CN104447854B - Preparation method of phosphatidic acid sodium - Google Patents
Preparation method of phosphatidic acid sodium Download PDFInfo
- Publication number
- CN104447854B CN104447854B CN201410625592.6A CN201410625592A CN104447854B CN 104447854 B CN104447854 B CN 104447854B CN 201410625592 A CN201410625592 A CN 201410625592A CN 104447854 B CN104447854 B CN 104447854B
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- China
- Prior art keywords
- phosphatidic acid
- acid sodium
- preparation
- phosphatidic
- phosphatide
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Abstract
The invention relates to a preparation method of phosphatidic acid sodium, which belongs to the technical field of fine chemical engineering. The preparation method is characterized in that soybean phosphatidic acid, rapeseed phosphatidic acid and cotton seed phosphatidic acid are adopted as raw materials, the phosphatidic acid is dissolved in a certain amount of normal butanol, a phosphatidic acid solution is heated to a certain temperature, a 95% ethanol solution of sodium hydroxide is added while the solution is stirred to obtain phosphatidic acid sodium precipitates. The precipitates are washed by 95% ethanol for two times and then dried to obtain a phosphatidic acid sodium product.
Description
Technical field
A kind of preparation method of phosphatidic acid sodium, belongs to technical field of fine.
Technical background
Phosphatidic acid sodium is a kind of important surfactant, can be used for Fine Chemical and biomedicine field,
Recently liposome research field also has important use.China is production and the consumption big country of soybean oil, is also that phosphatide produces greatly
State.China in 2012 produces soybean oil per year and reaches 11,700,000 tons, and its accessory substance can obtain 50,000 tons about of phospholipid prod.Plus dish
Phosphatide and cottonseed phosphatide, its potential phosphatide yield reaches 150,000 tons about.In these phosphatide, only soybean lecithin obtains
Preferably develop, rapeseed phosphatide and cottonseed phosphatide are not still effectively developed mostly.The processing of these phosphatide
One of product is exactly phosphatidic acid, thus China's phosphatidic acid distant view yield is considerable.The preparation of therefore phosphatidic acid sodium is not only to big
Fabaceous Lecithin, rapeseed phosphatide and cottonseed phosphatide using having important practical significance, also Fine Chemical and biological medicine are led
Domain is significant.Preparation about phosphatidic acid sodium domestic at present it is not yet reported that, the invention discloses a kind of phosphatidic acid sodium
Preparation method, be industrial requirement phosphatidic acid sodium preparation open a kind of new approach.
Content of the invention
It is an object of the invention to provide a kind of preparation method of phosphatidic acid sodium.The method is with soybean lecithin acid, vegetable seed phosphorus
Resin acid and cottonseed phosphatidic acid are raw material, and phosphatidic acid is dissolved in a certain amount of n-butanol, heat phosphatide acid solution to uniform temperature, while stirring
Mix side and add NaOH 95% ethanol solution, obtain phosphatidic acid sodium precipitation.Precipitation is washed with 95% ethanol and is obtained after 2 dryings
Phosphatidic acid sodium product.
Technical scheme: it is an object of the invention to provide a kind of preparation method of phosphatidic acid sodium.The method with
Soybean lecithin acid, rapeseed phosphatide acid and cottonseed phosphatidic acid are raw material, weigh 100 grams of phosphatidic acids and are dissolved in the positive fourth of 1000ml～2000ml
In alcohol, heat phosphatide acid solution to 35～45 DEG C, be stirred with 200 revs/min of rotating speed, while stirring, 60～90
It is uniformly added into NaOH 95% ethanol solution of 250ml40% in minute, finish continuation stirring 10 minutes, normal temperature stands 30 points
Suction filtration after clock, filter cake 250ml95% ethanol washs 2 times, obtains more than 120 grams this product after vacuum drying, after measured its product
In product, the content of phosphatidic acid calcium reaches more than 75%.
Beneficial effects of the present invention: a kind of preparation method of phosphatidic acid sodium, provide a kind of simplicity for preparing phosphatidic acid sodium
Feasible method, the method is that the phosphatidic acid sodium preparation of industrial requirement opens a kind of new approach.
Specific embodiment
Embodiment 1
Weigh 100 grams of soybean lecithin acid to be dissolved in 1000ml n-butanol, heat phosphatide acid solution to 45 DEG C, with 200 revs/min
The rotating speed of clock is stirred, and while stirring, NaOH 95% ethanol being uniformly added into 250ml40% in 90 minutes is molten
Liquid, finishes continuation stirring 10 minutes, normal temperature standing suction filtration after 30 minutes.Filter cake washs 2 times with 250ml95% ethanol, and vacuum is done
120.6 grams of this product are obtained, in its product, the content of phosphatidic acid sodium reaches 75.8% after measured after dry.
Embodiment 2
Weigh 100 grams of soybean lecithin acid to be dissolved in 2000ml n-butanol, heat phosphatide acid solution to 35 DEG C, with 200 revs/min
The rotating speed of clock is stirred, and while stirring, NaOH 95% ethanol being uniformly added into 250ml40% in 60 minutes is molten
Liquid, finishes continuation stirring 10 minutes, normal temperature standing suction filtration after 30 minutes.Filter cake washs 2 times with 250ml95% ethanol, and vacuum is done
121.7 grams of this product are obtained, in its product, the content of phosphatidic acid calcium reaches 75.1% after measured after dry.
Embodiment 3
Weigh 100 grams of soybean lecithin acid to be dissolved in 1500ml n-butanol, heat phosphatide acid solution to 30 DEG C, with 200 revs/min
The rotating speed of clock is stirred, and while stirring, NaOH 95% ethanol being uniformly added into 250ml40% in 80 minutes is molten
Liquid, finishes continuation stirring 10 minutes, normal temperature standing suction filtration after 30 minutes.Filter cake washs 2 times with 250ml95% ethanol, and vacuum is done
121.2 grams of this product are obtained, in its product, the content of phosphatidic acid calcium reaches 76.4% after measured after dry.
Embodiment 4
Weigh 100 grams of rapeseed phosphatide acid to be dissolved in 1500ml n-butanol, heat phosphatide acid solution to 30 DEG C, with 200 revs/min
The rotating speed of clock is stirred, and while stirring, NaOH 95% ethanol being uniformly added into 250ml40% in 70 minutes is molten
Liquid, finishes continuation stirring 10 minutes, normal temperature standing suction filtration after 30 minutes.Filter cake washs 2 times with 250ml95% ethanol, and vacuum is done
123.2 grams of this product are obtained, in its product, the content of phosphatidic acid calcium reaches 77.8% after measured after dry.
Embodiment 5
Weigh 100 grams of cottonseed phosphatidic acids to be dissolved in 1500ml n-butanol, heat phosphatide acid solution to 45 DEG C, with 200 revs/min
The rotating speed of clock is stirred, and while stirring, NaOH 95% ethanol being uniformly added into 250ml40% in 90 minutes is molten
Liquid, finishes continuation stirring 10 minutes, normal temperature standing suction filtration after 30 minutes.Filter cake washs 2 times with 250ml95% ethanol, and vacuum is done
124.1 grams of this product are obtained, in its product, the content of phosphatidic acid calcium reaches 75.3% after measured after dry.
Claims (1)
1. a kind of preparation method of phosphatidic acid sodium, is characterized in that with soybean lecithin acid, rapeseed phosphatide acid and cottonseed phosphatidic acid be former
Material, weigh 100 grams of phosphatidic acids and be dissolved in 1000ml-2000ml n-butanol, heat phosphatide acid solution to 35-45 DEG C, with 200 turns/
The rotating speed of minute is stirred, and while stirring, is uniformly added into NaOH 95% second of 250ml40% in 60-90 minute
Alcoholic solution, finishes continuation stirring 10 minutes, normal temperature stand 30 minutes after suction filtration, filter cake 250ml95% ethanol washs 2 times, very
Sky obtains 120 grams of this product after being dried, and in its product, the content of phosphatidic acid sodium reaches 75% after measured.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625592.6A CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625592.6A CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104447854A CN104447854A (en) | 2015-03-25 |
| CN104447854B true CN104447854B (en) | 2017-01-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410625592.6A Expired - Fee Related CN104447854B (en) | 2014-11-06 | 2014-11-06 | Preparation method of phosphatidic acid sodium |
Country Status (1)
| Country | Link |
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| CN (1) | CN104447854B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109517007A (en) * | 2017-09-20 | 2019-03-26 | 丰益(上海)生物技术研发中心有限公司 | A kind of preparation method of phosphatide |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096814A (en) * | 1993-06-25 | 1994-12-28 | 杨鹄昉 | The quick preparation technology of natural phospholipid soap powder and single stage method thereof |
| JP2001078792A (en) * | 1999-09-14 | 2001-03-27 | Nof Corp | Production of phosphatidic acid alkali metal salt or phosphatidic acid ammonium salt |
| CN1075505C (en) * | 1999-12-30 | 2001-11-28 | 清华大学 | Preparation method of saturated phosphatidate and its salts |
| JP2001342196A (en) * | 2000-06-02 | 2001-12-11 | Nof Corp | Method for producing high-purity acidic phospholipid |
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2014
- 2014-11-06 CN CN201410625592.6A patent/CN104447854B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN104447854A (en) | 2015-03-25 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170118 Termination date: 20181106 |