CN104322509A - Emulsion containing bactericide methanesulfonylazole - Google Patents
Emulsion containing bactericide methanesulfonylazole Download PDFInfo
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- CN104322509A CN104322509A CN201410556658.0A CN201410556658A CN104322509A CN 104322509 A CN104322509 A CN 104322509A CN 201410556658 A CN201410556658 A CN 201410556658A CN 104322509 A CN104322509 A CN 104322509A
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- Prior art keywords
- bacterium azoles
- aqueous emulsion
- methylsulfonyl bacterium
- bactericide
- ether
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Abstract
The invention provides a pesticide emulsion. The pesticide emulsion is prepared from effective amounts of active ingredients including methanesulfonylazole, a surfactant, a thickening agent, an anti-freezing agent and deionized water by virtue of processes of dissolving, or fusion, homogenization and dispersion. Except for the active ingredients, the emulsion is mostly water, and the content of organic solvents is extremely low, so that the pesticide emulsion is safe to transport and use and does not pollute the environment; the emulsion is an environmental-friendly pesticide preparation.
Description
Technical field
The invention belongs to technical field of pesticide, particularly relate to a kind of pesticide emulsion in water.
Background technology
For the great disease problem of agricultural, carry out the guide structure optimizing research of disease regulation and control, find safety scientific and efficiently and have green candidate's agricultural chemicals of potential market vitality to be the vital task faced in China's New pesticides discovery basic research.Guide finds it is the key realizing innovation green chemical pesticide, and design optimization synthesizes some class agricultural chemicals guide structures, the green chemical pesticide of development of new low toxicity, low-residual, safety, seems very urgent and important.2007, Guizhou University's fine chemistry industry center with the lead compound gallic acid filtered out in natural products for initiation material, design and synthesis a series of newly containing 1,3,4-thiophene (Evil) di azoly sulfone (sulfoxide) derivative, adopt growth rate method, with fusarium graminearum (
gibberella zeae), botrytis cinerea pers (
botrytis cinerea), Sclerotinia sclerotiorum (
sclerotinia sclerotiorum) etc. disease be tested object, bacteriostatic activity research has been carried out to partial target compound.Result shows, its EC of partial target compound
50value between 2.9-23.3mg/mL, have well suppress disease activity [
bioorg. Med. Chem. 2007,
15, 3981;
bioorg. & Med. Chem.
2008, 16,3632.].On this basis, carry out more deep study on the synthesis, find methylsulfonyl bacterium azoles.
Methylsulfonyl bacterium azoles (Universal Chinese character name, the Secretariat of national pesticide standard technical committee names).
Molecular formula: C9H7FN2O3S.Former medicine is acicular crystal, fusing point 102-104 DEG C.Water insoluble, be soluble in conventional organic solvent.Former medicine, to light, thermally-stabilised, easily decomposes under alkali condition (pH10).
Under 75-150 gram/ha of consumption, methylsulfonyl bacterium azoles has excellent preventive effect (test approval number: SY 201303170, SY 201400217) to bacteriosises such as bacterial blight of rice, bacterial leaf streak of rice, bacterial wilt of tomato and fruit tree cankers.
Methylsulfonyl bacterium azoles physicochemical property: molecular weight 242.02.
Methylsulfonyl bacterium azoles mammalian toxicity: rat acute per os LD
50>383mg/kg.Rat acute is through skin and suck LD
50>2000mg/kg.To the medium stimulation of Rabbits with Acute skin, to the weak sensitization of guinea pig skin.
Methylsulfonyl bacterium azoles eco-toxicity: to Japanese quail acute oral LD
50>2000mg/kg.bw, to newbora baky earthworm honeybee Acute exposure LC
50(14 d) is 138 mg a.i./kg
dry ground,to goat's horn crescent moon algae acute toxicity EC
50(72 h) is 2.54 mg a.i./L, to the half-inhibition concentration EC of Daphnia magna
50(48 h) is 2.31 mg a.i./L.
The present invention is the aqueous emulsion of open methylsulfonyl bacterium azoles.With water to replace organic solvent, not only preparation production cost can be reduced but also reduce the impact on environment.
The aqueous emulsion of the open methylsulfonyl bacterium azoles of the present invention, with water to replace organic solvent, reduces production cost, reduces the pollution to environment.
Summary of the invention
The object of the present invention is to provide a kind of pesticide emulsion in water, include the active component methylsulfonyl bacterium azoles of effective amount, it consists of: supply 100g containing methylsulfonyl bacterium azoles 1-50g, solvent 1-20g, surfactant 1-20g, antifreeze 1-6g, thickener 0.1-0.3g, defoamer 0.1-0.5g, water in every 100g aqueous emulsion.
Described solvent is one or both the mixture in toluene, dimethylbenzene, methyl alcohol, ethanol, isopropyl alcohol, butanols, a line oil, cyclohexanone, acetonitrile, carrene, chloroform, dimethyl formamide, dioxane, naphthalene, methyl naphthalene, dimethyl sulfoxide (DMSO), 1-METHYLPYRROLIDONE, ethyl acetate, acetone, butanone, ether, gylcol ether.
Described surfactant is the one in castor oil polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, phenethyl phenol APEO, alkyl phenol formaldehyde resin polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, calcium dodecyl benzene sulfonate.
Described antifreeze is one or both in ethylene glycol, propane diols, glycerine, urea.
Selected thickener is xanthans, CMC, gum Arabic, gelatin or modified starch.
Described defoamer is one or both in dimethyl silicone polymer, silicone oil, isooctanol, n-octyl alcohol.
Described preservative is one or both in Sodium Benzoate, Kathon CG, lactic acid.
Preparation process: by bactericide methylsulfonyl bacterium azoles solvent and surfactant melting or dissolving, form homogeneous oil phase; Water, antifreeze, thickener etc. are uniformly mixed, form homogeneous aqueous phase; Under high velocity agitation, aqueous phase is added oil phase, or oil phase is added aqueous phase, form finely disseminated aqueous emulsion, average grain diameter is below 10 microns.Mixing speed is at 200-10000 rev/min, and mixing time is 5-60 minute.
The aqueous emulsion of the open methylsulfonyl bacterium azoles of the present invention, with water to replace organic solvent, reduces production cost, reduces the pollution to environment.
Embodiment
Embodiment 1 25% methylsulfonyl bacterium azoles aqueous emulsion
Methylsulfonyl bacterium azoles 25 grams (rolling over hundred content), two wires oil 10 grams, castor oil polyoxyethylene ether (epoxide number 40) 5 grams, neopelex 3 grams, sodium cellulose glycolate 0.3 gram, propane diols 3 grams, dimethyl silicone polymer 0.2 gram, water complements to 100 grams.Stir 20 minutes under 2000 revs/min of speed, obtain homogeneous flowable white " milky " liquid product, its average grain diameter is 2.5 μm, and viscosity is 250mpa.s.
Embodiment 2 50% methylsulfonyl bacterium azoles aqueous emulsion
Methylsulfonyl bacterium azoles 50 grams (rolling over hundred content), 10 grams, ethyl acetate, phenethyl phenol polyoxyethylene poly-oxygen propylene aether 8 grams, Sodium Lauryl sulphate 1 gram, xanthans 0.1 gram, 1 gram, urea, n-octyl alcohol 0.1 gram, Kathon CG 0.1 gram, water complements to 100 grams.Under 1500 revs/min of speed, stir 50 minutes to obtain homogeneous flowable white " milky " liquid product, its average grain diameter is 6 μm, and viscosity is 420mpa.s.
Embodiment 3 10% methylsulfonyl bacterium azoles aqueous emulsion
Methylsulfonyl bacterium azoles 10 grams (rolling over hundred content), dimethylbenzene 8 grams, 7 grams, alkylaryl polyoxyethylene polyoxypropylene ether, xanthans 0.1 gram, 1 gram, urea, n-octyl alcohol 0.3 gram, Kathon CG 0.1 gram, 3 grams, gelatin; Propane diols 5 grams, 0.2 gram, urea, water complements to 100 grams.Under 5000 revs/min of speed, stir 50 minutes to obtain homogeneous flowable white " milky " liquid product, its average grain diameter is 2.5 μm, and viscosity is 300mpa.s.
Embodiment 4 20% methylsulfonyl bacterium azoles aqueous emulsion
Methylsulfonyl bacterium azoles 20 grams (rolling over hundred content), cyclohexanone 20 grams, fatty alcohol oxygen vinethene 14 grams, calcium dodecyl benzene sulfonate 6 grams, 0.3 gram, gelatin, 5 grams, urea, silicone oil 0.5 gram, Sodium Benzoate 0.3 gram, water complements to 100 grams.Under 3000 revs/min of speed, stir 30 minutes to obtain homogeneous flowable white " milky " liquid product, its average grain diameter is 3.5 μm, and viscosity is 280mpa.s.
Embodiment 5 40% methylsulfonyl bacterium azoles aqueous emulsion
Methylsulfonyl bacterium azoles 40 grams (rolling over hundred content), 1-METHYLPYRROLIDONE 10 grams, phenethyl phenol APEO 6 grams, neopelex 4 grams, 0.3 gram, gum Arabic glue, glycerine 5 grams, silicone oil 0.2 gram, water complements to 100 grams.Under 2000 revs/min of speed, stir 30 minutes to obtain homogeneous flowable white " milky " liquid product, its average grain diameter is 4.5 μm, and viscosity is 320mpa.s.
Claims (7)
1. containing an aqueous emulsion for bactericide methylsulfonyl bacterium azoles, it consists of: supply 100g containing methylsulfonyl bacterium azoles 1-50g, solvent 1-20g, surfactant 1-20g, antifreeze 1-6g, thickener 0.1-0.3g, defoamer 0.1-0.5g, water in every 100g aqueous emulsion.
2., according to the aqueous emulsion containing bactericide methylsulfonyl bacterium azoles described in claim 1, wherein said solvent is one or both the mixture in toluene, dimethylbenzene, methyl alcohol, ethanol, isopropyl alcohol, butanols, a line oil, cyclohexanone, acetonitrile, carrene, chloroform, dimethyl formamide, dioxane, naphthalene, methyl naphthalene, dimethyl sulfoxide (DMSO), 1-METHYLPYRROLIDONE, ethyl acetate, acetone, butanone, ether, gylcol ether.
3., according to the aqueous emulsion containing bactericide methylsulfonyl bacterium azoles described in claim 1, it is characterized in that described surfactant is the one in castor oil polyoxyethylene ether, phenethyl phenol polyoxyethylene poly-oxygen propylene aether, phenethyl phenol APEO, alkyl phenol formaldehyde resin polyoxyethylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, calcium dodecyl benzene sulfonate.
4. according to described in claim 1 containing the aqueous emulsion of bactericide methylsulfonyl bacterium azoles, it is characterized in that described antifreeze is one or both in ethylene glycol, propane diols, glycerine, urea.
5., according to the aqueous emulsion containing bactericide methylsulfonyl bacterium azoles described in claim 1, it is characterized in that selected thickener is xanthans, CMC, gum Arabic, gelatin or modified starch.
6. according to described in claim 1 containing the aqueous emulsion of bactericide methylsulfonyl bacterium azoles, it is characterized in that described defoamer is one or both in dimethyl silicone polymer, silicone oil, isooctanol, n-octyl alcohol.
7. according to described in claim 1 containing the aqueous emulsion of bactericide methylsulfonyl bacterium azoles, it is characterized in that described preservative is one or both in Sodium Benzoate, Kathon CG, lactic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410556658.0A CN104322509A (en) | 2014-10-20 | 2014-10-20 | Emulsion containing bactericide methanesulfonylazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410556658.0A CN104322509A (en) | 2014-10-20 | 2014-10-20 | Emulsion containing bactericide methanesulfonylazole |
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| Publication Number | Publication Date |
|---|---|
| CN104322509A true CN104322509A (en) | 2015-02-04 |
Family
ID=52397441
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|---|---|---|---|
| CN201410556658.0A Pending CN104322509A (en) | 2014-10-20 | 2014-10-20 | Emulsion containing bactericide methanesulfonylazole |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632773A (en) * | 2019-01-08 | 2019-04-16 | 贵州大学 | A kind of screening technique of dihydrolipoic acid succinyltransferase inhibitor |
| CN111685111A (en) * | 2020-06-01 | 2020-09-22 | 广西雅胜环境科技有限公司 | Water-based environment-friendly auxiliary agent special for smoke cooling machine and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
-
2014
- 2014-10-20 CN CN201410556658.0A patent/CN104322509A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102499247A (en) * | 2011-10-17 | 2012-06-20 | 贵州大学 | Oxadiazole sulfone compound for controlling bacterial crop diseases |
Non-Patent Citations (1)
| Title |
|---|
| 刘步林: "《农药剂型加工技术》", 31 October 1998 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109632773A (en) * | 2019-01-08 | 2019-04-16 | 贵州大学 | A kind of screening technique of dihydrolipoic acid succinyltransferase inhibitor |
| CN109632773B (en) * | 2019-01-08 | 2021-11-12 | 贵州大学 | Screening method of dihydrolipoic acid succinyltransferase inhibitor |
| CN111685111A (en) * | 2020-06-01 | 2020-09-22 | 广西雅胜环境科技有限公司 | Water-based environment-friendly auxiliary agent special for smoke cooling machine and application thereof |
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Application publication date: 20150204 |