CN104318541A - Method for processing ophthalmology OCT images - Google Patents
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Abstract
The invention discloses a method for processing ophthalmology OCT images. The method comprises the steps that common part OCT images of any group of ophthalmology OCT images are selected as standard ophthalmology OCT images, common part OCT images of at least one group of the remaining ophthalmology OCT images are matched with the standard ophthalmology OCT images in a one-to-one mode, and the corresponding rotating amount and the translation amount are obtained; according to the optical path difference of the space positions corresponding to all human eye part OCT images of each group of ophthalmology OCT images, all the human eye part OCT images are spliced into a first OCT image with a large depth; the first OCT image is processed to obtain a second OCT image; the standard ophthalmology OCT images are kept unmovable, corresponding parts of the second OCT image are selected for the other human eye part OCT images, and according to the optical path difference of the space positions corresponding to all the human eye part OCT images, an ophthalmology OCT image comprising a plurality of human eye parts is obtained through splicing. The complex degree of ophthalmology OCT equipment is reduced, and cost is saved.
Description
Technical field
The invention belongs to image processing field, be related specifically to and utilize ophthalmology OCT device scan human eye and the splicing of ophthalmology OCT image that obtains of machine process as calculated, these ophthalmology OCT image shows the tomoscan image of the reaction human eye different parts that ophthalmology OCT equipment detection human eye different depth obtains.
Background technology
Current OCT technology divides time domain, frequency domain and frequency sweep three kinds.Wherein time domain OCT technology investigation depth is comparatively dark, but speed is too slow, after tested human eye is dynamic, can affect the faulted scanning pattern of human eye; Frequency domain OCT and frequency sweep OCT system speed are fast, but all difficult tomoscan realized whole human eye of investigation depth, and the technology of corresponding frequency sweep OCT ophthalmic medical equipment is more complicated, cost is also higher; If cannot numerous structural parameters of Simultaneously test human eye, just crystalline lens front and rear surfaces curvature or curvature distribution cannot be recorded, or eye ground curvature or curvature distribution etc.
To be the patent disclosure of 201290000031.1 a kind of can realize anterior ocular segment and oculi posterior segment measures the ophthalmology OCT system switched fast for application number, but this system once can only obtain human eye two positions---such as cornea and crystalline lens front surface or cornea and amphiblestroid OCT image, and an ophthalmology OCT image containing multiple human eye position cannot be obtained.Though human eye to be measured is watched the fixation lamp of instrument attentively but still can not independently move by eye during owing to measuring at every turn, therefore when equipment cannot ensure that homogeneous is not measured, human eye to be measured is always constant relative to the position of checkout equipment, thus image rectification cannot be carried out to surveyed OCT image, just cannot draw the crystalline lens front and rear surfaces of tested human eye and the curvature of human eye eye ground or curvature distribution.Simultaneously, the ophthalmology OCT equipment related in this patent because of its investigation depth dark not, need switching device shifter could realize the quick handover measurement at the multiple position of above-mentioned human eye, but the complexity of the quick switching device of multiple location will inevitably improve greatly simultaneously, thus add cost and technical difficulty.
Summary of the invention
The invention provides a kind of disposal route of ophthalmology OCT image, its object is to solve and how to utilize ophthalmology OCT equipment all to contain the OCT image at the total position of human eye by many groups ophthalmology OCT image-these each groups organizing ophthalmology OCT images that switching gradation collects fast more, be processed into one and be equivalent to the problem comprising the ophthalmology OCT image at multiple human eye position once collected.
Technical scheme of the present invention is as follows:
A disposal route for ophthalmology OCT image, comprises the steps:
Ophthalmology OCT equipment is by switching gradation collection at least two group ophthalmology OCT image fast, and each group all comprises at least one total position OCT image;
By treated for described at least two group ophthalmology OCT images obtain one be equivalent to once collect containing the ophthalmology OCT image at multiple human eye position;
Wherein, described total position is the combination at cornea, crystalline lens front surface, crystalline lens rear surface and amphiblestroid arbitrary position or any two positions.
Further: described by treated at least two group ophthalmology OCT images obtain one be equivalent to once collect containing the ophthalmology OCT image at multiple human eye position, comprise the steps:
Described in choosing, the total position OCT image of any a group of at least two group ophthalmology OCT images is standard ophthalmology OCT image, the total position OCT image all the other respectively being organized ophthalmology OCT image rotates respectively by rotation translation or translation and mates one by one with described standard ophthalmology OCT image, tries to achieve the data that at least one group comprises rotation amount and translational movement;
According to the optical path difference of locus corresponding to described human eye each position OCT image, each is organized the OCT image that described ophthalmology OCT image mosaic becomes the degree of depth darker;
According to translational movement and the rotation amount of described at least one group of data, translation rotates or rotates an OCT image described in translation one by one, obtains the 2nd OCT image;
Total position OCT image chooses described standard ophthalmology OCT image, other human eye position OCT image chooses the corresponding site of all the other the 2nd OCT images described, the optical path difference of the locus corresponding to the OCT image of described each position, splicing obtains the ophthalmology OCT image containing multiple human eye position described in.
Further: described rotation amount and described translational movement manually mate or Auto-matching obtains.
Further: described automatic matching method is: the distance calculating lower surface according to the upper surface each point at described total position along beam flying direction or row pixel orientation or radial direction, simulate the thickness distribution curve at the described total position that each time is measured, and draw the described translational movement at described total position to be matched and described rotation amount.
Further: when described total position is retina, it is two-layer arbitrarily that described upper and lower surface is got on retina, and described distance is recorded by eye ground OCT image; When described total position is cornea, described upper and lower surface is respectively anterior surface of cornea and posterior surface of cornea, and described distance is recorded by cornea OCT image.
Further: the optical path difference of the locus that described human eye each position OCT image is corresponding produces according to the length difference of the sample arm of the ophthalmology OCT imaging system measuring described each position.
Further: when described total position OCT image is cornea OCT image, in described cornea OCT image, have strong reflecting pole, during described strong reflecting pole eye cornea basic vertical by scanning light beam, flashlight obtains through cornea vertical reflection; When described total position OCT image is retina OCT image, described retina OCT image has strong reflective spot.
Further: the locus corresponding to the OCT image of arbitrary position of described human eye is determine according to the reference arm of OCT imaging system when surveying this position and the length of sample arm to the distance connecing order object lens of ophthalmology OCT device.
Useful technique effect of the present invention: due at least two group ophthalmology OCT images gathered, each group ophthalmology OCT image all contains the total position of human eye, with the OCT image at the total position of wherein group for standard ophthalmology OCT image, the translation rotation or rotary flat shift-in is capable mates one by one of the total position OCT image of all the other OCT images of remaining each group and standard ophthalmology OCT image, tries to achieve at least one group of translation spin data; Simultaneously, to at least two group ophthalmology OCT images gathered, the optical path difference of the locus corresponding to the human eye different parts OCT image in arbitrary group of ophthalmology OCT image, be spliced into the OCT image that the degree of depth is darker, then according to foregoing at least one group of translation spin data, rotation translation or translation rotation are carried out to an at least one group of OCT image, obtains the 2nd OCT image; Finally standard ophthalmology OCT image is kept motionless, the corresponding site of the 2nd OCT image is chosen at other non-shared positions, then to the optical path difference of the locus corresponding to the OCT image of human eye each position, splicing obtains the OCT image that comprises multiple human eye position.This comprises multiple human eye positions OCT image and is equivalent to higher with cost and the ophthalmic medical equipment that technical difficulty is more complicated once gathers the image that multiple human eye position obtains.But gather the cost of the equipment of many group ophthalmology OCT images, technology realizes difficulty all lower than the ophthalmic medical equipment once gathering multiple human eye position and obtain OCT image.The treated ophthalmology OCT image containing multiple human eye position obtained for the scanning correction of image and refraction correction, thus can obtain the human eye important parameters such as crystalline lens front and rear surfaces curvature or curvature distribution; Should may be used for containing multiple human eye positions ophthalmology OCT image the OCT image correcting eye ground in addition, thus obtain the parameters such as amphiblestroid curvature or curvature distribution, the clinical diagnosis for doctor provides numerous useful human eye parameter.In addition, the impact that the eye that the ophthalmology OCT image because eliminate containing multiple human eye position that finally splicing obtains produces because of repetitive measurement is dynamic, realize the splicing of the OCT image that not homogeneous is measured, the cost and the technology that reduce ophthalmic medical equipment realize difficulty.
Accompanying drawing explanation
Fig. 1 is the total process flow diagram of the present invention;
Fig. 2 is light channel structure sketch of the present invention;
Fig. 3 is the exploded view of step S102 in Fig. 1;
Fig. 4 is the light path schematic diagram once gathering cornea OCT image and retina OCT image;
Fig. 5 is the cornea OCT image and retina OCT image that once gather;
Fig. 6 is the light path schematic diagram once gathering cornea OCT image and crystalline lens front surface OCT image;
Fig. 7 is the cornea OCT image and crystalline lens front surface OCT image that once gather;
Fig. 8 is the light path schematic diagram once gathering cornea OCT image and crystalline lens rear surface OCT image;
Fig. 9 is the cornea OCT image and crystalline lens rear surface OCT image that once gather;
Figure 10 is that the cornea OCT image in Fig. 7 and the cornea OCT image in Fig. 5 carry out coupling schematic diagram;
Figure 11 is the splicing schematic diagram of cornea OCT image and crystalline lens front surface OCT image in Fig. 7, and defining this OCT image is an OCT image;
Figure 12 is cornea OCT image in Figure 11 after coupling and rotates through translation or rotate the crystalline lens front surface OCT image of translation, and defining this OCT image is the 2nd OCT image;
Figure 13 be treated that finally obtain, be equivalent to once gather containing the ophthalmology OCT image at multiple human eye position.
Figure 14 is that human eye has position OCT image automatic matching method process flow diagram.
Figure 15 saves first the light channel structure schematic diagram switched fast before and after being, this light path can realize the collection of the many groups ophthalmology OCT image taking retina as total position;
Figure 16 saves second the light channel structure schematic diagram switched fast before and after being, this light path can realize the collection of the many groups ophthalmology OCT image taking cornea as total position.
Embodiment
In order to make technical matters to be solved by this invention, technical scheme and beneficial effect clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
Be the total process flow diagram of the present invention with reference to figure 1, Fig. 1, comprise the steps:
S101: ophthalmology OCT equipment is by switching gradation collection at least two group ophthalmology OCT image fast, and each group all comprises at least one total position OCT image;
S102: by treated for described at least two group ophthalmology OCT images obtain one be equivalent to once collect containing the ophthalmology OCT image at multiple human eye position.
Launch to specifically describe to step S101 and step S102 below.
With reference to the 20B in 20A or Figure 16 in the survey anterior ocular segment in figure 2, Figure 15 and Figure 16, Fig. 2, oculi posterior segment assembly and Figure 15.In Figure 15 and Figure 16, by the cooperatively interacting of Y-direction scanning element 11O and rotatable completely reflecting mirror 401-namely while rotation Y-direction scanning element 11O, rotatable completely reflecting mirror 401 also does corresponding rotation, thus the paths path changed between Y-direction scanning element 11O and rotatable completely reflecting mirror 401, achieve the switching of quick and precisely real time imagery and front and back joint imaging in human eye different depth position.Above-mentioned principle of work and method of work are shown in authorized patent 201290000031.1, are not repeated at this.But, the ophthalmology OCT equipment of patent 201290000031.1 can not realize once gathering and comprise from cornea to amphiblestroid OCT image, can only obtain the OCT image that is wherein a part of or wherein a few part in the cornea of human eye, crystalline lens front surface, crystalline lens rear surface and retina.Therefore, the object of step S101 is exactly to obtain at least two group ophthalmology OCT images, and wherein each group all contains the OCT image at one of them position as human eye.It should be noted that, in the present invention, no matter the OCT image of collection has several groups, but each group only comprises wherein two positions of human eye.As concrete embodiment, exemplaryly in the present embodiment enumerated the situation that total position is cornea OCT image, and the ophthalmology OCT image gathered is three groups.If the ophthalmology OCT image gathered is two groups, be under the prerequisite of cornea OCT image at total position, first group of OCT image is respectively the combination (not shown) of cornea OCT image and retina OCT image, and second group of OCT image is the combination (not shown) of cornea OCT image and crystalline lens OCT image.If the ophthalmology OCT image gathered is three groups, be under the prerequisite of cornea OCT image at total position, these three groups of ophthalmology OCT images are respectively: the cornea OCT image in Fig. 5 and retina OCT image are as one group, cornea OCT image in Fig. 7 and crystalline lens front surface OCT image are as second group, and the cornea OCT image in Fig. 9 and crystalline lens rear surface OCT image are as the 3rd group.It should be noted that, it is only exemplary that total position is chosen as cornea OCT image, and when ophthalmology OCT is two groups, crystalline lens OCT image or retina OCT image also can be selected in total position; When ophthalmology OCT image is three groups, total position can be crystalline lens front surface OCT image or crystalline lens rear surface OCT image or retina OCT image.But no matter select the OCT image at which position of human eye to have position as human eye, the handling principle that the treated width finally obtained contains the ophthalmology OCT image at multiple human eye position is identical.Therefore, in discourse process below, human eye has position only exemplary selection cornea OCT image; Simultaneously, although " at least two group ophthalmology OCT images " that collect described in following steps and rotate obtain " at least one group " data through rotating translation or translation, but, in concrete elaboration all with three groups of ophthalmology OCT images as embodiment, and by three groups wherein two groups respectively relative to two groups of data that group including standard ophthalmology OCT image rotates through rotating translation or translation and obtains, often organize data and include rotation amount and translational movement.It should be noted that, if the human eye OCT image gathered is more than three groups, the handling principle of image be two groups or be that the principle of three groups is identical.
After utilizing step S101 to obtain at least two group ophthalmology OCT images, by carrying out a series of process to described at least two group ophthalmology OCT images, splicing obtains the ophthalmology OCT image that includes multiple human eye position, and this ophthalmology OCT image including multiple human eye position is equivalent to the ophthalmology OCT image once gathered from cornea to crystalline lens rear surface.But the equipment complexity of the ophthalmology OCT image containing multiple human eye position once collected and cost are all far away higher than the ophthalmology OCT equipment that the present invention's said collection at least two group ophthalmology OCT image uses, therefore, use method of the present invention, the complexity and the technology that reduce ophthalmology OCT equipment realize difficulty, thus have saved cost.
For step S102, concrete expansion sees Fig. 3.Fig. 3 is the exploded view of step 201 in Fig. 1, comprises the steps:
S201: described in choosing, the total position OCT image of any a group of at least two group ophthalmology OCT images is standard ophthalmology OCT image, the total position OCT image all the other respectively being organized ophthalmology OCT image mates one by one respectively by rotating translation or translation rotation and described standard ophthalmology OCT image, and tries to achieve the data that at least one group comprises translational movement and rotation amount respectively;
S202: according to the optical path difference of locus corresponding to described human eye each position OCT image, each is organized the OCT image that described ophthalmology OCT image mosaic becomes the degree of depth darker;
S203: according to translational movement and the rotation amount of described at least one group of data, translation rotates or rotates an OCT image described in translation one by one, obtains the 2nd OCT image;
S204: total position OCT image chooses described standard ophthalmology OCT image, other human eye position OCT image chooses the corresponding site of all the other the 2nd OCT images described, the optical path difference of the locus corresponding to the OCT image of described each position, splicing obtains an ophthalmology OCT image containing multiple human eye position.
The step concrete analysis of above-mentioned S201-S204 will by setting forth below.
For at least two group ophthalmology OCT images described in step S101, collected by switching fast by the anterior ocular segment in Fig. 2, Figure 15 and Figure 16, oculi posterior segment assembly.In the present embodiment, the ophthalmology OCT image obtained is three groups, respectively: the cornea OCT image in Fig. 5 and retina OCT image are as one group, cornea OCT image in Fig. 7 and crystalline lens front surface OCT image are as second group, and the cornea OCT image in Fig. 9 and crystalline lens rear surface OCT image are as the 3rd group.From above-mentioned three groups of ophthalmology OCT images optional one group, be standard ophthalmology OCT image by the total position OCT image of this group, by the OCT image at the total position in all the other two groups of ophthalmology OCT images respectively with standard ophthalmology OCT image for benchmark, rotate mate one by one by rotating translation or translation.Mentioned herely to mate one by one, refer to and the total position OCT image of all the other two groups of ophthalmology OCT images is mated separately with standard ophthalmology OCT image respectively.By mating one by one, obtain at least two group data, each group data includes translational movement and rotation amount.As concrete embodiment, in the present embodiment, the cornea OCT image got in ophthalmology OCT image is total position.With reference to Figure 10, Fig. 6 and Fig. 7, Figure 10 is that the cornea OCT image in Fig. 7 and the cornea OCT image in Fig. 5 carry out coupling schematic diagram, and Fig. 6 is for gathering the light path sketch of the OCT image shown in Fig. 7.In the present embodiment, foregoing first group of ophthalmology OCT image Fig. 5 being comprised cornea OCT image C1 and retina OCT image R1 is chosen for standard ophthalmology OCT image, the cornea OCT image C1 in cornea OCT image C2 and Fig. 5 in the second group of ophthalmology OCT image comprised described in cornea OCT image C2 and crystalline lens front surface image LF2OCT image is mated in Fig. 7.Please continue to refer to Figure 10, by represented by dashed line for the region of interest of the cornea OCT image C2 in Fig. 7, these region of interest are: anterior surface of cornea CF2, posterior surface of cornea CB2, the strong reflecting pole CCRL2 of cornea.This region of interest rotates or rotates representing with dot-and-dash line of the intermediate state of translation through translation, become: the strong reflecting pole CCRL22 of posterior surface of cornea CB22 peace angle of lag film after translation after anterior surface of cornea CF22, translation.Indicated by the solid line again through postrotational cornea OCT image on the basis being defined in translation, now becomes: the cornea OCT image C2 in Fig. 7 that postrotational anterior surface of cornea CF23, postrotational posterior surface of cornea CB23, postrotational cornea strong reflecting pole CCRL3. now rotate after first translation and the Fig. 5 without any rotation translation overlaps completely as the cornea OCT image C1 of " standard ophthalmology OCT image ".In the matching process, computing machine can show that the move horizontally amount of cornea OCT image C2 in translation rotary course in Fig. 7 is Δ X2, and vertical amount of movement is Δ Y2, and the anglec of rotation is Δ θ 2.The corresponding numerical value of Computer Storage, prepares for follow-up.It should be noted that, the cornea OCT image C2 in Fig. 7 also can realize mating with the cornea OCT image C1 in Fig. 5 by the mode first rotating rear translation, and its result is the same with rotation after aforesaid first translation.In addition, it is identical that the matching process of the cornea OCT image in Fig. 9 and the cornea OCT image in Fig. 5 and coupling schematic diagram (not shown) carry out matching process with the cornea OCT image in Fig. 7 and the cornea OCT image in Fig. 5; Obtain another group data after cornea OCT image in Fig. 9 and the cornea OCT images match in Fig. 5, these group data also comprise rotation amount and translational movement.
For step S202, after the three groups of ophthalmology OCT images collected, also need, by the optical path difference of the locus of the correspondence of the OCT image at each position of human eye of each group OCT image, to be spliced into the OCT image that the degree of depth is darker.Particularly, reference Figure 11, Figure 11 is the OCT image obtained after the splicing of cornea OCT image and crystalline lens front surface OCT image in Fig. 7.The distance of the locus LFDK corresponding to the locus CDK corresponding to cornea OCT image to crystalline lens front surface OCT image in definition Figure 11 is LCDKtoLFDK, according to Fig. 4, LCDKtoLFDK=LLFDKto206-LCDKto206, this distance can be recorded by the length difference of angle measurement film OCT imaging system and the sample arm surveying crystalline lens front surface OCT imaging system, and this distance becomes the optical path difference required for splicing of cornea OCT image and crystalline lens front surface OCT image in Figure 11.And picture centre line because of angle measurement film and when surveying crystalline lens front surface the light path primary optical axis of OCT system be overlap, therefore the center line in Figure 11 is the center line of OCT image corresponding to angle measurement film light path primary optical axis, it is also the center line surveying OCT image corresponding to crystalline lens front surface light path primary optical axis.It should be noted that, Figure 11 is only exemplary has enumerated the splicing situation that an OCT image is cornea OCT image and crystalline lens front surface OCT image, if what show in Figure 11 is as the cornea OCT image in Fig. 9 and crystalline lens rear surface OCT image pass through the cornea OCT image as shown in the OCT image or Fig. 5 spliced and the OCT image of retina OCT image through splicing, its splicing principle is identical, the distance of the distance of the locus corresponding to the locus also corresponding to cornea OCT image to crystalline lens rear surface OCT image or the locus corresponding to the locus corresponding to cornea OCT image to retina OCT image is tried to achieve.By step S202, obtain the OCT image that three groups of degree of depth of passing through to splice are darker.
After completing step S202, then enter step S203.The object of step S203 is exactly that obtain in step S202 three groups of darker OCT images are carried out rotations translation or translation rotation by utilizing the corresponding rotation amount that obtains in step s 201 and translational movement.Particularly, please refer to Figure 12, as previously mentioned, measure cornea and crystalline lens front surface OCT image still represented by dashed line, obtained anterior surface of cornea OCT image still comprise: anterior surface of cornea OCT image CF2, posterior surface of cornea OCT image CB2 and the strong reflecting pole CCRL2 of cornea, the OCT image of the crystalline lens front surface LensF2 obtained is also represented by dashed line.The cornea in the amount of moving horizontally Δ X2, vertically the amount of movement Δ Y2 and anglec of rotation Δ θ 2 couples of Figure 12 obtained in step s 201 and crystalline lens front surface OCT image is utilized to carry out translation and rotation.The same with aforesaid, represent with dot-and-dash line after cornea OCT image translation, be specially: the strong reflecting pole CCRL22 of posterior surface of cornea CB22 peace angle of lag film after anterior surface of cornea CF22, translation; And then become indicated by the solid line through rotation: postrotational anterior surface of cornea CF23, postrotational posterior surface of cornea CB23, the strong reflecting pole CCRL3 of postrotational cornea.For crystalline lens front surface LensF2, become after translation and represent with dot-and-dash line: the crystalline lens front surface LensF22 after translation, then rotate and become postrotational crystalline lens front surface LensF23 indicated by the solid line.Defining the ophthalmology OCT image obtained after step S203 is the 2nd OCT image.It should be noted that, in this step, the OCT image of cornea OCT image and crystalline lens front surface LensF2 also can first realize through translation and first after translation, reach same effect through over-rotation after over-rotation, does not state at this tired.In addition, remaining that group the one OCT image in three groups, what the degree of depth namely obtained was darker comprise cornea OCT image and that group the one OCT image of crystalline lens rear surface OCT image carry out rotating translation or translation spinning solution with obtain the degree of depth darker to comprise cornea OCT image identical with disposal route of that group the one OCT image of crystalline lens front surface OCT image, but another obtaining after the cornea OCT image in Fig. 9 of saying before being of used data and the cornea OCT images match in Fig. 5 organizes data.
After completing step S203, next enter step S204.In step S204, human eye has position OCT image and chooses in step s 201 as that group of standard ophthalmology OCT image.Specifically, total position OCT image chooses the cornea OCT image in Fig. 5; The OCT image of other non-shared parts chooses the corresponding site in the 2nd OCT image.Particularly, with reference to Figure 13, cornea OCT image adopts the cornea OCT image C1 in Fig. 5, and the OCT image of crystalline lens front surface LensB33 choose in Figure 12 the corresponding site of the 2nd OCT image, the OCT image of crystalline lens rear surface chooses the corresponding site of corresponding 2nd OCT image.After the selection completing human eye each position OCT image, according to each position---the optical path difference of the locus corresponding to image of cornea OCT image, crystalline lens front surface OCT image and crystalline lens rear surface OCT image, is spliced into a width degree of depth and can reaches the OCT image of measurement cornea to crystalline lens rear surface.Particularly, with reference to Figure 13, the distance of the locus LBDK corresponding to the locus CDK corresponding to cornea OCT image to crystalline lens rear surface OCT image is LCDKtoLBDK, this distance is recorded by the length difference of angle measurement film OCT imaging system with the sample arm surveying crystalline lens rear surface OCT imaging system, i.e. LCDKtoLBDK=LLBDKto206-LCDKto206.In fig. 13, the light path primary optical axis of picture centre line OCT system because of angle measurement film with when surveying crystalline lens front and rear surfaces overlaps, so be also overlap in detail in this figure.According to described optical path difference through splicing, finally obtain comprising the OCT image of cornea to crystalline lens rear surface.
Refer to cornea OCT image in step s 201 and rotate the method for carrying out mating by rotating translation or translation, the method can adopt manual coupling or through image procossing Auto-matching.The present invention also describes a kind of method that can realize Auto-matching, realizes comprising using cornea OCT image or retina OCT image as the matching process at total position, and its concrete grammar is shown in Figure 14.Figure 14 comprises the steps:
S301: on the upper surface of the OCT image at the total position of at least two group ophthalmology OCT images described in calculating, each point is to the distance of each point corresponding on radially or along pixel column to lower surface, and fits at least two group range distribution curves;
S302: using a wherein range distribution curve as standard, carry out related calculation using range distribution curve described in remaining with as that range distribution curve of standard, obtain the amount of the moving horizontally Δ X of Auto-matching, the vertical amount of movement Δ Y of Auto-matching and anglec of rotation Δ θ.
Particularly, respectively by the anterior surface of cornea image of the cornea OCT image obtained in Fig. 5, Fig. 7 and Fig. 9 and posterior surface of cornea image, the distance of each point on anterior surface of cornea image to the relevant position on posterior surface of cornea is then calculated.As calculated on anterior surface of cornea each point along pixel column to the distance of posterior surface of cornea, or calculate each point on anterior surface of cornea and radially arrive multiple distances of posterior surface of cornea, simulate range distribution curve according to multiple distance.Using according to the cornea front and rear surfaces spacing distribution curve simulated in the cornea OCT image obtained when the angle measurement film in Fig. 5 and retina OCT image as standard, the cornea front and rear surfaces spacing distribution curve corresponding to cornea OCT image that other time collection obtains and above-mentioned typical curve do correlation computations, obtain the Auto-matching amount of moving horizontally Δ Xi, Auto-matching vertical amount of movement Δ Yi and anglec of rotation Δ θ i.
It should be noted that, the method of Figure 14 is also applicable to realizing Auto-matching using retina OCT image as common sites, if select retina OCT image, two-layer arbitrarily respectively as the upper and lower surface in step S301 between the internal limiting membrane layer ILM1 of desirable retina OCT image and layer of retina,pigment epithelium RPE1, tries to achieve the corresponding Auto-matching amount of moving horizontally, the vertical amount of movement of Auto-matching and the anglec of rotation by the method identical with Figure 14.In addition retina OCT image can identify amphiblestroid sandwich construction, therefore the selection of above-mentioned upper and lower surface also can select other layers to realize above-mentioned matching process.Retina comprises internal limiting membrane, nerve fibre layer, ganglion-cell layer, inner plexiform layer, inner nuclear layer, outer plexiform layer, outer nuclear layer, external limiting membrane, column and taper photosensory cell and retinal pigment epithelium from top to bottom.Mentioned here arbitrarily two-layer just refer to above-mentioned in comprise internal limiting membrane and comprise between retinal pigment epithelium two-layer arbitrarily, can be such as internal limiting membrane and nerve fibre layer, nerve fibre layer and inner plexiform layer, or outer nuclear layer and nerve fibre layer, do not exemplifying at this.
It should be noted that, in the present invention, if the total position OCT image cornea OCT image in the OCT image gathered, then all there is strong reflecting pole in cornea OCT image, during this strong reflecting pole eye cornea basic vertical by scanning light beam, flashlight obtains through cornea vertical reflection; If the total position OCT image chosen is retina OCT image, then what often occur in retina OCT image is strong reflective spot.
It should be noted that, in the present invention, the OCT image at arbitrary position of human eye is determine according to the reference arm of OCT imaging system when surveying this position and the length of sample arm to the distance connecing order object lens of ophthalmology OCT system.Specifically, in Fig. 4, when surveying the OCT image of the cornea of anterior ocular segment, the locus CDK corresponding to cornea OCT image is system given value to the distance LCDKto206 connecing order object lens 206, because this value determines according to the reference arm of the cornea OCT imaging system surveying anterior ocular segment and the length of sample arm.In Fig. 6, when surveying the OCT image of the crystalline lens front surface of anterior ocular segment, locus LFDK corresponding to crystalline lens front surface OCT image is system given value to the distance LLFDKto206 connecing order object lens 206, because this value determines according to the reference arm of the crystalline lens front surface OCT imaging system surveying anterior ocular segment and the length of sample arm.In Fig. 8, when surveying the OCT image of the crystalline lens rear surface of anterior ocular segment, locus LBDK corresponding to the OCT image of crystalline lens rear surface is system given value to the distance LLBDKto206 connecing order object lens 206, because this value determines according to the reference arm of the crystalline lens rear surface OCT imaging system surveying anterior ocular segment and the length of sample arm.
It should be noted that, in the present invention, although only enumerated using the cornea OCT image in the ophthalmology OCT image gathered as total position, but, for getting other positions of human eye, as crystalline lens front surface OCT image, crystalline lens rear surface OCT image and retina OCT image one of them or with cornea OCT image, crystalline lens front surface OCT image, the combination of any two width images of crystalline lens rear surface OCT image and retina OCT image is as total position, its splicing principle is with the same as total position using cornea OCT image, also the ophthalmology OCT image that comprises multiple human eye position can be obtained.Obviously, the ophthalmology OCT image obtained by the method is the same with the effect of the OCT image obtained as total position using cornea OCT image.
By step S201 to step S204, by the OCT image that the three groups of ophthalmology OCT image mosaic comprising human eye different parts gathered once gather for being equivalent to shown in Figure 13, thus achieve the collection of cornea to the OCT image of crystalline lens rear surface, the technical sophistication degree not increasing system light path has expanded the investigation depth of system.That is, by the process to image, achieve the splicing of the OCT image that not homogeneous is measured, make the ophthalmology OCT image comprising multiple human eye position finally obtained eliminate the dynamic impact of human eye eye to be measured, its effect reached is the same with once gathering the ophthalmology OCT image comprising multiple human eye position that human eye obtains with the ophthalmology OCT equipment of more complicated.And, scanning correction and the refraction correction that can be used for image through splicing the OCT image comprising multiple human eye position obtained of acquisition, thus the human eye important parameters such as crystalline lens front and rear surfaces curvature or curvature distribution can be obtained.In addition according to the series of parameters of cornea to crystalline lens rear surface, can be used for the OCT image correcting eye ground, thus can obtain the important human eye parameters such as amphiblestroid curvature or curvature distribution, the clinical diagnosis for doctor provides numerous useful human eye parameter.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a disposal route for ophthalmology OCT image, is characterized in that, comprises the steps:
Ophthalmology OCT equipment is by switching gradation collection at least two group ophthalmology OCT image fast, and each group all comprises at least one total position OCT image;
By treated for described at least two group ophthalmology OCT images obtain one be equivalent to once collect containing the ophthalmology OCT image at multiple human eye position;
Wherein, described total position is the combination at cornea, crystalline lens front surface, crystalline lens rear surface and amphiblestroid arbitrary position or any two positions.
2. the disposal route of ophthalmology OCT image as claimed in claim 1, is characterized in that: describedly obtain one and be equivalent to treated at least two group ophthalmology OCT images the ophthalmology OCT image containing multiple human eye position once collected, and comprises the steps:
Described in choosing, the total position OCT image of any a group of at least two group ophthalmology OCT images is standard ophthalmology OCT image, the total position OCT image all the other respectively being organized ophthalmology OCT image rotates respectively by rotation translation or translation and mates one by one with described standard ophthalmology OCT image, tries to achieve the data that at least one group comprises rotation amount and translational movement;
According to the optical path difference of locus corresponding to described human eye each position OCT image, each is organized the OCT image that described ophthalmology OCT image mosaic becomes the degree of depth darker;
According to translational movement and the rotation amount of described at least one group of data, translation rotates or rotates an OCT image described in translation one by one, obtains the 2nd OCT image;
Total position OCT image chooses described standard ophthalmology OCT image, other human eye position OCT image chooses the corresponding site of all the other the 2nd OCT images described, the optical path difference of the locus corresponding to the OCT image of described each position, splicing obtains the ophthalmology OCT image containing multiple human eye position described in.
3. the disposal route of ophthalmology OCT image as claimed in claim 2, is characterized in that: described rotation amount and described translational movement manually mate or Auto-matching obtains.
4. the disposal route of ophthalmology OCT image as claimed in claim 3, it is characterized in that: described automatic matching method is: the distance calculating lower surface according to the upper surface each point at described total position along beam flying direction or row pixel orientation or radial direction, simulate the thickness distribution curve at the described total position that each time is measured, and draw the described translational movement at described total position to be matched and described rotation amount.
5. the disposal route of ophthalmology OCT image as claimed in claim 4, is characterized in that: when described total position is retina, and it is two-layer arbitrarily that described upper and lower surface is got on retina, and described distance is recorded by eye ground OCT image; When described total position is cornea, described upper and lower surface is respectively anterior surface of cornea and posterior surface of cornea, and described distance is recorded by cornea OCT image.
6. the disposal route of the ophthalmology OCT image according to any one of claim 2-5, is characterized in that: the optical path difference of the locus that described human eye each position OCT image is corresponding produces according to the length difference of the sample arm of the ophthalmology OCT imaging system measuring described each position.
7. the disposal route of the ophthalmology OCT image according to any one of claim 1-4, it is characterized in that: when described total position OCT image is cornea OCT image, strong reflecting pole is had in described cornea OCT image, during described strong reflecting pole eye cornea basic vertical by scanning light beam, flashlight obtains through cornea vertical reflection; When described total position OCT image is retina OCT image, described retina OCT image has strong reflective spot.
8. the disposal route of the ophthalmology OCT image as described in claim 2-5, is characterized in that: the locus corresponding to the OCT image of arbitrary position of described human eye determines to the distance connecing order object lens of ophthalmology OCT device according to the reference arm of OCT imaging system when surveying this position and the length of sample arm.
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