CN104383154A - Traditional Chinese medicine preparation for treating constipation and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating constipation and preparation method thereof Download PDFInfo
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- CN104383154A CN104383154A CN201410713828.1A CN201410713828A CN104383154A CN 104383154 A CN104383154 A CN 104383154A CN 201410713828 A CN201410713828 A CN 201410713828A CN 104383154 A CN104383154 A CN 104383154A
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 60
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating constipation and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine preparation for treating constipation comprises the following raw materials in parts by weight: 10-30 parts of Chinese angelica, 5-10 parts of twotooth achyranthes root, 5-15 parts of desertliving cistanche, 1-5 parts of oriental waterplantain rhizome, 1-5 parts of largetrifoliolious bugbane rhizome, 5-10 parts of bitter orange, 5-15 parts of ginger-processed officinal magnolia bark, 5-10 parts of largehead atractylodes rhizome, 10-15 parts of tuber fleeceflower root, 8-10 parts of peach seed and 10-20 parts of plantain seed. The traditional Chinese medicine preparation for treating constipation, disclosed by the invention, is simple and convenient to prepare and good in taste and curative effect, does not have dependence and toxic or side effects, and has the effects of warming the kidneys and tonifying essence, lubricating the intestines and relaxing bowels, and promoting qi circulation and removing food retention; and meanwhile, the invention provides a simple and convenient preparation method of the traditional Chinese medicine preparation for treating constipation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of constipation and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Constipation is common disease clinically, is also one of various diseases common sympton simultaneously.Its main clinical manifestation is difficult defecation, number of times reduces, feces scleroma.Foreign data shows, and the sickness rate of constipation is 3% in youngster, and middle-aged and elderly people 8%, old people reaches 20%.In recent years, along with people's work and social life pressure increase, psychiatric, the impact of social factor and the adjustment of dietary structure, especially protide food intake is too much, and vegetable takes in relative deficiency etc., and the sickness rate of constipation presents rising and the trend of rejuvenation.It brings very large misery to patient, and has a strong impact on the live and work of people, especially more serious to the harm of gerontal patient, and Chang Yinwei defecation effort brings out coronary heart diseases and angina pectoris even myocardial infarction etc.
The prevalence of current China chronic constipation rises gradually, has a strong impact on the quality of life of the people.Epidemiological study also finds, the consultation rate of constipation patient only has 10.6%, but has the patient of 45.7% to take nonprescription drugs voluntarily.The cathartic of conventional treatment constipation has several as follows: osmotic laxative, emollient laxative, hyperosmolar agent, irritant laxative, above cathartic all has good defecating feces excretion, but also has certain side effect.The digestive tract power reinforcing medicines such as cisapride and erythromycin all have the effect promoting enterokinesia, are therefore also used for the treatment of constipation by some.People are after life-time service cathartic, and the normal creepage of gastrointestinal functions function of intestinal can weaken gradually, and the sensitivity of rectum defecation reflex can reduce gradually, and the plexus nervorum between myenteron also can sustain damage.Now, patient, once cut out cathartic, just there will be more serious constipation.Abuse cathartic causes the untoward reaction such as cathartic dependence, cathartic colon, increases medical expense, causes medical resource to waste.
Adjust Check to find according to epidemiology, constipation is common in children's and old people.Children's's immature yin and yang; Woman seventy-seven, and conception vessel is empty, and taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function; Man seven or eight, and irritability declines, exhaustion of kidney-essence with promoting reproductive function, oligospermia, and kidney is hidden and declined, and physique and configuration of the body being very feeble and atrophied, in addition " Nian Sishi and half of YIN QI consumed ", some patients yang-energy also declines.Zhang Jingyue Jing-Yue Complete Works cloud: " all diseases relate to deficient and constipation is obstructed, then the agent such as nitre, yellow attack must be unavailable.If gesture must not have obstructed person, should mend it, this is with leading in benefit also." the kidney controlling urination and defecation, kidney qi virtual loss, lower unit is not warm, and five liquid are not changed, and intestinal loses and moistens and constipation, and method is when the kidney warming intestine moistening.Therefore, the constipation of middle-aged and elderly people and children's all needs to pay attention to empty pathogenesis, can not violate ring in appearance or in fact.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of constipation, its preparation be easy, mouthfeel and good effect, no dependence, to have no side effect, there is effect of the kidney warming benefit essence, loosening bowel to relieve constipation, circulation of qi promoting removing food stagnancy; The invention provides a kind of preparation method of Chinese medicine preparation of simple and convenient treatment constipation simultaneously.
The Chinese medicine preparation of described treatment constipation, comprises the raw material of following parts by weight: Radix Angelicae Sinensis 10-30 part, Radix Achyranthis Bidentatae 5-10 part, Herba Cistanches 5-15 part, Rhizoma Alismatis 1-5 part, Rhizoma Cimicifugae 1-5 part, Fructus Aurantii 5-10 part, Cortex Magnoliae Officinalis(processed with ginger) 5-15 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Polygoni Multiflori 10-15 part, Semen Persicae 8-10 part, Semen Plantaginis 10-20 part.
Preferably, the raw material of following parts by weight is comprised: Radix Angelicae Sinensis 15 parts, Radix Achyranthis Bidentatae 6 parts, Herba Cistanches 9 parts, Rhizoma Alismatis 4.5 parts, Rhizoma Cimicifugae 3 parts, Fructus Aurantii 5 parts, Cortex Magnoliae Officinalis(processed with ginger) 9 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Radix Polygoni Multiflori 15 parts, 10 parts, Semen Persicae, Semen Plantaginis 10 parts.
The preparation method of the Chinese medicine preparation of described treatment constipation, can adopt in following two kinds of methods any one:
(1) comprise the following steps: the solvent adding 6-12 times of weight in the mixed material of Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Herba Cistanches, Rhizoma Alismatis, Rhizoma Cimicifugae, Fructus Aurantii, Cortex Magnoliae Officinalis(processed with ginger), the Rhizoma Atractylodis Macrocephalae, the Radix Polygoni Multiflori, Semen Persicae and Semen Plantaginis, soak 0-2 hour, then decocting method, reflux extraction or continuous circumfluence extraction method is adopted to extract 2-3 time, each 1-2 hour, merge extractive liquid, gradation is filtered, merging filtrate, and when filtrate being concentrated into 60 DEG C, relative density is 1.08 ~ 1.30g/cm
3, obtained extractum, finally conventionally obtains required dosage form.
(2) comprise the following steps: Cortex Magnoliae Officinalis(processed with ginger) solvent extraction twice, each 1-2 hour, filtration, filtrate is for subsequent use; Fructus Aurantii adds water distillation, collects distillate, and the aqueous solution after distillation filters for subsequent use; After Fructus Aurantii medicinal residues and all the other nine kinds of raw materials are mixed, add the solvent of 6-12 times of weight, then decocting method, reflux extraction or continuous circumfluence extraction method is adopted to extract 2-3 time, each 1-2 hour, merge extractive liquid, gradation is filtered, merging filtrate, and when filtrate being concentrated into 60 DEG C, relative density is 1.08-1.15g/cm
3, then the ethanol adding 1-5 times of weight makes extract precipitate, filters, and filtrate and Cortex Magnoliae Officinalis(processed with ginger) filtrate is merged, then adds Fructus Aurantii distillate, mixing, conventionally obtained required dosage form.
Described solvent is water, methanol, ethanol, 5-95wt% aqueous methanol, 5-95wt% aquiferous ethanol or ethyl acetate.
Described adjuvant is different according to the difference of preparation dosage form.
The dosage form of the Chinese medicine preparation of described treatment constipation is oral liquid, tablet, capsule or granule.
In the Chinese medicine preparation for the treatment of constipation of the present invention the character of related component and effect as follows:
Herba Cistanches is warm in nature, sweet in the mouth, salty, enters kidney, large intestine channel, has the kidney warming benefit essence, effect of warm waist intestine moistening.Radix Angelicae Sinensis is warm in nature, sweet in the mouth, pungent, enters liver, the heart, spleen channel, has effect of enriching blood for moistening the intestine; Radix Achyranthis Bidentatae is put down, bitter in the mouth, acid, and liver and kidney tonifying, can draw all medicines descending; The wide intestinal therapeutic method to keep the adverse QI flowing downwards of Fructus Aurantii and help just; Cortex Magnoliae Officinalis(processed with ginger) circulation of qi promoting removing food stagnancy, dampness is except full; Rhizoma Cimicifugae draws positive bright clearing heat in QI system and rises, lucid YANG getting to ascend, and spontaneous descending of turbid YIN, match with Fructus Aurantii, make to rise clearly turbid falling, and constipation is from logical; The sweet light profit of multiplexing Rhizoma Alismatis is fallen, and it is turbid point to let out kidney, makes turbidly to fall that internal organs is logical and constipation must be separated, then gets the dry and middle QI invigorating of Rhizoma Atractylodis Macrocephalae dehumidifying benefit, warming middle-JIAO, goes to wet in taste, except gastric heat, and strong taste; Radix Polygoni Multiflori nourishing the blood and yin, helps with Semen Persicae, Semen Plantaginis loosening bowel to relieve constipation.
The Chinese medicine preparation for the treatment of constipation of the present invention, with Herba Cistanches, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Radix Polygoni Multiflori the kidney warming benefit essence, enriching blood for moistening the intestine is main, and under gentle prerequisite of effecting a permanent cure, consider gasification dereliction of duty of suffering from a deficiency of the kidney, the metabolism of water liquid is not normal, so that turbid YIN failing to descend, therefore it is turbid to enter diarrhea due to kidney-dificiency with Rhizoma Alismatis, the wide intestinal of Fructus Aurantii sending down the abnormal ascending QI, Cortex Magnoliae Officinalis(processed with ginger) circulation of qi promoting removing food stagnancy, the turbid internal organs that falls is made to lead to and defecate, to increase the merit of its relaxing the bowels with lubricant drugs; Again because turbid YIN failing to descend is former in clear YANG failing to ascend, therefore help Rhizoma Cimicifugae the lucid yang sending up less with the turbid descending, the Rhizoma Atractylodis Macrocephalae goes in taste wet, and except gastric heat, strong taste, Semen Persicae, Semen Plantaginis loosening bowel to relieve constipation, outstanding being apt to controls aged debility constipation.
The Pharmacodynamic test of active extract of the Chinese medicine preparation for the treatment of constipation of the present invention is as follows:
(1) on the impact of mice defecation
1, material
Animal: select SPF level mice, male and female half and half, body weight 18-24g.
Medical material: the Chinese medicine preparation for the treatment of constipation of the present invention.
Positive control: jichuan decoction decoction.
2, Constipation Model
Mice is divided into 3 groups at random, often organize 20, be respectively dryness accumulated in the stomach and intestine constipation group, diphenoxylate constipation group, blank group.
Modeling method: (1) dryness accumulated in the stomach and intestine constipation group: before experiment, 72h starts to prohibit water non-fasting, before experiment, fasting after 16h, causes dryness accumulated in the stomach and intestine Constipation Model.(2) diphenoxylate constipation group: the front 16h of experiment starts fasting and can't help water, gives compound diphenoxylate suspension (0.02ml/g), cause diphenoxylate Constipation Model after 30min by the dosage of 10mg/kg.
3, mice defecation measures
Medicinal liquid used, distilled water and positive control medicinal liquid all dissolve in eosin (consumption is 1% of medicinal liquid) before administration, after modeling, press 0.6ml/ gastric infusion for each group, record administration time and mice discharge the time of first red feces, calculate the mice relieving constipation time, Continuous Observation 6h, in record 6h, mice is always arranged red feces and counts, and the results are shown in Table 1.
Table 1 Chinese medicine preparation of the present invention is on the impact of constipation type mice defecation
Result shows, and compared with blank group, model group arranges red just time significant prolongation first, and red just the counting of 6h is significantly reduced, and shows that Constipated mice is successfully established (P<0.01); Compared with model group, the row first of administration group and positive controls all shortens (P<0.01) the red just time, and red just counting all is increased (P<0.05), has significant difference; Administration group is compared with positive controls, and Chinese medicine preparation of the present invention can significantly shorten arranges red just time, increase feces volume first.
(2) on the impact that constipation type mouse small intestine advances
Select SPF level mice 60, male and female half and half, body weight 18-24g, evenly divide 3 groups by body weight, be respectively blank group, administration group, positive group, positive control is jichuan decoction decoction.Medicinal liquid used, distilled water and positive control solution are all mixed into charcoal end (consumption is 5% of medicinal liquid) before administration.Mice fasting to be can't help after water 16h, by 0.6ml/ gastric infusion, putting to death after 20min.Cut open the belly and take out small intestinal measurement.Enter farthest for advancing length with pylorus to charcoal footline, pylorus is total length to returning the region between the heart and the diaphragm lobe, and the former is advance rate divided by the latter, the results are shown in Table 2.
The impact that table 2 Chinese medicine preparation of the present invention advances constipation type mouse small intestine
| Group | Small intestinal total length (cm) | Black intestinal long (cm) | Propelling rate (%) |
| Blank group | 21.44±3.46 | 7.57±2.03 | 36.25±11.56 |
| Administration group | 23.40±3.90 | 15.49±4.83 | 65.41±14.81 |
| Positive group | 24.73±3.55 | 15.03±5.92 | 59.51±16.38 |
Result shows, and compared with blank group, administration group and positive group all significantly can strengthen mice enterokinesia effect; Administration group is compared with positive group and is shown, Chinese medicine preparation of the present invention is better to mice enterokinesia effect.
Clinical trial and curative effect as follows:
Randomized double-blind parallel control multi-center clinical trial is adopted to evaluate effectiveness and the safety of this medicine treatment senile constipation.
The present invention chooses 201 routine senile constipation cases, wherein male 101 example, women 100 example, the age be in 64-89 year.Random A group 101 people, male 51 people, women 50 people; B group 100 people, male 50 people, women 50 people.Two groups of data all meet screening criteria above.Roughly the same through the sex of statistical analysis two groups of patients, age, no significant difference, P>0.05, has comparability.A group gives Chinese medicine preparation of the present invention and takes 15, and B group takes jichuan decoction decoction to remission or to 15 days, and clinical efficacy judges patient treatment outcome according to " Chinese medical disease Standardization of diagnosis and curative effect ".
Clinical middle A group patient has 73 examples to cure, and 23 examples are alleviated, and 5 routine symptoms are invalid, and cure rate is 73%, and remission rate is 95%, and inefficiency is 5%; B group patient has 50 examples to cure, and 27 examples are alleviated, and 23 examples are invalid, and cure rate is 50%, and remission rate is 77%, and inefficiency is 23%.A, B two groups of patients occur without special circumstances following up a case by regular visits to after two months.
Compared with prior art, the present invention has following beneficial effect:
(1) Chinese medicine preparation for the treatment of constipation of the present invention, prepares easy, mouthfeel and good effect, no dependence, has no side effect, and has effect of the kidney warming benefit essence, loosening bowel to relieve constipation, circulation of qi promoting removing food stagnancy, effectively treats constipation, especially applicable old people and child;
(2) Chinese medicine preparation for the treatment of constipation of the present invention, also avoid the untoward reaction such as cathartic dependence, cathartic colon, reduces medical expense, avoid the waste of medical resource;
(3) preparation method of the Chinese medicine preparation for the treatment of constipation of the present invention is simple and convenient, and product quality is convenient to control.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated, but it does not limit enforcement of the present invention.
Embodiment 1
Take Radix Angelicae Sinensis 15 parts, Radix Achyranthis Bidentatae 6 parts, Herba Cistanches 9 parts, Rhizoma Alismatis 4.5 parts, Rhizoma Cimicifugae 3 parts, Fructus Aurantii 5 parts, Cortex Magnoliae Officinalis(processed with ginger) 9 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Radix Polygoni Multiflori 15 parts, 10 parts, Semen Persicae, Semen Plantaginis 10 parts, mix homogeneously, add the water of 10 times of weight, decoct 2 hours, filter, medicinal residues continue with 8 times of soak by water 1 hour, filtration, merging filtrate, when filtrate being concentrated into 60 DEG C, relative density is 1.08g/cm
3, obtained extractum.Take 15 parts of adjuvant dextrin, add the water of 40 parts, at 80 DEG C, heating makes dextrin dissolve, then adds the extractum of gained, mix homogeneously, then dry at 100 ± 10 DEG C, granulates, must treat the Chinese medicine preparation of constipation.
Embodiment 2
Take Radix Angelicae Sinensis 15 parts, Radix Achyranthis Bidentatae 10 parts, Herba Cistanches 5 parts, Rhizoma Alismatis 5 parts, Rhizoma Cimicifugae 1 part, Fructus Aurantii 10 parts, Cortex Magnoliae Officinalis(processed with ginger) 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, the Radix Polygoni Multiflori 10 parts, 8 parts, Semen Persicae, Semen Plantaginis 20 parts, wherein the Cortex Magnoliae Officinalis(processed with ginger) 60wt% aquiferous ethanol of 8 times of weight extracts twice, each 1 hour, filter, filtrate is for subsequent use; Fructus Aurantii adds water distillation, collects distillate, and the aqueous solution after distillation filters, for subsequent use; Fructus Aurantii medicinal residues mix with all the other nine taste raw materials, add the water of 8 times of weight, decoct 2 hours, filter, and medicinal residues continue with 6 times of soak by water 1 hour, filtration, merging filtrate, and when filtrate being concentrated into 60 DEG C, relative density is 1.15g/cm
3, the ethanol adding 2 times of weight makes extract precipitate, filters, and filtrate and Cortex Magnoliae Officinalis(processed with ginger) filtrate are merged, reclaim ethanol, then add Fructus Aurantii distillate, mixing, adds water to 1000ml, leaves standstill, and filter, fill, must treat the Chinese medicine preparation of constipation.
Embodiment 3
Take Radix Angelicae Sinensis 10 parts, Radix Achyranthis Bidentatae 5 parts, Herba Cistanches 15 parts, Rhizoma Alismatis 1 part, Rhizoma Cimicifugae 5 parts, Fructus Aurantii 6 parts, Cortex Magnoliae Officinalis(processed with ginger) 15 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, the Radix Polygoni Multiflori 11 parts, 9 parts, Semen Persicae, Semen Plantaginis 10 parts, mix homogeneously, add the water of 6 times of weight, soak 2 hours, then decoct 1 hour, filter, medicinal residues continue the soak by water 1 hour by 10 times of weight, filter, merging filtrate, when filtrate is concentrated into 60 DEG C, relative density is 1.30g/cm
3, add starch, Magnesium Stearate proper quantity, mixing, granulate, dry, be pressed into 1000, film coating, the Chinese medicine preparation of constipation must be treated.
Embodiment 4
Take Radix Angelicae Sinensis 30 parts, Radix Achyranthis Bidentatae 6 parts, Herba Cistanches 9 parts, Rhizoma Alismatis 4.5 parts, Rhizoma Cimicifugae 3 parts, Fructus Aurantii 8 parts, Cortex Magnoliae Officinalis(processed with ginger) 6 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, the Radix Polygoni Multiflori 10 parts, 8 parts, Semen Persicae, Semen Plantaginis 15 parts, mix homogeneously, add the water of 12 times of weight, soak 1 hour, then decoct 1 hour, filter, medicinal residues continue the soak by water 1 hour by 10 times of weight, filter, merging filtrate, when filtrate is concentrated into 60 DEG C, relative density is 1.10g/cm
3, add starch, Magnesium Stearate proper quantity, mixing, granulate, dry, be pressed into 1000, film coating, the Chinese medicine preparation of constipation must be treated.
Claims (4)
1. treat a Chinese medicine preparation for constipation, it is characterized in that the raw material comprising following parts by weight: Radix Angelicae Sinensis 10-30 part, Radix Achyranthis Bidentatae 5-10 part, Herba Cistanches 5-15 part, Rhizoma Alismatis 1-5 part, Rhizoma Cimicifugae 1-5 part, Fructus Aurantii 5-10 part, Cortex Magnoliae Officinalis(processed with ginger) 5-15 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Polygoni Multiflori 10-15 part, Semen Persicae 8-10 part, Semen Plantaginis 10-20 part.
2. the Chinese medicine preparation for the treatment of constipation according to claim 1, is characterized in that the raw material comprising following parts by weight: Radix Angelicae Sinensis 15 parts, Radix Achyranthis Bidentatae 6 parts, Herba Cistanches 9 parts, Rhizoma Alismatis 4.5 parts, Rhizoma Cimicifugae 3 parts, Fructus Aurantii 5 parts, Cortex Magnoliae Officinalis(processed with ginger) 9 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, the Radix Polygoni Multiflori 15 parts, 10 parts, Semen Persicae, Semen Plantaginis 10 parts.
3. treat a preparation method for the Chinese medicine preparation of constipation described in claim 1 or 2, it is characterized in that any one in two kinds of methods below adopting:
(1) comprise the following steps: the solvent adding 6-12 times of weight in the mixed material of Radix Angelicae Sinensis, Radix Achyranthis Bidentatae, Herba Cistanches, Rhizoma Alismatis, Rhizoma Cimicifugae, Fructus Aurantii, Cortex Magnoliae Officinalis(processed with ginger), the Rhizoma Atractylodis Macrocephalae, the Radix Polygoni Multiflori, Semen Persicae and Semen Plantaginis, soak 0-2 hour, then decocting method, reflux extraction or continuous circumfluence extraction method is adopted to extract, merge extractive liquid, filtration, when filtrate being concentrated into 60 DEG C, relative density is 1.08-1.30g/cm
3, obtained extractum, finally obtained required dosage form;
(2) comprise the following steps: Cortex Magnoliae Officinalis(processed with ginger) solvent extraction, filtration, filtrate is for subsequent use; Fructus Aurantii adds water distillation, and the aqueous solution after distillation filters for subsequent use; After being mixed by Fructus Aurantii medicinal residues and all the other nine kinds of raw materials, add the solvent of 6-12 times of weight, then adopt decocting method, reflux extraction or continuous circumfluence extraction method to extract, merge extractive liquid, filtration, when filtrate being concentrated into 60 DEG C, relative density is 1.08-1.15g/cm
3, then the ethanol adding 1-5 times of weight makes extract precipitate, filters, and filtrate and Cortex Magnoliae Officinalis(processed with ginger) filtrate is merged, then adds Fructus Aurantii distillate, the obtained required dosage form of mixing.
4. treat the preparation method of the Chinese medicine preparation of constipation according to claim 3, it is characterized in that: solvent is water, methanol, ethanol, 5-95wt% aqueous methanol, 5-95wt% aquiferous ethanol or ethyl acetate.
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| CN1876074A (en) * | 2006-04-27 | 2006-12-13 | 广西北生药业股份有限公司 | A constipation-treating medicament and preparation method thereof |
| CN101199638A (en) * | 2007-12-14 | 2008-06-18 | 武汉马应龙药业集团股份有限公司 | Granules for treating enteric canal constipation disease and preparing method thereof |
| CN102188561A (en) * | 2010-03-10 | 2011-09-21 | 济南瑞安药业发展有限公司 | Traditional Chinese medicine preparation for treating constipation and its preparation method |
| CN103040997A (en) * | 2012-12-25 | 2013-04-17 | 中国人民解放军第二军医大学 | Prokinetic traditional Chinese medicinal composition and preparation and application thereof |
| CN103083459A (en) * | 2013-02-05 | 2013-05-08 | 贾忠 | Traditional Chinese medicinal compound preparation for treating constipation, and preparation method and application thereof |
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- 2014-11-28 CN CN201410713828.1A patent/CN104383154A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876074A (en) * | 2006-04-27 | 2006-12-13 | 广西北生药业股份有限公司 | A constipation-treating medicament and preparation method thereof |
| CN101199638A (en) * | 2007-12-14 | 2008-06-18 | 武汉马应龙药业集团股份有限公司 | Granules for treating enteric canal constipation disease and preparing method thereof |
| CN102188561A (en) * | 2010-03-10 | 2011-09-21 | 济南瑞安药业发展有限公司 | Traditional Chinese medicine preparation for treating constipation and its preparation method |
| CN103040997A (en) * | 2012-12-25 | 2013-04-17 | 中国人民解放军第二军医大学 | Prokinetic traditional Chinese medicinal composition and preparation and application thereof |
| CN103083459A (en) * | 2013-02-05 | 2013-05-08 | 贾忠 | Traditional Chinese medicinal compound preparation for treating constipation, and preparation method and application thereof |
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Application publication date: 20150304 |