CN104367986A - Composition for treating and preventing alopecia - Google Patents

Composition for treating and preventing alopecia Download PDF

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Publication number
CN104367986A
CN104367986A CN201410713823.9A CN201410713823A CN104367986A CN 104367986 A CN104367986 A CN 104367986A CN 201410713823 A CN201410713823 A CN 201410713823A CN 104367986 A CN104367986 A CN 104367986A
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parts
radix
root
hair
alopecia
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段丽杰
温军海
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract

The invention relates to a composition for treating and preventing alopecia. The composition comprises 1-10 parts of ginger, 0.5-2 parts of musk, 0.5-2 parts of bezoar, 0.5-3 parts of epimedium herb, 0.5-2 parts of sandalwood, 0.5-5 parts of astragalus root, 0.5-5 parts of licorice extract, 0.5-5 parts of root-bark of peony tree, 0.5-10 parts of angelica root, 0.5-10 parts of root of red-rooted salvia, 0.5-10 parts of Chinese magnoliavine fruit, 5-10 parts of fleeceflower root, 0.5-10 parts of cypress leaf, 0.5-10 parts of dried rehamnnia root, 0.5-2 parts of mint, 0.5-10 parts of stem of false tomentoseanther clematis, 0.5-10 parts of saffron, 0.5-2 parts of vitamin E, 0.5-1 part of cimetidine, 0.1-2 parts of capsicum tincture and 0.1-2 parts of penetration enhancer. The composite has no evident simulation and is applicable to the treatment of madarosis and sparse eyebrows and eyelashes; 1670 clinical cases show that significant efficiency in 1515 cases continuously tracked is 95.7%; the composition has no toxic and side effects and is suitable for continuous application.

Description

The combination formula of a kind of hair growth and pre-Anti-hair loss
Technical field
The present invention relates to the combination formula of a kind of hair growth and pre-Anti-hair loss, belong to technical field of Chinese medicines.
Background technology
Along with the development that modern fast pace is lived, the dual-pressure of work and life, and the deterioration of living environment, the phenomenon of the hair that the crowd in the past only more than person in middle and old age just occurs, eyebrow, deplumation, progressively becomes younger to the young and the middle aged and without restraint spreads.
Coming off of hair and eyebrow and eyelashes, is a kind of very common and be difficult to the disease for the treatment of, particularly brings great misery for the young and the middle aged more focusing on look.Traditional treatment by Chinese herbs combination is all generally according to theory of Chinese medical science proportioning Chinese medicine, but have ignored the reality of the endocrine regulation that the real-life state due to Modern human populations causes, stay up late, pressure, underproof food, electron radiation, haze, scald dyeing hair etc. negative effect to be centered around whenever and wherever possible at one's side, the decline of overall crowd's function is inevitable.So what the morbid state just occurred as former a lot of old crowd was too early appears at it youngster, just becomes a kind of normality, alopecia wherein the most obvious often.
Alopecia inducement is a lot, mainly contain: (1) life and work pressure: life and work pressure can make that people feels vexatious, nervous, emotional lability, insomnia, these factors can affect hormone secretion, make oils and fats cross and contain and block hair follicle, the final alimentation affecting blood circulation and hair, causes alopecia.(2) dietetic nutrition is bad: excessively pursue slender stature, lose weight in the mode of going on a diet, and can cause for want of sufficient nutrient of hair and become withered matt, and then causing a large amount of alopecia.(3) boiling hot, hair dyeing overfrequency: perm continually and bleaching and dyeing and can cause damage to hair, cause alopecia.(4) Women’s climacteric: during Women’s climacteric, various organ all falls into a decline, and estrogen secretion reduces gradually, and depilation phenomenon may also can adjointly occur.In addition, some disease, air-borne dust, hair are pricked the reasons such as tension, long-term taking contraceptive, heredity also can cause alopecia.
Alopecia, specific to kind, is divided into: (1) androgenetic alopecia: be autosomal dominant inheritance, AD, and its inherited characteristic just need show under androgenic effect.(2) nervous alopecia: usually occur when stress is excessive that alopecia increases.Under the effect of stress, human body arrectores pilorum shrinks, hair is upright, and vegetative nerve or nervus centralis function get muddled, and hair follicle hair papilla occurs.(3) endocrine alopecia: hair growth is subject to the impact of multiple endocrine hormone, so cause hair loss disorders, as puerperal, climacteric alopecia when there is cryptorrhea more.(4) trophism alopecia: hair is the outward manifestation of health, body malnutrition and pathobolism can cause the change of hair quality and color development, and severe malnutrition even causes alopecia generalisata.(5) physical property alopecia: the common physical factor of alopecia that causes comprises mechanical irritation and contacts radioactive substance.(6) alopecia of chemical origin: chemical factor can cause hair color to change even alopecia.(7) infectious baldness: the infection of various pathogen is a class key factor in hair diseases, mainly comprises the infection such as antibacterial, virus, fungus, spirillum, parasite.(8) symptomatic alopecia: some systematicness or local disease all can occur together alopecia.(9) congenital alopecia: the hair caused by developmental defect lacks or sparse completely, and the common hair of patient is sparse tiny, or during birth, hair is normal, shortly comes off and does not regenerate, and can be divided into isolated defects and other deformities.(10) seasonal alopecia: general easy alopecia in summer, because the expansion of summer temperature height pore causes [alopecia] alopecia, not easily alopecia when the autumn and winter, because this period temperature decline pore closes.
Summary of the invention
The object of the present invention is to provide the combination formula of a kind of hair growth and pre-Anti-hair loss, on the basis of Chinese medicine hair growth, the increase cimetidine of novelty, for the fat secretion that too much causes antiandrogen and hair follicle atrophy, increases vitamin E and promotes the effect of peripheral vessel blood flow; Increase capsicum tincture plays local irritant effect; Increase enhancer of cutaneous penetration, promote that the quick infiltration of medicine effective ingredient is subcutaneous and produce drug effect.
To achieve these goals, technical scheme of the present invention is as follows.
The combination formula of a kind of hair growth and pre-Anti-hair loss, be made up of following component by mass fraction: 1 ~ 10 part, Rhizoma Zingiberis Recens, 0.5 ~ 2 part, Moschus, Calculus Bovis 0.5 ~ 2 part, sheep 0.5 ~ 3 part suddenly, 0.5 ~ 2 part, Lignum Santali Albi, the Radix Astragali 0.5 ~ 5 part, Radix Glycyrrhizae extract 0.5 ~ 5 part, Cortex Moutan 0.5 ~ 5 part, Radix Angelicae Sinensis 0.5 ~ 10 part, Radix Salviae Miltiorrhizae 0.5 ~ 10 part, Fructus Schisandrae Chinensis 0.5 ~ 10 part, Radix Polygoni Multiflori 5 ~ 10 parts, Cacumen Cupressi 0.5 ~ 10 part, 0.5 ~ 10 part, the Radix Rehmanniae, Herba Menthae 0.5 ~ 2 part, Caulis Clematidis pseudopogonandrae 0.5 ~ 10 part, Stigma Croci 0.5 ~ 10 part, vitamin E 0.5 ~ 2 part, cimetidine 0.5 ~ 1 part, capsicum tincture 0.1 ~ 2 part, enhancer of cutaneous penetration 0.1 ~ 2 part.
Further, the combination formula of above-mentioned hair growth and pre-Anti-hair loss, be made up of following component by mass fraction: 5 ~ 10 parts, Rhizoma Zingiberis Recens, 1 ~ 2 part, Moschus, Calculus Bovis 1 ~ 2 part, sheep 2 ~ 3 parts suddenly, 1 ~ 2 part, Lignum Santali Albi, the Radix Astragali 3 ~ 5 parts, Radix Glycyrrhizae extract 35 parts, Cortex Moutan 3 ~ 5 parts, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Salviae Miltiorrhizae 5 ~ 10 parts, Fructus Schisandrae Chinensis 5 ~ 10 parts, Radix Polygoni Multiflori 5 ~ 10 parts, Cacumen Cupressi 5 ~ 10 parts, 5 ~ 10 parts, the Radix Rehmanniae, Herba Menthae 1 ~ 2 part, Caulis Clematidis pseudopogonandrae 5 ~ 10 parts, Stigma Croci 5 ~ 10 parts, vitamin E 1 ~ 2 part, cimetidine 0.5 ~ 1 part, capsicum tincture 0.5 ~ 1 part, enhancer of cutaneous penetration 0.1 ~ 0.5 part.
In combinations thereof formula; novelty by natural Chinese medicine composition; as Rhizoma Zingiberis Recens, Moschus, Calculus Bovis, sheep suddenly, Lignum Santali Albi, the Radix Astragali, Radix Glycyrrhizae extract, Cortex Moutan, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Radix Polygoni Multiflori, Cacumen Cupressi, the Radix Rehmanniae, Herba Menthae, Caulis Clematidis pseudopogonandrae, Stigma Croci and western medicine composition vitamin E, cimetidine, capsicum tincture, enhancer of cutaneous penetration combine; reach the maximum availability of effective ingredient, obtain the combination formula for hair growth promoting, hair care promoter and blood circulation accelerant.On the basis of Chinese medicine hair growth, the increase cimetidine of novelty, for the fat secretion that too much causes antiandrogen and hair follicle atrophy, increases vitamin E and promotes the effect of peripheral vessel blood flow; Increase capsicum tincture plays local irritant effect; Increase enhancer of cutaneous penetration, promote that the quick infiltration of medicine effective ingredient is subcutaneous and produce drug effect.Can be made into external hair agent and also effectively can prevent baldness, and have preventive and therapeutic effect to alopecia, the dandruff and scalp itch, the variforms such as lotion, liniment and gel can be made, facilitate patient's choice for use.
This beneficial effect of the invention is: this combination formula, without obvious irritation, also may be used for eyebrow and deplumation, sparse treatment uses.Use through clinical 1670 routine patients, wherein have continuous tracking crowd number 1515 people, obvious effective rate 95.7%, and without any side effects, can persistence use.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described, better to understand the present invention.
embodiment 1
The combination formula of the hair growth in the present embodiment and pre-Anti-hair loss, is made up of following component by mass fraction: 10 parts, Rhizoma Zingiberis Recens, 2 parts, Moschus, Calculus Bovis 2 parts; sheep 3 parts suddenly, 2 parts, Lignum Santali Albi, the Radix Astragali 5 parts, Radix Glycyrrhizae extract 5 parts; Cortex Moutan 5 parts, Radix Angelicae Sinensis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Fructus Schisandrae Chinensis 10 parts; Radix Polygoni Multiflori 10 parts, Cacumen Cupressi 10 parts, 10 parts, the Radix Rehmanniae; Herba Menthae 2 parts, Caulis Clematidis pseudopogonandrae 10 parts, Stigma Croci 10 parts; vitamin E 2 parts, cimetidine 1 part, capsicum tincture 2 parts, enhancer of cutaneous penetration 2 parts.Combination formula in the present embodiment makes external hair agent in order to prevent baldness, and has preventive and therapeutic effect to alopecia, the dandruff and scalp itch, or makes the variforms such as lotion, liniment and gel, facilitates patient's choice for use.
embodiment 2
The combination formula of the hair growth in the present embodiment and pre-Anti-hair loss, is made up of following component by mass fraction: 1 part, Rhizoma Zingiberis Recens, 0.5 part, Moschus; Calculus Bovis 0.5; sheep 0.5 part suddenly, 0.5 part, Lignum Santali Albi, the Radix Astragali 0.5 part; Radix Glycyrrhizae extract 0.5 part; Cortex Moutan 0.5 part, Radix Angelicae Sinensis 0.5 part, Radix Salviae Miltiorrhizae 0.5 part; Fructus Schisandrae Chinensis 0.5 part; Radix Polygoni Multiflori 5 parts, Cacumen Cupressi 0.5 part, 0.5 part, the Radix Rehmanniae; Herba Menthae 0.5 part; Caulis Clematidis pseudopogonandrae 0.5 part, Stigma Croci 0.5 part, vitamin E 0.5 part; cimetidine 0.5 part, capsicum tincture 0.1 part, enhancer of cutaneous penetration 0.1 part.Combination formula in the present embodiment makes external hair agent also in order to prevent baldness, and has preventive and therapeutic effect to alopecia, the dandruff and scalp itch, or makes the variforms such as lotion, liniment and gel, facilitates patient's choice for use.
embodiment 3
The combination formula of the hair growth in the present embodiment and pre-Anti-hair loss, is made up of following component by mass fraction: 5 parts, Rhizoma Zingiberis Recens, 1 part, Moschus, Calculus Bovis 1 part; sheep 2 parts suddenly, 1 part, Lignum Santali Albi, the Radix Astragali 3 parts, Radix Glycyrrhizae extract 3 parts; Cortex Moutan 3 parts, Radix Angelicae Sinensis 5 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Schisandrae Chinensis 5 parts; Radix Polygoni Multiflori 8 parts, Cacumen Cupressi 5 parts, 5 parts, the Radix Rehmanniae; Herba Menthae 1 part, Caulis Clematidis pseudopogonandrae 5 parts, Stigma Croci 5 parts; vitamin e1 part, cimetidine 0.8 part, capsicum tincture 1 part, enhancer of cutaneous penetration 1 part.Combination formula in the present embodiment makes external hair agent in order to prevent baldness, and has preventive and therapeutic effect to alopecia, the dandruff and scalp itch, or makes the variforms such as lotion, liniment and gel, facilitates patient's choice for use.Combination formula in the present embodiment, uses through clinical 1670 routine patients, wherein has continuous tracking crowd number 1515 people, obvious effective rate 95.7%, and without any side effects, can persistence use.Treatment case load is according to statistics as shown in table 1 institute.
Table 1:
The above is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.

Claims (2)

1. the combination formula of a hair growth and pre-Anti-hair loss, it is characterized in that: be made up of following component by mass fraction: 1 ~ 10 part, Rhizoma Zingiberis Recens, 0.5 ~ 2 part, Moschus, Calculus Bovis 0.5 ~ 2 part, sheep 0.5 ~ 3 part suddenly, 0.5 ~ 2 part, Lignum Santali Albi, the Radix Astragali 0.5 ~ 5 part, Radix Glycyrrhizae extract 0.5 ~ 5 part, Cortex Moutan 0.5 ~ 5 part, Radix Angelicae Sinensis 0.5 ~ 10 part, Radix Salviae Miltiorrhizae 0.5 ~ 10 part, Fructus Schisandrae Chinensis 0.5 ~ 10 part, Radix Polygoni Multiflori 5 ~ 10 parts, Cacumen Cupressi 0.5 ~ 10 part, 0.5 ~ 10 part, the Radix Rehmanniae, Herba Menthae 0.5 ~ 2 part, Caulis Clematidis pseudopogonandrae 0.5 ~ 10 part, Stigma Croci 0.5 ~ 10 part, vitamin E 0.5 ~ 2 part, cimetidine 0.5 ~ 1 part, capsicum tincture 0.1 ~ 2 part, enhancer of cutaneous penetration 0.1 ~ 2 part.
2. the combination formula of hair growth according to claim 1 and pre-Anti-hair loss, it is characterized in that: be made up of following component by mass fraction: 5 ~ 10 parts, Rhizoma Zingiberis Recens, 1 ~ 2 part, Moschus, Calculus Bovis 1 ~ 2 part, sheep 2 ~ 3 parts suddenly, 1 ~ 2 part, Lignum Santali Albi, the Radix Astragali 3 ~ 5 parts, Radix Glycyrrhizae extract 35 parts, Cortex Moutan 3 ~ 5 parts, Radix Angelicae Sinensis 5 ~ 10 parts, Radix Salviae Miltiorrhizae 5 ~ 10 parts, Fructus Schisandrae Chinensis 5 ~ 10 parts, Radix Polygoni Multiflori 5 ~ 10 parts, Cacumen Cupressi 5 ~ 10 parts, 5 ~ 10 parts, the Radix Rehmanniae, Herba Menthae 1 ~ 2 part, Caulis Clematidis pseudopogonandrae 5 ~ 10 parts, Stigma Croci 5 ~ 10 parts, vitamin E 1 ~ 2 part, cimetidine 0.5 ~ 1 part, capsicum tincture 0.5 ~ 1 part, enhancer of cutaneous penetration 0.1 ~ 0.5 part.
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