CN102784221A - Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof - Google Patents
Traditional Chinese medicine composition for treating constipation and preparation method and clinical preparation thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines and discloses a traditional Chinese medicine composition for treating constipation and a preparation method and a clinical preparation thereof. The traditional Chinese medicine composition is prepared by prepared rhubarb, linum, white paeony root, fructus aurantii, mangnolia officinalis, costusroot, semen cassiae, unprepared fleece-flower root and licorice roots northwest origin, and the traditional Chinese medicine composition has effects of clearing heat, lubricating intestines, regulating vital energy and clearing hollow viscera. According to modern pharmacology study and clinical tests, the traditional Chinese medicine composition has the advantages that the function of relaxing bowels is effectively achieved, the usage is convenient, the curative effect is remarkable, the traditional Chinese medicine composition is comfortable and safe and free of toxic and side effects, besides, the traditional Chinese medicine composition serving as a good remedy for treating the constipation can be widely applied to clinical treatment for constipation patients with functional constipation and senile constipation and other constipation patients which are required to take cathartics for ages, and particularly applicable to treatment for dryness-heat and body fluid deficiency type constipation and excessive heat and vital energy stagnation type constipation. Simultaneously, medicinal materials of the traditional Chinese medicine composition has the advantages of being free of toxics, small in medicine dependence by long-term usage, low in price, applicable to short-term and long-term usage, and having a broad market prospect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of treating constipation and preparation method thereof and clinical preparation.
Background technology
Constipation is one of modal gastroenteropathy clinically, often shows as the defecation effort, stool is hard, defecation is less than 3 times weekly, and it is more common that the while usually symptom, especially female patient such as feels with abdominal discomfort, defecation not to the utmost.The prevalence of constipation is higher, and patient's quantity is huge in the world.Epidemiology statistics data according in February, the 2011 global constipation that " clinical gastroenterology best practices and research " magazine is delivered; The sickness rate that is in the geographic China in Asia is 10.8%, is published in sickness rate that " digestive system pharmacology and therapeutics " show constipation to China five city residents' investigation simultaneously about 6%.Comprehensive above research, China's constipation patient nearly about 8,000 ten thousand to 100,000,000 4 thousand ten thousand.
Cause the reason of constipation to have a lot; Irregular such as diet, food-intake is few, it is less to take the photograph people's fiber fruit, fresh vegetables and moisture; Quantity of motion reduces and factor affecting such as anal and intestinal disease or life-time service laxative and gastric acid, pepsinia minimizing; Intestinal wall smooth muscle atrophy enterokinesia is slow, unable, bowel dysfunction takes place and causes constipation.Factor such as spirit depressing also is the risk factor that constipation takes place in addition, and what of what and amount of drinking water of the people's amount of taking the photograph of dietary fiber often have nothing to do with constipation.
Constipation is one of more common puzzlement problem of current society, and a kind of symptom that is multiple disease also is a kind of disease.Constipation has different implications for different people.Modal symptom is that the number of times of abdominal distention, stomachache, defecation obviously reduces.Have plenty of 2～3 days once or the longer time do not wait irregular.Feces is dry, often with discharging difficulty.With the quickening of modern life rhythm, prevalence also increases to some extent with advancing age.In case the symptom of many discomforts can appear in the patient who the constipation phenomenon occurs,, have a strong impact on people's quality of life like symptoms such as dizziness, cardiopalmus, weak, dysphoria, insomnias; Constipation meeting simultaneously can not in time be got rid of because of the harmful substance that produces in the body and causes abdominal distention, belch, gastric acid, toxic reaction etc.; Cause the intestinal eubiosis imbalance; The danger that increases the colorectal cancer generation also can cause serious diseases such as intestinal obstruction, and complication such as urine retention and feces incontinence can be brought out cardiovascular disease, cerebrovascular accident, myocardial infarction even died suddenly in addition.Therefore, the active prevention constipation is the important content of the very important health of current social people.
It is different that doctor and patient treat the angle of constipation clinically; For the doctor, particularly do not have the doctor of Chinese medicine study background often only to pay attention to the problem of patient's stool, and for the patient of constipation, force seek help doctor's main demand of patient because the symptom of the various clinical discomforts that constipation causes is only.Use Chinese medicine knowledge to come the diagnosis and treatment constipation to be only optimum selection on this problem.
Chinese medicine is thought the sick position of constipation mainly at large intestine, and pathogenesis is that the large intestine conduction function is not normal, and the whether normal key of function of intestinal canal depends on the up-down of taste.Taste occupy middle Jiao, are the hinges of human functional activity of vital energy up-down, and the up-down of taste mechanism of qi is the key that human functional activity of vital energy goes up and down, and have only the strong fortune of taste, just can keep lucid YANG ascending to the upper orifices, turbid YIN being discharged from the lower orifices.Weakness of the spleen and stomach, dysfunction of the stomach and spleen in receiving and transporting, then in burnt ascending or descending movement of vital Qi not normal, cause clear YANG failing to ascend, turbid YIN failing to descend and send out and to be primary disease is so the source of constipation is taste." medical center carpenter's line marker " meaning: " people is main with taste, is earlier and cure the disease with the spleen invigorating ".Therefore the constipation root is at taste, and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs function of spleen and stomach regulating function is answered in treatment.Diet go into stomach through the fortune absorption of the corruption of stomach, spleen its precise and tiny after remaining waste matter then go out to become stool by the large intestine transmission; The overall process that forms stool needs 1-2 days, if make of a specified duration excessively, moisture of feces time of staying in intestinal be absorbed often to cause being hard and dry discharging and cause constipation unusually because of certain factor causes taste and large intestine conduction function on time.Traditional Chinese medical science constipation pathological changes mechanism mainly comprises following two aspects: 1, the long-pending heat of gastrointestinal: waste heat is reluctant to leave or the lung-heat dryness of the intestine moves down large intestine or surfeit pure wine savoury or surfeit is pungent or cross and obey scorching medicine and all can cause accumulated heat in gastrointestinal tract consumption impairment of body fluid liquid after patient's innate excess of YANG in the body or the calentura; Intestinal is dry and astringent, excrement matter dry; Be difficult to discharge, i.e. so-called " functional constipation ".Say as Jing-Yue Complete Works: " the constipation caused by accumulation of heat card must be had a surplus because of pathogenic fire, and is dry with the bringing about the spread of body fluid." 2, depression and stagnation of QI: sorrow is pondered over, damage of the spleen is depressed, or depressed angry, stagnation of QI due to depression of the liver, or sitting is moving less, disorder of QI movement; all can cause the internal organs stagnation of QI to stagnate, and logically falls not normally, and conduction dereliction of duty; must not stop descendingly in the waste matter is perhaps discharged not freely, and constipation with dry stool forms constipation due to disorder of QI.As " the golden deficient wing. constipation " institute says: " the constipation due to disorder of QI person stagnate in the gas, and thing is also not all right.”
Chinese patent CN 200810100939.X discloses a kind of Chinese medicine composition of treating constipation, is processed by pockmarks core, Semen Persicae, holy Radix Polygoni Multiflori, Radix Scrophulariae, Ganoderma, Radix Notoginseng, Semen Pruni, Semen pini koraiensis, Radix Angelicae Sinensis etc.Chinese patent CN200910020039.9 discloses a kind of Chinese medicine composition of treating constipation, and said composition is made up of Radix Et Rhizoma Rhei, pockmarks core, Radix Achyranthis Bidentatae, Radix Platycodonis, Semen Armeniacae Amarum, the Rhizoma Atractylodis Macrocephalae, Semen Platycladi, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Semen Sesami Nigrum, Radix Polygoni Multiflori, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Semen Raphani, Aloe, Semen Cassiae, Folium Sennae, Radix Scutellariae, the Radix Astragali, Radix Angelicae Sinensis etc.Chinese patent CN 201010131640.8 discloses a kind of Chinese medicine composition of treating constipation, and said composition is processed by Radix Rehmanniae, Semen Cassiae, the Radix Astragali, Fructus Aurantii, Semen Pruni, Herba Cistanches, Radix Angelicae Sinensis, Fructus Cannabis.Chinese patent CN 201110441847.X discloses a kind of Chinese medicine composition that is used to treat constipation, and said composition is formulated by radix linderae, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Radix Notoginseng, Radix Clematidis, Radix Aconiti Lateralis Preparata, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Bupleuri, Rhizoma Chuanxiong, Oletum Trogopterori, Margarita powder, artificial Calculus Bovis, Borneolum Syntheticum, Ganoderma spore powder, oligochitosan, Radix Sophorae Flavescentis, Semen Vitis viniferae, white hellebore, Radix Ginseng, Herba Epimedii, Herba Lysimachiae, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae etc.Chinese patent CN201010263765.6 discloses a kind of Chinese medicine composition that is used to treat constipation, and said composition is formulated by the Radix Paeoniae Alba, Radix Angelicae Sinensis, Cortex Magnoliae Officinalis, Herba Pogostemonis, Poria, the Radix Astragali, Fructus Cannabis, Fructus Aurantii, Semen Sesami Nigrum, Semen Juglandis, Semen Armeniacae Amarum, Radix Aconiti Lateralis Preparata, Radix Et Rhizoma Rhei, Radix Glycyrrhizae.Yet problem that above-mentioned Chinese medicine composition exists that the prescription flavour of a drug are more, effect is indeterminate in prescription, the part medical material is rare or cost an arm and a leg etc. causes it clinically to use and not only cause the waste in medicine source but also obviously cause the patient to pay increase when processing Chinese patent medicine.The food materials of botanical, animality medical material and integration of edible and medicinal herbs are different because of concocting method when the preparation Chinese medicine composition in the pharmaceutical composition that these prescriptions comprised in addition; Effective ingredient is very easily loss in the preparation process, and it is not high that the quality control of Chinese medicine composition is difficult to grasp when tending to cause clinical use drug effect.
Therefore, provide a kind of curative effect certainly and also medicine source abundance Chinese medicine composition, method for preparing and the Chinese medicine preparation that can effectively treat constipation have realistic meaning.
Summary of the invention
In view of this, the object of the present invention is to provide Chinese medicine composition, method for preparing and the preparation that a kind of curative effect is affirmed, the medicine source is sufficient, obvious results is treated constipation.
For realizing the object of the invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition of treating constipation, process by following bulk drugs:
5～15 parts of 10～20 portions of Radix Paeoniae Albas of 5～15 parts of pockmarks core of Radix et Rhizoma Rhei (processed)
5～15 parts of 5～15 parts of Radix Aucklandiae of 10～20 parts of Cortex Magnoliae Officinalis of Fructus Aurantii
2～10 parts of 5～15 parts of Radix Glycyrrhizae of 20～40 parts of Radix Polygoni Multifloris of Semen Cassiae.
The traditional Chinese medical science thinks that constipation is mainly caused by dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold.The formation of constipation should be started with from the function of conditioning human body in the treatment, and Yin Yang balancing, clearing away heat and moistening the bowels, pleasant intestinal stasis relieving, replenishing QI to invigorate the spleen are principle; Constipation relieving problem, free movement of the bowels then appetite are promoted, and sleep takes a turn for the better; Taste have had the machine of biochemistry, and nutrient blood and body fluid then are able to recover.Chinese medicine composition according to the invention selects for use nine flavor Chinese crude drugs such as Radix et Rhizoma Rhei (processed), pockmarks core, the Radix Paeoniae Alba, Fructus Aurantii, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Semen Cassiae, Radix Polygoni Multiflori, Radix Glycyrrhizae to process to the main pathogenesis such as dryness-heat stagnating in the interior, depression and stagnation of QI, deficiency of body fluid and spleen-kidney vacuity cold that the patient forms constipation.
Wherein, Radix Et Rhizoma Rhei, another name general, Huang Liang etc. are Polygonaceae (Polygonaceae) Rheum (Rheum) herbaceos perennials, are used as medicine with root stock and root.Radix Et Rhizoma Rhei bitter in the mouth, cold in nature is gone into stomach, large intestine, Liver Channel.Have the effect of attacking stagnant, clearing away damp-heat, pathogenic fire purging, logical intestinal, removing heat from blood, blood stasis dispelling, stimulating the menstrual flow, detoxifying, cure mainly that excess-heat constipation, delirium are gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi 、 lumps in the chest and abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, haematemesis, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinate, diseases such as carbuncle and ulcer toxic swelling, furuncle, burn and scald.
Pockmarks core is the another name of Fructus Cannabis, is the core of cannabis seeds, and sweet in the mouth, property are put down, and be slightly poisonous, returns spleen, stomach, large intestine channel.Pockmarks core have moisturize, the effect of laxation, relieving constipation, be used for blood deficiency and depleted fluid, dryness of the intestine constipation.In addition, pockmarks core can stimulate intestinal mucosa, and secretion is increased, and wriggling is accelerated, and reduces big intestinal absorption moisture, so discharge function is arranged." concise exposition on febrile disease ": " profit can be gone withered." " medicineization justice ": " the body profit can be gone dry for Fructus Cannabis, ability intestine moistening, and the patent large intestine is depressed just to be closed.All old blood is uninteresting, and puerperal, QI and blood had some setbacks, and vigour is not multiple after being ill, or can not move all a little less than reporting and control.It is obstructed that large intestine closes knot, should not push away and swing, and also do not allow to close for a long time, with its lung qi of this same Radix Asteris, Semen Armeniacae Amarum profit, grows its large intestine, then just diarrhea.”
The Radix Paeoniae Alba is the another name of Ranunculaceae Paeonia plant Radix Paeoniae Alba, is used as medicine with root, and bitter in the mouth acid, cold nature are gone into liver, spleen, lung, large intestine channel, have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region, spontaneous sweating, fever due to yin deficiency.In addition; Pharmaceutical research thinks that the Radix Paeoniae Alba has the effect of the abdominal cramps of releasing; Stomach, intestinal tube, uterine smooth muscle all had suppress or spasmolysis, and analgesic, analgesia, calmness and anticonvulsant effect are arranged, also have antiinflammatory, antiulcer and various pathogens and some virus are had inhibitory action etc.
Fructus Aurantii is the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. and variety thereof; Bitter in the mouth, acid; Cold nature; Return lung, spleen, liver, stomach, large intestine channel, have the effect of dispelling the stagnated QI, row expectorant, removing food stagnancy, cure mainly diseases such as weight behind septum pectorale feeling of fullness, distending pain over the hypochondrium, accumulation of food in the stomach and intes tine due to indigestion, Anhui distention and fullness in the abdomen, the dysentery, proctoptosis.Through test confirm Fructus Aurantii also have the intestinal smooth muscle of enhancing tensity with a position phasic property contractile function, improve the wriggling function of intestinal, thereby have regulate the flow of vital energy, the effect of relieving constipation.
Cortex Magnoliae Officinalis, another name pachydermia, pipe, magnolia hypoleuca, strong Piao, Cortex Magnoliae Officinalis, CORTEX MAGNOLIAE OFFICINALIS are bark, root bark and the branch skin of Magnoliacea plant Cortex Magnoliae Officinalis and Mount Lushan Cortex Magnoliae Officinalis.Cortex Magnoliae Officinalis is warm in nature, bitter in the mouth is hot, returns spleen, stomach, large intestine channel, has the effect of promoting the circulation of QI to remove dampness, lowering the adverse QI to relieve asthma, is used for that abdominal distention, dyspepsia do not disappear, disease such as vomiting dysentery, the QI rising in reverse order are breathed with cough.Modern pharmacology research shows, Cortex Magnoliae Officinalis has the effect that antalgic and inflammation relieving, relieve muscle spasms, extract Cortex Magnoliae Officinalis alcohol antibiotic and that reduce the effect, particularly Cortex Magnoliae Officinalis of nerve excitability have obvious gastric acid inhibitory secretion, antiulcer action and adjusting intestinal peristalsis promoting function.
The Radix Aucklandiae is the common name of feverfew Saussurea lappa Clarke and Radix Vladimiriae, is used as medicine with root.The Radix Aucklandiae is warm in nature, acrid in the mouth is bitter, returns spleen, stomach, large intestine, Liver Channel, has that fragrance is good for the stomach, the effect of promoting the circulation of QI to relieve pain, cures mainly diseases such as stomach distension, dyspepsia, vomiting, stomachache and diarrhoea, is QI regulating medicine commonly used.Modern pharmacology research shows: the Radix Aucklandiae has the protection gastric mucosa, regulates gastrointestinal motility, promotes effects such as gallbladder contraction, antiinflammatory.
Semen Cassiae is the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae, cold nature, and sweet in the mouth, hardship, salty are returned liver, kidney, large intestine channel.Have clearing away liver-fire, wind-damp dispelling, tonifying kidney and improving eyesight relieving constipation etc., dizzy, diseases such as conjunctival congestion is dim-sighted, constipation, wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation are used to have a headache.Shennong's Herbal is classified Semen Cassiae as top grade.Modern study shows that Semen Cassiae also contains Seedling body chemical compound, chrysophanol, emodin etc. in except that containing saccharide, protein, fat, also has the trace element of needed by human.So Semen Cassiae brings high blood pressure down in having, the effect of resisting pathogenic microbes, reduction serum cholesterol and triglyceride and diarrhea relieving constipation.
The Radix Polygoni Multiflori has another name called Radix Polygoni Multiflori, and red white branch is arranged, and medicinal is the tuber of CHISHOU crow.The Chinese medicine Radix Polygoni Multiflori has the branch of Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata, and direct slicing is used as medicine and is Radix Polygoni Multiflori, uses the Semen sojae atricolor liquor to mix and dry to be used as medicine after the steaming to be Radix Polygoni Multiflori Preparata.Chinese medicine composition according to the invention is raw material with the Radix Polygoni Multiflori.The Radix Polygoni Multiflori slightly warm in nature, bitter in the mouth, sweet wet is returned liver, kidney channel, has detoxifcation, cuts the effect of skin ulcer, loosening bowel to relieve constipation.Modern pharmacology research shows that this medical instrument has antioxidation, enhances human body immunologic function, endocrine regulation, the antibiotic influence that reaches enterokinesia, wherein, because Radix Polygoni Multiflori contains the associativity anthraquinone derivative, can promote enterokinesia, produces discharge function.
Radix Glycyrrhizae, Latin is called Glycyrrhiza uralensis, is the pulse family herbaceos perennial, and root and rhizome is used as medicine, and is a kind of tonification Chinese herbal medicine.Radix Glycyrrhizae property is flat, sweet in the mouth; GUIXIN, lung, spleen, stomach are used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity and strong through having the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The clinical practice branch " is given birth to and uses " with " processed with honey " not." give birth to " Radix Glycyrrhizae has another name called Radix Glycyrrhizae, SHENGCAO, and Radix Glycyrrhizae is for crude drug is removed impurity, cleaned, runs through the section life with being used as medicine; " processed with honey " has another name called Radix Glycyrrhizae Preparata, Radix Glycyrrhizae Preparata, Radix Glycyrrhizae, Radix Glycyrrhizae (processed with honey), and the Radix Glycyrrhizae tabellae of making a living is mixed thoroughly with Mel, fries to tack-free taking-up airing again, is used as medicine then.Radix Glycyrrhizae according to the invention is that crude drug is removed impurity, cleaned, runs through section and give birth to being used as medicine, and property is put down, and sweet in the mouth has the effect of heat-clearing and toxic substances removing, pathogenic fire purging, lung moistening, expelling phlegm for arresting cough, is used for carbuncle, laryngopharynx swelling and pain and medicine, alimentary toxicosis, diseases such as cough and asthma.
Radix et Rhizoma Rhei (processed) described in the present invention, pockmarks core, the Radix Paeoniae Alba, Fructus Aurantii, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Semen Cassiae, Radix Polygoni Multiflori, Radix Glycyrrhizae are well known to a person skilled in the art; Can through commercial sources from pharmacy buy obtain or through disclosed method cultivation the prior art, gathering obtains, its specification meets country or industry standard gets final product.Used medical material is all nontoxic simultaneously, and it is little to take drug dependence for a long time, and cheap, is fit to ordinary consumer and uses.
As preferably, Chinese medicine composition according to the invention, process by following weight portion raw material:
10 parts of 15 portions of Radix Paeoniae Albas of 10 parts of pockmarks core of Radix et Rhizoma Rhei (processed)
10 parts of 10 parts of Radix Aucklandiae of 15 parts of Cortex Magnoliae Officinalis of Fructus Aurantii
6 parts of 10 parts of Radix Glycyrrhizae of 30 parts of Radix Polygoni Multifloris of Semen Cassiae.
The present invention also provides the method for preparing of said Chinese medicine composition.
A kind of method for preparing of treating the Chinese medicine composition of constipation comprises:
Step 1: the pockmarks core of getting 10～20 weight portions is mashed, and decocte with water is filtered, and collects filtrate for later use;
Step 2: with 20～40 weight portion Semen Cassiae grating; Mix with 5～15 weight portion Radix et Rhizoma Rhei (processed), 5～15 weight portion Radix Paeoniae Albas, 10～20 weight portion Fructus Aurantiis, 5～15 weight portion Cortex Magnoliae Officinalis, 5～15 weight portion Radix Aucklandiae, 5～15 weight portion Radix Polygoni Multifloris and 2～10 weight portion Radix Glycyrrhizae; Add water retting 1h; Heating and refluxing extraction is extracted back 1h extracting liquid filtering then, and collection filtrating is filtrated to mix promptly with step 1 gained and got.
The method for preparing of Chinese medicine composition of the present invention has kept the active constituents of medicine in Radix et Rhizoma Rhei (processed), pockmarks core, the Radix Paeoniae Alba, Fructus Aurantii, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Semen Cassiae, Radix Polygoni Multiflori and the Radix Glycyrrhizae to greatest extent.
As preferably, method for preparing according to the invention comprises:
Step 1: the pockmarks core of getting 15 weight portions is mashed, and decocte with water is filtered, and collects filtrate for later use;
Step 2: with 30 weight portion Semen Cassiae grating; Mix with 10 weight portion Radix et Rhizoma Rhei (processed), the 10 weight portion Radix Paeoniae Albas, 15 weight portion Fructus Aurantiis, 10 weight portion Cortex Magnoliae Officinalis, the 10 weight portion Radix Aucklandiae, 10 weight portion Radix Polygoni Multifloris and 6 weight portion Radix Glycyrrhizae; Add water retting 1h; Heating and refluxing extraction is extracted back 1h extracting liquid filtering then, and collection filtrating is filtrated to mix promptly with step 1 gained and got.
As preferably, method for preparing according to the invention is after the said decocte with water of step 1 is decocte with water 30min; Collect first decoction liquor and first medicinal residues respectively; After getting the first medicinal residues decocte with water 30min then, collect second decoction liquor, merge first decoction liquor and second decoction liquor.
The amount of water of decocte with water is a very important problem, and what of amount of water directly influence content of effective.The many water of medicine are few, can cause " boil and do not pass through, fry in shallow oil endless ", and effective ingredient leaches not exclusively, and an evaporation medicine juice is promptly dry slightly, and effective ingredient can be destroyed because of local hyperpyrexia; The few water of medicine is many, though can increase the stripping quantity of effective ingredient, the decoction liquid measure is excessive, is unfavorable for the later stage concentration.As preferably, method for preparing according to the invention, the amount of water of the said decocte with water first time is 5～10 times of pockmarks core weight, the amount of water of decocte with water for the second time is 6～12 times of the first medicinal residues weight.
As preferably; Method for preparing according to the invention; After the said heating and refluxing extraction of step 2 is heating and refluxing extraction 2-8h, collects first extracting solution and first respectively and extract slag, get then first extract slag and add hydro-thermal reflux, extract, 2-8h after; Collect second extracting solution, merge first extracting solution and second extracting solution.
The content of effective that the amount of water of heating and refluxing extraction extracts medicine has material impact.Therefore method for preparing according to the invention, said first time, the amount of water of heating and refluxing extraction was preferably 10 times of mixed material weight, and the amount of water of heating and refluxing extraction was preferably first and extracted 8 times of slag weight said second time.Wherein said mixed material is the mixing of Semen Cassiae, Radix et Rhizoma Rhei (processed), the Radix Paeoniae Alba, Fructus Aurantii, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Radix Polygoni Multiflori and Radix Glycyrrhizae.
The present invention also provides the Chinese medicine composition of above-mentioned method for preparing preparation.
The present invention also provides the clinical preparation of said Chinese medicine composition.It is required various pharmaceutically conventional adjuvants that those skilled in the art can add the preparation different dosage form with Chinese medicine composition according to the invention according to requirement of different patients; Like disintegrating agent, lubricant, emulsifying agent, binding agent etc.; With conventional method of Chinese medicinal, process common dosage forms such as tablet, granule, capsule, powder, pill, oral liquid and syrup etc. through the direct or indirect adding acceptable auxiliary pharmaceutically of conventional processing.
Preferably, the clinical preparation of Chinese medicine composition according to the invention is granule, capsule, tablet, pill or oral liquid, is easy to take, and with strong points, curative effect is obvious.
The using dosage of pharmaceutical composition of the present invention and method for using depend on many factors, comprise activity intensity, Time of Administration, metabolic rate, the course of disease order of severity and the diagnosis and treatment doctor's of patient's age, body weight, sex, natural health situation, nutriture, chemical compound subjective judgment.Those skilled in the art can easily determine the using dosage and the method for using of pharmaceutical composition according to above-mentioned factor.
Preferably, its effective dose of pharmaceutical composition of the present invention is calculated with contained crude drug amount in the Chinese medicine composition of the present invention, is each 5-15g, 2-3 time on the one.
In specific embodiments; It is that laboratory animal is carried out the animal models of constipation experiment that the present invention selects the SD rat for use; From the food ration of laboratory animal, body weight, feces output, stool water content, 6 hours feces volumes, arrange many aspects such as melena (label) time first and observe, understand the safety and the therapeutic effect of medicine.The result shows that Chinese medicine composition according to the invention all is significantly improved for feces volume and the defecation time of test constipation rat, and the intestinal fltting speed for test constipation rat has remarkable lifting simultaneously, is a kind of medicine of ideal treatment constipation therefore.The Chinese medicine composition that shows treatment constipation according to the invention has fairly obvious therapeutical effect to the mice constipation.
The present invention is through clinical observation on the therapeutic effect, in the patient of the prolonged constipation of 30 examples, use traditional Chinese medicine composition for treating according to the invention, and treating obvious effective rate is 90%, and effective percentage is 96.67%.In the patient of 22 routine short-term constipation, use traditional Chinese medicine composition for treating according to the invention, the treatment total effective rate is 95.45%.The Chinese medicine composition that shows treatment constipation according to the invention is evident in efficacy.In the patient of reason treatment, do not have an example untoward reaction to occur, show that Chinese medicine composition according to the invention is to the human body safety non-toxic.
The invention provides a kind of Chinese medicine composition of treating constipation and preparation method thereof and clinical preparation.Chinese medicine composition according to the invention is that feedstock production forms by Radix et Rhizoma Rhei (processed), pockmarks core, the Radix Paeoniae Alba, Fructus Aurantii, Cortex Magnoliae Officinalis, the Radix Aucklandiae, Semen Cassiae, Radix Polygoni Multiflori and Radix Glycyrrhizae, has clearing away heat and moistening the bowels, the effect of the purging FU-organs of regulating the flow of vital energy.Modern pharmacology research and clinical trial show that Chinese medicine composition according to the invention is loosening bowel to relieve constipation effectively, and is easy to use; Evident in efficacy; Comfortable safety has no side effect, and is the good medicine of treatment constipation; Can be widely used in functional constipation, senile constipation and other need take the clinical treatment of the constipation patient of charthartic for a long time, be particularly useful for the treatment of scorching body fluid deficiency and excess-heat astriction of stagnation of qi.The used medical material of the present invention simultaneously is all nontoxic, and the life-time service drug dependence is little, and cheap, is fit to short-term and life-time service, has vast market prospect.
The specific embodiment
The embodiment of the invention discloses a kind of treat constipation Chinese medicine composition and preparation method thereof and clinical preparation.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as and are included in the present invention.Method of the present invention is described through preferred embodiment, and the related personnel obviously can change or suitably change and combination method as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use technology of the present invention.
In order further to understand the present invention, below in conjunction with embodiment the present invention is provided to be elaborated.Embodiment 1: the Chinese medicine composition of treatment constipation according to the invention
Said Chinese medicine composition is by processing like crude drug: Radix et Rhizoma Rhei (processed) 10g, pockmarks core 15g, Radix Paeoniae Alba 10g, Fructus Aurantii 15g, Cortex Magnoliae Officinalis 10g, Radix Aucklandiae 10g, Semen Cassiae 30g, Radix Polygoni Multiflori 10g, Radix Glycyrrhizae 6g;
Method for preparing is to get the above 9 flavor raw materials of said weight, gets pockmarks core and mashes, and it is an amount of to add water; Decoct 2 times, the amount of water of decocte with water for the first time is 8 times of pockmarks core weight, and the amount of water of decocte with water for the second time is 10 times of the first medicinal residues weight; 30min leaching medicinal liquid is subsequent use after boiling at every turn; With the Semen Cassiae grating; Add water retting 1h with surplus medicines such as Radix et Rhizoma Rhei (processed); Heating and refluxing extraction 2 times, for the first time the amount of water of heating and refluxing extraction is 10 times of mixed material weight, extraction time is 2 hours; For the second time the amount of water of heating and refluxing extraction is first to extract 8 times of slag weight, and extraction time is 8 hours; Extracting liquid filtering behind the extraction 1h, with pockmarks core combining medicine, concentrating under reduced pressure becomes 200mL to 250mL, promptly gets.
Embodiment 2: the Chinese medicine composition of treatment constipation according to the invention
Said Chinese medicine composition is by processing like crude drug: Radix et Rhizoma Rhei (processed) 5g, pockmarks core 20g, Radix Paeoniae Alba 5g, Fructus Aurantii 20g, Cortex Magnoliae Officinalis 5g, Radix Aucklandiae 15g, Semen Cassiae 20g, Radix Polygoni Multiflori 15g, Radix Glycyrrhizae 2g;
Method for preparing is to get the above 9 flavor raw materials of said weight, gets pockmarks core and mashes, and it is an amount of to add water; Decoct 2 times, the amount of water of decocte with water for the first time is 5 times of pockmarks core weight, and the amount of water of decocte with water for the second time is 12 times of the first medicinal residues weight; 30min leaching medicinal liquid is subsequent use after boiling at every turn; With the Semen Cassiae grating; Add water retting 1h with surplus medicines such as Radix et Rhizoma Rhei (processed); Heating and refluxing extraction 2 times, for the first time the amount of water of heating and refluxing extraction is 10 times of mixed material weight, extraction time is 8 hours; For the second time the amount of water of heating and refluxing extraction is first to extract 8 times of slag weight, and extraction time is 2 hours; Extracting liquid filtering behind the extraction 1h, with pockmarks core combining medicine, concentrating under reduced pressure becomes 200mL to 250mL, promptly gets.
Embodiment 3: the Chinese medicine composition of treatment constipation according to the invention
Said Chinese medicine composition is by processing like crude drug: Radix et Rhizoma Rhei (processed) 15g, pockmarks core 10g, Radix Paeoniae Alba 15g, Fructus Aurantii 10g, Cortex Magnoliae Officinalis 15g, Radix Aucklandiae 5g, Semen Cassiae 40g, Radix Polygoni Multiflori 5g, Radix Glycyrrhizae 10g;
Method for preparing is to get the above 9 flavor raw materials of said weight, gets pockmarks core and mashes, and it is an amount of to add water; Decoct 2 times, the amount of water of decocte with water for the first time is 10 times of pockmarks core weight, and the amount of water of decocte with water for the second time is 6 times of the first medicinal residues weight; 30min leaching medicinal liquid is subsequent use after boiling at every turn; With the Semen Cassiae grating, add water retting 1h, heating and refluxing extraction 2 times with surplus medicines such as Radix et Rhizoma Rhei (processed); Each 4 hours, for the first time the amount of water of heating and refluxing extraction was 10 times of mixed material weight, and said second time, the amount of water of heating and refluxing extraction was first to extract 8 times of slag weight; Extracting liquid filtering behind the extraction 1h; With pockmarks core combining medicine, concentrating under reduced pressure becomes 200mL to 250mL, promptly gets.
Embodiment 4: the preparation of the tablet of treatment constipation according to the invention
The medicinal liquid of getting embodiment 1 gained carries out vacuum drying, obtains spissated medicated powder; With the spissated medicated powder of gained, add right amount of auxiliary materials, granulation, tabletting, coating, packing promptly get the tablet of treatment constipation according to the invention.
Embodiment 5: the preparation of the capsule of treatment constipation according to the invention
The medicinal liquid of getting embodiment 1 gained carries out vacuum drying, obtains spissated medicated powder; The spissated medicated powder of gained is added right amount of auxiliary materials, and granulation, encapsulated, packing promptly get Chinese medicinal composition capsules agent of the present invention.
Embodiment 6: the preparation of the granule of treatment constipation according to the invention
The medicinal liquid of getting embodiment 1 gained carries out vacuum drying, obtains spissated medicated powder; The spissated medicated powder of gained is added right amount of auxiliary materials, and granulation, drying, granulate, packing promptly get Chinese medicinal composition granules of the present invention.
Embodiment 7: the preparation of the pill of treatment constipation according to the invention
The medicinal liquid of getting embodiment 1 gained carries out vacuum drying, obtains spissated medicated powder; The spissated medicated powder of gained is added right amount of auxiliary materials, and pill, polishing, coating, packing promptly get Chinese medicine composition pill of the present invention.
Embodiment 8: the preparation of the oral liquid of treatment constipation according to the invention
The medicinal liquid of getting embodiment 1 gained carries out vacuum drying, obtains spissated medicated powder; The spissated medicated powder of gained is added right amount of auxiliary materials, and configuration, packing promptly get Chinese medicine composition oral liquid of the present invention.
Embodiment 9: the test of pesticide effectiveness of Chinese medicine composition according to the invention
1, experiment material: SPF level Kunming mouse. body weight (20 ± 2) g, male and female half and half are provided by Shanghai Si Laike Experimental Animal Center; Chinese crude drug is identified and processing by the moral professor of pharmacy of Shao family of Jiangsu TCM Hospital available from sky, Suzhou City spirit prepared slices of Chinese crude drugs company limited; R-1132, Henan demutation pharmaceutcal corporation, Ltd; One clearing capsule: Chengdu Kanghong Pharmaceutical Co., Ltd; Prepared Chinese ink: Radix Acaciae senegalis 100g, add water 800mL, boil to solution transparently, add active carbon 50g, boil 3 times, add water and be settled to 1000mL.
2, experimental technique and result:
2.1 Chinese medicine composition of the present invention is to the influence of constipation model mice bowel movement function
Get 24 of Kunming mouses, be divided into 4 groups at random, be i.e. normal group, model group, matched group and treatment group, 6 every group.Test fasting in preceding 24 hours and can't help water.Model group, matched group and treatment group are irritated clothes compound diphenoxylate suspension (10mg/kg); After 30 minutes; The Chinese medicine composition of one clearing capsule and the embodiment of the invention 1 preparation is configured to contain the suspension of crude drug 1g/mL; Dosage according to 0.1mL/kg gives matched group and treatment group mice, and model group is irritated clothes equal-volume distilled water.Normal group is all irritated clothes equal-volume distilled water synchronously in the experiment.Observation is respectively organized mice and is arranged melena time, six hours defecation grain number and weight first after administration, and table 1 is seen in statistical result.
The influence of table 1 pair constipation model mice defecation
| Group | Defecation time (h) for the first time | Six hours feces volumes (grain) | Six hours feces volumes (g) |
| Normal group | 3.71±0.61 | 12.34±5.88 | 6.23±0.32 |
| Model group | 4.54±0.34 | 7.25±2.52 | 4.16±0.52 |
| Matched group | 4.17±0.43 | 8.14±1.14 | 4.33±0.21 |
| The treatment group | 3.98±0.42 | 10.68±4.85 | 4.84±0.18 |
Visible by table 1 result; Each grain number and normal matched group of dry weight of organizing defecation obviously reduces, and first grain stool efflux time obviously prolongs, and the rat stool is discharged quantity and reduces; But the treatment group than model group first defecation time obviously shift to an earlier date; Defecation grain number and dry weight also increase than model group first, and comparing difference has significance between group, i.e. curative effect difference statistical analysis has significance (P < 0.05) between two groups of treatment group and the model group comparisons; And the group of defecation time treatment first obviously shortens than matched group, and defecation grain number and dry weight treatment group also obviously increase than matched group first.The clinical preparation of the Chinese medicine composition of the embodiment of the invention 2 and embodiment 3 preparations and embodiment 4-8 preparation has identical effect, show Chinese medicine composition according to the invention for the feces volume of test constipation rat and defecation time by remarkable improvement.
2.2 Chinese medicine composition of the present invention is to the influence of constipation model mice gastrointestinal peristalsis
Get 24 of Kunming mouses, be divided into 4 groups at random, be i.e. normal group, model group, matched group and treatment group, 6 every group.Test fasting in preceding 24 hours and can't help water.Model group, matched group and treatment group are irritated clothes compound diphenoxylate suspension (10mg/kg); Normal group is irritated clothes equal-volume distilled water; After 30 minutes, the Chinese medicine composition of a clearing capsule and the embodiment of the invention 1 preparation is configured to contain the suspension of crude drug 1g/mL, irritates stomach respectively according to the dosage of 0.1mL/kg and give matched group and treatment group mice; Normal group and model group are irritated clothes equal-volume distilled water, wherein respectively organize and all contain 0.2% prepared Chinese ink in administered agents or the distilled water.Disconnected neck is put to death behind the administration 20min, cuts open the belly, and the digestive tract pylorus is intactly taken out to returning the region between the heart and the diaphragm part, measures total length and prepared Chinese ink advance distance in small intestinal, calculates the intestinal propulsion rate, and table 2 is seen in statistical result.Wherein, advance distance/small intestinal total length * 100% of intestinal propulsion rate=prepared Chinese ink in small intestinal.
The influence of table 2 pair constipation model mice intestinal propulsion rate
| Divide into groups | Prepared Chinese ink advances length (cm) | Small intestinal length (cm) | Intestinal propulsion rate (%) |
| Normal group | 74.66±21.86 | 100.23±25.47 | 78.85±36.17 |
| Model group | 58.23±20.31 | 106.52±27.63 | 56.32±31.20 |
| Matched group | 61.12±21.45 | 100.32±23.35 | 59.48±27.06 |
| The treatment group | 65.84±24.14 | 99.58±25.98 | 63.85±33.13 |
Visible by table 2 result; Chinese medicine composition according to the invention is behind mouse stomach 30min; The prepared Chinese ink propelling rate of its small intestinal is obviously greater than the constipation model group; Have significance for comparing difference between the treatment curative effect group of constipation, i.e. curative effect difference statistical analysis has significance (P < 0.05) between two groups of treatment group and the model group comparisons, and prepared Chinese ink propelling rate treatment group obviously strengthens than matched group.The Chinese medicine composition of the embodiment of the invention 2 and embodiment 3 preparations and the clinical preparation of embodiment 4-8 preparation have identical effect, show that Chinese medicine composition according to the invention can make small intestinal peristalsis obviously strengthen, and have the effect that promotes defecation.
Embodiment 10: the clinical test of pesticide effectiveness of Chinese medicine composition provided by the invention
Case is selected: from Chinese medicine, analyze the clinical disease of constipation and the characteristics that pathological changes takes place, most clinically its etiology and pathogenesis of patient should be from clearing away heat and moistening the bowels, and the purging FU-organs of regulating the flow of vital energy opinion is controlled.Therefore syndrome-classification standard in we " the new Chinese medicine clinical research guideline " developed and published in 2002 according to national drug and food Surveillance Authority; The syndrome of heat in the stomach clinical manifestation that selection possesses scorching body fluid deficiency and excess-heat Qi-stagnation type syndrome is constipation patient patient 30 examples; Male's 12 examples wherein, women's 18 examples, the oldest person 64 years old; Reckling 16 years old, average 38 years old; The course of disease the shortest 1 month, the longest 15 years.
Therapeutic Method: the oral embodiment of the invention 1 said Chinese medicine composition, 2 times on the one, 1 week of the course of treatment.One week was 1 course of treatment, stop using in the course of treatment other treatment this sick medicine and method.
Curative effect determinate standard:
Recovery from illness: the constipation symptom is alleviated fully, or the relevant clinical disease of constipation reduces >=90%.
Produce effects: the constipation symptom is obviously alleviated, or the relevant clinical disease of constipation reduces >=70%.
Effectively: the constipation symptom is partly alleviated, or the relevant clinical disease of constipation reduces >=30%.
Invalid: the constipation symptom is partly alleviated, or the relevant clinical disease of constipation reduces≤30%.
Result of the test: the result of this test lists in the table 3.
Table 3 efficacy result
| Total case load | Recovery from illness | Produce effects | Effectively | Invalid |
| 30 | 5 | 22 | 2 | 1 |
Can be found out that by table 3 result Chinese medicine composition provided by the invention is 90% to the treatment obvious effective rate of constipation, effective percentage is 96.67%.Experiment shows that the said Chinese medicine composition of embodiment of the invention 2-3 has identical effect with the said clinical preparation of embodiment 4-8 in addition.Therefore Chinese medicine composition according to the invention and clinical preparation thereof have the kidney tonifying spleen invigorating, and the effect of blood circulation promoting and blood stasis dispelling can be used for the treatment of constipation, and stable curative effect has no side effect, be suitable for taking for a long time, and be a kind of medicine of ideal treatment constipation therefore.
Embodiment 11: the clinical test of pesticide effectiveness of Chinese medicine composition provided by the invention or Chinese medicine preparation
Case is selected: select in case 22 examples in outpatient service or ward male 10 examples, women 12 examples; 6～33 years old age, average 15.6 years old; The course of disease 1～30 day.(1) meets State Administration of Traditional Chinese Medicine and publish " new Chinese medicine clinical research guideline "-syndrome of heat in the stomach diagnostic criteria; (2) course of disease is in 30 days; (3) eliminating has severe hepatic renal function injury person; (4) eliminating has clear and definite organic disease of digestive tract and nervous system disease to cause; (5) eliminating can not be adhered to the person of taking traditional Chinese medicine.(5) the dialectical syndrome of heat in the stomach disease characteristics that meet scorching body fluid deficiency and excess-heat Qi-stagnation type syndrome of patient.
Therapeutic Method: the oral embodiment of the invention 1 said Chinese medicine composition, 2 times on the one, 1 week of the course of treatment.One week was 1 course of treatment, stop using in the course of treatment other treatment this sick medicine and method.
Curative effect determinate standard:
Recovery from illness: the constipation symptom is alleviated fully, or the relevant clinical disease of constipation reduces >=90%.
Produce effects: the constipation symptom is obviously alleviated, or the relevant clinical disease of constipation reduces >=70%.
Effectively: the constipation symptom is partly alleviated, or the relevant clinical disease of constipation reduces >=30%.
Invalid: the constipation symptom is partly alleviated, or the relevant clinical disease of constipation reduces≤30%.
Efficacy result is seen table 4.
Table 4 efficacy result
| Total case load | Recovery from illness | Produce effects | Effectively | Invalid |
| 22 | 7 | 11 | 3 | 1 |
Can find out that by table 4 result Chinese medicine composition provided by the invention is 95.45% to the treatment total effective rate of constipation.Experiment shows that the said Chinese medicine composition of embodiment of the invention 2-3 has identical effect with the said clinical preparation of embodiment 4-8 in addition.Therefore Chinese medicine composition according to the invention and clinical preparation thereof can be used for the treatment of constipation, and stable curative effect has no side effect, and is suitable for taking for a long time.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (10)
1. a Chinese medicine composition of treating constipation is characterized in that, is processed by the raw material of following weight portion:
5～15 parts of 10～20 portions of Radix Paeoniae Albas of 5～15 parts of pockmarks core of Radix et Rhizoma Rhei (processed)
5～15 parts of 5～15 parts of Radix Aucklandiae of 10～20 parts of Cortex Magnoliae Officinalis of Fructus Aurantii
2～10 parts of 5～15 parts of Radix Glycyrrhizae of 20～40 parts of Radix Polygoni Multifloris of Semen Cassiae.
2. according to the said Chinese medicine composition of claim 1, it is characterized in that, process by following weight portion raw material:
10 parts of 15 portions of Radix Paeoniae Albas of 10 parts of pockmarks core of Radix et Rhizoma Rhei (processed)
10 parts of 10 parts of Radix Aucklandiae of 15 parts of Cortex Magnoliae Officinalis of Fructus Aurantii
6 parts of 10 parts of Radix Glycyrrhizae of 30 parts of Radix Polygoni Multifloris of Semen Cassiae.
3. a method for preparing of treating the Chinese medicine composition of constipation is characterized in that, comprising:
Step 1: the pockmarks core of getting 10～20 weight portions is mashed, and decocte with water is filtered, and collects filtrate for later use;
Step 2: with 20～40 weight portion Semen Cassiae grating; Mix with 5～15 weight portion Radix et Rhizoma Rhei (processed), 5～15 weight portion Radix Paeoniae Albas, 10～20 weight portion Fructus Aurantiis, 5～15 weight portion Cortex Magnoliae Officinalis, 5～15 weight portion Radix Aucklandiae, 5～15 weight portion Radix Polygoni Multifloris and 2～10 weight portion Radix Glycyrrhizae; Add water retting 1h; Heating and refluxing extraction is extracted back 1h extracting liquid filtering then, and collection filtrating is filtrated to mix promptly with step 1 gained and got.
4. according to the said method for preparing of claim 3, it is characterized in that, after the said decocte with water of step 1 is decocte with water 30min; Collect first decoction liquor and first medicinal residues respectively; After getting the first medicinal residues decocte with water 30min then, collect second decoction liquor, merge first decoction liquor and second decoction liquor.
5. according to the said method for preparing of claim 4, it is characterized in that the amount of water of the said decocte with water first time is 5～10 times of pockmarks core weight, the amount of water of decocte with water for the second time is 6～12 times of the first medicinal residues weight.
6. according to the said method for preparing of claim 3; It is characterized in that; After the said heating and refluxing extraction of step 2 is heating and refluxing extraction 2-8h, collects first extracting solution and first respectively and extract slag, get then first extract slag and add hydro-thermal reflux, extract, 2-8h after; Collect second extracting solution, merge first extracting solution and second extracting solution.
7. according to the said method for preparing of claim 6, it is characterized in that said first time, the amount of water of heating and refluxing extraction was 10 times of mixed material weight, said second time, the amount of water of heating and refluxing extraction was first to extract 8 times of slag weight.
8. the Chinese medicine composition of any said method for preparing preparation of claim 3-7.
9. a Chinese medicine preparation of treating constipation is characterized in that, is processed by claim 1,2 or 8 described Chinese medicine compositions and acceptable accessories.
10. according to the said clinical preparation of claim 9, it is characterized in that it is granule, capsule, tablet, pill or oral liquid.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988755A (en) * | 2012-12-05 | 2013-03-27 | 陕西博森生物制药股份集团有限公司 | Oral medicine for treating constipation |
| CN103463520A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | Qi moving and bowel relaxing plaster and preparation method thereof |
| CN103463259A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | External use Chinese medicine bag for moving qi and relaxing bowel and preparation method thereof |
| CN104784282A (en) * | 2014-01-20 | 2015-07-22 | 中国中医科学院中药研究所 | Traditional Chinese medicinal compound preparation for treating constipation |
| CN106668299A (en) * | 2017-02-18 | 2017-05-17 | 四川双鑫生物科技有限公司 | Pill medicine for treating constipation, and preparation method of pill medicine |
| CN110801017A (en) * | 2019-11-06 | 2020-02-18 | 湖北中医药大学 | Chitosan oligosaccharide composition for improving constipation and application thereof |
-
2012
- 2012-08-29 CN CN201210312331XA patent/CN102784221A/en active Pending
Non-Patent Citations (1)
| Title |
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| 方红燕: "便秘的药物治疗现状", 《结直肠***外科》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988755A (en) * | 2012-12-05 | 2013-03-27 | 陕西博森生物制药股份集团有限公司 | Oral medicine for treating constipation |
| CN102988755B (en) * | 2012-12-05 | 2013-12-11 | 陕西博森生物制药股份集团有限公司 | Oral medicine for treating constipation |
| CN103463520A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | Qi moving and bowel relaxing plaster and preparation method thereof |
| CN103463259A (en) * | 2013-08-10 | 2013-12-25 | 安玉霞 | External use Chinese medicine bag for moving qi and relaxing bowel and preparation method thereof |
| CN104784282A (en) * | 2014-01-20 | 2015-07-22 | 中国中医科学院中药研究所 | Traditional Chinese medicinal compound preparation for treating constipation |
| CN106668299A (en) * | 2017-02-18 | 2017-05-17 | 四川双鑫生物科技有限公司 | Pill medicine for treating constipation, and preparation method of pill medicine |
| CN110801017A (en) * | 2019-11-06 | 2020-02-18 | 湖北中医药大学 | Chitosan oligosaccharide composition for improving constipation and application thereof |
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