CN104306803A - Traditional Chinese medicine composition for treating minimal residual leukemia - Google Patents

Traditional Chinese medicine composition for treating minimal residual leukemia Download PDF

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Publication number
CN104306803A
CN104306803A CN201410554501.4A CN201410554501A CN104306803A CN 104306803 A CN104306803 A CN 104306803A CN 201410554501 A CN201410554501 A CN 201410554501A CN 104306803 A CN104306803 A CN 104306803A
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minimal residual
chinese medicine
medicine composition
traditional chinese
residual leukemia
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CN104306803B (en
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姜国胜
李霞
丁慧芳
崔兴
张建海
赖楠楠
郭菲
禹林昌
史美燕
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INSTITUTE OF BASIC MEDICINE SAMS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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  • Health & Medical Sciences (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
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  • Medicines Containing Plant Substances (AREA)
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Abstract

The invention provides a traditional Chinese medicine composition for treating minimal residual leukemia. The composition is prepared from the following medicinal materials: 30g of codonopsis pilosula, 30g of astragalus membranaceus, 15g of poria cocos, 15g of rhizoma atractylodis macrocephalae, 12g of angelica sinensis, 12g of coix seed, 12g of oldenlandia diffusa, 12g of scutellariae barbatae, 9g of donkey-hide gelatin, 9g of glossy privet fruit, 9g of rhizoma atractylodis, 9g of pericarpium arecae and 6g of licorice root. The traditional Chinese medicine composition has a remarkable curative effect on minimal residual leukemia.

Description

A kind of Chinese medicine composition for the treatment of minimal residual leukemia
Technical field
The present invention relates to a kind of medicine for the treatment of minimal residual leukemia, be specifically related to a kind of medicine of the treatment minimal residual leukemia be prepared from by Chinese herbal medicine.
Background technology
Minimal residual leukemia, refers to that leukemia is through effective chemotherapy or bone marrow transplantation, reaches clinical and hematological complete incidence graph, the state of residual minim leukaemia in body.The propagation once again of residual leukemic cell and sending out is leukemia relapse, main causes of death.Current leukemia treating is mainly by maintenance chemotherapy or bone marrow transplantation, but most leukaemic still difficulty avoids Recurrent death, therefore find method and the medicine of effective treatment minimal residual leukemia, improving the life quality of patient, is those skilled in the art's technical problems urgently to be resolved hurrily.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of minimal residual leukemia.
Technical scheme of the present invention is as follows: a kind of Chinese medicine composition for the treatment of minimal residual leukemia, is prepared from by following medicine: Radix Codonopsis 30g, Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 12g, Semen Coicis 12g, Herba Hedyotidis Diffusae 12g, Herba Scutellariae Barbatae 12g, Colla Corii Asini 9g, Fructus Ligustri Lucidi 9g, Rhizoma Atractylodis 9g, Pericarpium Arecae 9g, Radix Glycyrrhizae 6g.
Preparation method of the present invention is as follows:
Take medical material by weight, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, and high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; Add 5 times of volume water again, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; The medicinal liquid leached twice merges, and heating is concentrated, and adding ethanol in concentrated solution to concentration of alcohol is 60%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 75%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 85%, fully mixes, precipitates overnight, leaching supernatant; By the supernatant of three precipitate with ethanol leachings mixing final vacuum negative pressure heating recovery ethanol, heating is concentrated, makes its concentration for containing crude drug 2.0 ~ 4.5 grams per milliliter.
clinical data
Collect the minimal residual leukemia reaching complete incidence graph from 2010 to 2013 years acute leukemic patients after treatment, totally 100 examples, all cases derives from Hospital Attached to Shandong Chinese Medical Univ..Patient is divided into matched group and treatment group at random, each 50 examples.Matched group continues to give chemotherapeutic treatment, and treatment group takes medicine of the present invention on the basis of chemotherapy, and every day 2 times, each 150ml, takes 3 months continuously.Follow up a case by regular visits to from from last is taken medicine, to death day, with continued complete remission time and life span for criterion judges curative effect.After treatment group treats three months, continued complete remission 37 example, recurrence 7 example, dead 6 examples; Matched group continued complete remission 27 example, recurrence 8 example, 15 Cases of Death; The treatment group continued complete remission rate of 3 years, 5 years is respectively 82%, 74%, and matched group is respectively 64%, 58%.Treatment group 3 years, 5 years survival rates are respectively 84%, 78%, and matched group is respectively 68%, 64%.Both have significant difference by therapeutic effect, and proved invention Chinese medicine compound has good therapeutic effect to minimal residual leukemia, can significantly improve patient's lasting remission time and life span.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
Get Radix Codonopsis 30g, Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 12g, Semen Coicis 12g, Herba Hedyotidis Diffusae 12g, Herba Scutellariae Barbatae 12g, Colla Corii Asini 9g, Fructus Ligustri Lucidi 9g, Rhizoma Atractylodis 9g, Pericarpium Arecae 9g, Radix Glycyrrhizae 6g, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; Add 5 times of volume water again, high pressure concentrates boiling machine 120 DEG C and decocts 90 minutes, leaches medicinal liquid; The medicinal liquid leached twice merges, and heating is concentrated, and adding ethanol in concentrated solution to concentration of alcohol is 60%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 75%, fully mixes, precipitates overnight, leaching supernatant; Adding ethanol in precipitation to concentration of alcohol is 85%, fully mixes, precipitates overnight, leaching supernatant; By the supernatant of three precipitate with ethanol leachings mixing final vacuum negative pressure heating recovery ethanol, heating is concentrated, makes its concentration for containing crude drug 2.0 ~ 4.5 grams per milliliter.

Claims (1)

1. treat the Chinese medicine composition of minimal residual leukemia for one kind, it is characterized in that, be prepared from by following medicine: Radix Codonopsis 30g, Radix Astragali 30g, Poria 15g, Rhizoma Atractylodis Macrocephalae 15g, Radix Angelicae Sinensis 12g, Semen Coicis 12g, Herba Hedyotidis Diffusae 12g, Herba Scutellariae Barbatae 12g, Colla Corii Asini 9g, Fructus Ligustri Lucidi 9g, Rhizoma Atractylodis 9g, Pericarpium Arecae 9g, Radix Glycyrrhizae 6g.
CN201410554501.4A 2014-10-20 2014-10-20 A kind of Chinese medicine composition for treating parvovirus B19 Active CN104306803B (en)

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CN201410554501.4A CN104306803B (en) 2014-10-20 2014-10-20 A kind of Chinese medicine composition for treating parvovirus B19

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825644A (en) * 2015-05-18 2015-08-12 冯锦初 Traditional Chinese medicine preparation for treating leukaemia
CN105770660A (en) * 2016-05-29 2016-07-20 贾洪军 Preparation method of medicine preparation for treating leukemia through adjuvant radiotherapy method
CN105853856A (en) * 2016-05-29 2016-08-17 贾洪军 Pharmaceutical preparation for treating leukemia by cooperating with radiotherapy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1562091A (en) * 2004-03-15 2005-01-12 白璋华 Medicine for treating leukaemia
CN101543533A (en) * 2008-03-28 2009-09-30 孙长志 Medicament for treating leukemia
CN103893542A (en) * 2012-12-29 2014-07-02 张涛 Traditional Chinese medicine for treating acute leukemia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1562091A (en) * 2004-03-15 2005-01-12 白璋华 Medicine for treating leukaemia
CN101543533A (en) * 2008-03-28 2009-09-30 孙长志 Medicament for treating leukemia
CN103893542A (en) * 2012-12-29 2014-07-02 张涛 Traditional Chinese medicine for treating acute leukemia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
岑冰等: "扶正祛邪法治疗微小残留白血病探析", 《天津中医药》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825644A (en) * 2015-05-18 2015-08-12 冯锦初 Traditional Chinese medicine preparation for treating leukaemia
CN104825644B (en) * 2015-05-18 2020-09-25 冯锦初 Chinese medicinal preparation for treating leukemia
CN105770660A (en) * 2016-05-29 2016-07-20 贾洪军 Preparation method of medicine preparation for treating leukemia through adjuvant radiotherapy method
CN105853856A (en) * 2016-05-29 2016-08-17 贾洪军 Pharmaceutical preparation for treating leukemia by cooperating with radiotherapy

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Inventor after: Li Xia

Inventor after: Yin Xunqiang

Inventor after: Zhang Yunhong

Inventor after: Jiang Guosheng

Inventor after: Cui Xing

Inventor after: Wang Bin

Inventor after: Zhao Lin

Inventor after: Zhu Xiaoxiao

Inventor after: Zhang Zhen

Inventor after: Guo Qiang

Inventor after: Wei Ran

Inventor before: Jiang Guosheng

Inventor before: Li Xia

Inventor before: Ding Huifang

Inventor before: Cui Xing

Inventor before: Zhang Jianhai

Inventor before: Lai Nannan

Inventor before: Guo Fei

Inventor before: Yu Linchang

Inventor before: Shi Meiyan

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