CN104399038A - 一种治疗胃炎的药物及其制备方法 - Google Patents

一种治疗胃炎的药物及其制备方法 Download PDF

Info

Publication number
CN104399038A
CN104399038A CN201410703226.8A CN201410703226A CN104399038A CN 104399038 A CN104399038 A CN 104399038A CN 201410703226 A CN201410703226 A CN 201410703226A CN 104399038 A CN104399038 A CN 104399038A
Authority
CN
China
Prior art keywords
fructus
parched
stir
rhizoma
bran
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410703226.8A
Other languages
English (en)
Inventor
高春娟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201410703226.8A priority Critical patent/CN104399038A/zh
Publication of CN104399038A publication Critical patent/CN104399038A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/754—Evodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种治疗胃炎的药物及其制备方法，由砂仁、麸炒枳壳、党参、莱菔叶、建曲、焦山楂、炒麦芽、炮姜、制吴茱萸、炒白芍、麸炒白术、炙鸡内金、姜半夏、紫苏梗、茯苓、炒稻芽、木香、黄连、紫苏叶配伍组合而成，具有止痛消炎，补气益血，散瘀消肿，消食健胃，健脾和胃，宁心安神，治反胃、食积气滞、吐酸、呃逆的功效，疗效显著，毒副作用小。

Description

一种治疗胃炎的药物及其制备方法
技术领域
本发明涉及一种由中草药为原料药的中药组合物及其制备方法，具体的说是涉及一种治疗胃炎的药物及其制备方法。
背景技术
胃炎是多种不同病因引起的胃黏膜急性和慢性炎症，常伴有上皮损伤、黏膜炎症反应和上皮再生。胃炎是最常见的消化***疾病之一。按临床发病的缓急和病程长短，一般将胃炎分为急性胃炎和慢性胃炎。急性胃炎由多种病因引起的急性胃黏膜炎症。临床上急性发病，常表现为上腹部不适、隐痛等症状。慢性胃炎由各种病因引起的胃黏膜慢性炎症或萎缩性病变，临床上十分常见，约占接受胃镜检查患者的80%～90%，随年龄增长萎缩性病变的发生率逐渐增高。不同胃炎的临床表现会有所不同，常见的临床表现：上腹痛：大多数胃炎患者有上腹痛。上腹部疼痛多数无规律，与饮食无关。疼痛一般为弥漫性上腹部灼痛、隐痛、胀痛等。腹胀：部分患者会感腹胀。常常因为胃内潴留食物、排空延迟、消化不良所致。.嗳气有嗳气。表明胃内气体增多，经食管排出，使上腹饱胀暂时缓解。反复出血：出血是在胃炎基础上并发的一种胃黏膜急性炎症改变。其他症状 :食欲不振、反酸、恶心、呕吐、乏力、便秘或腹泻等。体征:检查时有上腹压痛，少数患者可有消瘦及贫血。
发明内容
本发明从临床医疗用药需求及中医组方辩证原则出发，提出一种治疗胃炎的药物及其制备方法。它是由以下重量份数配比的原料药制备而成的药剂：砂仁2-5g、麸炒枳壳8-12g、党参8-12g、莱菔叶13-17g、建曲10-14g、焦山楂10-14g、炒麦芽10-14g、炮姜4-8g、制吴茱萸2-4g、炒白芍18-22g、麸炒白术8-12g、炙鸡内金8-12g、姜半夏8-12g、紫苏梗8-12g、茯苓10-14g、炒稻芽10-14g、木香4-8g、黄连2-5g、紫苏叶2-6g。优选配比为：砂仁3g、麸炒枳壳10g、党参10g、莱菔叶15g、建曲12g、焦山楂12g、炒麦芽12g、炮姜6g、制吴茱萸2g、炒白芍20g、麸炒白术10g、炙鸡内金10g、姜半夏10g、紫苏梗10g、茯苓12g、炒稻芽12g、木香6g、黄连3g、紫苏叶4g。所述药剂为胶囊剂、片剂或丸剂。
所述胶囊剂、片剂、丸剂的制备方法步骤如下： 
（1）取方中砂仁、麸炒枳壳、党参、莱菔叶、建曲、焦山楂、炒麦芽、炮姜、制吴茱萸、炒白芍、麸炒白术、炙鸡内金、姜半夏、紫苏梗、茯苓、炒稻芽、木香、黄连、紫苏叶粉碎筛析；
（2）将步骤（1）中筛制的混合物加水煎煮2-3次，合并煎液、过滤，将虑液浓缩成70-80度时，胶囊、丸剂相对密度为1.0-1.6的稠膏，片剂相对密度为1.0-1.4的稠膏；
（3）制作胶囊、丸剂时：
将稠膏分离纯化、干燥，制成干颗粒；将步骤干颗粒混合均匀，填充胶囊内即制成胶囊；将干颗粒喷加炼蜜、混合均匀，制成小丸即制成丸剂；
制作片剂时：
将2-4份淀粉与步骤（2）中的稠膏混合均匀，制成颗粒、干燥，制成干颗粒，将干颗粒压制成片剂，包糖衣，即制成片剂。
步骤（2）中所述的混合物，加水煎煮的优选次数为2次，第一次为60-80分钟，第二次为40-60分钟。
有益效果
本发明中药组合物原料药药理如下：
砂仁：主要作用于人体的胃、肾和脾，能够行气调味，和胃醒脾；
麸炒枳壳：气宽中，行滞消胀，用于胸胁气滞，胀满疼痛，食积不化，痰饮内停，胃下垂，脱肛，子官脱垂，治反胃，霍乱泻痢，消食，破症结痃癖，五膈气；
党参：补中，益气，生津，治脾胃虚弱，气血两亏，体倦无力，食少，口渴，久泻，脱肛；
莱菔叶：具有消食，理气，化痰，止咳，清肺利咽，散瘀消肿的功效。主治食积气滞，脘腹痞满，吐酸，呃逆，泄泻，痢疾，咽喉肿痛，咳痰，音哑，妇女***肿痛，乳汁不通，外治损伤瘀肿等症；
建曲：解表和中。用于寒热头痛，食滞阻中，呕吐胀满；
焦山楂：消食健胃，行气散瘀。用于肉食积滞，胃脘胀满，泻痢腹痛，瘀血经闭，产后瘀阻，心腹刺痛，疝气疼痛；高脂血症，焦山楂消食导滞作用增强，用于肉食积滞，泻痢不爽；
炒麦芽：主治食积不消，脘腹胀痛，脾虚食少；
炮姜：温中散寒，温经止血。用于脾胃虚寒，腹痛吐泻，吐衄崩漏，阳虚失血；现代医学发现，其能显著的缩短出血和凝血时间，对应激性及幽门结扎型胃溃疡、醋酸诱发的胃溃疡均有抑制作用；
制吴茱萸：药性辛、苦热，有小毒，归肝、脾、胃、肾经，具有散寒止痛，降逆止呕，助阳止泻的功效；
炒白芍：别名：白芍、花子、金芍药、杭芍、大白芍、生白芍、炒白芍、炒杭芍、酒白芍、醋白芍、焦白芍、白芍炭等。白芍药（学名：Paeonia lactiflora Pall.）也称白花芍药，是毛茛科芍药属植物。在中国已有悠久的栽培历史，驰名中外，其根并入药。多年生草本或亚灌木，生于山坡、山谷的灌木丛或草丛中。我国大部分地区都栽植。化学成分：芍药甙、牡丹酚、芍药花甙，尚含苯甲酸、挥发油、脂肪油、树脂、鞣质、糖、淀粉、粘液质、蛋白质、β－谷甾醇和三萜类等。药性功效：白芍性凉，味苦酸，微寒，具有补血养血、平抑肝阳、柔肝止痛、敛阴止汗等功效，适用于阴虚发热、***、胸腹胁肋疼痛、四肢挛急，泻痢腹痛、自汗盗汗、崩漏、带下等症。芍药甙有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。白芍煎剂能抑制痢疾杆菌、肺炎链球菌、大肠杆菌、伤寒杆菌、溶血性链球菌、绿脓杆菌等。具有补气益血、滋养调理血气，疏通人的肝部平复肝部虚火，止痛消炎，对人体阴气尤其是女性具有很好地治疗作用；
麸炒白术：能缓和燥性，借麸入中，增强健脾、消肿作用；
炙鸡内金：用于消化不良、遗精盗汗等症，效果极佳；
姜半夏：主治：降逆止呕。用于呕吐反胃，胸脘痞闷，梅核气；
紫苏梗：用于脾胃气滞，胸闷呕吐；
茯苓：具有渗湿利水，健脾和胃，宁心安神的功效；
炒稻芽：和中消食，健脾开胃，用于食积不消，腹胀口臭，脾胃虚弱，不饥食少；
木香：具有行气，止痛，健脾，消食的功效；
黄连：具有抗菌、抗真菌、抗病毒、抗阿米巴、抗炎、抗腹泻、抗溃疡作用，用于肝胃不和，呕吐吞酸，寒热互结，湿热中阻，痞满呕吐；
紫苏叶：用于脾胃气滞，胸闷，呕吐之证，治胃炎，具有解热镇静，抑菌，促肠蠕动的作用。
本发明以炒白芍为君药，消炎止痛，治疗胃炎。
以莱菔叶、建曲、焦山楂、炒麦芽、茯苓、炒稻芽为臣药，消食理气，化痰止咳，清肺利咽，散瘀消肿，解表和中，消食健胃，行气散瘀，和中消食，健脾开胃，宁心安神，治疗食滞阻中、呕吐胀满。
以麸炒枳壳、党参、麸炒白术、炙鸡内金、姜半夏、紫苏梗为佐药，用于补气益血、滋养调理血气，治疗食积气滞，吐酸，呃逆，脘腹痞满，肉食积滞，胃脘胀满，食积不消，脘腹胀痛，脾虚食少，腹胀口臭，脾胃虚弱，不饥食少，胀满疼痛，食积不化，行滞消胀，反胃食少，消肿消食，脾胃虚弱，气血两亏，体倦无力，消化不良，呕吐反胃，胸脘痞闷，脾胃气滞，胸闷呕吐。
使以炮姜、木香、紫苏叶、砂仁、制吴茱萸、黄连，用于温中散寒，温经止血，行气，止痛，健脾，消食，解热镇静，抑菌，促肠蠕动。
本发明所述的药物承中医之精髓、严谨组方，诸药君臣佐使合用，补破结合、相得益彰，符合中医用药规律和辨证施治的原则。
本发明的中药组合物具有止痛消炎，补气益血，散瘀消肿，消食健胃，健脾和胃，宁心安神，治反胃、食积气滞、吐酸、呃逆的功效，成效显著，毒副作用小。
临床试验：
1、  选择病例：
2003年-2013年，临床病例867例，男543，女324例，年龄17-72岁；
2、  诊断标准
上腹痛：大多数胃炎患者有上腹痛。上腹部疼痛多数无规律，与饮食无关。疼痛一般为弥漫性上腹部灼痛、隐痛、胀痛等。腹胀：部分患者会感腹胀。常常因为胃内潴留食物、排空延迟、消化不良所致。.嗳气有嗳气。表明胃内气体增多，经食管排出，使上腹饱胀暂时缓解。反复出血：出血是在胃炎基础上并发的一种胃黏膜急性炎症改变。其他症状 :食欲不振、反酸、恶心、呕吐、乏力、便秘或腹泻等。体征:检查时有上腹压痛，少数患者可有消瘦及贫血。
3、  治疗方案
服用实施例2中胶囊，每次4粒，每粒0.3g，早中晚各一次，10天为一个疗程。
4、  疗效评价标准
痊愈： 临床症状消失，胃镜X线所见胃黏膜恢复正常；
有效：临床主要症状基本消失或缓解，胃镜X线所见胃黏膜好转或病变范围缩小50%以上；
无效：临床主要症状无明显改善，胃镜X线所见胃黏膜无明显变化；
总有效率=痊愈率+有效率。
5、  数据统计
病例数 痊愈 有效 无效 痊愈率 总有效率
867例 721 112 34 83.16% 96.08%
6、  结论
本发明配伍药物，867例胃炎患者，痊愈721例，痊愈率达83.16%，有效112例，无效34例，总有效率达96.08%，成效显著。
急毒性试验：较大剂量和较长疗程服用对大鼠的生长无显著毒性，对大鼠的脑、心、肝、肾等切片形态学检查未见明显毒性损伤改变，试验显示，本药物毒性甚小。
具体实施方式
实施例1：一种治疗胃炎的药物及其制备方法。它是由以下重量份数配比的原料药制备而成的药剂：砂仁2-5g、麸炒枳壳8-12g、党参8-12g、莱菔叶13-17g、建曲10-14g、焦山楂10-14g、炒麦芽10-14g、炮姜4-8g、制吴茱萸2-4g、炒白芍18-22g、麸炒白术8-12g、炙鸡内金8-12g、姜半夏8-12g、紫苏梗8-12g、茯苓10-14g、炒稻芽10-14g、木香4-8g、黄连2-5g、紫苏叶2-6g。所述药剂为胶囊剂、片剂或丸剂。
按照下述重量份数配比称取原料药：
砂仁2-5g、麸炒枳壳8-12g、党参8-12g、莱菔叶13-17g、建曲10-14g、焦山楂10-14g、炒麦芽10-14g、炮姜4-8g、制吴茱萸2-4g、炒白芍18-22g、麸炒白术8-12g、炙鸡内金8-12g、姜半夏8-12g、紫苏梗8-12g、茯苓10-14g、炒稻芽10-14g、木香4-8g、黄连2-5g、紫苏叶2-6g。
所述胶囊剂、片剂、丸剂的制备方法步骤如下： 
（1）取方中砂仁、麸炒枳壳、党参、莱菔叶、建曲、焦山楂、炒麦芽、炮姜、制吴茱萸、炒白芍、麸炒白术、炙鸡内金、姜半夏、紫苏梗、茯苓、炒稻芽、木香、黄连、紫苏叶粉碎筛析；
（2）将步骤（1）中筛制的混合物加水煎煮2-3次，合并煎液：过滤，将虑液浓缩成70-80度时，胶囊：丸剂相对密度为1.0-1.6的稠膏，片剂相对密度为1.0-1.4的稠膏；
（3）制作胶囊、丸剂时：
将稠膏分离纯化、干燥，制成干颗粒；将步骤干颗粒混合均匀，填充胶囊内即制成胶囊；将干颗粒喷加炼蜜、混合均匀，制成小丸即制成丸剂；
制作片剂时：
将2-4份淀粉与步骤（2）中的稠膏混合均匀，制成颗粒：干燥，制成干颗粒，将干颗粒压制成片剂，包糖衣，即制成片剂。
步骤（2）中所述的混合物，加水煎煮的优选次数为2次，第一次为60-80分钟，第二次为40-60分钟。
实施例2：一种治疗胃炎的药物及其制备方法。它是由以下重量份数配比的原料药制备而成的药剂：砂仁3g、麸炒枳壳10g、党参10g、莱菔叶15g、建曲12g、焦山楂12g、炒麦芽12g、炮姜6g、制吴茱萸2g、炒白芍20g、麸炒白术10g、炙鸡内金10g、姜半夏10g、紫苏梗10g、茯苓12g、炒稻芽12g、木香6g、黄连3g、紫苏叶4g。所述药剂为胶囊剂、片剂或丸剂。
按照下述重量份数配比称取原料药：
砂仁3g、麸炒枳壳10g、党参10g、莱菔叶15g、建曲12g、焦山楂12g、炒麦芽12g、炮姜6g、制吴茱萸2g、炒白芍20g、麸炒白术10g、炙鸡内金10g、姜半夏10g、紫苏梗10g、茯苓12g、炒稻芽12g、木香6g、黄连3g、紫苏叶4g。
所述胶囊剂、片剂、丸剂的制备方法步骤如下： 
（1）取方中砂仁、麸炒枳壳、党参、莱菔叶、建曲、焦山楂、炒麦芽、炮姜、制吴茱萸、炒白芍、麸炒白术、炙鸡内金、姜半夏、紫苏梗、茯苓、炒稻芽、木香、黄连、紫苏叶粉碎筛析；
（2）将步骤（1）中筛制的混合物加水煎煮2-3次，合并煎液：过滤，将虑液浓缩成70-80度时，胶囊：丸剂相对密度为1.0-1.6的稠膏，片剂相对密度为1.0-1.4的稠膏；
（3）制作胶囊：丸剂时：
将稠膏分离纯化、干燥，制成干颗粒；将步骤干颗粒混合均匀，填充胶囊内即制成胶囊；将干颗粒喷加炼蜜、混合均匀，制成小丸即制成丸剂；
制作片剂时：
将2-4份淀粉与步骤（2）中的稠膏混合均匀，制成颗粒：干燥，制成干颗粒，将干颗粒压制成片剂，包糖衣，即制成片剂。
步骤（2）中所述的混合物，加水煎煮的优选次数为2次，第一次为60-80分钟，第二次为40-60分钟。
实施例3：本发明药物还可以为汤剂、口服液、颗粒剂等。

Claims (5)

1.一种治疗胃炎的药物，其特征在于它是由以下重量份数配比的原料药制备而成的药剂：砂仁2-5g、麸炒枳壳8-12g、党参8-12g、莱菔叶13-17g、建曲10-14g、焦山楂10-14g、炒麦芽10-14g、炮姜4-8g、制吴茱萸2-4g、炒白芍18-22g、麸炒白术8-12g、炙鸡内金8-12g、姜半夏8-12g、紫苏梗8-12g、茯苓10-14g、炒稻芽10-14g、木香4-8g、黄连2-5g、紫苏叶2-6g。
2.根据权利要求1所述的治疗胃炎的药物，其特征在于它是由以下重量份数配比的原料药制备而成的药剂：砂仁3g、麸炒枳壳10g、党参10g、莱菔叶15g、建曲12g、焦山楂12g、炒麦芽12g、炮姜6g、制吴茱萸2g、炒白芍20g、麸炒白术10g、炙鸡内金10g、姜半夏10g、紫苏梗10g、茯苓12g、炒稻芽12g、木香6g、黄连3g、紫苏叶4g。
3.根据权利要求1或2所述的治疗胃炎的药物，其特征在于：所述药剂为胶囊剂、片剂或丸剂。
4.根据权利要求3所述的治疗胃炎的药物，其特征在于：所述胶囊剂、片剂、丸剂的制备方法步骤如下： 
（1）取方中砂仁、麸炒枳壳、党参、莱菔叶、建曲、焦山楂、炒麦芽、炮姜、制吴茱萸、炒白芍、麸炒白术、炙鸡内金、姜半夏、紫苏梗、茯苓、炒稻芽、木香、黄连、紫苏叶粉碎筛析；
（2）将步骤（1）中筛制的混合物加水煎煮2-3次，合并煎液、过滤，将虑液浓缩成70-80度时，胶囊、丸剂相对密度为1.0-1.6的稠膏，片剂相对密度为1.0-1.4的稠膏；
（3）制作胶囊、丸剂时：
将稠膏分离纯化、干燥，制成干颗粒；将步骤干颗粒混合均匀，填充胶囊内即制成胶囊；将干颗粒喷加炼蜜、混合均匀，制成小丸即制成丸剂；
制作片剂时：
将2-4份淀粉与步骤（2）中的稠膏混合均匀，制成颗粒、干燥，制成干颗粒，将干颗粒压制成片剂，包糖衣，即制成片剂。
5.根据权利要求4所述的治疗胃炎的药物的制备方法，其特征在于步骤（2）中所述的混合物，加水煎煮的次数为2次，第一次为60-80分钟，第二次为40-60分钟。
CN201410703226.8A 2014-11-29 2014-11-29 一种治疗胃炎的药物及其制备方法 Pending CN104399038A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410703226.8A CN104399038A (zh) 2014-11-29 2014-11-29 一种治疗胃炎的药物及其制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410703226.8A CN104399038A (zh) 2014-11-29 2014-11-29 一种治疗胃炎的药物及其制备方法

Publications (1)

Publication Number Publication Date
CN104399038A true CN104399038A (zh) 2015-03-11

Family

ID=52636747

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410703226.8A Pending CN104399038A (zh) 2014-11-29 2014-11-29 一种治疗胃炎的药物及其制备方法

Country Status (1)

Country Link
CN (1) CN104399038A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105597061A (zh) * 2016-01-20 2016-05-25 夏放军 一种治疗胃炎的中药配方及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824182A (zh) * 2005-12-28 2006-08-30 巴悦霞 治疗慢性胃炎的中药配方
CN1899582A (zh) * 2006-07-20 2007-01-24 孙喜灵 一种治疗慢性胃炎的药及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824182A (zh) * 2005-12-28 2006-08-30 巴悦霞 治疗慢性胃炎的中药配方
CN1899582A (zh) * 2006-07-20 2007-01-24 孙喜灵 一种治疗慢性胃炎的药及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
丛庆国: "自拟疏肝和胃汤治疗慢性胃炎的临床疗效观察", 《中国医药指南》 *
沈志杰: "胃炎灵治疗慢性萎缩性胃炎100例", 《现代中西医结合杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105597061A (zh) * 2016-01-20 2016-05-25 夏放军 一种治疗胃炎的中药配方及其制备方法

Similar Documents

Publication Publication Date Title
CN104940784B (zh) 一种治疗慢性胃炎的中药组合物
CN101518594B (zh) 一种抗肿瘤及增强免疫力的中药制剂及其制备方法
CN104258330A (zh) 一种治疗慢性胃炎的中药组合物
CN109289033A (zh) 一种治疗寒湿胃病的中药组合物及制备方法
CN103860773A (zh) 用于治疗心肌缺血的中药组合物及其制备方法
CN101780220B (zh) 一种治疗慢性胃炎的中药
CN102895445A (zh) 一种治疗痢疾病的中药
CN102178866A (zh) 用于气郁、血瘀体质人袪湿活血、软坚散结的中药制剂及其制备方法和应用
CN105944059A (zh) 用于治疗胃病的中药组合物
CN104399038A (zh) 一种治疗胃炎的药物及其制备方法
CN105106916A (zh) 一种产后护理用中药
CN104383403A (zh) 一种治疗慢性胃炎的中药组合物
CN104352899A (zh) 一种治疗慢性胃炎的中药制剂
CN103908616A (zh) 缓解肿瘤病人放疗反应的药剂及制备方法
CN106362074A (zh) 一种治疗纳呆的新型中药组合物及其制备方法
CN105853882A (zh) 一种用于治疗胃病的药物及制备方法
CN105770760A (zh) 主治胃溃疡的制剂及其制备方法
CN105726695A (zh) 一种治疗慢性浅表性胃炎的药物组合物
CN105902766A (zh) 治疗消化性溃疡的药物及制备方法
CN105456951A (zh) 一种治疗***纤维腺瘤的中药制剂及其制备方法
CN104524535A (zh) 一种治疗慢性肺源性心脏病的中药组合物及其制备方法
CN105709005A (zh) 一种乳康丸
CN104857415A (zh) 一种胃癌患者服用的糯米粥及制法
CN104758620A (zh) 胆囊炎患者疏肝利胆剂及制备方法
CN104306930A (zh) 一种治疗急性重症胰腺炎的中药配方及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150311