CN104432065A - Effervescent tablets with anti-fatigue effect and preparation method of effervescent tablets - Google Patents
Effervescent tablets with anti-fatigue effect and preparation method of effervescent tablets Download PDFInfo
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- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 94
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 74
- 230000000694 effects Effects 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 47
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 28
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims abstract description 27
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 26
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims abstract description 22
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims abstract description 22
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 15
- 229960004543 anhydrous citric acid Drugs 0.000 claims abstract description 14
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 13
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 12
- 229940013618 stevioside Drugs 0.000 claims abstract description 12
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000019202 steviosides Nutrition 0.000 claims abstract description 12
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 6
- 239000008118 PEG 6000 Substances 0.000 claims abstract description 3
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims abstract description 3
- 239000007788 liquid Substances 0.000 claims description 18
- 239000003826 tablet Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 230000008569 process Effects 0.000 claims description 15
- 239000000314 lubricant Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 9
- 210000001161 mammalian embryo Anatomy 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 235000020985 whole grains Nutrition 0.000 claims description 8
- 239000003205 fragrance Substances 0.000 claims description 4
- 238000007908 dry granulation Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 235000019640 taste Nutrition 0.000 abstract description 7
- 230000001684 chronic effect Effects 0.000 abstract description 2
- 230000004217 heart function Effects 0.000 abstract description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 2
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 2
- 235000009508 confectionery Nutrition 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000008821 health effect Effects 0.000 abstract 1
- 238000004080 punching Methods 0.000 description 60
- 238000013112 stability test Methods 0.000 description 18
- 229940079593 drug Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000005030 aluminium foil Substances 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000004806 packaging method and process Methods 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 238000004513 sizing Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 241000208843 Arctium Species 0.000 description 2
- 235000003130 Arctium lappa Nutrition 0.000 description 2
- 235000008078 Arctium minus Nutrition 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000222336 Ganoderma Species 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- 244000241838 Lycium barbarum Species 0.000 description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 2
- 235000018167 Reynoutria japonica Nutrition 0.000 description 2
- 240000001341 Reynoutria japonica Species 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
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- 239000008101 lactose Substances 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002740 Muscle Rigidity Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 235000013361 beverage Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses effervescent tablets with an anti-fatigue effect and a preparation method of the effervescent tablets. The effervescent tablets comprise the following main components: D-ribose, anhydrous citric acid, sodium hydrogen carbonate, sodium carbonate, PEG6000, stevioside and the like; and specifically, the effervescent tablets comprise the following components in percentage by mass: 10%-40% of D-ribose, 15%-60% of anhydrous citric acid, 10%-50% of sodium hydrogen carbonate, 1%-10% of sodium carbonate, 0.1%-15% of fruit essence or fruit powder and 0.1%-15% of stevioside. The prepared D-ribose effervescent tablets with the anti-fatigue effect tastes sour and sweet, and are palatable; and D-ribose in the effervescent tablets has the effects of improving heart functions, enhancing organism energy and resisting fatigues so that the effervescent tablets are particularly suitable for athletes, chronic patients and patients after operation to take and have the health effect when taken by weak people and healthy people.
Description
Technical field
The present invention relates to field of health care food, specifically relate to a kind of effervescent tablet with antifatigue effect and preparation method thereof.
Background technology
D-ribose is a kind of five-carbon ring aldehydo sugar that nature exists, and being present in all life cell, is the important component part of nucleic acid, coenzyme and cytogene, decides the growth of biological cell, division, growth, procreation, plays an important role to vital movement.The regeneration of the formation ATP of it and adenylate has close relationship, plays a crucial role, can promote the recovery of local organization ischemic, anoxic in heart and muscle metabolism.When heart CBF reduces, cardiac muscular tissue is in anaerobic condition, and lasting result consumes greatly by making the energy in tissue, and ATP contents level reduces rapidly, so directly have influence on the function of heart.Research proves, ribose application can alleviate or stop completely the reduction of experimental myocardial ATP metabolic pool, and supplementary ribose can improve the cardiac function of humans and animals, the resume speed of ATP after quickening myocardial ischemia, strengthen the exercise tolerance ability of heart patient, promote distributing again of thallium-201.Therefore, by oral D-ribose, the object of antifatigue, resist oxygen lack can be reached.There are some researches show, in some meat fibers, ATP regeneration needs 24 ~ 96 hours completely, and after supplementing D-ribose, can make the generating rate of ATP about 3 ~ 4 times soon, that is, the recovery that ATP stores can reduce to 6 ~ 24 hours from 24 ~ 96 hours, this can accelerate treatment because of kinetic DOMS, promotes the recovery of the human body of sportsman or overexercise.New research finds, supplements ribose and also contribute to increasing muscle quality and reducing fat in motion.Also can be used for simultaneously alleviate caused by MAD muscle rigidity, ache.In addition, D-ribose also have antitumor, antiviral, delay senility, prevent and treat the functions such as diabetes.
Along with the quickening of modern life rhythm, the aggravation of social competition, because the pressure etc. of work, study, fatigue becomes the health problem perplexing a lot of people, and people are also more and more urgent to requirement that is healthy and high-quality life.D-ribose has stronger hygroscopicity, not easily preserves and carries, and has not yet to see the report using D-ribose to prepare effervescent tablet.
Summary of the invention
The object of this invention is to provide a kind of effervescent tablet with antifatigue effect and preparation method thereof.This effervescent tablet taking convenience, mouthfeel is better, effervesce is rapid, drug release rate is fast, preparation technology is simple, there is the effect strengthening human body antifatigue, resist oxygen lack and prevention of various diseases, be specially adapted to sportsman, chronic patients and patients after surgery drink, weakling and Healthy People are taken with health role.
For achieving the above object, the present invention is by the following technical solutions:
There is an effervescent tablet for antifatigue effect, according to each component proportion of mass percentage be: D-ribose 10-40%, anhydrous citric acid 15-60%, sodium acid carbonate 10-50%, sodium carbonate 1-10%, odorant 0.1-15%, lubricant 0.1-10%, stevioside 0.1-15%.
Described lubricant is PEG6000.
Described odorant is fruit essence or fruit powder.
There is a preparation method for the effervescent tablet of antifatigue effect, comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven and toast 1-6 hour at 40-80 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine makes embryo sheet, then becomes after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) particle after sieving adds lubricant, is mixed by V-Mixer, uses THP-10 type flower basket type tablet press machine tabletted, i.e. the obtained effervescent tablet with antifatigue effect.
In described step (2), baking temperature is 55 DEG C, and baking time is 2 hours.
In described step (3) dry granulation process, it is 2.0-4.0Mpa that liquid rolls wheel pressure, and it is 9-12r/min that liquid rolls wheel speed.
Because D-ribose and anhydrous citric acid easily absorb water in malaria, for avoiding, in tableting processes, sticking occurs, and guarantee the quality of effervescent tablet, strictly controlled environment temperature and humidity is wanted in preparation process, in described step (4), during tabletting machine, compressing tablet room temperature is less than 28 DEG C, and relative humidity is less than 25%.
Acid source of the present invention is anhydrous citric acid, carbon dioxide source is sodium acid carbonate and sodium carbonate.
Compared with prior art, beneficial effect of the present invention is:
The present invention is by repeatedly optimizing, screening, determine the rational proportion of each composition in effervescent tablet, the advantage such as the effervesce time is short, liquid clarity is good, mouthfeel is good, stability is strong and effect is obvious that makes it have, has the feature of solid pharmaceutical preparation and liquid preparation concurrently, is easy to carry and preserves.In addition, outward appearance of the present invention and mouthfeel are like beverage, and fragrant odour, facilitates the colony of old man or dysphagia to take.D-ribose of the present invention is functional component and sweetener, after drinking the antifatigue effervescent tablet in the present invention, not only can well resist physical fatigue, build up health, simultaneously also can prevention of various diseases.
Detailed description of the invention
Explain the present invention further below in conjunction with embodiment, but embodiment not limiting in any form to the present invention, providing the object of these embodiments to be to make reader more comprehensively thorough to the understanding of disclosure in the present invention.
Embodiment 1
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, Cordyceps sinensis polysaccharide, taurine, matrimony vine, burdock compound sugar, oligoisomaltose, amino acid, lactose, the fleece-flower root, glossy ganoderma, sealwort, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 2 hours at 55 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 2.0Mpa, to roll wheel speed be 9r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 25 DEG C, and relative humidity is 20%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 1.
The parametric measurement results such as table 1:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 80 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 80 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 88 | Basic clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 90 | Basic clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 85 | Clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 90 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 82 | Clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 85 | Clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 85 | Clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 2.
Table 2: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 2 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Embodiment 2
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, Cordyceps sinensis polysaccharide, taurine, matrimony vine, burdock compound sugar, oligoisomaltose, amino acid, lactose, the fleece-flower root, glossy ganoderma, sealwort, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 6 hours at 40 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 3.0Mpa, to roll wheel speed be 10r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 20 DEG C, and relative humidity is 20%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 3.
The parametric measurement results such as table 3:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 82 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 80 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 85 | Clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 88 | Basic clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 80 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 85 | Basic clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 84 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 80 | Clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 85 | Clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 4.
Table 4: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 4 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Embodiment 3
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 1 hour at 80 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 4.0Mpa, to roll wheel speed be 12r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 15 DEG C, and relative humidity is 15%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 5.
The parametric measurement results such as table 5:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 82 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 81 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 80 | Clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 85 | Clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 84 | Clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 82 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 85 | Clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 84 | Clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 88 | Basic clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 6.
Table 6: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 6 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Embodiment 4
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 3 hours at 50 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 4.0Mpa, to roll wheel speed be 12r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 25 DEG C, and relative humidity is 10%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 7.
The parametric measurement results such as table 7:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 80 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 81 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 80 | Clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 83 | Clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 86 | Basic clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 82 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 85 | Clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 83 | Clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 88 | Clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 8.
Table 8: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 8 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Embodiment 5
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 1 hour at 80 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 2.5Mpa, to roll wheel speed be 10r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 22 DEG C, and relative humidity is 20%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 9.
The parametric measurement results such as table 9:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 82 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 81 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 83 | Clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 86 | Clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 81 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 85 | Clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 82 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 83 | Basic clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 85 | Clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 10.
Table 10: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 10 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Embodiment 6
The label composition that the present embodiment has the effervescent tablet of antifatigue effect is (in 10,000) by weight ratio:
The preparation method that the present embodiment has the effervescent tablet of antifatigue effect is: comprise the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven to toast 2 hours at 70 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine, wheel pressure is 4.0Mpa, to roll wheel speed be 9r/min to liquid to regulate the liquid of dry granulating machine to roll, sample after roasting is made embryo sheet, then become after granule to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) lubricant is added in particle after sizing, mixed by V-Mixer, use THP-10 type flower basket type tablet press machine tabletted, the i.e. obtained effervescent tablet with antifatigue effect, strictly controlled environment temperature and humidity is wanted in tableting processes, compressing tablet room temperature is 25 DEG C, and relative humidity is 15%.
10 batches that prepare for this formula of the present embodiment and the preparation method sheet shapes with the effervescent tablet sample of antifatigue effect, weight differential, pH value, disintegration time, the capable mensuration of clarity of solution, result is as shown in table 11.
The parametric measurement results such as table 11:10 batch effervesce blade shape, disintegration time
| Lot number | Sheet shape | Weight differential | PH value | Disintegration time/s | Clarity of solution |
| 131001 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 81 | Clear |
| 131002 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 80 | Clear |
| 131003 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 82 | Clear |
| 131004 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 83 | Clear |
| 131005 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.3 | 83 | Clear |
| 131006 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.1 | 81 | Clear |
| 131007 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 86 | Clear |
| 131008 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 82 | Clear |
| 131009 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.2 | 82 | Basic clear |
| 131010 | Sheet shape is good, without glutinous punching | Conform with the regulations | 4.0 | 85 | Clear |
Result shows: the effervescent tablet that the present embodiment has an antifatigue effect in process of production sheet shape is good, and without glutinous generation of rushing phenomenon, during effervescent tablet effervesce, disintegration is rapid, and complete drug dissolution, clarity of solution is good, meets Chinese Pharmacopoeia 2010 editions requirements.
From above-mentioned 10 batches, the sample of random picking 3 batches, carries out stability test.By after having the effervescent tablet polybag of antifatigue effect, aluminium foil bag double-layer seal packaging during test, be placed on temperature 40 DEG C, in the environment of relative humidity 75% 3 months, the end of each month is sampling and measuring index of correlation respectively, the results are shown in Table 12.
Table 12: the effervescent tablet stability test result with antifatigue effect
The effervescent tablet stability test result in table 12 with antifatigue effect shows, the effervescent tablet with antifatigue effect was placed after 3 months in hot and humid environment, compared with initial value, the indexs such as outward appearance, taste, content, acidity, disintegration time limited have no significant change, shows the effervescent tablet good stability prepared by the present embodiment.
Claims (7)
1. there is an effervescent tablet for antifatigue effect, it is characterized in that: according to each component proportion of mass percentage be: D-ribose 10-40%, anhydrous citric acid 15-60%, sodium acid carbonate 10-50%, sodium carbonate 1-10%, odorant 0.1-15%, lubricant 0.1-10%, stevioside 0.1-15%.
2. the effervescent tablet with antifatigue effect according to claim 1, is characterized in that: described lubricant is PEG6000.
3. the effervescent tablet with antifatigue effect according to claim 1 and 2, is characterized in that: described odorant is fruit essence or fruit powder.
4. a preparation method with the effervescent tablet of antifatigue effect according to claim 3, is characterized in that comprising the following steps: (1) takes D-ribose, anhydrous citric acid, sodium acid carbonate, sodium carbonate, stevioside according to prescription requirements amount, mixes; (2) mixed raw material is put into baking oven and toast 1-6 hour at 40-80 DEG C; (3) sample taken out after step (2) baking joins in dry granulating machine makes embryo sheet, then becomes after particle to cross the whole grain of 24 eye mesh screen through crusher in crushing, for subsequent use; (4) particle after sieving adds lubricant, is mixed by mixer, uses tablet press machine tabletted, i.e. the obtained effervescent tablet with antifatigue effect.
5. the preparation method with the effervescent tablet of antifatigue effect according to claim 4, is characterized in that: in described step (2), baking temperature is 55 DEG C, and baking time is 2 hours.
6. the preparation method with the effervescent tablet of antifatigue effect according to claim 5, is characterized in that: in described step (3) dry granulation process, and it is 2.0-4.0Mpa that liquid rolls wheel pressure, and it is 9-12 r/min that liquid rolls wheel speed.
7. the preparation method with the effervescent tablet of antifatigue effect according to claim 6, is characterized in that: in described step (4), during tabletting machine, compressing tablet room temperature is less than 28 DEG C, and relative humidity is less than 25%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951034A (en) * | 2017-12-01 | 2018-04-24 | 郑州拓洋生物工程有限公司 | Vitamin effervescent formulation and preparation method thereof |
| CN109527325A (en) * | 2018-11-20 | 2019-03-29 | 江苏汉典生物科技股份有限公司 | A kind of sports type effervescent tablet and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142357A (en) * | 1995-08-09 | 1997-02-12 | 黄强图 | Solid drink effervescive pellets and preparation thereof |
| CN1344516A (en) * | 2001-09-14 | 2002-04-17 | 卢济台 | Healthy effervescent tablet and its prepn |
| CN1421209A (en) * | 2001-11-26 | 2003-06-04 | 江苏省微生物研究所 | Ribose oral liquid |
| CN1720810A (en) * | 2004-07-16 | 2006-01-18 | 王桂凤 | A cool sugar tablet with fruit flavor and its production process |
| CN101756207A (en) * | 2008-10-20 | 2010-06-30 | 宁小静 | Health-care food |
| CN101890055A (en) * | 2010-07-20 | 2010-11-24 | 郭景龙 | Medicinal composition with anti-fatigue effect |
| CN102389116A (en) * | 2011-11-23 | 2012-03-28 | 武汉工程大学 | Effervescent tablet for alleviating physical fatigue and preparation technology thereof |
| CN103211141A (en) * | 2012-10-19 | 2013-07-24 | 莫海仪 | Application of anti-hypoxia and anti-fatigue oral composition in health product |
| CN104173370A (en) * | 2013-05-22 | 2014-12-03 | 上海诺成药业股份有限公司 | Calcium-containing effervescent tablet and preparation method and application |
-
2014
- 2014-12-18 CN CN201410800234.4A patent/CN104432065A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142357A (en) * | 1995-08-09 | 1997-02-12 | 黄强图 | Solid drink effervescive pellets and preparation thereof |
| CN1344516A (en) * | 2001-09-14 | 2002-04-17 | 卢济台 | Healthy effervescent tablet and its prepn |
| CN1421209A (en) * | 2001-11-26 | 2003-06-04 | 江苏省微生物研究所 | Ribose oral liquid |
| CN1720810A (en) * | 2004-07-16 | 2006-01-18 | 王桂凤 | A cool sugar tablet with fruit flavor and its production process |
| CN101756207A (en) * | 2008-10-20 | 2010-06-30 | 宁小静 | Health-care food |
| CN101890055A (en) * | 2010-07-20 | 2010-11-24 | 郭景龙 | Medicinal composition with anti-fatigue effect |
| CN102389116A (en) * | 2011-11-23 | 2012-03-28 | 武汉工程大学 | Effervescent tablet for alleviating physical fatigue and preparation technology thereof |
| CN103211141A (en) * | 2012-10-19 | 2013-07-24 | 莫海仪 | Application of anti-hypoxia and anti-fatigue oral composition in health product |
| CN104173370A (en) * | 2013-05-22 | 2014-12-03 | 上海诺成药业股份有限公司 | Calcium-containing effervescent tablet and preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| J.斯沃布里克 等: "《制剂技术百科全书》", 31 January 2009, 科学出版社 * |
| 张丽锋等: "维生素C泡腾片的制备", 《山西医科大学学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951034A (en) * | 2017-12-01 | 2018-04-24 | 郑州拓洋生物工程有限公司 | Vitamin effervescent formulation and preparation method thereof |
| CN109527325A (en) * | 2018-11-20 | 2019-03-29 | 江苏汉典生物科技股份有限公司 | A kind of sports type effervescent tablet and preparation method thereof |
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