CN106963337B - One kind realizes big depth of field eye anterior segment analysis system - Google Patents
One kind realizes big depth of field eye anterior segment analysis system Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0016—Operational features thereof
- A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/107—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining the shape or measuring the curvature of the cornea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/11—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils
- A61B3/112—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring interpupillary distance or diameter of pupils for measuring diameter of pupils
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
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Abstract
The present invention relates to one kind to realize big depth of field eye anterior segment analysis system, the system includes wideband light source, spectral module, galvanometer module, sample arm module, high resolution spectrometer and reference arm, the incident light that wherein wideband light source is sent is divided into two beams after spectral module, it is wherein a branch of through galvanometer module, sample arm module returns after reaching detected eyeball, form the sample arm of collection eye information, scanning galvanometer in the galvanometer module per dimension uses off-axis scanning galvanometer, per dimension, off-axis scanning galvanometer rotation axis c deviates the distance that incident light center is t, form off-axis structure, modulation source is introduced all the way in sample arm.The modulation source of the present invention is arranged on sample arm, avoids the problem of modulation source is synchronous with scanning in other schemes, reduces system complexity；Image mosaic is not present in the present invention, avoids the measurement error of depth direction.
Description
Technical field
The invention belongs to ophthalmic medical equipment technical field, refers to one kind and realizes big depth of field eye anterior segment analysis system.
Background technology
Eyes are the most important sense organs of human body, and the external information that people are received about 80% by eyes above is obtained
.In medicine eye dissection concept field, anterior ocular segment includes cornea to lenticular ocular tissue part.In recent years, optical coherence
Chromatography (OCT) technology is quickly grown, and with it is quick, non-intruding the advantages that is widely used among medical research.In corneal, consolidate
Film, iris, the diagnosis aspect at room angle are with the obvious advantage, while in the diagnosis to glaucoma, cataract and refractive vision problem,
It is particularly important that crystal lesion situation is also.There is conjugation pseudomorphism in traditional OCT image, therefore its imaging depth is only that system is concerned with
The half of length.And the distance of anterior surface of cornea to crystal also wants bigger in 10mm or so, the distance to crystal rear surface, much
More than the imaging depth range of frequency domain OCT, therefore tradition OCT can not be suitable for the panoramic imagery of anterior ocular segment.
In order to expand the areas imaging of frequency domain OCT, some research groups have used the frequency swept laser of super-narrow line width to replace
Wideband light source, but the axial resolution of its system is generally less than common wide light-source system, and phase stability is bad, very according to
Rely in laser performance, involve great expense at the same time, be unfavorable for being widely popularized under current development level.On the other hand, use
Two classes can be substantially divided into by comparing the technology of more extended parallel port scopes：More plane of reference splicings and phase modulation technique.
Patent CN102670172 describes a kind of frequency domain OCT image system based on more plane of references.It is provided with the system
Two plane of references, are respectively placed in before anterior surface of cornea and after crystal rear surface, can obtain two width respectively under such configuration
The OCT image of artifact-free interference, then obtains a secondary complete anterior segment image through computer processing splicing.This kind of device lacks
Point is to need the distance between two plane of reference of Accurate Calibration difference, and stated accuracy should be higher than that the axial resolution of system, otherwise can
Larger depth survey error is introduced, causes diagnosis risk, its accuracy and repeatability can not ensure, be not suitable for commercial scale life
Production.
Patent WO2010011656 describes a kind of imaging method based on additional modulation source, which draws in reference arm
Enter modulation source, OCT pseudomorphisms can be removed by carrying out analyzing and processing to the signal of acquisition, although and the method can be extended scope
It is interior to be imaged at the same time, but need to synchronize between sample arm and modulation source and match, had a great influence by hardware case, added at the same time
System complexity, is not easy to adjustment.
It is contemplated that develop anterior ocular segment analysis a kind of simple in structure, can be imaged at the same time to cornea to crystal gamut
System.
The content of the invention
The purpose of the invention is to overcome the deficiencies of the prior art and provide one kind to realize big depth of field anterior ocular segment analysis system
System.
The present invention solves its technical problem and takes following technical scheme to realize：
One kind realizes big depth of field eye anterior segment analysis system, which includes wideband light source, spectral module, galvanometer module, sample
Product arm module, high resolution spectrometer and reference arm, the incident light that wherein wideband light source is sent are divided into after spectral module
The proportional light of two beam energies, wherein a branch of return after galvanometer module, sample arm module reach and be detected eyeball, is formed
The sample arm of eye information is gathered, the scanning galvanometer in the galvanometer module per dimension uses off-axis scanning galvanometer, each
The off-axis scanning galvanometer rotation axis c of dimension deviates the distance that incident light center is t, forms off-axis structure, i.e., in one pass of sample arm
Enter modulation source, wherein t meets that t=N λ/8a, N are the sampling number in scanning range, and λ is wideband light source centre wavelength, and a is light
Beam rotation angle.
Moreover, the spectral resolution of the high resolution spectrometer is more than or equal to 25 micromicrons, corresponding coherence length is big
In 14 millimeters.
Moreover, being further fitted with Diopter accommodation sighting target module in said system, the Diopter accommodation sighting target module is led to
Cross dichroscope to be sent into sighting target image in tested eyeball through sample arm module, focus on diverse location, induce measured and bend
Light adjusting force.
Moreover, it is further fitted with the spectral signal that high resolution spectrometer is sent out being converted to three-dimensional in said system
The data processing computer of optical coherence tomography scan image.
Moreover, the pupil monitoring module being connected with data processing computer, pupil are further fitted with said system
Monitoring module sends light beam and is radiated at through dichroscope, sample arm module on tested eyeball, and Returning beam carries pupil position
Confidence ceases, the pupil that the pupil position information that data processing computer gathers pupil monitoring module is sent out with high resolution spectrometer
Generation system compensation signal is compared in hole site information, and system compensation signal is used for the correction of system fine jitter or offset.
The advantages and positive effects of the present invention are：
1st, modulation source of the invention is arranged on sample arm, avoids the problem of modulation source is synchronous with scanning in other schemes,
Reduce system complexity；
2nd, high resolution spectrometer of the invention design spectral resolution is more than 25 micromicrons, and correspondence system coherence length is big
In 14 millimeters, modulation and demodulation algorithm is coordinated to realize that the panorama of cornea to crystal rear surface is imaged at the same time；
3rd, image mosaic is not present in the present invention, avoids the measurement error of depth direction.
4th, the three-dimensional optical coherent tomographic scan image that the present invention is sent out models for 3D algorithm for reconstructing, obtains corneal topography
Figure, crystal front and rear surfaces topographic map, anterior ocular segment three-dimensional configuration provide data basis.
5th, the present invention carries out vertical direction scanning imagery to measured's anterior ocular segment, obtains lacrimal river height measurement information, can use
In evaluation scheroma degree.
Brief description of the drawings
Fig. 1 is present system structure diagram；
Fig. 2 is the off-axis scanning galvanometer structure diagram of a dimension in present system；
Fig. 3 is modulation-demo-demodulation method schematic diagram of the present invention.
Embodiment
Present invention implementation is further described below in conjunction with attached drawing, following embodiments are descriptive, are not to limit
Property, it is impossible to protection scope of the present invention is limited with this.
One kind realizes big depth of field eye anterior segment analysis system, as shown in Figure 1, the system include wideband light source 3, spectral module 5,
Galvanometer module 7, sample arm module 6, high resolution spectrometer 4 and reference arm 8, the optical signal that wherein wideband light source is sent pass through
It is divided into the proportional light of two beam energies after spectral module, wherein a branch of reached through galvanometer module, sample arm module is detected
Returned after eyeball 9, form the sample arm of collection eye information, innovative point of the invention is, as shown in Fig. 2, the galvanometer module
In per the scanning galvanometer of dimension use off-axis scanning galvanometer, the off-axis scanning galvanometer rotation axis c deviations incident light per dimension
Center is the distance of t, forms off-axis structure, and wherein t meets that t=N λ/8a, N are the sampling number in scanning range, and λ is broadband
Light source center wavelength, a are Beam rotation angle, i.e., introduce modulation source all the way in sample arm.
By taking the scanning theory of a dimension as an example, scanning galvanometer is rotated along rotation axis penetrates incident light with different reflection angles
Go out, Beam rotation angle is a, and rotation axis and offset of the incident light axis on x scanning directions are t, due to the rotation of scanning galvanometer
Gyration is smaller, according to low-angle arc length formula, because scanning galvanometer can be approximately considered in the optical path difference b that different angle is formed
B=at, i.e., be different from being passed by adjacent scan position in any scan position, incident light in the light path that sample arm is passed by
Light path, and incident light light path with scanning galvanometer rotation angle change, in monotonicity.
It can be obtained by the π z/ λ of optical path difference phase formula Φ=4, δ Φ=4 π at/N λ, wherein N are the sampled point in scanning range
Number, λ is wideband light source centre wavelength, and therefore, when scanning ray in the x-direction samples sample, off-axis scanning galvanometer exists
Adjacent scanning element introduces approximate fixed optical path difference, produces time domain Doppler effect, i.e., adds a modulation frequency in the x-direction
Rate.When the phase difference between neighbouring sample point meets δ Φ=pi/2, i.e. t=N λ/8a, the OCT image obtained by demodulating algorithm
In pseudomorphism can be inhibited, realize the analysis of big depth of field anterior ocular segment.Scanning for two dimensions, its principle is identical, each
Realize that respective dimensions scanning adds modulating frequency using off-axis scanning galvanometer structure in a dimension.
As shown in figure 3, optical coherence tomography image be using wave number (* 2 π reciprocal of wavelength) and x scanning directions position as
The two-dimensional array of coordinate system.Due to scanning while adding modulation in the x-direction, the frequency distribution of sample tissue translates near 0
Fourier filtering is done to modulating frequency, therefore to x bearing datas, complex field sample information can be obtained, so as to eliminate
The pseudomorphism overlap problem caused by real number field does Fourier transformation, filtered data carry out OCT demodulation in complex field, you can
To the image of the artifact-free influence in whole coherence lengths, so as to fulfill to anterior ocular segment part from anterior surface of cornea to crystal after table
The panorama real time imagery in face.
In the specific implementation of the present invention, in order to match with the big depth of field optical signal that sample arm gathers, the high-resolution
Rate spectrometer selects achromatic lens, reduces aberration present in light path of optical spectrometer design, spectrum distortion is reduced, using high-speed line
Array CCD camera, improves sample frequency, the distortion of modulated signal is reduced, according to optical coherence tomography principle, coherence length L=λ2/
2 δ λ, high resolution spectrometer design spectral resolution are greater than or equal to 25 micromicrons, and corresponding coherence length is more than 14 millimeters, diagonally
Structure in the range of film front surface to crystal rear surface is imaged at the same time.
In the specific implementation of the present invention, to observe the anterior ocular segment tissue change situation such as crystal and pupil, in said system
In be further fitted with Diopter accommodation sighting target module 2, the Diopter accommodation sighting target module is passed through sighting target image by dichroscope
Sample arm module is sent into tested eyeball, focuses on diverse location, measured's diopter accommodation is induced, in optical coherence tomography
The anterior ocular segment tissue change such as crystal and pupil can be observed in image.
In the specific implementation of the present invention, wideband light source respectively enters sample as system source, incident light through spectral module
Product arm and reference arm, sample arm incident light focus on measured's eyes prosthomere part by off-axis scanning galvanometer module, backward to dissipate
Penetrate light and carry organizational information and phase modulation return, and return to optical superposition with reference arm and formed and interfere, interference light enters high-resolution
Rate spectrometer is sent out through Dispersive Devices with spectral form, to handle spectral form data, is further fitted with said system
The spectral signal that high resolution spectrometer is sent out is converted to three-dimensional optical phase by data processing computer 10, data processing computer
Dry tomography scan image, three-dimensional optical coherent tomographic scan image model for 3D algorithm for reconstructing, acquisition corneal topography, before crystal
Rear surface topographic map, anterior ocular segment three-dimensional configuration provide data basis.
In the specific implementation of the present invention, pupil monitoring module 1, pupil monitoring mould are further fitted with said system
Block is connected with data processing computer, and pupil monitoring module sends light beam through dichroscope, sample arm module in tested eye
On ball, Returning beam carries pupil position information, the pupil position information that data processing computer gathers pupil monitoring module
Generation system compensation signal is compared in the pupil position information sent out with high resolution spectrometer, and system compensation signal is for being
System fine jitter or the correction of offset.
In the specific implementation of the present invention, spectral module can be fiber optic splitter, or space Amici prism, or film point
Beam device etc., including can realize any species optics of light splitting function, its splitting ratio can be any ratio；
The above embodiments merely illustrate the technical concept and features of the present invention, and its object is to the brief elaboration present invention's
Content is simultaneously implemented according to this, can not limit the scope of the invention.All equivalent changes that Spirit Essence is done according to the present invention
Change or modification should be covered by the protection scope of the present invention.
Claims (5)
1. one kind realizes big depth of field eye anterior segment analysis system, which includes wideband light source, spectral module, galvanometer module, sample
The incident light that arm module, high resolution spectrometer and reference arm, wherein wideband light source are sent is divided into two after spectral module
The proportional light of beam energy, wherein a branch of return after galvanometer module, sample arm module reach and be detected eyeball, composition is adopted
Collect the sample arm of eye information, it is characterised in that：Scanning galvanometer in the galvanometer module per dimension is using off-axis scanning
Galvanometer, per dimension, off-axis scanning galvanometer rotation axis c deviates the distance that incident light center is t, forms off-axis structure, i.e., in sample
Arm introduces modulation source all the way, and wherein t meets that t=N λ/8a, N are the sampling number in scanning range, and λ is cardiac wave in wideband light source
Long, a is Beam rotation angle.
2. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：The high-resolution spectroscopy
The spectral resolution of instrument is more than or equal to 25 micromicrons, and corresponding coherence length is more than 14 millimeters.
3. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：Into one in said system
Step is provided with Diopter accommodation sighting target module, and the Diopter accommodation sighting target module is by dichroscope by sighting target image through sample arm mould
Block is sent into tested eyeball, focuses on diverse location, induces measured's diopter accommodation.
4. according to claim 1 realize big depth of field eye anterior segment analysis system, it is characterised in that：Into one in said system
Step, which is provided with, is converted to the spectral signal that high resolution spectrometer is sent out at the data of three-dimensional optical coherent tomographic scan image
Manage computer.
5. the big depth of field eye anterior segment analysis system of realization according to claim 1 or 4, it is characterised in that：In said system
The pupil monitoring module being connected with data processing computer is further fitted with, pupil monitoring module sends light beam through dichroic
Mirror, sample arm module are radiated on tested eyeball, and Returning beam carries pupil position information, and data processing computer is by pupil
Generation system is compared with the pupil position information that high resolution spectrometer is sent out in the pupil position information of monitoring module collection
Correction signal, system compensation signal are used for the correction of system fine jitter or offset.
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| CN108814544B (en) * | 2018-04-25 | 2020-10-16 | 天津市索维电子技术有限公司 | Anterior segment morphology analysis method |
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Inventor after: Zhao Peng Inventor after: Wang Xueqiao Inventor after: Niu Yanwei Inventor after: Wang Yuan Inventor after: Zhang Gun Inventor after: Qi Yue Inventor before: Zhao Peng Inventor before: Niu Yanwei Inventor before: Wang Yuan Inventor before: Zhang Gun Inventor before: Qi Yue Inventor before: Wang Xueqiao |
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