHAI RENSHENG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 264200 No. 20 Yong Jiang Street, Zhang Town, Huancui District, Shandong, Weihai Patentee before: Weihai Rensheng Group Co.,Ltd. |
|
CP01 | Change in the name or title of a patent holder | ||
TR01 | Transfer of patent right |
Effective date of registration: 20240605 Address after: 264200 Yongjiang Street, Zhangcun Town, Huancui District, Weihai City, Shandong Province Patentee after: WEIHAI RENSHENG PHARMACEUTICAL Co.,Ltd. Country or region after: China Address before: 264200 Yongjiang Street, Zhangcun Town, Huancui District, Weihai City, Shandong Province Patentee before: WEIHAI RENSHENG PHARMACEUTICAL GROUP CO.,LTD. Country or region before: China |
|
TR01 | Transfer of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for extracting fucoidan sulfate and fucoidin from kelp Granted publication date: 20160824 Pledgee: Weihai commercial bank Limited by Share Ltd. revitalization branch Pledgor: WEIHAI RENSHENG PHARMACEUTICAL Co.,Ltd. Registration number: Y2024980022070 |