CN103054999B - Traditional Chinese medicine preparation for preventing and treating highly pathogenic porcine reproductive and respiratory syndrome and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for preventing and treating highly pathogenic porcine reproductive and respiratory syndrome and a preparation method. The traditional Chinese medicine preparation comprises the following raw herbal materials in parts by weight: 35-65 parts of radix bupleuri, 15-25 parts of coptis chinensis, 20-40 parts of golden cypress, 22-58 parts of scutellaria baicalensis, 5-15 parts of caulis clematidis armandii, 5-15 parts of schizonepeta, 15-25 parts of divaricate saposhnikovia root, 45-75 parts of isatis root, 22-58 parts of ephedra herb, 35-65 parts of astragalus mongholicus, 30-50 parts of honeysuckle, 30-40 parts of fructus forsythiae, 20-40 parts of common andrographis herb, and 30-50 parts of folium mori. According to the invention, various raw herbal materials bring out the best in each other; body immunity is effectively increased; and the traditional Chinese medicine preparation is used for clearing heat and detoxifying and has a good effect for preventing and treating highly pathogenic porcine reproductive and respiratory syndrome.

Description

For preventing and treat Chinese medicine preparation and the preparation method of highly pathogenic PRRS

Technical field

The present invention relates to veterinary drug technical field, be specifically related to a kind of for preventing and treat Chinese medicine preparation and the preparation method of highly pathogenic PRRS.

Background technology

Pig breeding is called for short reproductive and respiratory syndrome with breathing syndrome, is a kind of to cause sow breeding difficulty and the each age in days pig respiratory disorder contagious disease as feature, and its cause of disease is pig breeding and breathing syndrome virus.Reproductive and respiratory syndrome is to affect at present one of disease that world's pig industry is the most serious, since it is found, has propagated rapidly, up to the present, only has and does not infect this disease for several little countries.

Highly pathogenic PRRS is the acute high lethal infectious disease of one being caused by pig breeding and breathing syndrome virus variant.Piglet sickness rate can reach 100%, mortality rate can reach more than 50%, and sow abortion ratio can reach more than 30%, and growing and fattening pigs can Mortality be also its features.A series of investigation and research have been carried out to it in Disease Diagnosis of Veterinary chamber, country Yi Kong center.Conclusion is: one, the PRRSV of variation is Etiological (protopathy is former); Two, virus, antibacterial, parasite mixing or secondary infection are the reasons that mortality rate rises; Three, the weather conditions of high temperature, high humidity and lack of standardization, the abuse of antibiotics of immunity, environmental health is poor is the main inducing that causes M & M higher.

At present, not for effectively prevention and Therapeutic Method of highly pathogenic PRRS, mostly adopt vaccinations, in feedstuff, add medicine spice in conjunction with the later stage and mode that environment is carried out disinfection is prevented and treats.But owing to there is no at present the vaccine for highly pathogenic PRRS, a lot of pig farmers just drench the multi-joint Seedling etc. of Seedling, import in addition to malicious Seedling, swine fever spleen a little less than malicious Seedling, PR a little less than similar oneself Seedling of pig inoculation, PRRS, but facts have proved to pig farm and inoculate too much vaccine, healthy and stable on swinery is to have critical impact, it is unpractical relying on vaccine to prevent highly pathogenic PRRS, even causes immunity of organism imbalance; In feedstuff, add medicine spice, be generally antipyretic-antalgic class, Antibiotics, sulfonamides and antiviral class medicine, but facts have proved, these medicines are in treatment highly pathogenic PRRS, effect is bad, especially sulfa drugs, is easy to cause toxic and side effects, immunosuppressant and the many accompanying infections of pig; Environment is carried out disinfection, can only serve as a kind of supplementary means, cannot realize real effectively prevention and treatment highly pathogenic PRRS.

Summary of the invention

Technical problem to be solved by this invention is to provide Chinese medicine preparation and the preparation method for preventing and treat highly pathogenic PRRS, and its cost is low, effective, has no side effect, thereby eliminates defect in above-mentioned background technology.

For solving the problems of the technologies described above, technical scheme of the present invention is:

For preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, comprise the raw medicinal material of following weight portion:

35～65 parts of Radix Bupleuri;

15～25 parts of Rhizoma Coptidis;

20～40 parts of Cortex Phellodendris;

22～58 parts of Radix Scutellariaes;

5～15 parts of Caulis Clematidis Armandiis;

5～15 parts of Herba Schizonepetae;

15～25 parts of Radix Saposhnikoviaes;

45～75 parts of Radix Isatidis;

22～58 parts of Herba Ephedrae;

35～65 parts of the Radixs Astragali;

30～50 parts of Flos Loniceraes;

30～40 parts of Fructus Forsythiaes;

20～40 parts of Herba Andrographis;

30～50 parts, Folium Mori.

Improve as one, for preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, comprise the raw medicinal material of following weight portion:

50 parts of Radix Bupleuri;

20 parts of Rhizoma Coptidis;

30 parts of Cortex Phellodendris;

40 parts of Radix Scutellariaes;

10 parts of Caulis Clematidis Armandiis;

10 parts of Herba Schizonepetae;

20 parts of Radix Saposhnikoviaes;

60 parts of Radix Isatidis;

40 parts of Herba Ephedrae;

50 parts of the Radixs Astragali;

40 parts of Flos Loniceraes;

35 parts of Fructus Forsythiaes;

30 parts of Herba Andrographis;

40 parts, Folium Mori.

Further improve as one, in described raw material, can also comprise that the Gypsum Fibrosum of 85～115 weight portions is as adjuvant.

For preventing and treat the preparation method of the Chinese medicine preparation of highly pathogenic PRRS, comprise the steps:

S1. raw materials weighing medical material, and add water in raw medicinal material, wherein the weight ratio of water and raw medicinal material is 100:(8～15), soak 7～9 hours, boil rear decoction 1～2 hour, filter and obtain a decoction liquor and medicinal residues;

S2. in described medicinal residues, add water, wherein the weight ratio of water and raw medicinal material is 80:(8～15), and add the Gypsum Fibrosum of 85～115 weight portions, boil rear decoction 0.5～1.5 hour, filter and obtain secondary decoction liquor and secondary medicinal residues;

S3. a described decoction liquor and secondary decoction liquor are merged, being then concentrated into weight is original 20wt%～30wt%, and the concentrated solution obtaining is described Chinese medicine preparation.

Chinese medicine preparation provided by the invention, can improve immunity of organisms, prevention and treatment swine influenza, especially prevention and treatment highly pathogenic PRRS is had to remarkable result.

Indication is highly pathogenic PRRS.Clinical manifestation is: high heat, and body temperature can reach 40 ℃ of left and right, anorexia or do not eat, ear, snout, abdominal part, rear quarters thigh inside skin cyanosis, congestion or have ecchymosis, pimple; Sow miscarriage, product mummy fetus, weak son; Cough, breathe heavily, have eye conjunctivitis, rear quarters is unable, can not stand or wave, and does circular motion, twitch, and the sick pig intractable diarrhea of part.

In the present invention, the pharmacological action of each taste medicine is as follows.

Radix Bupleuri cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, loose effect of fire, have that expelling pathogenic factors from the exterior expels the heat-evil, effect of dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, the saikoside containing in its composition has immunoloregulation function, improve pig body to viral resistance, also there is anti-endotoxin effect simultaneously, effectively prevent other toxi-infections that pig causes after ill.

Rhizoma Coptidis bitter in the mouth, cold in nature, nontoxic, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, there is effect of heat clearing and damp drying, eliminating fire and detoxication, the berberine containing in its composition can strengthen leukocyte phagocytosis, blood pressure lowering and the refrigeration function with tip, have extraordinary inhibition to various bacteria virus.

Cortex Phellodendri bitter in the mouth, cold in nature, return kidney, bladder, large intestine channel, there is heat clearing and damp drying, eliminating fire and detoxication, except effect of hectic fever due to YIN-deficiency clearind deficient heat.

Radix Scutellariae bitter in the mouth, cold in nature, return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian, there is effect of heat clearing and damp drying, eliminating fire and detoxication, antiabortive, blood pressure lowering, its antipathogen, antiinflammatory, adjusting immunologic function, antipyretic, calm, protect the liver, function of gallbladder promoting, especially cause sow miscarriage, weak son's symptom to there is remarkable result to highly pathogenic PRRS.

Caulis Clematidis Armandii is lightly seasoned, bitter, cold in nature, and GUIXIN, lung, small intestinal, urinary bladder channel, have clearing away heat and promoting diuresis, and effect of the stimulating milk secretion of stimulating the menstrual flow can promote pig body metabolism.

Herba Schizonepetae acrid in the mouth, micro-hardship, property is micro-wet, returns lung, Liver Channel, has effect of the loose wind that induces sweat, rash, the skin ulcer that disappears, hemostasis, especially causes disease porcine skin to occur that the symptom of pimple has remarkable result to highly pathogenic PRRS.

Radix Saposhnikoviae acrid in the mouth, sweet, slightly warm in nature, returns bladder, lung, spleen, Liver Channel, has expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic effect, and the tic especially highly pathogenic PRRS being caused, stomachache are had loose bowels, the symptom of rubella pruritus has remarkable result.

Radix Isatidis bitter in the mouth, cold in nature, nontoxic, return liver, stomach warp, there is effect of heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving, especially can effectively alleviate high heat, anorexia or aphagia shape that highly pathogenic PRRS causes.

Herba Ephedrae acrid in the mouth, micro-hardship, warm in nature, return lung, urinary bladder channel, there is effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, the cough that especially highly pathogenic PRRS caused, breathe heavily, there are the symptoms such as eye conjunctivitis to have remarkable result.

Radix Astragali sweet in the mouth, slightly warm in nature, return lung, spleen, liver, kidney channel, can invigorating the spleen and replenishing QI, the tired disease such as unable of weakness of the spleen and stomach, inappetence, anorexia and loose stool, limb is had to significant curative effect, especially the unable effect of rear quarters highly pathogenic PRRS being caused is excellent, and its effective ingredient calycosin can improve immunologic function, have antibacterial and antiviral effect.

Flos Lonicerae acrid in the mouth, micro-hardship, cold in nature, return lung, stomach, the heart, large intestine channel, in Flos Lonicerae, be rich in chlorogenic acid, by the cell-mediated immunoreation of promotion body T and the activity of NK cell, thereby improve the immunologic function of body to viral permissive cell.

Fructus Forsythiae bitter in the mouth, cold nature, GUIXIN, lung, small intestine meridian, have effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, dispelling wind and heat pathogens, share with Flos Lonicerae, antibacterial range complementation, and in the time of control and treatment highly pathogenic PRRS, play synergism.

Herba Andrographis bitter in the mouth, cold in nature, GUIXIN, lung, large intestine, urinary bladder channel, there is effect of heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness, it contains composition creat lactone, is antibacterial, antiinflammatory, heat clearing away, antidote, to golden Portugal bacterium, Hemolytic streptococcus, streptococcus pneumoniae, Bacillus typhi, dysentery bacterium, Bacillus proteus etc., have good antibacterial activity, virus, spirillum are also had to certain inhibitory action, the intractable diarrhea effect that highly pathogenic PRRS is caused is fine.

Folium Mori bitter in the mouth, sweet, cold in nature, returns lung, Liver Channel, has dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, and suppressing the hyperactive liver improving eyesight, effect of cooling blood for hemostasis, can improve high heat that highly pathogenic PRRS causes, have the symptoms such as eye conjunctivitis.

Chinese medicine preparation provided by the invention is to improve immunity of organisms as the rule for the treatment of, and furthermore heat-clearing and toxic substances removing, realizes effective prevention and treatment to highly pathogenic PRRS.Improve the immunity of body with Radix Bupleuri, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Flos Lonicerae and Herba Andrographis, add Cortex Phellodendri, Herba Schizonepetae, Radix Saposhnikoviae, Herba Ephedrae to strengthen drug effect, meanwhile, Radix Bupleuri, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Caulis Clematidis Armandii, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis and Folium Mori have the effect of heat-clearing and toxic substances removing.

In sum, Chinese medicine preparation provided by the invention, all kinds of raw medicinal materials bring out the best in each other, and can effectively improve the immunity of body, and heat-clearing and toxic substances removing has good effect to prevention and treatment highly pathogenic PRRS.

Usage and dosage:

Every 500 milliliters of Chinese medicine preparation are watered 100kg, one day 3 times, take continuously 6～8 days.

In addition, Chinese medicine preparation provided by the invention has no side effect, and can be used as the additive long-term taking of feedstuff, to reach better prevention effect.

Owing to having adopted technique scheme, the invention has the beneficial effects as follows:

Inventor has studied the reason of highly pathogenic PRRS morbidity in practice, take the hands section of preventing and treating and treating from cause of disease aspect and immunology, in the Chinese medicine preparation providing, Radix Bupleuri, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Caulis Clematidis Armandii, Radix Isatidis, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis and Folium Mori have heat-clearing toxin-expelling functions, can be to virus, spirillum has certain inhibitory action, also there is anti-endotoxin effect simultaneously, effectively prevent other toxi-infections that pig causes after ill, and Radix Bupleuri, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Flos Lonicerae and Herba Andrographis improve the immunity of body, add Cortex Phellodendri, Herba Schizonepetae, Radix Saposhnikoviae, Herba Ephedrae is to strengthen drug effect, all kinds of condition of illness that all kinds of raw medicinal materials not only cause highly pathogenic PRRS have significant curative effect, and play each other synergism, bring out the best in each other, effectively improve the immunity of body, heat-clearing and toxic substances removing, prevention and treatment highly pathogenic PRRS are had to good effect.

Preparation method provided by the invention, extracts at twice, and the parameter such as the water yield, time using in leaching process all draws through a large amount of practice of inventor, under condition provided by the invention, the effective ingredient in all kinds of raw medicinal materials fully can be extracted; The present invention utilizes Gypsum Fibrosum as adjuvant, and inventor finds in practice, and Gypsum Fibrosum can make the effective ingredient of Chinese medicine preparation when concentrated, be difficult for decomposing, and the Chinese medicine preparation curative effect making is better.

The specific embodiment

For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.

Embodiment 1

For preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, comprise the raw medicinal material of following weight:

Radix Bupleuri 105g;

Rhizoma Coptidis 45g;

Cortex Phellodendri 60g;

Radix Scutellariae 66g;

Caulis Clematidis Armandii 45g;

Herba Schizonepetae 45g;

Radix Saposhnikoviae 75g;

Radix Isatidis 225g;

Herba Ephedrae 174g;

Radix Astragali 105g;

Flos Lonicerae 90g;

Fructus Forsythiae 90g;

Herba Andrographis 60g;

Folium Mori 90g.

Preparation method comprises the steps:

S1. raw materials weighing medical material 1275g altogether, and add 15.9kg water in raw medicinal material, soak 7 hours, boil rear decoction 1 hour, filter and obtain a decoction liquor and medicinal residues;

S2. in described medicinal residues, add 12.7kg water, and add the Gypsum Fibrosum of 255g, boil rear decoction 0.5 hour, filter and obtain secondary decoction liquor and secondary medicinal residues;

S3. a described decoction liquor and secondary decoction liquor are merged, being then concentrated into weight is original 20wt%, and the concentrated solution obtaining is described Chinese medicine preparation.

Chinese medicine preparation is added in feedstuff and fed later, highly pathogenic PRRS does not occur so far again.

Embodiment 2

For preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, comprise the raw medicinal material of following weight:

Radix Bupleuri 150g;

Rhizoma Coptidis 60g;

Cortex Phellodendri 90g;

Radix Scutellariae 120g;

Caulis Clematidis Armandii 30g;

Herba Schizonepetae 30g;

Radix Saposhnikoviae 60g;

Radix Isatidis 180g;

Herba Ephedrae 120g;

Radix Astragali 150g;

Flos Lonicerae 120g;

Fructus Forsythiae 105g;

Herba Andrographis 90g;

Folium Mori 120g.

Preparation method comprises the steps:

S1. raw materials weighing medical material 1425g altogether, and add 14.3kg water in raw medicinal material, soak 8 hours, boil rear decoction 1.5 hours, filter and obtain a decoction liquor and medicinal residues;

S2. in described medicinal residues, add 11.4kg water, and add 300g Gypsum Fibrosum, boil rear decoction 1 hour, filter and obtain secondary decoction liquor and secondary medicinal residues;

S3. a described decoction liquor and secondary decoction liquor are merged, being then concentrated into weight is original 25wt%, and the concentrated solution obtaining is described Chinese medicine preparation.

Embodiment 3

For preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, comprise the raw medicinal material of following weight:

Radix Bupleuri 130g;

Rhizoma Coptidis 50g;

Cortex Phellodendri 80g;

Radix Scutellariae 116g;

Caulis Clematidis Armandii 10g;

Herba Schizonepetae 10g;

Radix Saposhnikoviae 30g;

Radix Isatidis 90g;

Herba Ephedrae 44g;

Radix Astragali 130g;

Flos Lonicerae 100g;

Fructus Forsythiae 80g;

Herba Andrographis 80g;

Folium Mori 100g.

Preparation method comprises the steps:

S1. raw materials weighing medical material 1050g altogether, and add 7kg water in raw medicinal material, soak 9 hours, boil rear decoction 2 hours, filter and obtain a decoction liquor and medicinal residues;

S2. in described medicinal residues, add 5.6kg water, and add 230g Gypsum Fibrosum, boil rear decoction 1.5 hours, filter and obtain secondary decoction liquor and secondary medicinal residues;

S3. a described decoction liquor and secondary decoction liquor are merged, being then concentrated into weight is original 30wt%, and the concentrated solution obtaining is described Chinese medicine preparation.

Treatment embodiment 1

In August, 2010, there is high heat in 78 pigs of so-and-so pig farm cultivation of Shandong Province Lee raiser, anorexia or do not eat, ear, snout, abdominal part, rear quarters thigh inside skin cyanosis, congestion or have the symptom such as ecchymosis, pimple, be highly pathogenic PRRS after diagnosing, first adopted traditional therapeutic modality, in feedstuff, add antipyretic-antalgic class, Antibiotics medicine, and treat in conjunction with antiviral injection, but effect is poor, die 35, cure 3; After use the Chinese medicine preparation that embodiment 1 provides instead, every 500 milliliters of Chinese medicine preparation are watered 100kg, one day 3 times, take continuously 8 days, cure 35,2 because of seriously ill death of later stage, 3 remissions, recovery from illness after taking medicine continuously.

Treatment embodiment 2

In October, 2011, there is highly pathogenic PRRS in so-and-so pig farm of Liu raiser of Jiangxi Province, and the Chinese medicine preparation that adopts immediately embodiment 2 to provide is treated, every 500 milliliters of Chinese medicine preparation are watered 100kg, one day 3 times, take continuously 6 days, 30 sick pigs, have cured 27.

Treatment embodiment 3

In October, 2012, there is large-area highly pathogenic PRRS in so-and-so other pig farms around, pig farm of Shandong Province grandson raiser, but due to grandson, so-and-so adds the Chinese medicine preparation that embodiment 3 provides for a long time in feedstuff, has no disease pig and occur in pig farm; The Chinese medicine preparation that simultaneously adopts embodiment 3 to provide to comparatively serious so-and-so pig farm of Liu of morbidity is treated, and every 500 milliliters of Chinese medicine preparation are watered 100kg, and one day 3 times, take continuously 8 days, 53 sick pigs, have cured 49.

The present invention is not limited to the above-mentioned specific embodiment, and all are based on technical conceive of the present invention, and the structural improvement of having done, all falls among protection scope of the present invention.

Claims (3)

1. for preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, it is characterized in that: the raw medicinal material by following weight portion forms:

The Gypsum Fibrosum of 85～115 weight portions is as adjuvant.

2. as claimed in claim 1 for preventing and treat the Chinese medicine preparation of highly pathogenic PRRS, it is characterized in that: the raw medicinal material that comprises following weight portion:

3. as claimed in claim 1 for preventing and treat the preparation side of highly pathogenic PRRS Chinese medicine preparation

Method, is characterized in that: comprise the steps:

S1. raw materials weighing medical material, and add water in raw medicinal material, wherein the weight ratio of water and raw medicinal material is 100:(8～15), soak 7～9 hours, boil rear decoction 1～2 hour, filter and obtain a decoction liquor and medicinal residues;

S2. in described medicinal residues, add water, wherein the weight ratio of water and raw medicinal material is 80:(8～15), and add the Gypsum Fibrosum of 85～115 weight portions, boil rear decoction 0.5～1.5 hour, filter and obtain secondary decoction liquor and secondary medicinal residues;

S3. a described decoction liquor and secondary decoction liquor are merged, being then concentrated into weight is original 20wt%～30wt%, and the concentrated solution obtaining is described Chinese medicine preparation.