CN104324429A - Heparinization simplified pre-flushing method for perfusion device - Google Patents
Heparinization simplified pre-flushing method for perfusion device Download PDFInfo
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- CN104324429A CN104324429A CN201410568771.0A CN201410568771A CN104324429A CN 104324429 A CN104324429 A CN 104324429A CN 201410568771 A CN201410568771 A CN 201410568771A CN 104324429 A CN104324429 A CN 104324429A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0021—Special media to be introduced, removed or treated removed from and reintroduced into the body, e.g. after treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/005—Anatomical parts of the body used as an access side to the body
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Abstract
The invention discloses a heparinization simplified pre-flushing method for a perfusion device. The method comprises the following steps: (1) injecting more than 20mg of heparin into an adsorption column of the perfusion device; (2) enabling the adsorption column to stand for more than 10 minutes; (3) pre-flushing the adsorption column with more than 1000ml of normal saline. According to the simplified pre-flushing method disclosed by the invention, during the standing process of the adsorption column, the heparin is gradually adsorbed by resin, and therefore the goal of heparinization is achieved; the method is capable of allowing an operator to perform other related pre-flushing operations of the perfusion device; under the condition that patients are excessive in number, pre-flushing of the multiple perfusion devices can be satisfied simultaneously, and the full heparinization of an adsorbent in the adsorption column is ensured and the goal that stock solution in the adsorption column is drained is achieved; on the premise that the safety is ensured, the use level of pre-flushing solution is reduced, and the identical pre-flushing effect can be achieved; compared with the traditional pre-flushing method, the heparinization simplified pre-flushing method disclosed by the invention has the advantages that time spent by pre-flushing is greatly shortened, the operation of medical care personnel is simplified, and the pre-flushing efficiency is improved.
Description
Technical field
The present invention relates to a kind of technical field of medical equipment, specifically, relate to a kind of method that perfusion device to blood purification carries out pre-punching.
Background technology
Hemoperfusion is the blood purification technology that rapid of emerging is new clinically in recent years, and treatment category has related to nephropathy, acute poisoning, hepatopathy, critical illness, dermatosis and immune disease etc.Hemoperfusion guides in extracorporeal circulation system by blood samples of patients in body, by adsorbent non-specific adsorption poisonous substance, medicine, metabolite in blood perfusion device, reaches a kind of blood purification treatment method or means of removing these materials.
Chinese utility model patent CN200820047979 discloses a kind of blood perfusion device common on the market at present, and the component parts of this perfusion device comprises an adsorption column and the two cover closing devices for sealing the axial two-port of adsorption column respectively.In adsorption column in pipe, various types of adsorbent can be installed according to different treatment orders, such as immunoadsorbent, acticarbon, resin sorbent etc.This type of blood perfusion device all needs to rush in advance before use, and main purpose is the stock solution in order to discharge in perfusion device adsorption column, enters in blood cause hemolytic reaction to avoid sterile water for injection, gets rid of the bubble in perfusion device simultaneously.Blood perfusion device breaking through in journey in advance before the use adds heparin, makes the resin heparinization in perfusion device, also makes pipeline heparinization simultaneously, thus avoids causing various untoward reaction, and as blood perfusion device intravascular coagulation, body is irritated; When in perfusion therapeutic process, timing supplements the heparin of doses from pipeline, is for preventing the untoward reaction such as the blood coagulation characteristic sum individual variation due to blood of human body causes blood coagulation, body irritated.Breaking through in advance in journey therefore before perfusion device uses has certain requirement to the consumption and flow velocity that rush liquid in advance.
For the blood perfusion device adopting Microporous resin to be adsorbent, traditional pre-punching method is: 1) rush in advance with the speed of 100ml/min with the heparin-saline 2500ml of low concentration, drain gas in adsorption column; 2) rush 500ml in advance with the heparin-saline of high concentration to rush in advance with the speed of 50ml/min; 3) perfusion device is rushed with one bottle of normal saline 500ml in advance with the speed of 100ml/min; 4) use on the machine.The consuming time of this pre-punching method is about 40min, and pre-momentum is about 3500ml.And for taking active carbon as the perfusion device of adsorbent, also need the glucose solution with 5% to rush in advance, more extend and rush the time in advance.There is following problem in above-mentioned pre-punching method:
The kind of 1, rushing liquid is in advance many, and trivial operations, wastes time and energy, and operator's amount of labour is large, and when taking, spirit high concentration guarantee is avoided occurring that wrong rushes liquid problem in advance; Simultaneously owing to increasing manpower demand, limit operator and realize the probability that a people rushes branched perfusion device simultaneously in advance, cause rushing in advance efficiency lower;
2, easily causing breaking through in advance gas in journey enters in adsorption column, and aerofluxus is insufficient, causes relevant blood coagulation risk;
3, it is longer to rush the operating time in advance, increases the waiting time of patient, the relevant disease that treatment time is urgent is easily missed to the golden hour of patient;
4, rush liquid consumption in advance large, cause the waste of resource, add treatment cost.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, provides a kind of heparinization for perfusion device to simplify pre-punching method, thus under the prerequisite ensureing safety, can reach same and rush effect in advance.
For solving the problems of the technologies described above, the heparinization that the invention provides a kind of perfusion device simplifies pre-punching method, and described perfusion device comprises adsorption column, and wherein said method comprises the following steps:
1) heparin injections step: the heparin injecting more than 20mg in described adsorption column;
2) stating step: above-mentioned adsorption column is left standstill more than 10 minutes;
3) step is rushed in advance: with the normal saline of more than 1000ml, above-mentioned adsorption column is rushed in advance.
From such scheme, simplify in pre-punching method in perfusion device heparinization of the present invention, the undiluted heparin of direct injection in perfusion device, and leaves standstill and deposits, to replace the mode of the pre-punching of traditional heparin-saline with multiple variable concentrations (heparin solution); Adsorption column is in the process left standstill, and absorbent resin little by little adsorbs heparin, thus reaches the object of heparinization.The method of this standing heparinization can allow operator to carry out the relevant of other perfusion devices and rush operation in advance, the pre-punching of branched perfusion device can be met when patient is comparatively saturated simultaneously, ensure that the abundant heparinization of adsorption column internal adsorption agent simultaneously and drain the object of stock solution in adsorption column, under the prerequisite ensureing safety, decrease the consumption rushing liquid in advance, and can reach same or better rush effect in advance.Compared with traditional pre-punching method, pre-punching method of the present invention substantially reduces the time of rushing in advance and spending, and simplifies the operation of medical personnel, improves the efficiency of pre-punching.
Further technical scheme is, after completing described heparin injections step and before carrying out described stating step, jolts described adsorption column, helps the diffusion of heparin in adsorption column inside.
Preferably, in described heparin injections step, the heparin amount of injecting in described adsorption column is 40 ~ 300mg.More preferably, in described heparin injections step, the heparin amount of injecting in described adsorption column is 100 ~ 200mg.
Preferably, in described stating step, the time of repose of described adsorption column is 10 ~ 75min.More preferably, in described stating step, the time of repose of described adsorption column is 30 ~ 40min, makes the adsorbance of adsorbent to heparin reach the optimal adsorption amount of clinical verification.
Preferably, rush in advance in step described, the amount of described normal saline is 1000 ~ 5000ml.
Preferably, rush in advance in step described, the pre-swash of wave speed of described normal saline is 50 ~ 300ml/min; More preferably, the pre-swash of wave speed of described normal saline is 100 ~ 200ml/min.
According to pre-punching method of the present invention, described perfusion device can be following any one: Microporous resin perfusion device, resin anion (R.A.) perfusion device, carbide resin perfusion device, active carbon perfusion device.
Detailed description of the invention
To describe various embodiment of the present invention below in detail, embodiment is wherein described and describes hereinafter.Although the present invention will be described in conjunction with illustrative embodiments, be to be understood that and the invention is not restricted to these illustrative embodiments.On the contrary, the present invention not only comprises these embodiments, but also comprises various distortion, improvement.In following all embodiments, be 100mg as the dose of heparin adopted in the pre-punching method of the tradition compared.
embodiment 1
Rush in advance the blood perfusion device taking Microporous resin as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 200mg of required heparin is injected directly in perfusion device, after jolting adsorption column 5 ~ more than 10s by wrist, leaves standstill 10min.
Because heparin injects each corner that can be diffused into rapidly perfusion device behind perfusion device inside by diffusion, thus make perfusion device inside resin can fully contact with heparin and absorb, reach heparinization effect.
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 200ml/min, and drain the bubble in adsorption column in the process.Normal saline is adopted to rush perfusion device in advance with certain flow velocity, thus go out in perfusion device by failing complete absorbed heparin in perfusion device, ensure that the heparin amount of resin absorption reaches the individual demand of patient, the granularity of perfusion device inside and pH value and reaches within the scope of safety value the use safety of perfusion device as ensured.Adopt normal saline punching when rushing on the other hand perfusion device in advance, it is single, easy to operate to rush liquid kind in advance, and avoids traditional method to rush the many and operational issue that occurs of liquid kind in advance.The saline volume of pre-punching comparatively traditional method minimizing simultaneously, thus reduce the consumption of normal saline, save resource and cost.
3) use on the machine.
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. pre existing punching method | 3500mL | 40min | -- | 72.58 | ＊＊＊＊ |
| 2. pre-punching method is simplified | 2000mL | 10min | 10min | 100 | ＊＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
Due to patient carry out hemoperfusion time, need preengage in advance, operator can penetrate heparin according to the individual character of reservation patient in advance to perfusion device note doses, and the injection work of multiple perfusion device can be operated simultaneously, make perfusion device carry out heparinization process, and arrive the time that patient can be to be made an appointment.Owing to rushing time shorten in advance, the waiting time of patient also shortens accordingly.When carrying out normal saline and rushing in advance, operator also can carry out the operation of multiple perfusion device simultaneously, thus increase work efficiency, and reduce manpower expenditure.
For special population, as emergency and severe disease patient, best treatment time is very crucial, the concise and to the point pre-punching method of perfusion device in this patent needs shorter heparin time of repose, and shorten heparin and rush the time in advance, the waiting time of emergency and severe disease patient is shortened, thus has won best treatment time.
embodiment 2
Rush in advance the blood perfusion device taking Microporous resin as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 40mg of required heparin is injected directly in perfusion device, after jolting adsorption column 5 ~ more than 10S by wrist, leaves standstill 10min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 100ml/min, and drain the bubble in adsorption column in the process;
3) use on the machine.
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. pre existing punching method | 3500mL | 40min | -- | 72.58 | ＊＊＊＊ |
| 2. pre-punching method is simplified | 2000ml | 20min | 10min | 39.5 | ＊＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 3
Rush in advance the blood perfusion device taking Microporous resin as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 200mg of required heparin is injected directly in perfusion device, after jolting adsorption column 5 ~ more than 10s by wrist, leaves standstill 30min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 100ml/min, and drain the bubble in adsorption column in the process;
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. pre existing punching method | 3500mL | 40min | -- | 72.58 | ＊＊＊＊ |
| 2. pre-punching method is simplified | 2000ml | 20min | 30min | 141.17 | ＊＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 4
Rush in advance the blood perfusion device taking Microporous resin as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 100mg of required heparin is injected directly in perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 60min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 100ml/min, and drain the bubble in adsorption column in the process;
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. pre existing punching method | 3500mL | 40min | -- | 72.58 | ＊＊＊＊ |
| 2. pre-punching method is simplified | 2000ml | 20min | 60min | 90.28 | ＊＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 5
Rush in advance the blood perfusion device taking Microporous resin as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 100mg of required heparin is injected directly in perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 10min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 100ml/min, and drain the bubble in adsorption column in the process;
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. pre existing punching method | 3500mL | 40min | -- | 72.58 | ＊＊＊＊ |
| 2. pre-punching method is simplified | 2000ml | 20min | 10min | 75.62 | ＊＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 6
Rush in advance the blood perfusion device taking resin anion (R.A.) as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 100mg of required heparin is injected directly in the adsorption column of perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 40min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 200ml/min, and drain the bubble in adsorption column in the process;
3) use on the machine.
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. the pre-punching method of tradition | 3000mL | 30min | -- | 97 | ＊＊＊ |
| 2. pre-punching method is simplified | 2000mL | 10min | 40min | 98 | ＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 7
Rush in advance the blood perfusion device taking resin anion (R.A.) as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 100mg of required heparin is injected directly in the adsorption column of perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 75min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 200ml/min, and drain the bubble in adsorption column in the process;
3) use on the machine.
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. the pre-punching method of tradition | 3000mL | 30min | -- | 97 | ＊＊＊ |
| 2. pre-punching method is simplified | 2000mL | 10min | 75min | 98 | ＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 8
Rush in advance the blood perfusion device taking resin anion (R.A.) as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 100mg of required heparin is injected directly in the adsorption column of perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 10min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 200ml/min, and drain the bubble in adsorption column in the process;
3) use on the machine.
Rush the contrast of scheme heparinization level in advance
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. the pre-punching method of tradition | 3000mL | 30min | -- | 97 | ＊＊＊ |
| 2. pre-punching method is simplified | 2000mL | 10min | 10min | 96 | ＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 9
Rush in advance the blood perfusion device taking resin anion (R.A.) as adsorbent, this pre-punching method comprises the following steps:
1) the dosage 40mg of required heparin is injected directly in the adsorption column of perfusion device, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 30min;
2) directly rush perfusion device in advance with 2000ml normal saline with the flow velocity of 200ml/min, and drain the bubble in adsorption column in the process;
3) use on the machine.
| Rush scheme in advance | Pre-momentum | Operating time consumes | Time of repose | Heparin adsorption amount (mg) | Manpower consumption |
| 1. the pre-punching method of tradition | 3000mL | 30min | -- | 97 | ＊＊＊ |
| 2. pre-punching method is simplified | 2000mL | 10min | 30min | 40 | ＊ |
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 10
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 200mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 30min;
3) use 1500ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 11
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 200mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 10min;
3) use 1500ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 12
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 100mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 10min;
3) use 1500ml normal saline, with the speed of 200ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 13
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 40mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 20min;
3) use 1500ml normal saline, with the speed of 200ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 14
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 100mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 20min;
3) use 1000ml normal saline, with the speed of 50ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 15
Rush in advance the blood perfusion device taking carbide resin as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 100mg is injected in adsorption column, after jolting adsorption column 5-10s by wrist, leaves standstill 30min;
3) use 5000ml normal saline, with the speed of 200ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 16
Rush in advance the blood perfusion device being adsorbent with active carbon resin, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 20mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 30min;
3) use 2000ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 17
Rush in advance the blood perfusion device being adsorbent with active carbon resin, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 20mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 10min;
3) use 2000ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 18
Rush in advance the blood perfusion device being adsorbent with active carbon resin, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 40mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 30min;
3) use 3500ml normal saline, with the speed of 200ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 19
Rush in advance the blood perfusion device being adsorbent with active carbon resin, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 100mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 20min;
3) use 2000ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 20
Rush in advance the blood perfusion device being adsorbent with active carbon resin, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 200mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 20min;
3) use 2000ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 21
Rush in advance the blood perfusion device taking acticarbon as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 300mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 30min;
3) use 2000ml normal saline, with the speed of 100ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
embodiment 22
Rush in advance the blood perfusion device taking acticarbon as adsorbent, this pre-punching method comprises the following steps:
1) be the glucose solution of 5% by 500ml concentration, rush in advance with the adsorption column of the speed of 100ml/min to blood perfusion device;
2) the heparin disposable syringe of 40mg is injected in adsorption column, after jolting adsorption column 5 ~ 10s by wrist, leaves standstill 30min;
3) use 2500ml normal saline, with the speed of 300ml/min, adsorption column is rushed in advance;
4) use on the machine.
Rush the contrast of scheme heparinization level in advance
Note: 1, injecting heparin leaves standstill and is not counted in operating time consumption; 2, * represents manpower consumption degree.
Because heparin injects each corner that can be diffused into rapidly perfusion device behind perfusion device inside by diffusion, thus make perfusion device inside resin can fully contact with heparin and absorb, good heparinization effect can be reached within a short period of time.
Normal saline is adopted to rush perfusion device in advance with certain flow velocity after injecting heparin operation, thus go out perfusion device by failing complete absorbed unnecessary heparin in perfusion device, also heparinization has been carried out to pipeline simultaneously, ensure that the heparin amount of resin absorption reaches the individual demand of patient, the granularity of perfusion device inside and pH value and reaches within the scope of safety value the use safety of perfusion device as ensured, avoids the blood coagulation risk of pipeline.Adopt normal saline punching when rushing on the other hand perfusion device in advance, it is single, easy to operate to rush liquid kind in advance, and avoids traditional method to rush the many and operation mistake problem that occurs of liquid kind in advance.The saline volume of pre-punching comparatively traditional method minimizing simultaneously, thus reduce the consumption of normal saline, save resource and cost.
Due to patient carry out hemoperfusion time, need preengage in advance, operator can penetrate heparin according to the individual character of reservation patient in advance to perfusion device note doses, and the injection work of multiple perfusion device can be operated simultaneously, make perfusion device carry out heparinization, and arrive the time that patient can be to be made an appointment.Owing to rushing time shorten in advance, the waiting time of patient also shortens accordingly.When carrying out normal saline and rushing in advance, simple to operate, operator also can carry out the operation of multiple perfusion device simultaneously, thus increase work efficiency, and reduce manpower expenditure.
For special population, as emergency and severe disease patient, best treatment time is very crucial, perfusion device in this patent simplifies pre-punching method needs shorter heparin time of repose, and shorten heparinization and rush the time in advance, the perfusion Waiting time of emergency and severe disease patient is shortened, thus has won best treatment time.It is simple to operate that heparinization of the present invention simplifies pre-punching method, and can carry out the pre-punching operation of multiple perfusion device simultaneously, increases work efficiency, reduce the waiting time of patient, save medical care cost of labor, and decrease the pre-momentum of normal saline, save resource, reduce treatment cost.
Above-described is only the preferred embodiment of the present invention, it should be pointed out that for the person of ordinary skill of the art, and without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.
Claims (10)
1. the heparinization of perfusion device simplifies pre-punching method, and described perfusion device comprises adsorption column, it is characterized in that, said method comprising the steps of:
1) heparin injections step: the heparin injecting more than 20mg in described adsorption column;
2) stating step: above-mentioned adsorption column is left standstill more than 10 minutes;
3) step is rushed in advance: with the normal saline of more than 1000ml, above-mentioned adsorption column is rushed in advance.
2. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, after completing described heparin injections step and before carrying out described stating step, jolts described adsorption column.
3. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, in described heparin injections step, the heparin amount of injecting in described adsorption column is 40 ~ 300mg.
4. the heparinization of perfusion device simplifies pre-punching method according to claim 3, it is characterized in that, in described heparin injections step, the heparin amount of injecting in described adsorption column is 100 ~ 200mg.
5. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, in described stating step, the time of repose of described adsorption column is 10 ~ 75min.
6. the heparinization of perfusion device simplifies pre-punching method according to claim 5, it is characterized in that, in described stating step, the time of repose of described adsorption column is 30 ~ 40min.
7. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, rushes in advance in step described, and the amount of described normal saline is 1000 ~ 5000ml.
8. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, rushes in advance in step described, and the pre-swash of wave speed of described normal saline is 50 ~ 300ml/min.
9. the heparinization of perfusion device simplifies pre-punching method according to claim 8, it is characterized in that, rushes in advance in step described, and the pre-swash of wave speed of described normal saline is 100 ~ 200ml/min.
10. the heparinization of perfusion device simplifies pre-punching method according to claim 1, it is characterized in that, described perfusion device be following any one: Microporous resin perfusion device, resin anion (R.A.) perfusion device, carbide resin perfusion device, active carbon perfusion device.
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| CN101164628A (en) * | 2007-06-05 | 2008-04-23 | 佛山市第一人民医院 | Device for purifying blood and application thereof |
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| CN201026321Y (en) * | 2007-04-28 | 2008-02-27 | 高光勇 | Artificial liver nephros support system |
| CN101164628A (en) * | 2007-06-05 | 2008-04-23 | 佛山市第一人民医院 | Device for purifying blood and application thereof |
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