CN104398400A - Preparation method for wet tissue containing water soluble compound cooling agent - Google Patents
Preparation method for wet tissue containing water soluble compound cooling agent Download PDFInfo
- Publication number
- CN104398400A CN104398400A CN201410704796.9A CN201410704796A CN104398400A CN 104398400 A CN104398400 A CN 104398400A CN 201410704796 A CN201410704796 A CN 201410704796A CN 104398400 A CN104398400 A CN 104398400A
- Authority
- CN
- China
- Prior art keywords
- wet tissue
- menthol
- menthyl
- weight ratio
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a preparation method for a wet tissue containing a water soluble compound cooling agent. The preparation method comprises the following steps: (1) uniformly mixing propanediol, cyclodextrin and Tween-80 to obtain a carrier solution; (2) adding a cooling agent mixed liquid into the carrier solution for dissolving, stirring and mixing the cooling agent mixed liquid and the carrier solution, adding a suitable amount of ultrapure water, and stirring and mixing uniformly to obtain a wet tissue liquid; (3)cutting spunlace non-woven cloth serving as a base cloth into specified dimensions, sterilizing and disinfecting; (4) soaking the cut, sterilized and disinfected spunlace non-woven cloth in a prepared solution for 1 to 2 hours, and sealing and performing aseptic packaging to obtain the wet tissue. According to the preparation method, the cooling agent mixed liquid is added into the carrier solution for dissolving, so that the problem that the cooling agent is insoluble in water is solved; meanwhile, the problems about the cool feel comfort degree and the cool feel duration of the cooling agent are also solved, so that the effect of the prepared wet tissue is better.
Description
Technical field
The present invention relates to daily-use chemical industry technical field, be specially the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble.
Background technology
Coolant agent allly can produce cooling effect and the general name of the not strong chemical substance of the property of medicine.Modal coolant agent is MENTHOL, MENTHOL has the fragrance of Herba Menthae and fragrance clearly and have bitterness, and consumption hour DeGrain, when consumption is large, have strong abnormal smells from the patient and the intense stimulus to skin, mucous membrane tissue and eye, therefore should not use in a large number.MENTHOL high volatility, cool taste is short for action time, only has 3-5 minute, non-refractory, water-soluble hardly.WS-23 (WS-23) is several subdiaphanous powder, the cool taste activity that tool sense is high, and does not have the side effect such as calcination, numbness and stimulation.WS-23 is long-acting coolant agent, itself has the effect of extremely strong cool taste and slow release and the cool taste of prolongation, and cooling effect is significantly lasting, sustainable 15-30 minute.The effect of N-ethyl-have menthyl-3-Methanamide (WS-3) extremely strong cool taste and slow release and the cool taste of prolongation, without burning sensation, cooling effect is significantly lasting, and sustainable 10-20 minute, cool feeling effect is 1.5 times of Mentholum.Menthyl lactate is a kind of long-acting tasteless coolant agent, has slight Herba Menthae fragrance, tastes almost insipidness, but with lasting, pleasant cooling effect, and being a kind ofly does not have untoward reaction as the freshener of burning sensation, excitement and sensation of pricking.Acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester (WS-5) is the white crystal of a kind of free from extraneous odour without pungent excitement, there is slight minty taste, cool feeling is 2.3 times of MENTHOL, and cool feeling is comparatively lasting, sustainable 18-30 minute.N-(4-methoxyphenyl)-to menthyl-3-carboxylic acid amides (WS-12) is also a kind of long-acting coolant agent, and cool feeling is 1.5 times of MENTHOL.Therefore can consider several person to carry out effectively compositely to reach the collaborative effect of cool taste, the application simultaneously reducing MENTHOL is to reduce its stimulation to skin.
But above several coolant agent is all water insoluble, is dissolved in organic solvent ethanol.But make the wet tissue making solvent of ethanol, concerning the consumer having the skin problem such as dermatitis, eczema, the sensations such as causalgia can be produced due to stimulation during use, and ethanol also can cause the problems such as xerosis cutis again.Therefore the most handy wet wipe solution or water.
Summary of the invention
Technical problem solved by the invention is the preparation method of the wet tissue providing the composite coolant agent of a kind of containing water-soluble, to solve the problem in above-mentioned background technology.
Technical problem solved by the invention realizes by the following technical solutions: the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble, comprises the steps:
(1), by propylene glycol, cyclodextrin and tween 80 mix homogeneously, carrier solution is obtained;
(2), by coolant agent mixed liquor join in described carrier solution and dissolve, add appropriate ultra-pure water after being uniformly mixed, be uniformly mixed, be wet tissue liquid;
(3), adopt spun-laced nonwoven fabric as base cloth, cut into given size specification, sterilizing, sterilization;
(4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared solution and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Preferably, the mass ratio of described propylene glycol, cyclodextrin, tween 80 is 5:1:1.
Preferred further, described cyclodextrin is the one or more combination in alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, methyl-B-cyclodextrin or hydroxy-beta-cyclodextrin.
Described coolant agent mixed liquor comprises MENTHOL, N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide (WS-3), N, 2,3-trimethyl-2-butanamide (WS-23), acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester (WS-5), N-(4-methoxyphenyl)-to the one in menthyl-3-carboxylic acid amides (WS-12), menthyl lactate or several arbitrarily.
Described coolant agent mixed liquor ratio is MENTHOL: the weight ratio of WS-23 is (1-2): (1-2);
Or MENTHOL: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is (1-4): (1-2);
Or MENTHOL: N-(4-methoxyphenyl)-to the weight ratio of menthyl-3-carboxylic acid amides is (1-2): (1-2);
Or MENTHOL: the weight ratio of acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is (1-10): (0.5-1);
Or MENTHOL: the weight ratio of menthyl lactate is (1-2): (1-4);
Or MENTHOL: WS-23: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is (1-4): (1-2): (0.5-1);
Or MENTHOL: WS-23: the weight ratio of menthyl lactate is (1-2): (0.5-1): (1-2).
Further preferred described coolant agent mixed liquor ratio is MENTHOL: the weight ratio of WS-23 is 1:1;
Or MENTHOL: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is 2:1;
Or MENTHOL: N-(4-methoxyphenyl)-to the weight ratio of menthyl-3-carboxylic acid amides is 2:1;
Or MENTHOL: the weight ratio of acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is 5:1;
Or MENTHOL: the weight ratio of menthyl lactate is 1:2;
Or MENTHOL: the weight ratio of WS-23: WS-3 is 4:2:1;
Or MENTHOL: WS-23: the weight ratio of menthyl lactate is 1:1:1.
Preferably, the preparation method of the wet tissue of the composite coolant agent of described containing water-soluble, is characterized in that, the mass ratio of described coolant agent mixed liquor and carrier solution is 1:10.
Described MENTHOL is 0.1-1% in the percetage by weight of wet tissue liquid; Or described WS-23 is 0.05-1.2% in the percetage by weight of wet tissue liquid; Or described N-ethyl-to menthyl-3-Methanamide is 0.05-0.8% in the percetage by weight of wet tissue liquid; Or described N-(4-methoxyphenyl)-to menthyl-3-carboxylic acid amides is 0.05-0.8% in the percetage by weight of wet tissue liquid; Or described acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is 0.05-0.5% in the percetage by weight of wet tissue liquid; Or described menthyl lactate is 0.1-2.0% in the percetage by weight of wet tissue liquid.
Compared with public technology, there is following advantage in the present invention: the present invention is dissolved by being joined in described carrier solution by coolant agent mixed liquor, solve the water-fast problem of coolant agent, also solve cool feeling comfort level and the cool feeling persistent period of coolant agent simultaneously, make the wet tissue better effects if prepared.
Detailed description of the invention
Object is reached and effect is easy to understand in order to make technological means of the present invention, creation characteristic, workflow, using method, below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
A preparation method for the wet tissue of the composite coolant agent of containing water-soluble, comprises the steps:
(1), by propylene glycol, cyclodextrin and tween 80 mix homogeneously, carrier solution is obtained;
(2), by coolant agent mixed liquor join in described carrier solution and dissolve, add appropriate ultra-pure water after being uniformly mixed, be uniformly mixed, be wet tissue liquid;
(3), adopt spun-laced nonwoven fabric as base cloth, cut into given size specification, sterilizing, sterilization;
(4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared solution and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Preferably, the mass ratio of described propylene glycol, cyclodextrin, tween 80 is 5:1:1.
Preferred further, described cyclodextrin is the one or more combination in alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, methyl-B-cyclodextrin or hydroxy-beta-cyclodextrin.
Described coolant agent mixed liquor comprises MENTHOL, N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide (WS-3), N, 2,3-trimethyl-2-butanamide (WS-23), acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester (WS-5), N-(4-methoxyphenyl)-to the one in menthyl-3-carboxylic acid amides (WS-12), menthyl lactate or several arbitrarily.
Embodiment 1
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, α-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by MENTHOL: the weight ratio of WS-23 is join in described carrier solution after the ratio mixing of 1:1 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of MENTHOL in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 2
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, beta-schardinger dextrin-and tween 80, obtain carrier solution;
Step (2), by MENTHOL: the weight ratio of WS-3 is join in described carrier solution after the ratio mixing of 2:1 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of MENTHOL in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 3
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, gamma-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by MENTHOL: the weight ratio of WS-12 is join in described carrier solution after the ratio mixing of 2:1 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of MENTHOL in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 4
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, methyl-B-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by MENTHOL: the weight ratio of WS-5 is join in described carrier solution after the ratio mixing of 5:1 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of MENTHOL in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 5
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, hydroxy-beta-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by MENTHOL: the weight ratio of menthyl lactate is join in described carrier solution after the ratio mixing of 1:2 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of MENTHOL in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 6
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, α-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by the weight ratio of L-menthol: WS-23:WS-3 be 4:2:1 ratio mixing after join in described carrier solution and dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of L-menthol in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
Embodiment 7
Step (1), be the ratio mix homogeneously of 5:1:1 according to mass ratio by propylene glycol, γ-cyclodextrin and tween 80, obtain carrier solution;
Step (2), by L-menthol: WS-23: the weight ratio of menthyl lactate is join in described carrier solution after the ratio mixing of 1:1:1 to dissolve, adding appropriate ultra-pure water after being uniformly mixed makes the content of L-menthol in wet tissue liquid be 0.5%, be uniformly mixed, be wet tissue liquid;
Step (3), employing spun-laced nonwoven fabric, as base cloth, cut into given size specification, sterilizing, sterilization;
Step (4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared wet tissue liquid and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Claimed scope of the present invention is defined by appending claims and equivalent thereof.
Claims (8)
1. a preparation method for the wet tissue of the composite coolant agent of containing water-soluble, is characterized in that: comprise the steps:
(1), by propylene glycol, cyclodextrin and tween 80 mix homogeneously, carrier solution is obtained;
(2), by coolant agent mixed liquor join in described carrier solution and dissolve, add appropriate ultra-pure water after being uniformly mixed, be uniformly mixed, be wet tissue liquid;
(3), adopt spun-laced nonwoven fabric as base cloth, cut into given size specification, sterilizing, sterilization;
(4), shearing, sterilizing, sterilization spun-laced nonwoven fabric be immersed in prepared solution and soak 1-2 hour, sealed, sterile packs to obtain wet tissue.
2. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1, is characterized in that: the mass ratio of described propylene glycol, cyclodextrin, tween 80 is 5:1:1.
3. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1 and 2, is characterized in that: described cyclodextrin is the one or more combination in alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, methyl-B-cyclodextrin or hydroxy-beta-cyclodextrin.
4. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1, it is characterized in that: described coolant agent mixed liquor comprises MENTHOL, N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide (WS-3), N, 2,3-trimethyl-2-butanamide (WS-23), acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester (WS-5), N-(4-methoxyphenyl)-to the one in menthyl-3-carboxylic acid amides (WS-12), menthyl lactate or several arbitrarily.
5. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1, it is characterized in that: described coolant agent mixed liquor ratio is MENTHOL: N, the weight ratio of 2,3-trimethyl-2-butanamide is (1-2): (1-2);
Or MENTHOL: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is (1-4): (1-2);
Or MENTHOL: N-(4-methoxyphenyl)-to the weight ratio of menthyl-3-carboxylic acid amides is (1-2): (1-2);
Or MENTHOL: the weight ratio of acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is (1-10): (0.5-1);
Or MENTHOL: the weight ratio of menthyl lactate is (1-2): (1-4);
Or MENTHOL: WS-23: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is (1-4): (1-2): (0.5-1);
Or MENTHOL: WS-23: the weight ratio of menthyl lactate is (1-2): (0.5-1): (1-2).
6. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1, is characterized in that: described coolant agent mixed liquor ratio is MENTHOL: the weight ratio of WS-23 is 1:1;
Or MENTHOL: the weight ratio of N-ethyl-2-isopropyl-5-methyl cyclohexane alkyl Methanamide is 2:1;
Or MENTHOL: N-(4-methoxyphenyl)-to the weight ratio of menthyl-3-carboxylic acid amides is 2:1;
Or MENTHOL: the weight ratio of acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is 5:1;
Or MENTHOL: the weight ratio of menthyl lactate is 1:2;
Or MENTHOL: the weight ratio of WS-23: WS-3 is 4:2:1;
Or MENTHOL: WS-23: the weight ratio of menthyl lactate is 1:1:1.
7. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 1, is characterized in that: the mass ratio of described coolant agent mixed liquor and carrier solution is 1:10.
8. the preparation method of the wet tissue of the composite coolant agent of a kind of containing water-soluble according to claim 4, is characterized in that: described MENTHOL is 0.1-1% in the percetage by weight of wet tissue liquid; Or described WS-23 is 0.05-1.2% in the percetage by weight of wet tissue liquid; Or described N-ethyl-to menthyl-3-Methanamide is 0.05-0.8% in the percetage by weight of wet tissue liquid; Or described N-(4-methoxyphenyl)-to menthyl-3-carboxylic acid amides is 0.05-0.8% in the percetage by weight of wet tissue liquid; Or described acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester is 0.05-0.5% in the percetage by weight of wet tissue liquid; Or described menthyl lactate is 0.1-2.0% in the percetage by weight of wet tissue liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410704796.9A CN104398400A (en) | 2014-11-27 | 2014-11-27 | Preparation method for wet tissue containing water soluble compound cooling agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410704796.9A CN104398400A (en) | 2014-11-27 | 2014-11-27 | Preparation method for wet tissue containing water soluble compound cooling agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104398400A true CN104398400A (en) | 2015-03-11 |
Family
ID=52636113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410704796.9A Pending CN104398400A (en) | 2014-11-27 | 2014-11-27 | Preparation method for wet tissue containing water soluble compound cooling agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104398400A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105124517A (en) * | 2015-09-11 | 2015-12-09 | 安徽爱迪香料股份有限公司 | Preparation method of cooling compound microcapsule |
| CN105168009A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Water-soluble dropping pills containing compound cooling agent and preparation method of dropping pills |
| CN105166835A (en) * | 2015-09-11 | 2015-12-23 | 安徽爱迪香料股份有限公司 | Preparation method for water soluble compound cooling agent |
| CN106262580A (en) * | 2016-08-08 | 2017-01-04 | 安徽丰乐香料有限责任公司 | A kind of coolant agent N (4 methoxyphenyl) using method to menthyl 3 carboxylic acid amides |
| CN107950983A (en) * | 2017-11-27 | 2018-04-24 | 昆山亚香香料股份有限公司 | A kind of compounding coolant agent composition based on menthol and preparation method thereof |
| CN109431871A (en) * | 2018-12-25 | 2019-03-08 | 安徽爱迪香料股份有限公司 | A kind of preparation method for the long-acting refrigerant preparation making an addition to the cool cream of external application |
| CN114681361A (en) * | 2022-04-02 | 2022-07-01 | 厦门金泰生物科技有限公司 | Ice-cold compound liquid and preparation method thereof |
-
2014
- 2014-11-27 CN CN201410704796.9A patent/CN104398400A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105124517A (en) * | 2015-09-11 | 2015-12-09 | 安徽爱迪香料股份有限公司 | Preparation method of cooling compound microcapsule |
| CN105166835A (en) * | 2015-09-11 | 2015-12-23 | 安徽爱迪香料股份有限公司 | Preparation method for water soluble compound cooling agent |
| CN105168009A (en) * | 2015-09-30 | 2015-12-23 | 安徽丰乐香料有限责任公司 | Water-soluble dropping pills containing compound cooling agent and preparation method of dropping pills |
| CN106262580A (en) * | 2016-08-08 | 2017-01-04 | 安徽丰乐香料有限责任公司 | A kind of coolant agent N (4 methoxyphenyl) using method to menthyl 3 carboxylic acid amides |
| CN107950983A (en) * | 2017-11-27 | 2018-04-24 | 昆山亚香香料股份有限公司 | A kind of compounding coolant agent composition based on menthol and preparation method thereof |
| CN109431871A (en) * | 2018-12-25 | 2019-03-08 | 安徽爱迪香料股份有限公司 | A kind of preparation method for the long-acting refrigerant preparation making an addition to the cool cream of external application |
| CN114681361A (en) * | 2022-04-02 | 2022-07-01 | 厦门金泰生物科技有限公司 | Ice-cold compound liquid and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104398400A (en) | Preparation method for wet tissue containing water soluble compound cooling agent | |
| JP2011256125A (en) | Dentifrice composition | |
| JP2012111948A5 (en) | ||
| JP2016505576A (en) | Improved antimicrobial composition | |
| CN105078781A (en) | Dental gel composition of papain for the atraumatic treatment of caries and method of preparing same | |
| EP3295932A3 (en) | Stable odf composition containing hardly soluble therapeutic agent | |
| JP2016113402A (en) | Bath agent composition | |
| JPWO2012029753A1 (en) | Cleaning composition | |
| CN107736375A (en) | A kind of thimerosal of floral type 84 and preparation method thereof | |
| JP2012219012A (en) | Aromatic | |
| CN103230386B (en) | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof | |
| JP6072186B1 (en) | Effervescent compression molding bath | |
| JP4819587B2 (en) | A cosmetic material comprising a method for producing a glycerin solution of ascorbic acid, a glycerin solution of ascorbic acid, and a glycerin solution of ascorbic acid. | |
| JP7335758B2 (en) | Effervescent solid bath agent | |
| CN103800235A (en) | Grapefruit perfume | |
| JP2008247825A (en) | Composition for washing nasal cavity | |
| CN104080460A (en) | Injectable composition containing phosphatidylcholine devoid of sodium deoxycholate and preparation method thereof | |
| JP2014101338A (en) | Anti-inflammation and analgesic topical medicament | |
| JP5191156B2 (en) | Composition for external use | |
| JP6984089B2 (en) | Deodorant / disinfectant | |
| JP6741433B2 (en) | Emulsion composition for disinfection | |
| CN104398404A (en) | Nontoxic nail polish remover and preparation method thereof | |
| CN105560134A (en) | Cucumber-aroma toothpaste and preparation method thereof | |
| CN105362090A (en) | Portable compound deodorant wet tissue | |
| JP2007332046A (en) | Hair shampoo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: High tech Zone of Hefei city of Anhui Province in 230088 Lake Road No. 1 Applicant after: Anhui Fengle Perfume Co., Ltd. Address before: 230088 Swan Lake No. 1, hi tech Development Zone, Anhui, Hefei Applicant before: Anhui Fengle Perfume Co., Ltd. |
|
| COR | Change of bibliographic data | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150311 |
|
| RJ01 | Rejection of invention patent application after publication |