CN104398739A - Composition for preventing pig diarrhea and preparation technology thereof - Google Patents

Composition for preventing pig diarrhea and preparation technology thereof Download PDF

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Publication number
CN104398739A
CN104398739A CN201410633512.1A CN201410633512A CN104398739A CN 104398739 A CN104398739 A CN 104398739A CN 201410633512 A CN201410633512 A CN 201410633512A CN 104398739 A CN104398739 A CN 104398739A
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parts
radix
rhizoma
fructus
diarrhea
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李燕
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JURONG MANYUANCHUN FAMILY FARM
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JURONG MANYUANCHUN FAMILY FARM
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention provides a composition for preventing pig diarrhea. The composition is composed of the following components in parts by weight: 5 parts of neomycin sulfate, 25 to 45 parts of ethyl lactate, 30 to 50 parts of cherokee rose fruit, 20 to 30 parts of radix codonopsis, 20 to 30 parts of bighead atractylodes rhizome, 25 to 35 parts of radix scutellariae, 25 to 35 parts of coptis, 15 to 25 parts of Chinese yam, 20 to 30 parts of dried orange peel, 25 to 35 parts of kudzu vine root, 10 to 20 parts of oriental waterplantain rhizome, 10 to 20 parts of nutmeg, 12 to 24 parts of raspberry, 10 to 30 parts of isatis root, 5 to 15 parts of haw, and 5 to 15 parts of licorice. Compared to the prior art, the prepared composition for preventing pig diarrhea has the advantages of low cost, simple technology, no side or toxic effect, safety, and reliability, and is capable of preventing the happening of pig diarrhea.

Description

A kind of prevention diarrhea of pigs compositions and preparation technology thereof
Technical field
The present invention relates to a kind of compositions, be specifically related to a kind of compositions and the preparation technology thereof that prevent diarrhea of pigs.
Background technology
Diarrhea of pigs is a kind of commonly encountered diseases clinically, and pathogenic factor is more complicated.Have plenty of because feeding and management is not good at, have plenty of because antibacterial or viral infection cause.Diarrhea of pigs popular when winter and the early spring, symptom and porcine epizootic diarrhea and transmissible gastroenteritis of swine closely similar, for raiser, if pig has infected this disease, all can fall ill in whole pig farm in a short time, reaches 1-2 month and just slowly calm down, can cause very large economic loss.Cause the reason of piglet diarrhea can be divided into avirulence factor and causative factors two kinds substantially, wherein avirulence factor comprise nutrition and feeding environment stress, as humidity, variations in temperature, ablactation stress, Seasonal Temperature Difference etc.
At present, the medicine of prevention diarrhea of pigs is various, but it is large to there is side effect, the defects such as preventive effect is not good.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of prevention diarrhea of pigs compositions and preparation technology thereof.
Technical scheme: for achieving the above object, the invention provides a kind of prevention diarrhea of pigs compositions, it primarily of following weight portion crude drug made by:
Polygynax 5 parts, ethyl lactate 25-45 part, Fructus Rosae Laevigatae 30-50 part, Radix Codonopsis 20-30 part,
Rhizoma Atractylodis Macrocephalae 20-30 part, Radix Scutellariae 25-35 part, Rhizoma Coptidis 25-35 part, Rhizoma Dioscoreae 15-25 part, Pericarpium Citri Reticulatae 20-30 part,
Radix Puerariae 25-35 part, Rhizoma Alismatis 10-20 part, Semen Myristicae 10-20 part, Fructus Rubi 12-24 part,
Radix Isatidis 10-30 part, Fructus Crataegi 5-15 part, Radix Glycyrrhizae 5-15 part.
As preferably, described prevention diarrhea of pigs compositions is mainly made by the crude drug of following weight portion:
Polygynax 5 parts, ethyl lactate 30-40 part, Fructus Rosae Laevigatae 35-45 part, Radix Codonopsis 22-28 part,
Rhizoma Atractylodis Macrocephalae 22-28 part, Radix Scutellariae 28-32 part, Rhizoma Coptidis 28-32 part, Rhizoma Dioscoreae 18-22 part, Pericarpium Citri Reticulatae 22-28 part,
Radix Puerariae 28-32 part, Rhizoma Alismatis 15-18 part, Semen Myristicae 12-18 part, Fructus Rubi 16-20 part,
Radix Isatidis 15-25 part, Fructus Crataegi 8-12 part, Radix Glycyrrhizae 8-12 part.
Preferred as another kind, described prevention diarrhea of pigs compositions is mainly made by the crude drug of following weight portion:
Polygynax 5 parts, ethyl lactate 35 parts, Fructus Rosae Laevigatae 40 parts, Radix Codonopsis 25 parts,
The Rhizoma Atractylodis Macrocephalae 25 parts, Radix Scutellariae 30 parts, Rhizoma Coptidis 30 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri Reticulatae 25 parts,
Radix Puerariae 30 parts, Rhizoma Alismatis 15 parts, Semen Myristicae 15 parts, Fructus Rubi 18 parts,
Radix Isatidis 20 parts, Fructus Crataegi 10 parts, 10 parts, Radix Glycyrrhizae.
Present invention also offers the preparation technology of described prevention diarrhea of pigs compositions, it is mainly made up of following steps:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add the 60-80% alcohol reflux 2 times of 6-10 times of volume, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.10-1.16, add polygynax and ethyl lactate, mixing, to obtain final product.
As preferably, described compositions conveniently technique makes decoction, suspensoid or granule.
Beneficial effect: relative to prior art, the prevention diarrhea of pigs compositions of gained of the present invention, cost is low, and technique is simple, has no side effect, safe and reliable, effectively can prevent the generation of diarrhea of pigs.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Polygynax 5g, ethyl lactate 25g, Fructus Rosae Laevigatae 30g, Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 20g, Radix Scutellariae 25g,
Rhizoma Coptidis 25g, Rhizoma Dioscoreae 15g, Pericarpium Citri Reticulatae 20g, Radix Puerariae 25g, Rhizoma Alismatis 10g, Semen Myristicae 10g, Fructus Rubi 12g,
Radix Isatidis 10g, Fructus Crataegi 5g, Radix Glycyrrhizae 5g.
Preparation technology:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add 60% alcohol reflux 2 times of 6 times of volumes, each 1 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8 times of volumes, each 1 hour, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.10, add polygynax and ethyl lactate, mixing, to obtain final product.
Conveniently technique makes decoction.
Embodiment 2
Prescription:
Polygynax 5g, ethyl lactate 45g, Fructus Rosae Laevigatae 50g, Radix Codonopsis 30g, Rhizoma Atractylodis Macrocephalae 30g, Radix Scutellariae 35g,
Rhizoma Coptidis 35g, Rhizoma Dioscoreae 25g, Pericarpium Citri Reticulatae 30g, Radix Puerariae 35g, Rhizoma Alismatis 20g, Semen Myristicae 20g, Fructus Rubi 24g,
Radix Isatidis 30g, Fructus Crataegi 15g, Radix Glycyrrhizae 15g.
Preparation technology:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add 80% alcohol reflux 2 times of 10 times of volumes, each 3 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 12 times of volumes, each 3 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.16, add polygynax and ethyl lactate, mixing, to obtain final product.
Conveniently technique makes suspensoid.
Embodiment 3
Prescription:
Polygynax 5g, ethyl lactate 35g, Fructus Rosae Laevigatae 40g, Radix Codonopsis 25g, Rhizoma Atractylodis Macrocephalae 25g, Radix Scutellariae 30g,
Rhizoma Coptidis 30g, Rhizoma Dioscoreae 20g, Pericarpium Citri Reticulatae 25g, Radix Puerariae 30g, Rhizoma Alismatis 15g, Semen Myristicae 15g, Fructus Rubi 18g,
Radix Isatidis 20g, Fructus Crataegi 10g, Radix Glycyrrhizae 10g.
Preparation technology:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add 70% alcohol reflux 2 times of 8 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 10 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.13, add polygynax and ethyl lactate, mixing, to obtain final product.
Conveniently technique makes granule.
Embodiment 4
Prescription:
Polygynax 5g, ethyl lactate 30g, Fructus Rosae Laevigatae 35g, Radix Codonopsis 22g, Rhizoma Atractylodis Macrocephalae 22g, Radix Scutellariae 28g,
Rhizoma Coptidis 28g, Rhizoma Dioscoreae 18g, Pericarpium Citri Reticulatae 22g, Radix Puerariae 28g, Rhizoma Alismatis 15g, Semen Myristicae 12g, Fructus Rubi 16g,
Radix Isatidis 15g, Fructus Crataegi 8g, Radix Glycyrrhizae 8g.
Preparation technology:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add 65% alcohol reflux 2 times of 7 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 9 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.12, add polygynax and ethyl lactate, mixing, to obtain final product.
Conveniently technique makes suspensoid.
Embodiment 5
Prescription:
Polygynax 5g, ethyl lactate 40g, Fructus Rosae Laevigatae 45g, Radix Codonopsis 28g, Rhizoma Atractylodis Macrocephalae 28g, Radix Scutellariae 32g,
Rhizoma Coptidis 32g, Rhizoma Dioscoreae 22g, Pericarpium Citri Reticulatae 28g, Radix Puerariae 32g, Rhizoma Alismatis 18g, Semen Myristicae 18g, Fructus Rubi 20g,
Radix Isatidis 25g, Fructus Crataegi 12g, Radix Glycyrrhizae 12g.
Preparation technology:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add 75% alcohol reflux 2 times of 9 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 11 times of volumes, each 2 hours, merge extractive liquid, obtained extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.14, add polygynax and ethyl lactate, mixing, to obtain final product.
Conveniently technique makes granule.
The test of experimental example present composition prevention diarrhea of pigs
1, animal and grouping and administration:
In pig plant, choose piglets 100 of the same age of the same race, be divided into 5 groups at random, often organize 20, be respectively blank group, matched group, embodiment 3 groups, embodiment 4 groups and embodiment 5 groups.
Blank group routine feeding, does not give any medicament;
Matched group, on the basis of routine feeding, gives polygynax, and dosage is with the embodiment of the present invention 3 prescription amount;
Embodiment 3-5 group, on the basis of routine feeding, gives embodiment of the present invention 3-5 resulting composition respectively.
All groups of equal administrations every day 1 time, the nursing time is two months, and other feeding conditions are all identical, investigates each group of diarrhea of pigs incidence rate.
2, result, in table 1
The piglets Incidence of Diarrhea that forage feed respectively organized by table 1 compares
Note: compared with blank group, * P<0.05; Compared with matched group, #P<0.05.
Upper table result display, compare blank group, the piglets Incidence of Diarrhea of matched group and three embodiment groups significantly reduces; Compared with matched group, resulting composition of the present invention significantly can reduce the Incidence of Diarrhea of piglets, and wherein embodiment 3 groups and embodiment 4 groups of pigletss are not ad initio all suffered from diarrhoea, and each group piglets all survives, not only effect is outstanding to prove the present composition, and safe and reliable.

Claims (5)

1. prevent a diarrhea of pigs compositions, it is characterized in that, it primarily of following weight portion crude drug made by:
Polygynax 5 parts, ethyl lactate 25-45 part, Fructus Rosae Laevigatae 30-50 part, Radix Codonopsis 20-30 part,
Rhizoma Atractylodis Macrocephalae 20-30 part, Radix Scutellariae 25-35 part, Rhizoma Coptidis 25-35 part, Rhizoma Dioscoreae 15-25 part, Pericarpium Citri Reticulatae 20-30 part,
Radix Puerariae 25-35 part, Rhizoma Alismatis 10-20 part, Semen Myristicae 10-20 part, Fructus Rubi 12-24 part,
Radix Isatidis 10-30 part, Fructus Crataegi 5-15 part, Radix Glycyrrhizae 5-15 part.
2. prevention diarrhea of pigs compositions according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
Polygynax 5 parts, ethyl lactate 30-40 part, Fructus Rosae Laevigatae 35-45 part, Radix Codonopsis 22-28 part,
Rhizoma Atractylodis Macrocephalae 22-28 part, Radix Scutellariae 28-32 part, Rhizoma Coptidis 28-32 part, Rhizoma Dioscoreae 18-22 part, Pericarpium Citri Reticulatae 22-28 part,
Radix Puerariae 28-32 part, Rhizoma Alismatis 15-18 part, Semen Myristicae 12-18 part, Fructus Rubi 16-20 part,
Radix Isatidis 15-25 part, Fructus Crataegi 8-12 part, Radix Glycyrrhizae 8-12 part.
3. prevention diarrhea of pigs compositions according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
Polygynax 5 parts, ethyl lactate 35 parts, Fructus Rosae Laevigatae 40 parts, Radix Codonopsis 25 parts,
The Rhizoma Atractylodis Macrocephalae 25 parts, Radix Scutellariae 30 parts, Rhizoma Coptidis 30 parts, Rhizoma Dioscoreae 20 parts, Pericarpium Citri Reticulatae 25 parts,
Radix Puerariae 30 parts, Rhizoma Alismatis 15 parts, Semen Myristicae 15 parts, Fructus Rubi 18 parts,
Radix Isatidis 20 parts, Fructus Crataegi 10 parts, 10 parts, Radix Glycyrrhizae.
4. prevent the preparation technology of diarrhea of pigs compositions described in any one of claim 1-3, it is characterized in that, it is mainly made up of following steps:
(1) get Fructus Rosae Laevigatae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Scutellariae, Rhizoma Coptidis, Semen Myristicae, Radix Puerariae and Rhizoma Alismatis, add the 60-80% alcohol reflux 2 times of 6-10 times of volume, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) get Rhizoma Dioscoreae, Pericarpium Citri Reticulatae, Fructus Rubi, Radix Isatidis, Fructus Crataegi and Radix Glycyrrhizae, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.10-1.16, add polygynax and ethyl lactate, mixing, to obtain final product.
5. prevent the preparation technology of diarrhea of pigs compositions according to claim 4, it is characterized in that, described compositions conveniently technique makes decoction, suspensoid or granule.
CN201410633512.1A 2014-11-11 2014-11-11 Composition for preventing pig diarrhea and preparation technology thereof Pending CN104398739A (en)

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