CN104324133B - A kind of clearing heat and detoxicating veterinary drug and preparation method thereof - Google Patents
A kind of clearing heat and detoxicating veterinary drug and preparation method thereof Download PDFInfo
- Publication number
- CN104324133B CN104324133B CN201410562896.2A CN201410562896A CN104324133B CN 104324133 B CN104324133 B CN 104324133B CN 201410562896 A CN201410562896 A CN 201410562896A CN 104324133 B CN104324133 B CN 104324133B
- Authority
- CN
- China
- Prior art keywords
- parts
- veterinary drug
- heat
- prepared
- pig
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of clearing heat and detoxicating veterinary drug and preparation method thereof.The veterinary drug is prepared by following Chinese medicine material：Kuh-seng, radix rehmanniae recen, honeysuckle, plantain seed is windproof, and silkworm sloughs off, licorice, the capsule of weeping forsythia, radix scutellariae, golden cypress, talcum.Veterinary drug of the present invention have conveniently, safely, it is economical the advantages of, and therapeutic effect is preferable.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of clearing heat and detoxicating veterinary drug and preparation method thereof.
Background technology
Pig category homeothermal animal, no matter environment temperature height, body temperature all preferably must be held in 38 DEG C or so.But pig category constant temperature moves
Thing, subcutaneous fat depth, sweat gland is undeveloped, is bad to adjust body temperature by skin perspiration, evaporative heat loss, internal heat energy distribute compared with
Slowly, therefore, pig is very thermo-labile, and bigger pig is more thermo-labile.
Raising is it was verified that the preference temperature that pig growth and development needs increases with body weight and age and declined, newborn piglet
For 27~29 DEG C, weanling pig is 21~24 DEG C, and growing-finishing pig is 15~25 DEG C, and farrowing and milking sow are 16~18 DEG C.
When the heat production of pig is more than radiating, body temperature raises, and physiological responses to heat stress easily occurs.
Lasting heat stress can make the feed intake of pig reduce by 6%~21% or more, and daily gain is reduced.Sow then shows as
Hypo-ovaria, conception rate decline, and third trimester of pregnancy stillborn foetus number increase, litter weight is reduced, or even miscarriage, under milk quality and quantity
Drop, finally cause delivery room baby pig diarrhea and slow-growing, influence piglet survival ratio and weaning weight.Boar mating is intended to weaken, seminal fluid
Quality reduces.
The optimum temperature of pig increases and declined with body weight and age：Newborn piglet：27—30℃；Weanling pig：21—24
℃；Growing and fattening pigs：15—22℃；Farrow sow：16—18℃.
If pig house environment temperature has exceeded optimum temperature range, the heat production of pig body is more than radiating, when excessive heat stores
When can not distribute in vivo, then the body temperature of pig starts to raise product, cause to circulate, be metabolized and neuroendocrine system occur it is disorderly
Disorderly, heat stress even thermoplegia is caused.
Prophylactico-therapeutic measures：
1st, build mat shelter or build sunshade net.Force ventilation excludes pernicious gas.House temperature can use sebific duct or spraying when too high
Device timing cools to pig body (except childbirth house) and roof spray cooling or artificial watering.Nonpregnant and in-pig, growth are educated
Big porker, using the method cooling rate of spraying or spraying cooling quickly, temperature in house can be reduced by 5-8 DEG C within 5-10 minutes,
And air can be purified.But it can increase and give up interior and bed surface humidity, therefore it is noted that ventilation is moistureproof.
2nd, feeding management is improved
The grease within 5% can be added in feed, increases crude protein content in feed, can so ensure in high temperature
Pig feed intake disclosure satisfy that nutritional need in the case of reducing, 200-500ppm vitamin Cs and 200ppm dimension lifes are added in feed
Plain E, the ability of anti-heat stress can be improved.
3rd, anti-heat stress medicine is added
Sucrose, the composition such as electrolyte are added in drinking-water, not only can anti-heat stress, moreover it is possible to remarkably promote piglet growth, carry
The high price of deed.10 mg/kg daizeols element or 400 mg/kg taurines are added in feed, heat stress pair can be mitigated
The influence of growing and fattening pigs.300 micro- g kg chromium (chromium picolinate) are supplemented in pig feed, Heat-temperature stress effect can be alleviated, improved
Pig feed intake and daily gain, reduce feed-weight ratio..
The content of the invention
It is an object of the invention to provide a kind of clearing heat and detoxicating veterinary drug；
It is a further object of the present invention to provide a kind of preparation method of clearing heat and detoxicating veterinary drug.
The purpose of the present invention is realized by following technical scheme：
Clearing heat and detoxicating veterinary drug of the present invention, it is prepared by the raw material of following parts by weight：
Kuh-seng 4-6 parts, radix rehmanniae recen 4-6 parts, honeysuckle 4-6 parts, plantain seed 2-4 parts, windproof 2-4 parts, silkworm slough off 2-4 parts, raw
Radix glycyrrhizae 1-3 parts, capsule of weeping forsythia 1-3 parts, radix scutellariae 1-3 parts, golden cypress 1-3 parts, talcum 0.5-1.5 parts.
Preferably, it is to be prepared by the raw material of following parts by weight：
5 parts of kuh-seng, 5 parts of radix rehmanniae recen, 5 parts of honeysuckle, 3 parts of plantain seed, windproof 3 parts, silkworm sloughs off 3 parts, 2 parts of licorice, the capsule of weeping forsythia 2
Part, 2 parts of radix scutellariae, 2 parts of golden cypress, 1 part of talcum.
It is Chinese medicine source and the primary efficacy of the clearing heat and detoxicating veterinary drug of the present invention below：
Kuh-seng：For legume kuh-seng Sophora flavescens Ait. dry root.Spring, the excavation of season in autumn two, are removed
Root head and small supporting root, cleaning, drying, or fresh slices are taken advantage of, dry.Nature and flavor and channel tropism】Hardship, tremble with fear.The thoughts of returning home, liver, stomach, large intestine, bladder
Through.【Function is with curing mainly】Heat-clearing and damp-drying drug, desinsection, diuresis.For hot dysentery, have blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae is wet
Rash, wet sore, pruitus, mange leprosy；Control trichomonas vaginitis outside.【Pay attention to】Should not be with black false hellebore with use.
Radix rehmanniae recen：For scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. fresh or dried root.
Autumn excavates, except removing LU, fibrous root and silt, using fresh herb；Or glutinous rehmannia is slowly bakeed to about most probably dry.The former practises title " freshly
It is yellow ", the latter, which practises, claims " radix rehmanniae recen ".【Nature and flavor and channel tropism】Radix rehmanniae recen is sweet, trembles with fear.The thoughts of returning home, liver and kidney channel.【Function is with curing mainly】Radix rehmanniae recen
Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid.For thermal man's ying blood, febrile virulent maculae, hematemesis and epistaxis, consumption of YIN caused by febrile disease, the deep red polydipsia of tongue, Tianjin hinder constipation,
Fever due to yin deficiency, hectic fever due to yin burdock heat, Heat Diabetes.
Honeysuckle：Dry flower for caprifoliaceae plant honeysuckle Lonicera japonica Thunb. or with just opening
Flower.The flowers are in blossom puts preceding harvesting for early summer, dries.【Nature and flavor and channel tropism】It is sweet, tremble with fear.Return lung, the heart, stomach.【Function is with curing mainly】It is clearing heat and detoxicating,
Dispelling wind and heat from the body.Sore, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating are treated for carbuncle swells.
Plantain seed：For plantago plant Chinese herbaceous peony Plantago asiatica L. or ordinary building Plantago depressa
Willd. dry mature seed.Fruit ear is harvested when summer, two season of autumn seed maturity, is dried, rubs seed, removes impurity.【Nature and flavor
With channel tropism】It is sweet, tremble with fear.Return liver, kidney, lung, small intestinl channel.【Function is with curing mainly】Reducing fever and causing diuresis is treating stranguria, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm.With
In puckery pain of heat gonorrhea, oedema turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough.
It is windproof：For umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk. drying
Root.The root of scape plant is not taken out in spring, the excavation of season in autumn two, removes fibrous root and silt, dries.【Nature and flavor and channel tropism】It is pungent, sweet, tepor.
Return bladder, liver, the spleen channel.【Function is with curing mainly】Expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion.For cold headache, arthralgia pain due to rheumatism, rubella
Itch, lockjaw.
Silkworm sloughs off：For the husking Bombyx mori L. of Bombycidae insect silkworm moth larvae.Also known as silkworm is moved back, Ma Ming is moved back, Ma Ming
Move back, silkworm husking, Buddhist move back, silkworm shedding, silkworm cocoon, silkworm clothing.【Nature and flavor】It is sweet, put down, it is nontoxic.【Function cures mainly】Uterine bleeding is controlled, with, dysentery
Disease, spit blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, noma, aphtha, watchtower in ancient times wind, mesh screen.
Licorice：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflate Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.In the spring, the excavation of season in autumn two, remove
Fibrous root, dry.【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.【Function is with curing mainly】Invigorate the spleen and benefit qi, it is clearing heat and detoxicating, dispel
Phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
The capsule of weeping forsythia：For Oleaceae plants the capsule of weeping forsythia Forsythia suspense (Thunb.) Vahl dry fruit.Autumn fruit
It is real it is just ripe still with it is green when harvest, remove impurity, cook, dry, practise and claim " green grass or young crops sticks up "；Harvest, dry when fruit is well-done, except impurity elimination
Matter, practise and claim " sticking up always ".【Nature and flavor and channel tropism】Hardship, it is slightly cold.Return lung, the heart, small intestinl channel.【Function is with curing mainly】It is clearing heat and detoxicating, Sweeling-eliminating medicine powder
Knot, dispelling wind and heat from the body.For ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma
Send out spot, puckery pain of heat gonorrhea.
Radix scutellariae：For labiate radix scutellariae Scutellaria baicalensis Georgi dry root.Spring, Qiu Erji
Excavation, fibrous root and silt are removed, tertia is hit after solarization, dries.【Nature and flavor and channel tropism】Hardship, tremble with fear.Return lung, courage, spleen, large intestine, small intestine
Through.【Function is with curing mainly】Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis are antiabortive.For damp-warm syndrome, summer-heat and damp, evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, rush down
Dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia blood-head tells nosebleeds, carbuncle sore tumefacting virus, fetal irritability.
Golden cypress：For rutaceae wampee Phellodendron chinense Schneid. dry bark.Practise and claiming
" CORTEX PHELLODENDRI CHINENSE ".After stripping bark, tertia is removed, is dried.【Nature and flavor and channel tropism】Hardship, tremble with fear.Return kidney, bladder warp.【Function is with curing mainly】
Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is knitted,
Hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing Yin and falling fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.
Talcum：For silicates mineral talc talc, main [Mg3 (Si4010) (OH) 2] containing hydrous magnesium silicate.Excavation
Afterwards, silt and miscellaneous stone are removed.【Nature and flavor and channel tropism】It is sweet, light, tremble with fear.Return bladder, lung, stomach.【Function is with curing mainly】Inducing diuresis for treating strangurtia, clearly
It is pyrolyzed heat, external application clearing damp sore.For heat gonorrhea, urolithiasis, the puckery pain of urine heat, summer-heat and damp polydipsia, damp and hot watery diarrhea；Control eczema, wet sore, miliaria outside
Son.
Another aspect of the present invention there is provided the preparation method of the active component of veterinary drug of the present invention, and this method is to use water
Carry or the ethanol of 40-80% concentration expressed in percentage by volume extracts.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, filtration, relative density is 1.10-1.25's when filtrate is concentrated into 70-80 DEG C
Clear cream, produce active component.
Scheme two：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, filtration, relative density is 1.05-1.20's when filtrate is concentrated into 70-80 DEG C
Clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into relatively close at 70-80 DEG C
The medicinal extract for 1.10-1.25 is spent, produces active component.
Scheme three：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is medicinal material total amount
4-10 times, extraction time is 1-3 hours, merges extract solution, filtering, relative density is 1.10- when filtrate is concentrated into 60-80 DEG C
1.25 medicinal extract, produces active component.
Clearing heat and detoxicating veterinary drug of the present invention, it can be made various normal with pharmaceutically acceptable carrier combination
With preparation, such as tablet, granule, capsule, syrup.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
From Chinese veterinarian's angle analysis, heat stress be caused by summer-heat and damp pincer attack, retention of damp-heat in the interior, kidney qi virtual loss, incoordination between the liver and the spleen, therefore
Preferably using clearing away summerheat, removing pattogenic heat from the blood and toxic material from the body, nourishing kidney qi as principle, kuh-seng heat-clearing and damp-drying drug of the present invention, radix rehmanniae recen clearing heat and cooling blood, honeysuckle
Clearing heat and detoxicating, dispelling wind and heat from the body, plantain seed reducing fever and causing diuresis is treating stranguria, windproof to expel pathogenic wind from the body surface, and silkworm sloughs off removing toxicity for detumescence, licorice tonifying spleen benefit
Gas, clearing heat and detoxicating, capsule of weeping forsythia dispelling wind and heat from the body, radix scutellariae heat-clearing and damp-drying drug, purging intense heat and detonicating, golden cypress purging intense heat, except steaming, talcum clearing away summerheat.This hair
Bright full side's collocation is scientific and reasonable, light clear table, dispelling wind and heat from the body, removing summer-heat heat toxin, can promptly dispel accumulated heat in pig body, promote damp and hot
Poison discharge, invigoration spleen qi, makes pig get well as early as possible.
A kind of clearing heat and detoxicating veterinary drug provided by the invention has advantages below：
1st, the light clear table of veterinary drug provided by the invention, dispelling wind and heat from the body, removing summer-heat heat toxin, can promptly dispel accumulated heat in pig body,
Promote damp and hot poison discharge, invigoration spleen qi, pig is got well as early as possible.Result in clinical application is shown：The present invention can effectively treat pig
Heat stress disease, it is simple and easy to do, safely and effectively treatment method.Totall effective rate in clinical treatment is 100%, it was demonstrated that present invention treatment
Effect is extremely notable.
2nd, for the present invention by taking treatment by Chinese herbs, clearing heat and detoxicating effect is preferable, have safety, thoroughly, conveniently, it is economical excellent
Point.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate
The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
Embodiment 1：
Take kuh-seng 5kg, radix rehmanniae recen 5kg, honeysuckle 5kg, plantain seed 3kg, windproof 3kg, silkworm slough off 3kg, licorice 2kg, even
Stick up 2kg, radix scutellariae 2kg, golden cypress 2kg, talcum 1kg, extracting in water 2 times, twice amount of water be respectively 10 times of medicinal material gross weight, 8
Times, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, filtrate concentration is 1 times of medicinal material total amount, is produced
Decoction.
Embodiment 2：
Take kuh-seng 4kg, radix rehmanniae recen 4kg, honeysuckle 4kg, plantain seed 2kg, windproof 2kg, silkworm slough off 2kg, licorice 1kg, even
1kg, radix scutellariae 1kg, golden cypress 1kg, talcum 0.5kg are stuck up, is extracted 3 times with 40% alcohol reflux, each ethanol consumption is respectively medicinal material
10 times, 8 times, 4 times of total amount, extraction time are distinguished 3 hours, 2 hours, 1 hour, merge extract solution, filtering, and filtrate is concentrated into 60
DEG C when relative density be 1.25 medicinal extract, add supplementary product starch, ethanol, talcum powder, be made tablet.
Embodiment 3：
Take kuh-seng 6kg, radix rehmanniae recen 6kg, honeysuckle 6kg, plantain seed 4kg, windproof 4kg, silkworm slough off 4kg, licorice 3kg, even
Stick up 3kg, radix scutellariae 3kg, golden cypress 3kg, talcum 1.5kg, extracting in water 3 times, three times amount of water be respectively equivalent to medicinal material gross weight
12 times, 8 times, 6 times, each extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtration, and filtrate is concentrated into 70 DEG C
When relative density be 1.20 clear cream, add ethanol, it is 40% to make alcohol content, stands 24 hours, and filtration, filtrate is concentrated into 70 DEG C
When relative density be 1.10 medicinal extract, add that purified water ad pond om is medicinal material gross weight 3 times are filling, produce conjunction of the present invention
Agent.
Embodiment 4：
Take kuh-seng 4kg, radix rehmanniae recen 6kg, honeysuckle 4kg, plantain seed 4kg, windproof 2kg, silkworm slough off 4kg, licorice 1kg, even
3kg, radix scutellariae 1kg, golden cypress 3kg, talcum 0.5kg are stuck up, is extracted 2 times with alcohol reflux, each concentration of alcohol is respectively 80%,
60%, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, merges extraction
Liquid, filtering, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, adds supplementary product starch, ethanol, talcum powder, and piece is made
Agent.
Embodiment 5：
Take kuh-seng 6kg, radix rehmanniae recen 4kg, honeysuckle 6kg, plantain seed 2kg, windproof 4kg, silkworm slough off 2kg, licorice 3kg, even
Stick up 1kg, radix scutellariae 3kg, golden cypress 1kg, talcum 1.5kg, extracting in water 3 times, three times amount of water be respectively 12 times of medicinal material gross weight,
8 times, 6 times, extraction time is respectively 3 hours, 2 hours, 1 hour three times, merges extract solution, filtration, when filtrate is concentrated into 70 DEG C
Relative density is 1.25 clear cream, adds supplementary product starch, ethanol, dextrin, magnesium stearate, loads capsule shells, capsule is made.
Embodiment 6：
Take kuh-seng 5kg, radix rehmanniae recen 4kg, honeysuckle 6kg, plantain seed 3kg, windproof 2kg, silkworm slough off 4kg, licorice 2kg, even
1kg is stuck up, radix scutellariae 3kg, golden cypress 2kg, talcum 0.5kg, extracting in water 2 times, each amount of water is respectively equivalent to medicinal material gross weight
12 times, 10 times, each extraction time is respectively 3 hours, 2 hours, merges extract solution, filtration, and filtrate is concentrated at 80 DEG C relatively
Density is 1.05 clear cream, adds ethanol, and it is 70% to make alcohol content, stands 12 hours, and filtration, filtrate is concentrated into relative at 70 DEG C
Density is 1.25 medicinal extract, adds auxiliary material Icing Sugar, starch, dextrin, ethanol, and granule is made.
Embodiment 7：
Weighing kuh-seng 6kg, radix rehmanniae recen 6kg, honeysuckle 4kg, plantain seed 2kg, windproof 3kg, silkworm slough off 4kg, licorice 2kg,
Capsule of weeping forsythia 3kg, radix scutellariae 1kg, golden cypress 2kg, talcum 1kg, extracting in water 2 times, twice amount of water be respectively 10 times of medicinal material gross weight,
8 times, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, relative density is when filtrate is concentrated into 80 DEG C
1.10 medicinal extract.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir, and syrup is made.
Embodiment 8：
Weighing kuh-seng 5kg, radix rehmanniae recen 5kg, honeysuckle 5kg, plantain seed 3kg, windproof 3kg, silkworm slough off 3kg, licorice 2kg,
Capsule of weeping forsythia 2kg, radix scutellariae 2kg, golden cypress 2kg, talcum 1kg, clean, crush, produce pulvis of the present invention.
Clinical treatment is summarized
1 clinical manifestation
Morbidity season is summer, the good time difference during appetite of ill pig, morning and it is relative at dusk eat food more, noon only eats several
Mouth is just no longer eaten, and some pigs even appetite is useless exhausted.Noon breathing is urged, and in thoracoabdominal breathing, some is in sitting position of dog formula, mill
Tooth, loll, mouth stream foam, and whole skin flush or presentation purple plague purpura；At dusk and morning pig is relatively tranquil, flush,
There is a small amount of purple plague purpura.Noon pig down in spirits, sleeping ground do not rise, are reluctant to walk about；Morning and dusk are compared with love activity.Indivedual pig belly drums
Gas, some pigs can discharge a small amount of graininess excrement ball, some to discharge a small amount of dark brown urine.Environment thermometric finds environment temperature in pig house
Degree from the morning 10 up to afternoon 5 when be 35.5-38.3 DEG C, morning and at dusk be 33 DEG C or so, night be 30.8-33.5 DEG C.Pig
Anus thermometric, noon pig body temperature are 41.6-42.8 DEG C, morning, are 40.5-41.2 DEG C at dusk, night is 40.2-40.6 DEG C.
2 cut open inspection lesions
Sick dead pig does not find viral infectious and the distinctive pathological change of bacterial infectious disease.Only see pulmonary emphysema, kidney
Hyperemia, swelling, gastremia, large intestine, mucous membrane of small intestine are congested, cystohemia, swollen lymph node, hyperemia.
3 treatment methods
Strengthen ventilation in pig house, open pig house door and window, ceiling fan, portable electric fan and exhaust are installed in pig house
Fan, and opened or closed according to the situation of change of environment temperature.Environment temperature is normally on and normally off at 31-35 DEG C；More than 35 DEG C with
When upper, to open all day, and ensure that every pig can blow to wind.
Spray cooling.Sprayed water toward roof, toward pig house ground, wall, the cooling of pig spray body, to reduce heat radiation, reduce house
The interior and temperature of pig body.When temperature is more than 30-35 DEG C, sprayed 1 time every 2-3 hours, during more than more than 35 DEG C, sprayed 1 every 1 hour
It is secondary.
Feed drink medicine soup：The decoction of the embodiment of the present invention 1 is given, 3 times a day.
4 observation of curative effect
Effectively：After medication in 15 days, although ambient temperature is still continuously more than 35 DEG C, the appetite and the state of mind of pig are bright
It is aobvious to recover normal；
It is invalid：The appetite and spirit of pig are without improvement, or even occur dead.
5 treatment results, are shown in Table 1
The recovery situation of pig after table 1 is treated
| Number of cases | Effectively | It is invalid | Total effective rate (%) |
| 106 | 100 | 0 | 100 |
6 discuss
With the development of large scale of pig farm, heat irritability syndrome influences getting worse to the normal growth of pig.Can not be simple
Prevent the generation of pig heat irritability syndrome from pig house environment is improved, added in the diet of pig the present invention it is clearing heat and detoxicating in
Medicine, promote the excretion of heat in pig body, from inner and prevent outside or treat the sick generation.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (7)
1. a kind of veterinary drug with treatment pig heat stress effect, it is characterised in that it is prepared by the raw material of following parts by weight
's：Kuh-seng 4-6 parts, radix rehmanniae recen 4-6 parts, honeysuckle 4-6 parts, plantain seed 2-4 parts, windproof 2-4 parts, silkworm slough off 2-4 parts, licorice 1-
3 parts, capsule of weeping forsythia 1-3 parts, radix scutellariae 1-3 parts, golden cypress 1-3 parts, talcum 0.5-1.5 parts.
2. veterinary drug according to claim 1, it is characterised in that it is prepared by the raw material of following parts by weight：Kuh-seng
5 parts, 5 parts of radix rehmanniae recen, 5 parts of honeysuckle, 3 parts of plantain seed, windproof 3 parts, silkworm sloughs off 3 parts, 2 parts of licorice, 2 parts of the capsule of weeping forsythia, 2 parts of radix scutellariae,
2 parts of golden cypress, 1 part of talcum.
3. the veterinary drug as described in any one of claim 1 or 2, it is characterised in that its active component be using water extraction or 40-
What the ethanol extraction of 80% concentration expressed in percentage by volume was prepared.
4. veterinary drug as claimed in claim 3, it is characterised in that its active component, which is prepared by the following method, to be formed：Take
Whole medicinal materials, extracting in water 2-3 times, for each amount of water equivalent to 6-12 times of medicinal material gross weight, each extraction time is that 1-3 is small
When, merge extract solution, filtration, relative density is 1.10-1.25 clear cream when filtrate is concentrated into 70-80 DEG C, produces the activity
Composition.
5. veterinary drug as claimed in claim 3, it is characterised in that its active component, which is prepared by the following method, to be formed：Take
Whole medicinal materials, extracting in water 2-3 times, for each amount of water equivalent to 6-12 times of medicinal material gross weight, each extraction time is that 1-3 is small
When, merge extract solution, filtration, relative density is 1.05-1.20 clear cream when filtrate is concentrated into 70-80 DEG C, adds ethanol, makes to contain
Alcohol amount is 40-70%, stands 12-24 hours, filtration, and relative density is 1.10-1.25 leaching when filtrate is concentrated into 70-80 DEG C
Cream, produce the active component.
6. veterinary drug as claimed in claim 3, it is characterised in that its active component, which is prepared by the following method, to be formed：Take
Whole medicinal materials, extracted 2-3 time with 40-80% alcohol refluxs, each ethanol consumption is 4-10 times of medicinal material total amount, and extraction time is
1-3 hours, merge extract solution, filtering, relative density is 1.10-1.25 medicinal extract when filtrate is concentrated into 60-80 DEG C, is produced described
Active component.
7. a kind of veterinary drug preparation with treatment pig heat stress effect, it is characterised in that as the veterinary drug described in claim 1 or 2
It is prepared with acceptable carrier combination in pharmaceuticals industry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410562896.2A CN104324133B (en) | 2014-10-21 | 2014-10-21 | A kind of clearing heat and detoxicating veterinary drug and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410562896.2A CN104324133B (en) | 2014-10-21 | 2014-10-21 | A kind of clearing heat and detoxicating veterinary drug and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104324133A CN104324133A (en) | 2015-02-04 |
| CN104324133B true CN104324133B (en) | 2017-12-12 |
Family
ID=52399023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410562896.2A Expired - Fee Related CN104324133B (en) | 2014-10-21 | 2014-10-21 | A kind of clearing heat and detoxicating veterinary drug and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104324133B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213252A (en) * | 2017-06-28 | 2017-09-29 | 禹州市合同泰药业有限公司 | A kind of Chinese medicine clearing heat and detoxicating for pig and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156917A (en) * | 2007-10-09 | 2008-04-09 | 北京农学院 | A medicine for preventing and treating livestock birds heat irritability syndrome |
| CN101297885A (en) * | 2007-10-25 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicine preparation for treating heat stress of cow in summer and preparation method thereof |
| CN102077917A (en) * | 2010-09-19 | 2011-06-01 | 周剑峰 | Feed additive for preventing and treating swine coccidiosis |
| CN103432273A (en) * | 2013-08-29 | 2013-12-11 | 王保胜 | Chinese medicament for treating foot-and-mouth disease |
-
2014
- 2014-10-21 CN CN201410562896.2A patent/CN104324133B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101156917A (en) * | 2007-10-09 | 2008-04-09 | 北京农学院 | A medicine for preventing and treating livestock birds heat irritability syndrome |
| CN101297885A (en) * | 2007-10-25 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicine preparation for treating heat stress of cow in summer and preparation method thereof |
| CN102077917A (en) * | 2010-09-19 | 2011-06-01 | 周剑峰 | Feed additive for preventing and treating swine coccidiosis |
| CN103432273A (en) * | 2013-08-29 | 2013-12-11 | 王保胜 | Chinese medicament for treating foot-and-mouth disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104324133A (en) | 2015-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105123612B (en) | Cultural method of the sheep in subtropical zone | |
| CN102845637B (en) | Chicken feed capable of preventing and treating avian influenza and Chinese herbal additive used therein | |
| CN104256168B (en) | One boar functional feed and preparation method thereof | |
| CN104872446A (en) | Feed of 2-3-week-old chicks and preparing method thereof | |
| CN105409875B (en) | The fast well-fattened cultural method of the high damp-heat area mutton sheep in south | |
| CN106386694A (en) | Culture method of stocking yellow cattle | |
| CN103039745A (en) | Daily ration concentrated feed of egg-laying sheldrake and preparation method thereof | |
| CN104187172B (en) | Functional feed for treating enterogastritis diseases of turtles and preparation method of functional feed | |
| CN102961640A (en) | Medicine for preventing swine foot and mouth disease and preparation method thereof | |
| CN106561564A (en) | Method for fostering goats in tea garden | |
| CN103893344A (en) | Chinese medicinal submicron powder for treating piglet's yellow-white dysentery and preparation method thereof | |
| CN106578477A (en) | Special feed for cattle and preparation method of special feed | |
| CN102552656A (en) | Chinese medicinal composition for treating chicken colibacillosis | |
| CN104107365A (en) | Stomach-tonifying and digestion-promoting powder | |
| CN106942133A (en) | A kind of cultural method of cockfighting | |
| CN106063927A (en) | A kind of summer uses swine feed additive | |
| CN105661108A (en) | Traditional Chinese medicinal feed additive for garrupa and preparation method of traditional Chinese medicinal feed additive | |
| CN103054999B (en) | Traditional Chinese medicine preparation for preventing and treating highly pathogenic porcine reproductive and respiratory syndrome and preparation method | |
| CN106359994A (en) | Piglet feed | |
| CN104706830B (en) | It is a kind of to prevent gal virus traditional Chinese powder medicine | |
| CN104324133B (en) | A kind of clearing heat and detoxicating veterinary drug and preparation method thereof | |
| CN103652490B (en) | Pig feed for treating blue-eared pig disease and preparation method thereof | |
| CN104547186A (en) | Compound fermented type traditional Chinese medicine for preventing and treating fowl cholera and preparation method of compound fermented type traditional Chinese medicine | |
| CN105192430A (en) | Chicken feed additive for preventing chicken diseases | |
| CN104922530A (en) | Drug combination for preventing and treating chicken colibacillosis and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gao Yafei Inventor after: Gu Youfang Inventor after: Yin Zongjun Inventor after: Gao Yacheng Inventor after: Li Shenghe Inventor after: Sun Pei Inventor after: Gao Jing Inventor after: Li Yu Inventor after: Jiang Guangzhi Inventor before: Wu Bao Inventor before: Huang Yifeng Inventor before: Zhang Jingxin |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170906 Address after: 236700 North Road, Yongxing Road, Lixin Industrial Park, Bozhou, Anhui Applicant after: ANHUI HAOXIANG AGRICULTURE AND ANIMAL HUSBANDRY Co.,Ltd. Applicant after: ANHUI SCIENCE AND TECHNOLOGY University Applicant after: ANHUI BAKEXIA BREEDING PIG BREEDING CO.,LTD. Applicant after: ANHUI DUROC BREEDING PIG BREEDING CO.,LTD. Address before: 243000 Anhui city of Ma'anshan province high tech Zone at 1669 North Road Huo sparkle Building No. 2 Applicant before: MAANSHAN FULAIYI ENVIRONMENTAL PROTECTION TECHNOLOGY CO.,LTD. Effective date of registration: 20170906 Address after: 243000 Anhui city of Ma'anshan province high tech Zone at 1669 North Road Huo sparkle Building No. 2 Applicant after: MAANSHAN FULAIYI ENVIRONMENTAL PROTECTION TECHNOLOGY CO.,LTD. Address before: Bobai County Dongping town Yulin city the Guangxi Zhuang Autonomous Region Bolong street 537626 Applicant before: GUANGXI HUIPENG FARMING Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20171212 Termination date: 20191021 |