CN104412983B - A kind of efficient bactericidal composite of fluorine-containing ether bacterium amide - Google Patents
A kind of efficient bactericidal composite of fluorine-containing ether bacterium amide Download PDFInfo
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Abstract
The invention discloses a kind of efficient bactericidal composite of fluorine-containing ether bacterium amide, the bactericidal composition containing active components A and active constituent B, wherein active components A are selected from fluorine ether bacterium amide, and active constituent B is selected from any one following compound：Cyazofamid, Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone, famoxadones, and active components A and the weight ratio of active constituent B are 1：80~60：1.The present composition has synergistic effect to the multiple diseases for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and disease is not likely to produce drug resistance.
Description
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of efficient bactericidal composite of fluorine-containing ether bacterium amide in crop disease
Application in evil.
Background technology
Fluorine ether bacterium amide (LH-2010A) selective fungicide fluopicolide more similar than structure has wider array of fungicidal spectrum.
Fluorine ether bacterium amide is to the bacteriostatic activity highest of cotton standing dead rhizoctonia and botrytis cinerea, to Phytophthora capsici and potato late blight
Germ has higher antibacterial work, and fluorine ether bacterium amide is apparent to cotton standing dead rhizoctonia bacteriostasis, can significantly inhibit its sclerotium
Generation and mycelium morphology factor, make mycelia branch increase, shorten, is thicker；Fluorine ether bacterium amide has various plants pathogen higher
Bacteriostatic activity, and can obviously inhibit the multinomial physical signs of cotton standing dead rhizoctonia.
Cyazofamid, Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone Huo famoxadones belong to common kill
Microbial inoculum is widely used in the disease of crops.
However, in the real process of agricultural production, the problem of controlling disease most easily produces is the production of disease drug resistance
It is raw.Different cultivars ingredient is compounded, and is to prevent the very common method of resistance disease.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of sterilization
All it is additive effect, really has the compounding of synergistic effect seldom, especially synergistic effect is clearly, synergy ratio is very high answers
With just less.It studies, is found fluorine ether bacterium amide and cyazofamid, Prochloraz or its salt, carbendazim, methyl sulphur by inventor
Can generate good synergistic effect after bacterium spirit, Fenamidone Huo famoxadones compounding, and about fluorine ether bacterium amide and cyazofamid,
The relevant report that Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone Huo famoxadones compound not yet discloses.
Invention content
There is synergistic function, the fluorine-containing ether bacterium acyl that use cost is low, preventive effect is good the purpose of the present invention is to propose to a kind of
The efficient bactericidal composite of amine.
The efficient bactericidal composite of fluorine-containing ether bacterium amide proposed by the present invention contains active components A and active constituent B, activity
It is 1 to be divided into A with active constituent B weight ratios：80~60：1, the active components A is selected from fluorine ether bacterium amide, active constituent B choosings
It is planted from one of cyazofamid, Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone Huo famoxadones, active components A
It is 1 with the preferred weight ratios of active constituent B：60~40：1；More preferably the weight ratio of fluorine ether bacterium amide and cyazofamid is 1：30
~30：1, fluorine ether bacterium amide is 1 with the weight ratio of Prochloraz or its salt：25~20：1, the weight of fluorine ether bacterium amide and carbendazim
Than being 1：35~20：1, the weight ratio of fluorine ether bacterium amide and thiophanate-methyl is 1：30~20：1, fluorine ether bacterium amide and imidazoles bacterium
The weight ratio of ketone is 1：30~30：1, the weight ratio of fluorine ether bacterium amide Yu famoxadones is 1：25~20：1；Most preferably fluorine ether
The weight ratio of bacterium amide and cyazofamid is 1：9~9：1, fluorine ether bacterium amide is 1 with the weight ratio of Prochloraz or its salt：9~5：1,
The weight ratio of fluorine ether bacterium amide and carbendazim is 1：14~4：1, the weight ratio of fluorine ether bacterium amide and thiophanate-methyl is 1：15~
5：1, the weight ratio of fluorine ether bacterium amide and Fenamidone is 1：9~9：1, the weight ratio of fluorine ether bacterium amide Yu famoxadones is 1：9
~4：1.
The efficient bactericidal composite of fluorine-containing ether bacterium amide proposed by the present invention is used to prevent the purposes of disease on crops, institute
The crops stated include cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit
Crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop；Institute
The disease stated includes gray mold, phytophthora root rot, epidemic disease, powdery mildew, downy mildew, scab, anthracnose, peronospora tabacina, head blight, sudden
Disease, spot defoliation, rice blast, bakanae disease, brown spot, sclerotiniose, leaf mold, leaf rot, banded sclerotial blight, shot hole or rust
Disease.
Active components A, the weight ratio of active constituent B are 1：80~60：1.The weight hundred of active component in usual composition
Divide content for the 0.5%~90% of total weight, preferably 5%~80%.According to different preparation types, active component content
Range is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；
Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of application when active component in water
Dispersion.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can used before through dilution or directly by user.Its preparation can be by usual
Processing method known in those skilled in the art prepare, i.e., after active material being mixed with liquid flux or solid carrier,
Add one kind in surfactant such as dispersant, stabilizer, wetting agent, binder, antifoaming agent, disintegrant, antifreeze
Or it is several.
The bactericidal composition of the present invention, can be processed into acceptable dosage form in any sterilization, wherein more preferably on demand
Dosage form be that wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or micro-capsule are outstanding
Floating-suspending agent, can also be made granule, seed coat agent, suspension seed-coating agent, ultra low volume liquids.
Composition includes following constituent content when wettable powder is made：Active components A 0.5%~60%, active constituent
B0.5%~80%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 0.5%~60%, active constituent
B0.5%~80%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binder 0~8%, filler
Surplus.
Composition includes following constituent content when suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, wetting agent 2%~10%, antifoaming agent 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, antifoaming agent 0.01%~2%, solvent 1%~15%, thickener 0~2%, breast
Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqueous emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, solvent 1%~30%, emulsifier 1%~15%, antifreeze 0~8%, thickener 0~2%, antifoaming agent
0.01%~2%, deionized water supplies surplus.
Composition includes following constituent content when microemulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, emulsifier 3%~25%, antifreeze 0~8%, antifoaming agent 0.01%~2%, is gone solvent 1%~30%
Ionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, organic solvent 1%~10%, emulsifier
1%~7%, antifoaming agent 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
It is ingredient B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~12%, wetting agent 1%~8%, organic
Solvent 1%~15%, emulsifier 1%~6%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~
5%, deionized water adds to 100%；
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
(1) fluorine ether bacterium amide and cyazofamid, Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone, oxazole bacterium
After ketone compounding, there is apparent synergy and lasting effect；(2) to cereal crops, legume crop, fibre crops, sugar crop, melon
Class crop, fruits crop, dry fruit crop, hobby crop, root crop, oil crops, flower crop, medicinal crop,
Disease on crop, green manure pasture crop has greater activity；(3) reduce pesticide usage amount, reduce pesticide and making
Residual quantity on object, alleviates environmental pollution；(4) to safety of human and livestock, Environmental compatibility is good；And preparation adhesion strength enhances, resistance to
Rain drop erosion.
Specific implementation mode
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~16 wettable powder of embodiment
Fluorine ether bacterium amide, active constituent B, dispersant, wetting agent, filler are uniformly mixed in mixed cylinder, through air-flow powder
Broken machine remixes uniformly after crushing, you can wettable powder product of the present invention is made, is specifically shown in Table 1.
1 embodiment of table, 1~16 each component and parts by weight
17~32 water dispersible granules of embodiment
Fluorine ether bacterium amide, active constituent B, dispersant, wetting agent, disintegrant, filler etc. are obtained through air-flow crushing together
The grain size needed adds other auxiliary agents such as binder (can add can be not added with), obtains granulation materials.Item is quantified into feeding fluidisation
In bed granulating drier after granulation and drying, you can water dispersible granules product of the present invention is made, is specifically shown in Table 2.
2 embodiment of table, 17~32 each component and parts by weight
It, can by cyazofamid, Fenamidone, thiophanate-methyl, carbendazim, cyazofamid, Prochloraz or its salt interchange in table 1,2
Novel formulation is made.
33~48 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), by high speed
Shear-mixed is uniform, fluorine ether bacterium amide, active constituent B is added, ball milling 2~3 hours, make diameter of particle all exist in the ball mill
5 μm hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 3.
3 embodiment of table, 33~48 each component and parts by weight
49~51 suspension emulsion of embodiment
Dispersant, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with) are mixed by high speed shear
Uniformly, fluorine ether bacterium amide is added, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm hereinafter, fluorine ether bacterium is made
Then active constituent B, solvent, emulsifier and various auxiliary agents are directly emulsified with high speed agitator and arrive suspending agent by amide suspending agents
In, surplus is supplied with deionized water, and suspension emulsion product of the present invention is made, is specifically shown in Table 4.
4 embodiment of table, 49~51 each component and parts by weight
52~61 aqueous emulsion of embodiment
Fluorine ether bacterium amide, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionization
Water, antifreeze (can add can be not added with), thickener (can add can be not added with), antifoaming agent mix, at uniform water phase.In high-speed stirring
It mixes down, oil phase is added in water phase, surplus is supplied with deionized water；Aqueous emulsion product of the present invention is can be prepared by, is specifically shown in
Table 5.
5 embodiment of table, 52~61 each component and parts by weight
Cyazofamid, Prochloraz, carbendazim, thiophanate-methyl, Fenamidone, famoxadones in table 3,5 are exchanged, can be made
Novel formulation.
62~64 microemulsion of embodiment
Fluorine ether bacterium amide, active constituent B, solvent, emulsifier, antifreeze (can add can be not added with), antifoaming agent are sufficiently mixed
At the oil phase of homogeneous transparent, it is slowly added into deionized water under stiring, forms WO emulsion, then agitated heating, makes
Rapid phase inversion at oil-in-water type, be cooled to room temperature and make up to balance, through filtering, surplus supplied with deionized water；It can be prepared by
Microemulsion product of the present invention, is specifically shown in Table 6.
6 embodiment of table, 6264 each component and parts by weight
Embodiment 65,66 microcapsule suspending agents
Fluorine ether bacterium amide, active constituent B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, cut
Under tangent condition, by oil phase be added to containing emulsifier, pH adjusting agent, dispersant aqueous phase solution in, surplus is mended with deionized water
Foot, two kinds of materials react in oil-water interfaces, form high score ascus wall, and it is outstanding that the well dispersed micro-capsule of the present composition is made
Floating agent product.Specifically it is shown in Table 7.
The real trip's example 65 of table 7,66 each components and parts by weight
Embodiment 67,68 microcapsule suspension-suspendinagent agents
Active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Profit agent, antifoaming agent, thickener (can add can be not added with) are uniformly mixed by high speed shear, fluorine ether bacterium amide are added, in the ball mill
Ball milling 2~3 hours makes diameter of particle all at 5 μm hereinafter, suspending agent is made, suspending agent is then added to microcapsules and is suspended
In the aqueous phase solution of agent, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent production of the present composition is made
Product are specifically shown in Table 8.
8 embodiment 67 of table, 68 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
It is fixed, define the synergy ratio (SR) after two kinds of medicaments compound by a certain percentage, SR<0.5 is antagonism, and 0.5≤SR≤1.5 are
Summation action, SR>1.5 be synergistic effect, on this basis, then carries out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 respectively by active constituent content
A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia
Rate method measures virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm (x), with minimum
Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC of each medicament50Value.Simultaneously according to Wadley method meters
Calculate two medicament different ratio synergy ratios (SR), SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, SR>
1.5 be synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active constituent B ratio shared in combination；
A is fluorine ether bacterium amide；
B is selected from one of cyazofamid, Prochloraz or its salt, carbendazim, thiophanate-methyl, Fenamidone, famoxadones kind.
Application Example two：
For trying disease：Cucumber downy mildew
Test medicine is provided by applicant.
Experimental design：Having for fluorine ether bacterium amide and cyazofamid active compound and the two different ratio mixture is determined by pilot study
Imitate inhibition concentration range.
Toxicity test result
9 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to cucumber downy mildew with cyazofamid
As shown in Table 9, fluorine ether bacterium amide is matched with cyazofamid 1：80~60：To the synergy ratio of cucumber downy mildew when 1
SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and cyanogen frost
The proportioning of azoles is 1：30~30：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide and cyanogen
The proportioning of white azoles is 1：9~9：When 1, synergistic effect is more prominent, and synergy ratio is 2.40 or more.It tests and finds through applicant
The optimum ratio of fluorine ether bacterium amide and cyazofamid is 30：1、20：1、15：1、10：1、6：1、5：1、4：1、3：1、2：1、1：1、1：
2、1：3、1：4、1：5、1：6、1：10、1：13、1：15、1：20、1：25、1：30, especially when fluorine ether bacterium amide and cyazofamid weight
Amount is than being 1：Synergy ratio is maximum when 1, and synergistic effect is the most apparent.
Application Example three
For trying disease：Rice blast
Test medicine is provided by applicant.
Experimental design：Having for fluorine ether bacterium amide and Prochloraz active compound and the two different ratio mixture is determined by pilot study
Imitate inhibition concentration range.
10 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to rice blast with Prochloraz
As shown in Table 10, fluorine ether bacterium amide is matched with Prochloraz 1：80~60：To the synergy ratio of rice blast when 1
SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and miaow are fresh
The proportioning of amine is 1：25~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium amide and miaow
The proportioning of fresh amine is 1：9~5：When 1, synergistic effect is more prominent, and synergy ratio is 2.40 or more.It tests and finds through applicant
The optimum ratio of fluorine ether bacterium amide and Prochloraz is 20：1、15∶1、10∶1、6：1、5：1、2：1、1：1、1：2、1：3、1：4、1：5、
1：6、1：7、1：8、1：9、1：10、1：13、1：15、1：20、1：25, especially when fluorine ether bacterium amide and Prochloraz weight ratio are 1：
Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example four
For trying disease：Watermelon blight
Test medicine is provided by applicant.
Experimental design：The salt active compound and the two different ratio mixture of fluorine ether bacterium amide and Prochloraz are determined by pilot study
Effective inhibition concentration range.
The salt of 11 fluorine ether bacterium amide of table and Prochloraz compounds the toxicity test analysis of results table to watermelon blight
As shown in Table 11, the salt of fluorine ether bacterium amide and Prochloraz proportioning is 1：80~60：To the synergy of watermelon blight when 1
Ratio SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide with
The proportioning of the salt of Prochloraz is 1：25~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more；When fluorine ether bacterium
The proportioning of the salt of amide and Prochloraz is 1：9~5：When 1, synergistic effect is more prominent, and synergy ratio is 2.40 or more.Through Shen
The optimum ratio for asking someone to test the salt for finding fluorine ether bacterium amide and Prochloraz is 20：1、15：1、10：1、6：1、5：1、2：1、1：1、
1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：13、1：15、1：20、1：25, especially when fluorine ether bacterium amide with
The salt weight ratio of Prochloraz is 1：Synergy ratio is maximum when 3, and synergistic effect is the most apparent.
Application Example five
For trying disease：Apple peels and cores
Test medicine is provided by applicant.
Experimental design：Having for fluorine ether bacterium amide and carbendazim active compound and the two different ratio mixture is determined by pilot study
Imitate inhibition concentration range.
12 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to apple peels and cores with carbendazim
As shown in Table 12, fluorine ether bacterium amide is matched with carbendazim 1：80~60：To the increasing of apple peels and cores when 1
Effect ratio SR is all higher than 1.5, illustrates the two in l：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide
Proportioning with carbendazim is 1：35~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.30 or more.Especially work as fluorine
Ether bacterium amide is 1 with carbendazim weight ratio：Synergy ratio is maximum when 7, and synergistic effect is the most apparent.
Application Example six
For trying disease：Flowers powdery mildew
Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and thiophanate methyl raw pesticide and the two different ratio mixture are determined by pilot study
Effective inhibition concentration range.
13 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to flowers powdery mildew with thiophanate-methyl
As shown in Table 13, fluorine ether bacterium amide is matched with thiophanate-methyl 1：80~60：To the synergy of flowers powdery mildew when 1
Ratio SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide with
The proportioning of thiophanate-methyl is 1：30~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more.Especially when
Fluorine ether bacterium amide is 1 with thiophanate-methyl weight ratio：Synergy ratio is maximum when 4, and synergistic effect is the most apparent.
Application Example seven
For trying disease：Downy mildew of garpe
Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide and Fenamidone active compound and the two different ratio mixture are determined by pilot study
Effective inhibition concentration range.
14 fluorine ether bacterium amide of table compounds the toxicity test analysis of results table to downy mildew of garpe with Fenamidone
As shown in Table 14, fluorine ether bacterium amide is matched with Fenamidone 1：80~60：To the synergic ratio of downy mildew of garpe when 1
Value SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, when fluorine ether bacterium amide and miaow
The proportioning of cycloheximide triazole is 1：30~30：When 1, synergistic effect is more prominent, and synergy ratio is 2.30 or more.Especially when fluorine ether
Bacterium amide is 1 with Fenamidone weight ratio：Synergy ratio is maximum when 1, and synergistic effect is the most apparent.
Application Example eight
For trying disease：Powdery mildew of cucumber
Test medicine is provided by applicant.
Experimental design：Fluorine ether bacterium amide Yu famoxadones active compound and the two different ratio mixture are determined by pilot study
Effective inhibition concentration range.
15 fluorine ether bacterium amide Yu famoxadones of table compound the toxicity test analysis of results table to powdery mildew of cucumber
As shown in Table 15, fluorine ether bacterium amide Yu famoxadones proportioning is 1：80~60：To the synergic ratio of powdery mildew of cucumber when 1
Value SR is all higher than 1.5, illustrates the two 1：80~60：Mixture shows synergistic effect in 1 range, as fluorine ether bacterium amide Yu Evil
The proportioning of cycloheximide triazole is 1：25~20：When 1, synergistic effect is more prominent, and synergy ratio is 2.25 or more.Especially when fluorine ether
Bacterium amide Yu famoxadone weight ratios are 1：Synergy ratio is maximum when 2, and synergistic effect is the most apparent.
It is found through experiment that：To gray mold, phytophthora root rot, the epidemic disease in various crop after fluorine ether bacterium amide and active constituent B compoundings
Disease, downy mildew, scab, anthracnose, peronospora tabacina, head blight, samping off, spot defoliation, rice blast, dislikes seedling at powdery mildew
The prevention of disease, brown spot, sclerotiniose, leaf mold, leaf rot, banded sclerotial blight, shot hole or rust has apparent synergistic effect, increases
Effect ratio SR is all higher than 1.5.
Effect experiment part：Test medicine is researched and developed by applicant, is provided, 20% fluorine ether bacterium amide suspending agents of comparison medicament
(autogamy), 100 grams per liter cyazofamid suspending agents (purchased in market), 25% Prochloraz missible oil (purchased in market), 25% carbendazol wettable powder
(purchased in market), 70% thiophanate-methyl wettable powder (purchased in market), 50% Fenamidone suspending agent (autogamy), 6.25% oxazole bacterium
Ketone wettable powder (autogamy).
Nine fluorine ether bacterium amide of Application Example and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness.
This test arrangement investigates powdery mildew of cucumber disease index before Xian District, Shanxi Province suburban area, medicine, occurs just in disease
Phase dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
16 fluorine ether bacterium amide of table and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 16, powdery mildew of cucumber can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, finds effectively prevent after fluorine ether bacterium amide is compounded with active constituent B cucumber downy mildew, epidemic disease, sclerotiniose, black
Star disease, samping off, control effect are above 96%, are better than the preventive effect of single dose, and preventive effect phase is long.To mark in experiment scope of medication
Target crop has no adverse effects.
Ten fluorine ether bacterium amide of Application Example and active constituent B and its compounding prevention graw mold of tomato test of pesticide effectiveness.
This test arrangement investigates graw mold of tomato disease index before Xian District, Shanxi Province suburban area, medicine, occurs just in disease
Phase dispenser 5 days after dispenser, investigates disease indexes and calculates preventive effect for 15 days, 30 days.Test result is as follows：
17 fluorine ether bacterium amide of table and active constituent B and its compounding prevention graw mold of tomato test of pesticide effectiveness
As can be seen from Table 17, graw mold of tomato can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, to be found effectively prevent leaf muld of tomato, epidemic disease, leaf rot after fluorine ether bacterium amide is compounded with active constituent B, is prevented
It controls effect and is above 95%, be better than the preventive effect of single dose, and preventive effect phase is long.To target crop without bad shadow in experiment scope of medication
It rings.
Ten monofluoro-ether bacterium amide of Application Example and Prochloraz or its salt and its compounding prevention rice blast drug effect examination
It tests.
This test arrangement investigates rice blast disease index before Shaanxi Province Hanzhong suburban area, medicine, occurs just in disease
Phase dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 7 days, 15 days.Test result is as follows：
18 fluorine ether bacterium amide of table and Prochloraz or its salt and its compounding prevention rice blast test of pesticide effectiveness
As can be seen from Table 18, fluorine ether bacterium amide and Prochloraz or its salt and its compounding prevention rice blast, through application
People, which tests, to be found effectively prevent rice sheath blight disease, bakanae disease, white powder after fluorine ether bacterium amide is compounded with Prochloraz or its salt
Disease, banded sclerotial blight, control effect are above 96%, are better than the preventive effect of single dose, and preventive effect phase is long.To target in experiment scope of medication
Crop has no adverse effects.
Ten difluoro ether bacterium amide of Application Example and active constituent B and its compounding prevention apple peels and cores drug effect
Experiment.
This test arrangement investigates apple peels and cores disease index before Shaanxi Province's Weinan City Baishui County, medicine, in disease
Evil early period of origination dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
19 fluorine ether bacterium amide of table and active constituent B and its compounding prevention apple peels and cores test of pesticide effectiveness
As can be seen from Table 19, fluorine ether bacterium amide and energy effectively preventing and treating apple-tree spot defoliation after active constituent B compoundings,
Through applicant test find fluorine ether bacterium amide with after active constituent B compounding can also effectively preventing and treating apple-tree powdery mildew, brown spot,
Scab, rust, control effect are above 96%, are better than the preventive effect of single dose, and preventive effect phase is long.To mark in experiment scope of medication
Target crop has no adverse effects.
Ten trifluoro bacterium amide of Application Example and active constituent B and its compounding prevention citrus scab test of pesticide effectiveness.
This test arrangement investigates citrus scab disease index before Shaanxi Province Hanzhong suburban area, medicine, occurs just in disease
Phase dispenser 10 days after dispenser, investigates disease indexes and calculates preventive effect for 20 days, 30 days.Test result is as follows：
20 fluorine ether bacterium amide of table and active constituent B and its compounding prevention citrus scab test of pesticide effectiveness
As can be seen from Table 20, citrus scab can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, to be found effectively prevent citrus anthracnose, powdery mildew, control effect after fluorine ether bacterium amide is compounded with active constituent B
It is above 96%, is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten tetrafluoro ether bacterium amide of Application Example and active constituent B and its compounding prevention downy mildew of garpe test of pesticide effectiveness.
This test arrangement investigates downy mildew of garpe disease index before Shaanxi Province Weinan City Dali County, medicine, occurs in disease
Initial stage dispenser 7 days after dispenser, investigates disease indexes and calculates preventive effect for 14 days, 25 days.Test result is as follows：
21 fluorine ether bacterium amide of table and active constituent B and its compounding prevention downy mildew of garpe test of pesticide effectiveness
As can be seen from Table 21, downy mildew of garpe can be effectively prevented after fluorine ether bacterium amide and active constituent B compoundings, through application
People, which tests, to be found effectively prevent uncinula necator, anthracnose, control effect after fluorine ether bacterium amide is compounded with active constituent B
It is above 95%, is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
The experiment by different places throughout the country obtains afterwards, fluorine ether bacterium amide with after active constituent B compounding to a variety of
Gray mold, phytophthora root rot, epidemic disease, powdery mildew, downy mildew on crop, anthracnose, peronospora tabacina, head blight, are dampinged off at scab
Disease, spot defoliation, rice blast, bakanae disease, brown spot, sclerotiniose, leaf mold, leaf rot, banded sclerotial blight, shot hole or rust etc.
The preventive effect of Common Diseases 95% or more, is better than single dose preventive effect, and synergistic effect is apparent.
Claims (4)
1. a kind of efficient bactericidal composite of fluorine-containing ether bacterium amide, effective active composition is active components A and active constituent B,
It is characterized in that：Active components A is 1: 30~30: 1 with active constituent B weight ratios, and the active components A is selected from fluorine ether bacterium acyl
Amine, active constituent B are cyazofamid.
2. the efficient bactericidal composite of fluorine-containing ether bacterium amide according to claim 1, it is characterised in that：Composition is made can
Wet powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-suspendinagent agent.
3. the efficient bactericidal composite of fluorine-containing ether bacterium amide according to claim 2 is used to prevent the use of disease on crops
On the way.
4. purposes according to claim 3, it is characterised in that：The disease is gray mold, phytophthora root rot, epidemic disease, white powder
Disease, downy mildew, scab, anthracnose, peronospora tabacina, head blight, samping off, spot defoliation, rice blast, bakanae disease, foxiness
Disease, sclerotiniose, leaf mold, leaf rot, banded sclerotial blight, shot hole or rust.
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| CN201310400958.5A CN104412983B (en) | 2013-08-28 | 2013-08-28 | A kind of efficient bactericidal composite of fluorine-containing ether bacterium amide |
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| CN109566634A (en) * | 2017-09-28 | 2019-04-05 | 佛山市盈辉作物科学有限公司 | The synergistic composition of bacterium azoles is disliked containing fluorine ether bacterium amide and dichloro |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139653A1 (en) * | 2009-06-04 | 2010-12-09 | Basf Se | Fungicidal mixtures comprising heteraromatic sulfonamides |
| CN102726401A (en) * | 2011-04-16 | 2012-10-17 | 青岛凯源祥化工有限公司 | Bactericidal composition containing fluopicolide and cyazofamid |
| CN102845426A (en) * | 2012-09-19 | 2013-01-02 | 山东省联合农药工业有限公司 | Bactericide combination containing fluorine ether bacteria amide and chlorothalonil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102754650A (en) * | 2012-07-24 | 2012-10-31 | 山东省联合农药工业有限公司 | Desflurane bacteria amide compound bactericide |
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2013
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139653A1 (en) * | 2009-06-04 | 2010-12-09 | Basf Se | Fungicidal mixtures comprising heteraromatic sulfonamides |
| CN102726401A (en) * | 2011-04-16 | 2012-10-17 | 青岛凯源祥化工有限公司 | Bactericidal composition containing fluopicolide and cyazofamid |
| CN102845426A (en) * | 2012-09-19 | 2013-01-02 | 山东省联合农药工业有限公司 | Bactericide combination containing fluorine ether bacteria amide and chlorothalonil |
Non-Patent Citations (1)
| Title |
|---|
| 氟醚菌酰胺液相色谱法含量的测定;张晓霞 等;《山东化工》;20120915;第41卷;第67-68、71页 * |
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| CN108812672A (en) | 2018-11-16 |
| CN104412983A (en) | 2015-03-18 |
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Effective date of registration: 20191209 Address after: 715500 Pucheng County High-tech Industrial Development Zone, Weinan City, Shaanxi Province Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 middle section of North Ring Road, Pucheng County, Shaanxi Patentee before: Zhang Tong |
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