CN104435200A - Chinese medicine composition for treating ulcerative colitis and preparation method of Chinese medicine composition - Google Patents

Chinese medicine composition for treating ulcerative colitis and preparation method of Chinese medicine composition Download PDF

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CN104435200A
CN104435200A CN201410842371.4A CN201410842371A CN104435200A CN 104435200 A CN104435200 A CN 104435200A CN 201410842371 A CN201410842371 A CN 201410842371A CN 104435200 A CN104435200 A CN 104435200A
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chinese medicine
medicine composition
herba
ulcerative colitis
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张冬
郝秀仙
薛莉
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • A61K36/515Gentiana
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention discloses a Chinese medicine composition for treating ulcerative colitis and a preparation method of the Chinese medicine composition. The Chinese medicine composition is prepared from Chinese medicines including, by weight, 35-49 parts of hairyvein agrimony, 30-42 parts of elephantopus scaber, 28-36 parts of water-chestnut roots, 20-31 parts of rhizoma atractylodis, 9-16 parts of jute leaves, 11-17 parts of Chinese pulsatilla roots, 8-13 parts of synedrella, 2-8 parts of geranium wilfordii, 1-7 parts of hedge hyssop and 8-13 parts of liquorice. The Chinese medicine composition is fine in treatment effect, has no toxic and side effects during treatment, and avoids recurrence after healing.

Description

A kind of Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine being used for the treatment of ulcerative colitis, belong to the field of Chinese medicines.
Background technology
Ulcerative colitis is a kind of agnogenic rectum and colonitis type of disease, may be relevant with Nervous and Mental Factors to infection, heredity, immunity, is Immunoinflammatory Disorders, the genus traditional Chinese medical science " intestinal is warded off ", " hemorrhoidal hamorrhage ", the sick category such as " having loose bowels ".Be mainly feelings will unsuccessful, eating and drinking without temperance, eating cold and uncooked food excessively, addicted to food, sweet greasy to cause taste impaired, raw in water is wet, strongly fragrant and heat-transformation, and pent up large intestine, internal organs gas is smooth, and coagulation of QI-blood forms." Jing Yue's complete work is had loose bowels ": " have loose bowels this, invariably by taste, if eating and drinking without temperance, frequently, so that taste are injured in daily life, then water be instead wet, and paddy be anti-stagnant, the gas of elite, can not defeatedization, are cause to close dirt decline and dysentery work ".Primary disease is multiple is born in 20 ~ 40 years old crowd, men and women's no significant difference.Western medicine primary disease effect is undesirable, and side effect is many.
Summary of the invention
Technical problem to be solved by this invention is: provide a kind of therapeutic effect good, the Chinese medicine composition of the ulcerative colitis had no side effect
For solving the problems of the technologies described above, the technical solution used in the present invention is:
The Chinese medicine composition for the treatment of ulcerative colitis of the present invention, be made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 35-49 part, Elephantopus scaber L. 30-42 part, Angiopteris magna Ching (Angiopteris majuscula Ching) 28-36 part, Rhizoma Atractylodis 20-31 part, Folium corchori 9-16 part, Radix Pulsatillae 11-17 part, golden waist 8-13 part, Herba Erodii 2-8 part, Herba Begoniae Yunnanensis 1-7 part, Radix Glycyrrhizae 8-13 part.
Preferably, the Chinese medicine composition of described treatment ulcerative colitis is made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 40 parts, Elephantopus scaber L. 36 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 33 parts, Rhizoma Atractylodis 26 parts, Folium corchori 13 parts, the Radix Pulsatillae 14 parts, 9 parts, golden waist, Herba Erodii 5 parts, Herba Begoniae Yunnanensis 4 parts, 10 parts, Radix Glycyrrhizae.
Preferably, the Chinese medicine composition of described treatment ulcerative colitis is made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 38 parts, Elephantopus scaber L. 33 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 30 parts, Rhizoma Atractylodis 23 parts, Folium corchori 11 parts, the Radix Pulsatillae 12 parts, 8 parts, golden waist, Herba Erodii 3 parts, Herba Begoniae Yunnanensis 2 parts, 8 parts, Radix Glycyrrhizae.
Preferably, the Chinese medicine composition of described treatment ulcerative colitis is made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 45 parts, Elephantopus scaber L. 40 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 35 parts, Rhizoma Atractylodis 29 parts, Folium corchori 15 parts, the Radix Pulsatillae 16 parts, 12 parts, golden waist, Herba Erodii 7 parts, Herba Begoniae Yunnanensis 6 parts, 12 parts, Radix Glycyrrhizae.
The present invention also provides the preparation method of the Chinese medicine composition of described treatment ulcerative colitis, comprises the following steps:
(1) get described medical material according to weight proportion, adding weight is medical material gross weight 5-8 water doubly, and 50-60 degree Celsius is soaked 10-18 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained.
Preferably, before immersion, the medical material in step (1) is ground to form 300-500 object powder.
The water temperature gradient that the invention provides in a kind of step (2) is elevated to the mode of boiling, specifically: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
One, general data:
This Chinese medicine composition is applied to clinical observation case 65 example, wherein man 31 example, female 34 example, 25 ~ 70 years old age.The shortest person's two weeks of the course of disease, most elder reaches half a year.
Two, diagnostic criteria:
(1) stool is rare clearly or as water sample, borborygmus of suffering from abdominal pain, fear of cold lack of appetite; (2) namely stomachache rush down, and rush down urgently lower, stool being yellowish-brown is dirty smelly, burning sensation of the anus, can with heating; (3) abdominal distention distending pain, defecates smelly as loses ovum, rushing down rear alleviation of pain, indigestion and loss of appetite, belching and acid regurgitation; (4) stomachache increased borborygmus and diarrhea, often send out because feelings will is smooth, rushing down rear pain delays; (5) large loose stool is thin, and accompany indigestion food, slightly oil-feed is greasy, just secondaryly increases, with spiritlessness and weakness; (6) rise morning and have loose bowels, stool accompanies indigestion food, umbilicus abdomen cold type of pain, and happiness is warm, coldness of the body with chills.
Three, usage and dosage:
Get Herba Agrimoniae 40 grams, Elephantopus scaber L. 36 grams, Angiopteris magna Ching (Angiopteris majuscula Ching) 33 grams, Rhizoma Atractylodis 26 grams, Folium corchori 13 grams, the Radix Pulsatillae 14 grams, 9 grams, golden waist, Herba Erodii 5 grams, Herba Begoniae Yunnanensis 4 grams, 10 grams, Radix Glycyrrhizae.Grind to form 700 object powder, add the water that weight is medical material gross weight 7 times, 55 degrees Celsius are soaked 16 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 4 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
Four, criterion of therapeutical effect:
(1) fully recover: stool is normal, other transference cures, and Clinical Laboratory is normal; (2) effective: times of defecation obviously reduces, other symptoms are improved; (3) invalid; Symptom has no improvement.
Five, therapeutic effect:
In this clinical observation case, take medicine 10-60 days, recovery from illness 51 example, effective 10 examples, invalid 4 examples.Treatment by Chinese herbs of the present invention is effective, and toxic and side effects does not occur treatments period, and no longer recurs after curing.
Detailed description of the invention
embodiment 1
The Chinese medicine composition of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Herba Agrimoniae 38 grams, Elephantopus scaber L. 33 grams, Angiopteris magna Ching (Angiopteris majuscula Ching) 30 grams, Rhizoma Atractylodis 23 grams, Folium corchori 11 grams, the Radix Pulsatillae 12 grams, 8 grams, golden waist, Herba Erodii 3 grams, Herba Begoniae Yunnanensis 2 grams, 8 grams, Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 8 times, 55 degrees Celsius are soaked 18 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 5 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 30 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
embodiment 2
The Chinese medicine composition of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Herba Agrimoniae 45 grams, Elephantopus scaber L. 40 grams, Angiopteris magna Ching (Angiopteris majuscula Ching) 35 grams, Rhizoma Atractylodis 29 grams, Folium corchori 15 grams, the Radix Pulsatillae 16 grams, 12 grams, golden waist, Herba Erodii 7 grams, Herba Begoniae Yunnanensis 6 grams, 12 grams, Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 67 times, 55 degrees Celsius are soaked 14 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
embodiment 3
The Chinese medicine composition of the treatment ulcerative colitis that the present embodiment provides is made up of the Chinese medicine of following weight grams: Herba Agrimoniae 35 grams, Elephantopus scaber L. 30 grams, Angiopteris magna Ching (Angiopteris majuscula Ching) 28 grams, Rhizoma Atractylodis 20 grams, Folium corchori 9 grams, the Radix Pulsatillae 11 grams, 8 grams, golden waist, Herba Erodii 2 grams, Herba Begoniae Yunnanensis 1 gram, 8 grams, Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment ulcerative colitis, comprises the following steps:
Get above-mentioned Chinese medicine, grind to form 400 object powder, add the water that weight is medical material gross weight 7 times, 55 degrees Celsius are soaked 13 hours;
Raised by water temperature gradient, water temperature raises 10 degrees Celsius in every 3 minutes, and often raises 10 degrees Celsius of maintenances 10 minutes, to boiling, keeps fluidized state 25 minutes, filters to obtain medicinal liquid and medicinal residues; Medicinal residues are repeated above-mentioned steps 3 times, merge the medicinal liquid of gained.
Consumption is each 300-400 milliliter, and twice daily, point early, late twice half an hour ante cibum warmly take.It within 7 days, is a course for the treatment of.
model case
Case 1:
Lee, man, 56 years old, continuous 1 week laxativeness, every day 2 times sooner or later, have minute quantity blood mucus just, blood condition was normal.Take decoction prepared by Chinese medicine composition of the present invention to suffer from diarrhoea after 5 days stopping; Continue to take defecated once a day after 30 days; Check not containing blood mucus just after 60 days, recovery from illness.
Case 2:
Wang, female, 42 years old, variable interval was suffered from diarrhoea, and every day at least 3 times, have grade fever symptom, leg joint is ached.Take decoction diarrhea frequency reduction after 3 days prepared by Chinese medicine composition of the present invention, heating paresthesia disappears; Suffer from diarrhoea after 7 days disappearance, leg joint is ached disappearance, within 2 days, once defecates; Continue to take and checked after 30 days, recovery from illness.

Claims (7)

1. treat the Chinese medicine composition of ulcerative colitis for one kind, be made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 35-49 part, Elephantopus scaber L. 30-42 part, Angiopteris magna Ching (Angiopteris majuscula Ching) 28-36 part, Rhizoma Atractylodis 20-31 part, Folium corchori 9-16 part, Radix Pulsatillae 11-17 part, golden waist 8-13 part, Herba Erodii 2-8 part, Herba Begoniae Yunnanensis 1-7 part, Radix Glycyrrhizae 8-13 part.
2. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 40 parts, Elephantopus scaber L. 36 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 33 parts, Rhizoma Atractylodis 26 parts, Folium corchori 13 parts, the Radix Pulsatillae 14 parts, 9 parts, golden waist, Herba Erodii 5 parts, Herba Begoniae Yunnanensis 4 parts, 10 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 38 parts, Elephantopus scaber L. 33 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 30 parts, Rhizoma Atractylodis 23 parts, Folium corchori 11 parts, the Radix Pulsatillae 12 parts, 8 parts, golden waist, Herba Erodii 3 parts, Herba Begoniae Yunnanensis 2 parts, 8 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, be made up of the Chinese medicine of following parts by weight: Herba Agrimoniae 45 parts, Elephantopus scaber L. 40 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 35 parts, Rhizoma Atractylodis 29 parts, Folium corchori 15 parts, the Radix Pulsatillae 16 parts, 12 parts, golden waist, Herba Erodii 7 parts, Herba Begoniae Yunnanensis 6 parts, 12 parts, Radix Glycyrrhizae.
5. the preparation method of the Chinese medicine composition of the treatment ulcerative colitis described in above-mentioned any one claim, comprises the following steps:
(1) get described medical material according to weight proportion, adding weight is medical material gross weight 5-8 water doubly, and 50-60 degree Celsius is soaked 10-18 hour;
(2) water temperature gradient in step (1) is elevated to boiling, keeps fluidized state 20-30 minute, filter to obtain medicinal liquid and medicinal residues;
(3) medicinal residues are repeated step (1) and step (2) 2-5 time, merge the medicinal liquid of gained.
6. preparation method according to claim 5, is characterized in that, before immersion, the medical material in step (1) is ground to form 300-500 object powder.
7. preparation method according to claim 5, is characterized in that, the mode that the water temperature gradient in step (2) is elevated to boiling is: within the every 3-5 of water temperature minute, raise 10 degrees Celsius, and often raises 10 degrees Celsius of maintenances 10 minutes.
CN201410842371.4A 2014-12-30 2014-12-30 Chinese medicine composition for treating ulcerative colitis and preparation method of Chinese medicine composition Pending CN104435200A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2098108C1 (en) * 1995-12-26 1997-12-10 Евгений Иванович Трифонов Apitherapeutic agent
CN101601743A (en) * 2008-06-10 2009-12-16 中山大学 A kind of pharmaceutical composition for the treatment of ulcerative colitis and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2098108C1 (en) * 1995-12-26 1997-12-10 Евгений Иванович Трифонов Apitherapeutic agent
CN101601743A (en) * 2008-06-10 2009-12-16 中山大学 A kind of pharmaceutical composition for the treatment of ulcerative colitis and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
徐丽等: "排毒清肠汤剂对溃疡性结肠炎豚鼠模型治疗作用的研究", 《吉林医药学院学报》 *

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Application publication date: 20150325