CN104447286A - 一种易溶柠檬酸钙硒及其制备方法 - Google Patents
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- 239000011669 selenium Substances 0.000 title claims abstract description 41
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000001354 calcium citrate Substances 0.000 title abstract 7
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 title abstract 7
- 235000013337 tricalcium citrate Nutrition 0.000 title abstract 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 44
- 238000006243 chemical reaction Methods 0.000 claims abstract description 15
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000292 calcium oxide Substances 0.000 claims abstract description 9
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 24
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- 235000011941 Tilia x europaea Nutrition 0.000 claims description 24
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- 239000011575 calcium Substances 0.000 abstract description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 9
- 229910052791 calcium Inorganic materials 0.000 abstract description 9
- 235000013305 food Nutrition 0.000 abstract description 5
- 230000036541 health Effects 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 3
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 abstract 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
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Abstract
本发明涉及一种新的物质柠檬酸钙硒及其制备方法，包括以下步骤：(1)将无水柠檬酸、氧化钙和二氧化硒投入反应容器，磨碎后发生固相化学反应；(2)充分反应后，获得产品易溶柠檬酸钙硒。本发明的柠檬酸钙硒由柠檬酸、氧化钙和二氧化硒制备而成。可以同时补充钙和硒两种无机元素，溶于水，可以被身体吸收，其柠檬酸成分在体内起到抗菌消炎和消解结石的作用，是一种很好的保健养生产品，可以在各种食品和保健品中，可以得到广泛的应用。
Description
技术领域
本发明涉及生物化工医药食品领域，尤其是涉及一种新物质柠檬酸钙硒及其制备方法。
背景技术
钙是生物必需的元素。对人体而言，无论肌肉、神经、体液和骨骼中，都有用Ca2+结合的蛋白质。钙是人类骨、齿的主要无机成分，也是神经传递、肌肉收缩、血液凝结、激素释放和乳汁分泌等所必需的元素。钙约占人体质量的1.4％，参与新陈代谢，每天必须补充钙；人体中钙含量不足或过剩都会影响生长发育和健康，阳离子钙Ca2+具有壮骨、健牙、消炎、镇痛、维持神经与肌肉的正常兴奋性，有治疗过敏性疾病的功效。
硒Se是人、动物的营养添加剂，有机硒人体容易吸收。具有抗衰老、提高***活力和排毒的功效。可以预防心血管病，维持心脏正常运作；抗氧化，提高免疫功能；防治癌症、高血压、冠心病、心肌炎、克山病、大骨节病等。因此世界卫生组织建议每天补充200微克硒，可有效预防多种疾病的高发。美国医学科学院认为，硒的最低中毒量为每天900微克，每天从饮食和硒制品中摄入的硒的含量若不超过400微克是安全的。
柠檬酸C6H8O7是食品风味酸络合剂，可以用作抗菌消炎，由于柠檬酸可络合胆肾膀胱输尿管结石的草酸钙成易溶柠檬酸钙，亦可以使结石变小而消失。
当今国内外市场上易溶柠檬酸钙硒还没有出现
发明内容
本发明的目的在于填补现有技术的空白，提供一种易溶柠檬酸钙硒的合成方法。
本发明是通过以下技术方案实现的：
一种易溶柠檬酸钙硒的制备方法，包括以下步骤：
(1)将无水柠檬酸、氧化钙和二氧化硒投入反应容器，磨碎后发生固相化学反应；
(2)充分反应后，获得产品易溶柠檬酸钙硒。
进一步，所述步骤(1)投入无水柠檬酸、氧化钙和二氧化硒的摩尔比为2202：3301：1。
进一步，所述步骤(1)的反应容器为搅拌球磨机。
进一步，所述步骤(1)的化学反应在常温下进行。
进一步，所述步骤(1)的化学反应的反应时间为30分钟。
进一步，所述易溶柠檬酸钙硒的制备方法还包括步骤(3)：对反应结束的产物分装，包装获得成品。
本发明的另一目的是提供一种新的物质柠檬酸钙硒，其按照上述任一所述的制备方法制得。
与现有技术相比，本发明具有以下优点：
本发明制备得到的柠檬酸钙硒，又名枸橼酸钙硒，化学结构分子式SeCa3301(C6H5O7)2202·3303H2O，白色结晶粉末，分子量608323.3，含硒0.01％，含钙21.75％，含柠檬酸68.46％，含结晶水9.78％，纯度在99％以上，溶于水(0.82g Ca/100ml,25℃，0.0004g Se/100ml,25℃)。
本发明的柠檬酸钙硒由柠檬酸、氧化钙和二氧化硒制备而成。可以同时补充钙和硒两种无机元素，易溶于水，可以被身体吸收。可以起到壮骨、健牙、消炎、镇痛、维持神经与肌肉的正常兴奋性，起到过敏性疾病的辅助治疗功效； 此外，还具有抗衰老、提高***活力和排毒的功效，可以预防心血管病，维持心脏正常运作，抗氧化，提高免疫功能，防治癌症、高血压、冠心病、心肌炎、克山病、大骨节病等；其柠檬酸成分在体内起到抗菌消炎和消解结石的作用，是一种很好的保健养生产品，可以在各种食品和保健品中，可以得到广泛的应用。
具体实施方式
以下对本发明的优选实施例进行说明。这些实施例的用意只是说明性的，而不应理解为对本发明的限制。
本实施例为柠檬酸钙硒的制备方法，包括以下步骤：
(1)称取二氧化硒110.96g、氧化钙185120.1g和无水柠檬酸423092.3，将上述材料混合，投入搅拌球磨机进行固相化学反应，开机反应半小时，反应生成谷氨酸铵硒，化学反应式为：
SeO2+3301CaO+2202C6H8O7＝SeCa3301(C6H5O7)2202·3303H2O，
反应条件是常温；
(2)充分反应30分钟后，从搅拌球磨机中放出产物；
(3)将获得的成品充分反应后，获得产品柠檬酸钙硒晶体称重，得到易溶柠檬酸钙硒晶体608323.3g，然后包装成品。
本发明的柠檬酸钙硒由柠檬酸、氧化钙和二氧化硒制备而成。可以同时补充钙和硒两种无机元素，易溶于水，可以被身体吸收，其柠檬酸成分在体内起到抗菌消炎和消解结石的作用，是一种很好的保健养生产品，可以在各种食品和保健品中，可以得到广泛的应用。
以上仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的 技术人员来说，凡在本发明的精神和原则之内所做的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (7)
1.一种易溶柠檬酸钙硒的制备方法，包括以下步骤：
(1)将无水柠檬酸、氧化钙和二氧化硒投入反应容器，磨碎后发生固相化学反应；
(2)充分反应后，获得产品易溶柠檬酸钙硒。
2.根据权利要求1所述的易溶柠檬酸钙硒的制备方法，其特征在于：所述步骤(1)投入无水柠檬酸、氧化钙和二氧化硒的摩尔之比为2202：3301：1。
3.根据权利要求1所述的易溶柠檬酸钙硒的制备方法，其特征在于：所述步骤(1)的反应容器为搅拌球磨机。
4.根据权利要求1所述的易溶柠檬酸钙硒的制备方法，其特征在于：所述步骤(1)的化学反应在常温下进行。
5.根据权利要求1所述的易溶柠檬酸钙硒的制备方法，其特征在于：所述步骤(1)的化学反应的反应时间为30分钟。
6.根据权利要求1所述的易溶柠檬酸钙硒的制备方法，其特征在于：所述溶柠檬酸钙硒的制备方法还包括步骤(3)：对反应结束的产物分装，包装获得成品。
7.一种按照权利要求1～6任一所述的制备方法制备得到的易溶柠檬酸钙硒。
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|---|---|---|---|---|
| CN106699782A (zh) * | 2016-12-28 | 2017-05-24 | 李玉成 | 柠檬酸抗坏血酸氢钙锌及其制备方法和应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101050134A (zh) * | 2007-05-18 | 2007-10-10 | 吴礼树 | 一种螯合钙肥及其制备方法 |
| US7351853B2 (en) * | 2006-01-23 | 2008-04-01 | Albion Advanced Nutrition | Method of manufacturing a granular mineral composition |
| US20100080856A1 (en) * | 2008-09-26 | 2010-04-01 | Costantino Peter D | Method and composition for postoperative wound healing |
| CN101823954A (zh) * | 2010-06-03 | 2010-09-08 | 西陇化工股份有限公司 | 柠檬酸亚锡二钠的制备方法 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351853B2 (en) * | 2006-01-23 | 2008-04-01 | Albion Advanced Nutrition | Method of manufacturing a granular mineral composition |
| CN101050134A (zh) * | 2007-05-18 | 2007-10-10 | 吴礼树 | 一种螯合钙肥及其制备方法 |
| US20100080856A1 (en) * | 2008-09-26 | 2010-04-01 | Costantino Peter D | Method and composition for postoperative wound healing |
| CN101823954A (zh) * | 2010-06-03 | 2010-09-08 | 西陇化工股份有限公司 | 柠檬酸亚锡二钠的制备方法 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106699782A (zh) * | 2016-12-28 | 2017-05-24 | 李玉成 | 柠檬酸抗坏血酸氢钙锌及其制备方法和应用 |
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