CN219720948U - Rat gas induction anesthesia box for animal experiments - Google Patents
Rat gas induction anesthesia box for animal experiments Download PDFInfo
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- CN219720948U CN219720948U CN202320419865.6U CN202320419865U CN219720948U CN 219720948 U CN219720948 U CN 219720948U CN 202320419865 U CN202320419865 U CN 202320419865U CN 219720948 U CN219720948 U CN 219720948U
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- 230000006698 induction Effects 0.000 title claims abstract description 60
- 206010002091 Anaesthesia Diseases 0.000 title claims abstract description 54
- 230000037005 anaesthesia Effects 0.000 title claims abstract description 54
- 238000002474 experimental method Methods 0.000 title claims abstract description 21
- 241001465754 Metazoa Species 0.000 title claims abstract description 17
- 101100067761 Rattus norvegicus Gast gene Proteins 0.000 title claims abstract description 13
- 230000007246 mechanism Effects 0.000 claims abstract description 26
- 239000005394 sealing glass Substances 0.000 claims abstract description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000000741 silica gel Substances 0.000 claims abstract description 13
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 13
- 238000007789 sealing Methods 0.000 claims abstract description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001301 oxygen Substances 0.000 claims abstract description 7
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 7
- 239000011521 glass Substances 0.000 claims abstract description 4
- 230000003444 anaesthetic effect Effects 0.000 claims description 20
- 238000005192 partition Methods 0.000 claims description 9
- 239000007789 gas Substances 0.000 abstract description 20
- 239000002912 waste gas Substances 0.000 abstract description 8
- 239000003994 anesthetic gas Substances 0.000 description 15
- 239000003814 drug Substances 0.000 description 9
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- 241000699666 Mus <mouse, genus> Species 0.000 description 6
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Abstract
The utility model discloses a rat gas induction anesthesia box for animal experiments, which comprises an induction box and a baffle plate movably arranged in the induction box, wherein the induction box is made of transparent organic glass, a double-layer sealing glass pipe and an air exchanging pipe are arranged on the side wall parallel to the moving direction of the baffle plate, a round hole for a mouse to pass through is arranged on the side wall perpendicular to the moving direction of the baffle plate, an iris mechanism is arranged outside the round hole of the induction box, the sealing and opening of the round hole are controlled through the iris mechanism, the air exchanging pipe is connected with a suction pump or an oxygen pump, the inner end of the double-layer sealing glass pipe is communicated with the inside of the induction box, a silica gel sleeve for sealing a gap between the inner pipe and the outer pipe of the double-layer sealing glass pipe is arranged at the outer end of the induction box, an annular groove for an anesthesia pipeline to pass through is arranged on the silica gel sleeve, and the anesthesia pipeline is sleeved between the inner pipe and the outer pipe of the double-layer sealing glass pipe. The utility model can solve the phenomenon of overflow and leakage of a large amount of waste gas and judge the residual proportion of the gas in the box.
Description
Technical Field
The utility model relates to the technical field of biological medicines, in particular to a rat gas induction anesthesia box used in animal experiments.
Background
Experimental animals are important models for researching human diseases, and basic information is provided for human elucidation of pathogenesis and searching for new treatment strategies. Since most experiments will cause unavoidable injuries to animals, such as: brain function studies of craniotomy and changes in organs after taking drugs. Thus, the animal will develop resistant behavior. Preoperative anesthesia and analgesia techniques provide the possibility for the development of these experiments. Currently, anesthesia can be classified into injection anesthesia and inhalation anesthesia according to the kind of active drug.
Injection anesthesia: the drug is injected through muscle or vein, and enters the nervous system through blood circulation to generate anesthetic effect. There are several obvious disadvantages to the method of injection anesthesia. (1) Selecting an appropriate anesthetic dose is difficult, especially in combination with different anesthetics, requiring a large number of fumbling attempts; (2) The recovery rate is slow, the recovery cannot be immediately carried out after injection, and a reversing agent (drug release) is needed to relieve the anesthesia state; (3) the anesthesia depth cannot be precisely controlled; (4) significant changes to both heart rate and respiration rate; (5) The viscera can be injured by mistake during intraperitoneal injection. Anesthesia is metabolized by the liver and kidneys and is expelled for a longer period of time.
(II) respiratory anesthesia: inhalation anesthesia is to enter the blood circulation through the lungs, the metabolism of the anesthetic is entirely expelled by the lungs, the metabolism rate is quite fast, and once the administration of respiratory drugs is stopped, the anesthetized animal will wake up quickly. Compared to injection anesthesia, inhalation anesthesia has the following advantages: (1) The application range is wide, and the safety is improved, especially for deep and long-term anesthesia experiments; (2) cardioprotective function, improving pulmonary immunity; (3) Inhalation and elimination are mostly carried out in the lung, are rarely absorbed, and cannot generate hepatotoxicity and nephrotoxicity; (4) The rapid recovery is suitable for short-term anesthesia, is favorable for changing the anesthesia strategy, and accurately regulates and controls the anesthesia depth. In addition, among a plurality of experimental animals, mice are the most widely used animal models, and are widely used in some experiments for exploring the occurrence of diseases due to their biological similarity with humans, easy reproduction, low cost, and easy operation. Compared with large animals, the body size of the rat is small, the metabolism and the elimination of the medicine are quicker, the half life of the medicine is reduced, the acting and maintaining time of the anesthetic can be influenced, a proper anesthetic dosage can not be determined, and the injection anesthesia is inconvenient to implement. More importantly, in some studies on brain nerves, it is desirable to minimize the effect of neurons caused by the course of the experiment, with respiratory anesthesia having a smaller effect on neurons than injection anesthesia.
(III) the existing gas anesthesia apparatuses all have a fundamental problem: and (5) air leakage. (1) The anesthesia effect is affected after the air leakage, the health and safety of the experimenters are affected by the prolonged experiment time (2), and the literature can show that the anesthesia waste gas is huge to the physical and psychological injuries of the medical staff, and a plurality of uncomfortable symptoms such as dizziness, nausea, hypodynamia and even memory disorder can occur. (3) The experimental medicines are expensive, and leakage can increase experimental expenditure pressure.
The existing operation mode at present has the following defects:
1. improper mouse taking mode
At present, the gas anesthesia induction box adopts a cover lifting mode, a mouse taking mode is opened in a push-pull mode, and waste gas overflows in a large area. The process of putting in and taking out experimental animals can make the inside of the anesthesia box contact with air, thereby causing the anesthetic gas leakage to a certain extent. When the rat is placed, leakage of anesthetic gas can be avoided by firstly placing the rat into the anesthetic box and then closing the anesthetic box for ventilation. However, after the anesthesia is finished, in the process of taking out the rat, if one smell is required to avoid air leakage, the anesthetic gas ventilation pipeline is closed firstly, the rat is taken out after the oxygen is filled into the box, and the rat is possibly difficult to breathe or awake due to overlarge oxygen filling pressure, and the anesthesia fails.
2. Lack of criteria for complete withdrawal of anesthetic gases
After the rat is taken out, the anesthetic box cover is closed, and the residual gas recovery device is started to recover the residual gas in the anesthetic box. However, the prior art lacks a measurement standard of the back-pumping quantity, and cannot ensure that the gas in the box is completely back-pumped.
3. The sealing performance of the connection part between the induction box opening and the anesthetic line is not strong
The opening of the induction box is not tightly sealed with the induction box body directly, and even in the anesthesia induction process, anesthetic gas can still leak to a certain extent. In the prior art, the sealing of the joint between the pipeline for inputting anesthetic gas into the induction box and the induction box is not strict enough, and the joint is generally blocked by only one layer of sealing gasket, so that gas leakage can still be caused to a certain extent in the use process.
Disclosure of Invention
In order to solve the defects and shortcomings of the prior art, the rat gas induction anesthesia box for animal experiments provided by the utility model has the advantages that the iris mechanism is used for improving the phenomenon of excessive leakage of a large amount of waste gas generated during gas induction rat anesthesia, the judgment of the gas residual proportion in the box is easily realized, the airtight treatment of the communicating part of the induction box and an anesthesia pipeline is enhanced, the experiment is more convenient and safer, and the success rate is higher.
The utility model provides a rat gas induction anesthesia box for animal experiments, which comprises an induction box and a baffle plate movably arranged in the induction box, wherein the induction box is made of transparent organic glass, a double-layer sealing glass pipe and an air exchanging pipe are arranged on the side wall parallel to the moving direction of the baffle plate of the induction box, a round hole for a mouse to pass through is formed in the side wall perpendicular to the moving direction of the baffle plate of the induction box, an iris mechanism is arranged outside the round hole of the induction box, the round hole is controlled to be closed and opened by the iris mechanism, the air exchanging pipe is connected with a suction pump or an oxygen pump, the inner end of the double-layer sealing glass pipe is communicated with the inside of the induction box, a silica gel sleeve for blocking a gap between the inner pipe and the outer pipe of the double-layer sealing glass pipe is arranged at the outer end of the induction box, the silica gel sleeve is provided with an annular groove for an anesthesia pipeline to pass through, the anesthesia pipeline is sleeved between the inner pipe and the outer pipe of the double-layer sealing glass pipe, and a plurality of spaced ventilation holes are formed in the inner end of the double-layer sealing glass pipe.
As a further improvement of the scheme, the iris mechanism consists of a fixed disc, a rotating disc and a sliding sheet, polygonal grooves are formed in the rotating disc, a plurality of strip-shaped grooves are formed in the fixed disc, sliding blocks are arranged at the upper ends and the lower ends of the sliding sheet, respectively, corresponding to the polygonal grooves and the strip-shaped grooves, the iris mechanism is driven to open and close by a deflector rod, the deflector rod is fixedly connected with the rotating disc, and the fixed disc is fixedly connected with an induction box.
As a further improvement of the scheme, the silica gel sleeve is provided with oblique cuts at two sides of the annular groove.
As a further improvement of the above scheme, the outer cover of the iris mechanism is provided with a screw cover.
As a further improvement of the above scheme, the inside of the induction box is provided with a sliding rail corresponding to the partition plate.
The beneficial effects of the utility model are as follows:
compared with the prior art, the rat gas induction anesthesia box for animal experiments provided by the utility model has the advantages that the iris mechanism is used for improving the phenomenon of excessive exhaust gas generated during gas induction rat anesthesia, the judgments of the gas residual proportion in the box are easily realized, the airtight treatment of the communicating part of the induction box and an anesthesia pipeline is enhanced, the experiments are more convenient and safer, and the success rate is higher. In particular, the method comprises the steps of,
1. by using the iris mechanism, the size of the opening can be adjusted by sliding the deflector rod, and simultaneously, a spiral cover is additionally arranged outside the iris mechanism for double-layer sealing, so that anesthetic gas overflows from the opening during taking the mice is reduced;
2. a baffle plate made of plastic is added in the induction box, and when anesthetic waste gas and oxygenation are extracted after the mice are taken out, the residual quantity of the gas in the induction box is judged through the movement and the position of the baffle plate, so that waste gas residue caused by insufficient exhaust gas extraction or excessive exhaust gas extraction is avoided, and negative pressure is generated;
3. the induction box is connected with the anesthesia pipeline, the wall of the induction box is connected with a double-layer sealing glass tube, a plurality of spaced ventilation holes are formed in the inner end of the double-layer sealing glass tube, the ventilation holes are positioned between the inner tube and the outer tube, anesthetic gas sent into the induction box from the anesthesia pipeline is mostly sent into the induction box through the inner tube, and the anesthetic gas overflowed between the anesthesia pipeline and the inner tube and between the anesthesia pipeline and the outer tube enters the induction box through the ventilation holes, so that the overflow of the anesthetic gas is reduced;
4. the inner tube and the outer tube are sealed through the silica gel sleeve, and the silica gel sleeve is provided with a circle of annular grooves which are enough to be inserted into the anesthetic tube, so that overflowing anesthetic gas can be prevented from being diffused into the air, the air tightness of the communication part of the induction box and the anesthetic tube is increased, and the diffusion of the anesthetic gas from the anesthetic tube to the environment is reduced.
Drawings
The utility model is described in further detail below with reference to the attached drawing figures, wherein:
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic view of the structure of the utility model with screw cap removed;
FIG. 3 is a schematic view of the internal structure of the present utility model;
FIG. 4 is a schematic diagram of an iris mechanism according to the present utility model;
FIG. 5 is a schematic view of the iris mechanism of the present utility model during closing;
FIG. 6 is a schematic illustration of the iris tail mechanism of the present utility model with the fixed disk removed;
FIG. 7 is a schematic diagram of a rotary plate and a shift lever of the iris mechanism according to the present utility model;
fig. 8 is a schematic flow diagram of anesthetic gases according to the present utility model.
Detailed Description
As shown in fig. 1-8, the rat gas induction anesthesia box for animal experiments provided by the utility model comprises an induction box 1 and a partition plate 2 movably arranged in the induction box 1, wherein the partition plate 2 capable of freely moving is arranged in the induction box 1, after the anesthesia of a mouse is completed, anesthetic waste gas is pumped out by connecting a suction pump, and the partition plate 2 moves along with the exhaust of the waste gas under the pressure difference of the two, and when the gas is completely exhausted, the partition plate 2 moves to the other end. I.e. the gas is considered to have been completely exhausted. Before the next use, the oxygen pump is connected to oxygenate the induction box 1, so that the baffle plate 2 moves back to the original position. The inside of the induction box 1 is provided with a sliding rail corresponding to the partition board 2. The induction box 1 is made of transparent organic glass, a double-layer sealing glass tube 3 and an air exchanging tube 4 are arranged on the side wall parallel to the moving direction of the baffle plate 2, a round hole 5 for a mouse to pass through is formed in the side wall perpendicular to the moving direction of the baffle plate 2, an iris mechanism 6 is arranged outside the round hole 5 in the induction box 1, a spiral cover 9 is arranged on the outer cover of the iris mechanism 6, the sealing and opening of the round hole 5 are controlled through the iris mechanism 6, the air exchanging tube 4 is connected with a suction pump or an oxygen pump, the inner end of the double-layer sealing glass tube 3 is communicated with the inside of the induction box 1, a silica gel sleeve 7 for sealing a gap between an inner tube 31 and an outer tube 32 of the double-layer sealing glass tube 3 is arranged at the outer end, an annular groove for an anesthetic tube 100 to pass through is formed in the silica gel sleeve 7, the anesthetic tube 100 is sleeved between the inner tube 31 and the outer tube 32 of the double-layer sealing glass tube 3, and leakage of gas is prevented. The clearance between the inner tube 31 and the outer tube 32 is beneficial to relieving the leakage of anesthetic gases and increasing the gas entry into the induction box 1.
Further improved, the iris mechanism 6 consists of a fixed disc 61, a rotating disc 62 and a sliding plate 63, polygonal grooves 65 are formed in the rotating disc 62, a plurality of strip-shaped grooves 66 are formed in the fixed disc 61, sliding blocks are arranged at the upper end and the lower end of the sliding plate 63, which correspond to the polygonal grooves 65 and the strip-shaped grooves 66 respectively, the iris mechanism 6 is driven to be opened and closed by a deflector rod 64, the deflector rod 64 is fixedly connected with the rotating disc 62, and the fixed disc 61 is fixedly connected with the induction box 1. The circular opening of iris mechanism 6 may take advantage of the boring tendency of mice to facilitate entry of the mice into induction box 1. The adjustable opening is convenient for two hands to get the mouse perpendicularly, reduces the opening area simultaneously, reduces the gas and overflows the degree.
Further improved, the silica gel sleeve 7 is provided with oblique cuts on two sides of the annular groove, and the oblique cuts facilitate the insertion of the anesthetic tube 100 and are also beneficial to the entry of anesthetic gas into the induction box 1.
The above embodiments are not limited to the technical solution of the embodiments, and the embodiments may be combined with each other to form a new embodiment. The above embodiments are only for illustrating the technical solution of the present utility model and not for limiting the same, and any modifications or equivalent substitutions without departing from the spirit and scope of the present utility model should be covered in the scope of the technical solution of the present utility model.
Claims (5)
1. The rat gas induction anesthesia box for animal experiments is characterized in that: the induction box is made of transparent organic glass, a double-layer sealing glass tube and an air exchanging tube are arranged on the side wall parallel to the moving direction of the partition plate, round holes for a mouse to pass through are formed in the side wall perpendicular to the moving direction of the partition plate, an iris mechanism is arranged outside the round holes, the round holes are controlled to be closed and opened through the iris mechanism, the air exchanging tube is connected with a suction pump or an oxygen pump, the inner end of the double-layer sealing glass tube is communicated with the inside of the induction box, a silica gel sleeve for sealing a gap between the inner tube and the outer tube of the double-layer sealing glass tube is arranged at the outer end of the double-layer sealing glass tube, an annular groove for an anesthetic tube to pass through is formed in the silica gel sleeve, the anesthetic tube is sleeved between the inner tube and the outer tube of the double-layer sealing glass tube, and a plurality of spaced vent holes are formed in the inner end of the double-layer sealing glass tube.
2. A rat gas induced anesthesia cassette for use in animal experiments according to claim 1 wherein: the iris mechanism consists of a fixed disc, a rotating disc and a sliding sheet, polygonal grooves are formed in the rotating disc, a plurality of strip-shaped grooves are formed in the fixed disc, sliding blocks are arranged at the upper end and the lower end of the sliding sheet, respectively, and correspond to the polygonal grooves and the strip-shaped grooves, the iris mechanism is driven to be opened and closed by a deflector rod, the deflector rod is fixedly connected with the rotating disc, and the fixed disc is fixedly connected with an induction box.
3. A rat gas induced anesthesia cassette for use in animal experiments according to claim 1 wherein: and oblique notches are formed in two sides of the annular groove in the silica gel sleeve.
4. A rat gas induced anesthesia cassette for use in animal experiments according to claim 1 wherein: the outer cover of the iris mechanism is provided with a spiral cover.
5. A rat gas induced anesthesia cassette for use in animal experiments according to claim 1 wherein: the inside of the induction box is provided with a sliding rail corresponding to the partition board.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320419865.6U CN219720948U (en) | 2023-03-07 | 2023-03-07 | Rat gas induction anesthesia box for animal experiments |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202320419865.6U CN219720948U (en) | 2023-03-07 | 2023-03-07 | Rat gas induction anesthesia box for animal experiments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219720948U true CN219720948U (en) | 2023-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202320419865.6U Active CN219720948U (en) | 2023-03-07 | 2023-03-07 | Rat gas induction anesthesia box for animal experiments |
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| Country | Link |
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| CN (1) | CN219720948U (en) |
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- 2023-03-07 CN CN202320419865.6U patent/CN219720948U/en active Active
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