CN104445142A - Glassy carbon for artificial trachea and preparation method of glassy carbon for artificial trachea - Google Patents

Glassy carbon for artificial trachea and preparation method of glassy carbon for artificial trachea Download PDF

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Publication number
CN104445142A
CN104445142A CN201410625934.4A CN201410625934A CN104445142A CN 104445142 A CN104445142 A CN 104445142A CN 201410625934 A CN201410625934 A CN 201410625934A CN 104445142 A CN104445142 A CN 104445142A
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parts
artificial trachea
polyacrylonitrile
vitreous carbon
titanium dioxide
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CN201410625934.4A
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CN104445142B (en
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潘林根
邱东成
刘乐峰
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Zhao Xiufang
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SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
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Priority to CN201610312354.9A priority Critical patent/CN105859293B/en
Application filed by SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd filed Critical SUZHOU VIVOTIDE BIOTECHNOLOGIES CO Ltd
Priority to CN201610310548.5A priority patent/CN106007719B/en
Priority to CN201610312351.5A priority patent/CN105999395B/en
Priority to CN201610310581.8A priority patent/CN106039397B/en
Priority to CN201610311124.0A priority patent/CN105800589B/en
Priority to CN201410625934.4A priority patent/CN104445142B/en
Priority to CN201610312249.5A priority patent/CN105948750B/en
Priority to CN201610310549.XA priority patent/CN105948749B/en
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    • C04B35/52—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbon, e.g. graphite
    • C04B35/524—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on carbon, e.g. graphite obtained from polymer precursors, e.g. glass-like carbon material
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61F2/02—Prostheses implantable into the body
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2002/046—Tracheae
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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Abstract

The invention discloses glassy carbon for an artificial trachea and a preparation method of the glassy carbon for the artificial trachea. The glassy carbon for the artificial trachea comprises the following raw materials in parts by weight: 40 to 100 parts of polyacrylonitrile, 30 to 40 parts of polysiloxane, 80 to 100 parts of cellulose acetate, 20 to 30 parts of polyvinyl chloride, 10 to 20 parts of tricalcium phosphate, 90 to 100 parts of potassium oxide, 20 to 70 parts of titanium dioxide and 60 to 90 parts of polydimethylsiloxane. The preparation method comprises the steps of uniformly mixing the polyacrylonitrile, the polysiloxane, the cellulose acetate, the polyvinyl chloride, the tricalcium phosphate, the potassium oxide, the titanium dioxide and the polydimethylsiloxane to obtain a mixture, smelting the mixture, cooling the mixture and forming the mixture; carrying out the carbonization treatment on the mixture in an oxygen-free medium, heating the mixture to 2000 to 3000 DEG C, and reacting for 1 to 2 hours. The glassy carbon is relatively good in stability, the elastic modulus is 22 to 24GPa, the fatigue strength is 93 to 100MPa, the compressive strength is 680 to 700MPa, and the bio-aging resistance is high.

Description

For the vitreous carbon and preparation method thereof of artificial trachea
Technical field
The present invention relates to biological medicine Material Field, particularly relate to a kind of vitreous carbon for artificial trachea and preparation method thereof.
Background technology
Vitreous carbon (GC) is a kind of novel carbon material. vitreous carbon, there is resistance to air loss and good conductivity, coefficient of thermal expansion is little, quality is hard and be easy to be polished to minute surface, unreactiveness, have the features such as higher hydrogen overpotential, is therefore applicable to the working electrode material doing electrochemistry and electroanalysis.Be referred to as vitreous carbon because of its port pattern and the similar glass of constitutional features, be almost invented by the Davison of Britain and Japanese Yamada for 1962 simultaneously.There is due to vitreous carbon the characteristics such as density is little, high temperature resistant, impermeabilisation, make it have been widely used at numerous areas such as chemical industry, metallurgical industry, electronic industry, biotechnology.
Vitreous carbon has resistance to air loss and good conductivity, coefficient of thermal expansion is little, quality is hard and be easy to be polished to minute surface, unreactiveness, have the features such as higher hydrogen overpotential, is therefore applicable to the working electrode material doing electrochemistry and electroanalysis.The form of electrode has bar-shaped, disk, rotating-disk, rotating ring disk electrode (r.r.d.e) etc.The potential range that glassy carbon electrode is suitable for is wider, both at negative potential district research inorganics, also can study many organic redox reactions occurred in positive potential district.Make matrix with it, mercury membrane glass-carbon electrode and chemically modified electrode can also be prepared.Electrode will carry out surface finish, chemical treatment and electrochemical treatment before use.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, provide a kind of vitreous carbon for artificial trachea and preparation method thereof, vitreous carbon resistance to biodeterioration can be strong.
In order to solve the problems of the technologies described above, the present invention by the following technical solutions:
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 40 ~ 100 parts, polysiloxane 30 ~ 40 parts, cellulose acetate 80 ~ 100 parts, polyvinyl chloride 20 ~ 30 parts, tricalcium phosphate 10 ~ 20 parts, potassium oxide 90 ~ 100 parts, titanium dioxide 20 ~ 70 parts, polydimethylsiloxane 60 ~ 90 parts.
As to further improvement of the present invention, for the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 70 parts, polysiloxane 35 parts, cellulose acetate 90 parts, polyvinyl chloride 25 parts, tricalcium phosphate 15 parts, potassium oxide 95 parts, titanium dioxide 50 parts, polydimethylsiloxane 70 parts.
As to further improvement of the present invention, the particle diameter of titanium dioxide is 40 ~ 150 μm.
As to further improvement of the present invention, the molecular weight of polyacrylonitrile is 10000 ~ 20000.
Present invention also offers a kind of preparation method of the vitreous carbon for artificial trachea.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2000 ~ 3000 DEG C of reaction 1 ~ 2h.
As to further improvement of the present invention, the carbonizing treatment time is 20 ~ 50min.
Beneficial effect: the vitreous carbon of prior art causes wherein metal ion to organize diffusion towards periphery due to bioenvironmental corrosion, vitreous carbon of the present invention can be applied as artificial trachea, not perishable diffusion, because the vitreous carbon biologically stable after carbonizing treatment is better, Young's modulus is 22 ~ 24GPa, fatigue strength is 93 ~ 100MPa, and ultimate compression strength is 680 ~ 700MPa, and resistance to biodeterioration can be strong.
Embodiment
Below in conjunction with specific embodiment, the invention will be further described.
embodiment 1
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 70 parts, polysiloxane 35 parts, cellulose acetate 90 parts, polyvinyl chloride 25 parts, tricalcium phosphate 15 parts, potassium oxide 95 parts, titanium dioxide 50 parts, polydimethylsiloxane 70 parts.
The particle diameter of titanium dioxide is 100 μm.
The molecular weight of polyacrylonitrile is 15000.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2500 DEG C of reaction 1.5h.
The carbonizing treatment time is 40min.
embodiment 2
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 40 parts, polysiloxane 30 parts, cellulose acetate 80 parts, polyvinyl chloride 20 parts, tricalcium phosphate 10 parts, potassium oxide 90 parts, titanium dioxide 20 parts, polydimethylsiloxane 60 parts.
The particle diameter of titanium dioxide is 40 μm.
The molecular weight of polyacrylonitrile is 10000.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2000 DEG C of reaction 1h.
The carbonizing treatment time is 20min.
embodiment 3
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 100 parts, polysiloxane 40 parts, cellulose acetate 100 parts, polyvinyl chloride 30 parts, tricalcium phosphate 20 parts, potassium oxide 100 parts, titanium dioxide 70 parts, polydimethylsiloxane 90 parts.
The particle diameter of titanium dioxide is 150 μm.
The molecular weight of polyacrylonitrile is 20000.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 3000 DEG C of reaction 2h.
The carbonizing treatment time is 50min.
embodiment 4
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 90 parts, polysiloxane 33 parts, cellulose acetate 85 parts, polyvinyl chloride 22 parts, tricalcium phosphate 12 parts, potassium oxide 93 parts, titanium dioxide 30 parts, polydimethylsiloxane 70 parts.
The particle diameter of titanium dioxide is 60 μm.
The molecular weight of polyacrylonitrile is 12000.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2200 DEG C of reaction 1.2h.
The carbonizing treatment time is 25min.
embodiment 5
For the vitreous carbon of artificial trachea, comprise the raw material of following parts by weight: polyacrylonitrile 80 parts, polysiloxane 38 parts, cellulose acetate 97 parts, polyvinyl chloride 28 parts, tricalcium phosphate 18 parts, potassium oxide 98 parts, titanium dioxide 60 parts, polydimethylsiloxane 80 parts.
The particle diameter of titanium dioxide is 130 μm.
The molecular weight of polyacrylonitrile is 18000.
For a preparation method for the vitreous carbon of artificial trachea, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2800 DEG C of reaction 1.8h.
The carbonizing treatment time is 40min.
comparative example 1
Identical with embodiment 1, difference is: be omitted in the step without carrying out carbonizing treatment in oxygen medium.
performance test
Measure the product performance of embodiment and comparative example, the results are shown in Table 1.
Table 1
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Comparative example 1
Elastic modulus G Pa 24 23 22 23 22 15
Fatigue strength MPa 100 97 93 94 95 67
Ultimate compression strength MPa 700 680 684 685 688 436
Conclusion: the vitreous carbon biologically stable after carbonizing treatment is better, can not as the vitreous carbon of prior art because bioenvironmental corrosion causes wherein metal ion to organize diffusion towards periphery, vitreous carbon Young's modulus of the present invention is 22 ~ 24GPa, fatigue strength is 93 ~ 100MPa, ultimate compression strength is 680 ~ 700MPa, and resistance to biodeterioration can be strong.

Claims (6)

1. for the vitreous carbon of artificial trachea, it is characterized in that, comprise the raw material of following parts by weight: polyacrylonitrile 40 ~ 100 parts, polysiloxane 30 ~ 40 parts, cellulose acetate 80 ~ 100 parts, polyvinyl chloride 20 ~ 30 parts, tricalcium phosphate 10 ~ 20 parts, potassium oxide 90 ~ 100 parts, titanium dioxide 20 ~ 70 parts, polydimethylsiloxane 60 ~ 90 parts.
2. the vitreous carbon for artificial trachea according to claim 1, it is characterized in that, comprise the raw material of following parts by weight: polyacrylonitrile 70 parts, polysiloxane 35 parts, cellulose acetate 90 parts, polyvinyl chloride 25 parts, tricalcium phosphate 15 parts, potassium oxide 95 parts, titanium dioxide 50 parts, polydimethylsiloxane 70 parts.
3. the vitreous carbon for artificial trachea according to claim 1, is characterized in that, the particle diameter of titanium dioxide is 40 ~ 150 μm.
4. the vitreous carbon for artificial trachea according to claim 1, is characterized in that, the molecular weight of polyacrylonitrile is 10000 ~ 20000.
5. based on the preparation method of the vitreous carbon for artificial trachea according to claim 1, it is characterized in that, comprise the following steps: polyacrylonitrile, polysiloxane, cellulose acetate, polyvinyl chloride, tricalcium phosphate, potassium oxide, titanium dioxide, polydimethylsiloxane mix, fusing, cooling forming; In without oxygen medium, carry out carbonizing treatment, be then warming up to 2000 ~ 3000 DEG C of reaction 1 ~ 2h.
6. the preparation method of the vitreous carbon for artificial trachea according to claim 5, is characterized in that, the carbonizing treatment time is 20 ~ 50min.
CN201410625934.4A 2014-11-10 2014-11-10 Vitreous carbon for artificial trachea and preparation method thereof Active CN104445142B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CN201610310548.5A CN106007719B (en) 2014-11-10 2014-11-10 A kind of preparation method of the strong vitreous carbon of resistance to biodeterioration energy, artificial trachea
CN201610312351.5A CN105999395B (en) 2014-11-10 2014-11-10 A kind of preparation method of vitreous carbon, artificial trachea
CN201610310581.8A CN106039397B (en) 2014-11-10 2014-11-10 The preparation method of vitreous carbon, artificial trachea
CN201610311124.0A CN105800589B (en) 2014-11-10 2014-11-10 A kind of vitreous carbon and its manufactured artificial trachea
CN201610312354.9A CN105859293B (en) 2014-11-10 2014-11-10 Vitreous carbon and its manufactured artificial trachea for artificial trachea
CN201610312249.5A CN105948750B (en) 2014-11-10 2014-11-10 Vitreous carbon and its manufactured artificial trachea
CN201410625934.4A CN104445142B (en) 2014-11-10 2014-11-10 Vitreous carbon for artificial trachea and preparation method thereof
CN201610310549.XA CN105948749B (en) 2014-11-10 2014-11-10 The preparation method of the strong vitreous carbon of resistance to biodeterioration energy, artificial trachea

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Application Number Priority Date Filing Date Title
CN201410625934.4A CN104445142B (en) 2014-11-10 2014-11-10 Vitreous carbon for artificial trachea and preparation method thereof

Related Child Applications (7)

Application Number Title Priority Date Filing Date
CN201610310549.XA Division CN105948749B (en) 2014-11-10 2014-11-10 The preparation method of the strong vitreous carbon of resistance to biodeterioration energy, artificial trachea
CN201610312249.5A Division CN105948750B (en) 2014-11-10 2014-11-10 Vitreous carbon and its manufactured artificial trachea
CN201610310548.5A Division CN106007719B (en) 2014-11-10 2014-11-10 A kind of preparation method of the strong vitreous carbon of resistance to biodeterioration energy, artificial trachea
CN201610312351.5A Division CN105999395B (en) 2014-11-10 2014-11-10 A kind of preparation method of vitreous carbon, artificial trachea
CN201610311124.0A Division CN105800589B (en) 2014-11-10 2014-11-10 A kind of vitreous carbon and its manufactured artificial trachea
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