CN104307582A - 一种开放式微流控芯片及其制作方法和操控方法 - Google Patents
一种开放式微流控芯片及其制作方法和操控方法 Download PDFInfo
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- CN104307582A CN104307582A CN201410525697.4A CN201410525697A CN104307582A CN 104307582 A CN104307582 A CN 104307582A CN 201410525697 A CN201410525697 A CN 201410525697A CN 104307582 A CN104307582 A CN 104307582A
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Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104826674A (zh) * | 2015-04-27 | 2015-08-12 | 北京工业大学 | 实现液滴生成的反y型通道微流控芯片 |
CN107475070A (zh) * | 2017-08-16 | 2017-12-15 | 深圳先进技术研究院 | 微流控芯片和制备细胞液滴的方法 |
CN107904155A (zh) * | 2017-10-19 | 2018-04-13 | 广州市第人民医院 | 一种用于液体分散的微流控芯片及其应用、使用方法 |
CN109810515A (zh) * | 2019-01-29 | 2019-05-28 | 重庆大学 | 光热定向操控弹性超疏水表面液滴迁移装置及使用方法 |
CN109926111A (zh) * | 2019-03-28 | 2019-06-25 | 武夷学院 | 一种压电基片上微流体输运的装置及方法 |
CN110385088A (zh) * | 2018-04-17 | 2019-10-29 | 上海交通大学 | 一种制备微颗粒的方法 |
CN110523451A (zh) * | 2019-09-30 | 2019-12-03 | 王殿宇 | 基于超润滑界面的磁控微液滴反应器制备方法 |
CN111250009A (zh) * | 2018-12-03 | 2020-06-09 | 成都市银隆新能源有限公司 | 一种利用微流控技术制备锂离子电池材料的方法 |
CN111659478A (zh) * | 2020-06-16 | 2020-09-15 | 南京大学 | 一种用于微粒子分离的超声表面驻波微流控芯片和应用 |
US11123729B2 (en) | 2018-02-28 | 2021-09-21 | Volta Labs, Inc. | Directing motion of droplets using differential wetting |
CN113907065A (zh) * | 2021-11-08 | 2022-01-11 | 深圳先进技术研究院 | 换液处理芯片和冷冻载杆 |
CN113967488A (zh) * | 2017-06-21 | 2022-01-25 | 光投发现有限公司 | 微流体分析设备 |
CN114054107A (zh) * | 2021-10-28 | 2022-02-18 | 重庆大学 | 一种开放式抗磁性液滴磁力操控方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014012039A1 (en) * | 2012-07-13 | 2014-01-16 | President And Fellows Of Harvard College | Slippery liquid-infused porous surfaces having improved stability |
CN103649240A (zh) * | 2011-01-19 | 2014-03-19 | 哈佛学院院长等 | 具有高压稳定性、光学透明性以及自修复特征的光滑表面 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103649240A (zh) * | 2011-01-19 | 2014-03-19 | 哈佛学院院长等 | 具有高压稳定性、光学透明性以及自修复特征的光滑表面 |
WO2014012039A1 (en) * | 2012-07-13 | 2014-01-16 | President And Fellows Of Harvard College | Slippery liquid-infused porous surfaces having improved stability |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104826674A (zh) * | 2015-04-27 | 2015-08-12 | 北京工业大学 | 实现液滴生成的反y型通道微流控芯片 |
CN113967488A (zh) * | 2017-06-21 | 2022-01-25 | 光投发现有限公司 | 微流体分析设备 |
CN113967488B (zh) * | 2017-06-21 | 2024-02-06 | 光投发现有限公司 | 微流体分析设备 |
CN107475070A (zh) * | 2017-08-16 | 2017-12-15 | 深圳先进技术研究院 | 微流控芯片和制备细胞液滴的方法 |
CN107904155A (zh) * | 2017-10-19 | 2018-04-13 | 广州市第人民医院 | 一种用于液体分散的微流控芯片及其应用、使用方法 |
US11123729B2 (en) | 2018-02-28 | 2021-09-21 | Volta Labs, Inc. | Directing motion of droplets using differential wetting |
CN110385088B (zh) * | 2018-04-17 | 2021-12-21 | 上海交通大学 | 一种制备微颗粒的方法 |
CN110385088A (zh) * | 2018-04-17 | 2019-10-29 | 上海交通大学 | 一种制备微颗粒的方法 |
CN111250009B (zh) * | 2018-12-03 | 2022-12-20 | 成都市银隆新能源有限公司 | 一种利用微流控技术制备锂离子电池材料的方法 |
CN111250009A (zh) * | 2018-12-03 | 2020-06-09 | 成都市银隆新能源有限公司 | 一种利用微流控技术制备锂离子电池材料的方法 |
CN109810515A (zh) * | 2019-01-29 | 2019-05-28 | 重庆大学 | 光热定向操控弹性超疏水表面液滴迁移装置及使用方法 |
CN109926111A (zh) * | 2019-03-28 | 2019-06-25 | 武夷学院 | 一种压电基片上微流体输运的装置及方法 |
CN110523451B (zh) * | 2019-09-30 | 2021-10-22 | 王殿宇 | 基于超润滑界面的磁控微液滴反应器制备方法 |
CN110523451A (zh) * | 2019-09-30 | 2019-12-03 | 王殿宇 | 基于超润滑界面的磁控微液滴反应器制备方法 |
CN111659478A (zh) * | 2020-06-16 | 2020-09-15 | 南京大学 | 一种用于微粒子分离的超声表面驻波微流控芯片和应用 |
CN114054107A (zh) * | 2021-10-28 | 2022-02-18 | 重庆大学 | 一种开放式抗磁性液滴磁力操控方法 |
CN113907065B (zh) * | 2021-11-08 | 2022-06-14 | 深圳先进技术研究院 | 换液处理芯片和冷冻载杆 |
WO2023077622A1 (zh) * | 2021-11-08 | 2023-05-11 | 深圳先进技术研究院 | 换液处理芯片和冷冻载杆 |
CN113907065A (zh) * | 2021-11-08 | 2022-01-11 | 深圳先进技术研究院 | 换液处理芯片和冷冻载杆 |
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