CN104306585A - Traditional Chinese medicine combination for curing prostatitis, and preparation method and application thereof - Google Patents

Traditional Chinese medicine combination for curing prostatitis, and preparation method and application thereof Download PDF

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CN104306585A
CN104306585A CN201410611919.4A CN201410611919A CN104306585A CN 104306585 A CN104306585 A CN 104306585A CN 201410611919 A CN201410611919 A CN 201410611919A CN 104306585 A CN104306585 A CN 104306585A
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chinese medicine
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CN104306585B (en
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王松华
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Abstract

The invention relates to the field of preparation of Chinese medicine, in particular to a traditional Chinese medicine combination for curing prostatitis, and a preparation method and the application thereof. The combination comprises the following crude drugs in parts by weight: 2 to 18 parts of cherokee rose fruit, 3 to 18 parts of herba epimedii, 3 to 18 parts of radix achyranthis bidentatae, 2 to 12 parts of seed of cowherb, 3 to 17 parts of fructus liquidambaris, 2 to 10 parts of the root of three-nerved spicebush, 2 to 14 parts of immature bitter orange, 1 to 10 parts of cimicifugae foetidae, 5 to 20 parts of sculellaria barbata, 1 to 14 parts of peach kernel, 1 to 14 parts of pericarpium citri reticulatae viride, 6 to 20 parts of Tuckahoe, 1 to 12 parts of dangshen, 1 to 12 parts of lumbricus, 4 to 18 parts of a talcum powder, and 6 to 18 parts of rhizoma alismatis. The traditional Chinese medicine combination has a good curative effect for curing prostatitis, and is high in cure rate and low in recurrence rate.

Description

One is used for the treatment of prostatitic Chinese medicine composition and preparation method thereof and application
Technical field
The present invention relates to field of traditional Chinese, particularly one is used for the treatment of prostatitic Chinese medicine composition and preparation method thereof and application.
Background technology
Prostatitis is the commonly encountered diseases of clinical middle Urology Surgery, in Urology Surgery male patient the right side of fifty, account for first place.Nineteen ninety-five NIH has formulated a kind of new prostatitis sorting technique: I type, is equivalent to the acute bacterial prostatitis in conventional sorting methods; II type, is equivalent to the chronic bacterial prostatitis in conventional sorting methods; III type, chronic prostatitis/chronic Pelvic Pain Syndrome; IV type, silent prostatitis.Wherein nonbacterial prostatitis is common far beyond bacterial prostatitis.
At present specific drug be there is no for prostatitic treatment, and due to the unsuitable Drug abuse of particularity of reproductive system disease, otherwise run counter to desire.At present, the prostatitic means of conventional treatment comprise antimicrobial drug treatment, antibiotic medicine is oral or smear treatment, physical massage treatment or operative treatment.
The diagnosis and treatment of the traditional Chinese medical science to prostatitis especially chronic prostatitis have the opinion of its uniqueness, and have obtained good curative effect and progress.The traditional Chinese medical science is started with from the macroscopic analysis cause of disease, pathogenesis, determines the attribute of chronic prostatitis.Treatment carrys out disease therapy attribute with medicine attribute, i.e. " treating cold syndrome with hot-nature drugs ", and " treating heat syndrome with cold-natured drugs ", " treating excess syndrome with purgative methods ", " treatment of deficiency-syndrome by reinforcement " etc.So the traditional Chinese medical science, according to pathogenesis and method for the treatment of, just can find corresponding side's medicine.Because the prostatitic cause of disease is various, pathogenesis is mixed, clinically according to the pathogenic characteristic of chronic prostatitis, the key affecting its lesion growth should be caught, change the process of disease, thus reach the object of progressively curing.Such as on the dosage of Chinese medicine medication, should carefully consider.In removing dampness heat clearing away medicine, compatibility warming YANG and invigorating QI medicine can improve curative effect, but Radix Aconiti Lateralis Preparata, Cortex Cinnamomi how much dosage need clinical practice.Visible, above-mentioned routine is used for the treatment of prostatitic prescription, though extensively can treat common disease, for whole treatment process, then there is the problem that onset is slow, specific aim is poor.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effectively can treat prostatitis and the little Chinese medicine composition of short treating period, side effect.
The present invention still further provides preparation method and its application of above-mentioned Chinese medicine composition.
The open one of the present invention is used for the treatment of prostatitic Chinese medicine composition, its crude drug consists of: Fructus Rosae Laevigatae 2-18 weight portion, Herba Epimedii 3-18 weight portion, Radix Achyranthis Bidentatae 3-18 weight portion, Semen Vaccariae 2-12 weight portion, Fructus Liquidambaris 3-17 weight portion, Radix Linderae 2-10 weight portion, Fructus Aurantii Immaturus 2-14 weight portion, Rhizoma Cimicifugae 1-10 weight portion, Herba Scutellariae Barbatae 5-20 weight portion, Semen Persicae 1-14 weight portion, Pericarpium Citri Reticulatae Viride 1-14 weight portion, Poria 6-20 weight portion, Radix Codonopsis 1-12 weight portion, Pheretima 1-12 weight portion, Pulvis Talci 4-18 weight portion, Rhizoma Alismatis 6-18 weight portion.
Further, described is used for the treatment of prostatitic Chinese medicine composition, its crude drug consists of: Fructus Rosae Laevigatae 5-15 weight portion, Herba Epimedii 6-14 weight portion, Radix Achyranthis Bidentatae 8-15 weight portion, Semen Vaccariae 4-10 weight portion, Fructus Liquidambaris 5-15 weight portion, Radix Linderae 3-8 weight portion, Fructus Aurantii Immaturus 4-10 weight portion, Rhizoma Cimicifugae 3-8 weight portion, Herba Scutellariae Barbatae 8-17 weight portion, Semen Persicae 3-10 weight portion, Pericarpium Citri Reticulatae Viride 3-9 weight portion, Poria 8-17 weight portion, Radix Codonopsis 3-8 weight portion, Pheretima 3-8 weight portion, Pulvis Talci 8-15 weight portion, Rhizoma Alismatis 8-14 weight portion.
Preferably, described is used for the treatment of prostatitic Chinese medicine composition, and its crude drug consists of: Fructus Rosae Laevigatae 10 weight portion, Herba Epimedii 8 weight portion, Radix Achyranthis Bidentatae 12 weight portion, Semen Vaccariae 8 weight portion, Fructus Liquidambaris 10 weight portion, the Radix Linderae 6 weight portion, Fructus Aurantii Immaturus 8 weight portion, Rhizoma Cimicifugae 6 weight portion, Herba Scutellariae Barbatae 12 weight portion, Semen Persicae 8 weight portion, Pericarpium Citri Reticulatae Viride 7 weight portion, Poria 12 weight portion, Radix Codonopsis 6 weight portion, Pheretima 6 weight portion, Pulvis Talci 12 weight portion, Rhizoma Alismatis 10 weight portion.
The invention also discloses and add customary adjuvant by arbitrary described prostatitic Chinese medicine composition selectivity that is used for the treatment of, conveniently the acceptable clinically preparation made of technique.
Further described preparation, comprises electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
The invention also discloses a kind of method preparing arbitrary described Chinese medicine composition: get Fructus Rosae Laevigatae, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected weight portion, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
Further, described preparation method, comprises the steps:
According to selected parts by weight Fructus Rosae Laevigatae, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, remix after pulverizing after mixing or pulverizing respectively, sieve, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
More excellent, described preparation method, comprises the steps:
Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus according to selected parts by weight, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus according to selected parts by weight, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
Preferred further, described preparation method, comprises the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
The invention also discloses Chinese medicine composition that arbitrary described Chinese medicine composition or arbitrary described method prepare for the preparation of the purposes in treatment prostatitis medicine.
In Chinese medicine composition of the present invention, Fructus Rosae Laevigatae: sour and astringent, property is put down, nontoxic, returns kidney, bladder, large intestine, spleen, lung meridian; Reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal, controls the enuresis, frequent micturition, insufficiency of the spleen dysentery, and the deficiency of the lung is breathed with cough, spontaneous sweating, bleeding not during menses.Herba Epimedii: acrid-sweet flavor is warm in nature, returns Liver and kidney warp; Expelling wind and removing dampness, controls dribbling urination, and muscles and bones contraction is anxious, weakness of the waist and knees, rheumatic arthralgia.Radix Achyranthis Bidentatae: acrid in the mouth, property is put down; Blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards, eliminating fire and detoxication; Control dysuria, Urethra astringent pain, soreness of the waist and knees, epistaxis, dizzy, carbuncle.Semen Vaccariae: property is bitter, flat, returns liver, stomach warp; Promoting blood circulation to restore menstrual flow, stimulating milk secretion is subsided a swelling, inducing diuresis for treating stranguria syndrome.Fructus Liquidambaris: property is bitter, flat, returns liver, kidney channel; For diseases such as edema, dysuria, rheumatic arthralgia.The Radix Linderae: property is pungent, warm, returns lung, spleen, kidney, urinary bladder channel; Pleasant pain relieving, warming kidney for dispelling cold, for chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea.Fructus Aurantii Immaturus: property is pungent, warm, bitter in the mouth, acid, spleen reinforcing diuresis, treatment cold-damp disturbing the spleen, edema edema.Rhizoma Cimicifugae: acrid in the mouth, sweet, cold nature, returns lung, spleen, large intestine, stomach warp; There is heat-clearing and toxic substances removing, effect of diarrhea due to hypofunction of the spleen, have the effect of anti-inflammatory and antalgic.Herba Scutellariae Barbatae: property is pungent, bitter in the mouth, cold, return lung, liver, kidney channel; Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.Semen Persicae: nature and flavor are bitter, sweet, flat, GUIXIN, liver, large intestine, lung, spleen channel; There is antiinflammatory action, main swelling and pain due to blood stasis, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria.Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature, returns liver, gallbladder, spleen, lung meridian; Anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, broken hard addiction, loose stagnant gas, goes the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels all wet.Poria: sweet in the mouth, light, property is put down, GUIXIN, spleen, kidney channel; Swelling is full, dysuria with harnessing the river for promoting diuresis to eliminate damp pathogen.Radix Codonopsis: sweet in the mouth, property is put down, nontoxic, returns spleen, lung meridian; Strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid, clearing heat and expelling damp.Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances, cures mainly urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.Pulvis Talci: sweet in the mouth, light, cold in nature, return bladder, lung, stomach warp, inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore, for pyretic stranguria, stranguria caused by urinary stone, urinates hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea.Rhizoma Alismatis: sweet in the mouth, cold in nature, return kidney, urinary bladder channel; Diuretic, eliminating dampness by diuresis, expels the heat-evil, and controls dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Pharmaceutical composition of the present invention with Fructus Rosae Laevigatae, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci and Rhizoma Alismatis are used as medicine, effect of its expelling wind and removing dampness of row, inducing diuresis for treating stranguria syndrome, invigorating the liver and kidney, bone and muscle strengthening, by the effective cooperation between monarch, have good curative effect to treatment prostatitis, clinical cure rate is up to 97%.
Detailed description of the invention
Embodiment 1
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 10 weight portion, Herba Epimedii 8 weight portion, Radix Achyranthis Bidentatae 12 weight portion, Semen Vaccariae 8 weight portion, Fructus Liquidambaris 10 weight portion, the Radix Linderae 6 weight portion, Fructus Aurantii Immaturus 8 weight portion, Rhizoma Cimicifugae 6 weight portion, Herba Scutellariae Barbatae 12 weight portion, Semen Persicae 8 weight portion, Pericarpium Citri Reticulatae Viride 7 weight portion, Poria 12 weight portion, Radix Codonopsis 6 weight portion, Pheretima 6 weight portion, Pulvis Talci 12 weight portion, Rhizoma Alismatis 10 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make pill.Specifically comprise:
Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, pulverize respectively, cross 100 mesh sieves, mixing, adds appropriate water according to every 100g powder refined honey 20 ~ 50g, pill, dry, make water-honeyed pill; Or add refined honey 80 ~ 110g and make small honey pill or big honeyed pills, to obtain final product.
Embodiment 2
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 2 weight portion, Herba Epimedii 3 weight portion, Radix Achyranthis Bidentatae 3 weight portion, Semen Vaccariae 2 weight portion, Fructus Liquidambaris 3 weight portion, the Radix Linderae 2 weight portion, Fructus Aurantii Immaturus 2 weight portion, Rhizoma Cimicifugae 1 weight portion, Herba Scutellariae Barbatae 5 weight portion, Semen Persicae 1 weight portion, Pericarpium Citri Reticulatae Viride 1 weight portion, Poria 6 weight portion, Radix Codonopsis 1 weight portion, Pheretima 1 weight portion, Pulvis Talci 4 weight portion, Rhizoma Alismatis 6 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make tablet.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(2) aqueous extract obtained in step (1) being evaporated to relative density is 1.05-1.30 (40 ~ 60 DEG C), obtains concentrated solution;
(3) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make tablet.
Embodiment 3
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 5 weight portion, Herba Epimedii 6 weight portion, Radix Achyranthis Bidentatae 8 weight portion, Semen Vaccariae 4 weight portion, Fructus Liquidambaris 5 weight portion, the Radix Linderae 3 weight portion, Fructus Aurantii Immaturus 4 weight portion, Rhizoma Cimicifugae 3 weight portion, Herba Scutellariae Barbatae 8 weight portion, Semen Persicae 3 weight portion, Pericarpium Citri Reticulatae Viride 3 weight portion, Poria 8 weight portion, Radix Codonopsis 3 weight portion, Pheretima 3 weight portion, Pulvis Talci 8 weight portion, Rhizoma Alismatis 8 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 75% alcohol reflux of 8 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) the alcohol extract concentrating under reduced pressure will obtained in step (1), obtains concentrated solution;
(3) be 1.05-1.30 (40 ~ 60 DEG C) by above-mentioned concentrated solution vacuum drying relative density, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make powder.
Embodiment 4
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 15 weight portion, Herba Epimedii 14 weight portion, Radix Achyranthis Bidentatae 15 weight portion, Semen Vaccariae 10 weight portion, Fructus Liquidambaris 15 weight portion, the Radix Linderae 8 weight portion, Fructus Aurantii Immaturus 10 weight portion, Rhizoma Cimicifugae 8 weight portion, Herba Scutellariae Barbatae 17 weight portion, Semen Persicae 10 weight portion, Pericarpium Citri Reticulatae Viride 9 weight portion, Poria 17 weight portion, Radix Codonopsis 8 weight portion, Pheretima 8 weight portion, Pulvis Talci 15 weight portion, Rhizoma Alismatis 14 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make granule.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 90% alcohol reflux of 4 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 15 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, 60 DEG C of concentrating under reduced pressure, obtain concentrated solution;
(4) fluidized bed granulation is carried out with the concentrated solution obtained in step (3), be that the dextrin of 30 ~ 75% is for fluidisation carrier to account for described concentrated solution mass ratio, with account for described concentrated solution mass ratio be 1 ~ 5% traditional binders granulate, control that its feed liquor flow velocity is 2.5ml/min, fluidized pressure is 0.2 ~ 0.5bar, atomizing pressure is 1.0 ~ 1.8bar, temperature 55 DEG C, granulate, and increase gradually along with particle in fluid bed, adjustment fluidized pressure and atomizing pressure, keep the fluidized state of material good, temperature of charge remains between 35 ~ 37 DEG C.After feed liquor terminates, continue fluidized drying 1 hour, obtain granule.
Embodiment 5
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 18 weight portion, Herba Epimedii 18 weight portion, Radix Achyranthis Bidentatae 18 weight portion, Semen Vaccariae 12 weight portion, Fructus Liquidambaris 17 weight portion, the Radix Linderae 10 weight portion, Fructus Aurantii Immaturus 14 weight portion, Rhizoma Cimicifugae 10 weight portion, Herba Scutellariae Barbatae 20 weight portion, Semen Persicae 14 weight portion, Pericarpium Citri Reticulatae Viride 14 weight portion, Poria 20 weight portion, Radix Codonopsis 12 weight portion, Pheretima 12 weight portion, Pulvis Talci 18 weight portion, Rhizoma Alismatis 18 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make capsule.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 50% alcohol reflux of 6 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 2h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 1 time of 10 volume times amount again, 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, directly encapsulated or encapsulated after adding customary adjuvant mix homogeneously, to obtain final product.
Embodiment 6
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 14 weight portion, Herba Epimedii 12 weight portion, Radix Achyranthis Bidentatae 10 weight portion, Semen Vaccariae 6 weight portion, Fructus Liquidambaris 14 weight portion, the Radix Linderae 8 weight portion, Fructus Aurantii Immaturus 6 weight portion, Rhizoma Cimicifugae 8 weight portion, Herba Scutellariae Barbatae 17 weight portion, Semen Persicae 5 weight portion, Pericarpium Citri Reticulatae Viride 9 weight portion, Poria 12 weight portion, Radix Codonopsis 8 weight portion, Pheretima 5 weight portion, Pulvis Talci 15 weight portion, Rhizoma Alismatis 16 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make mixture.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 10 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution cold preservation 24 hours, filter, filtrate is boiled, and it is appropriate to add customary adjuvant, makes dissolving, filters, let cool, add water to 1000ml, stir evenly, embedding, sterilizing, namely obtains required mixture.
Embodiment 7
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 2 weight portion, Herba Epimedii 18 weight portion, Radix Achyranthis Bidentatae 3 weight portion, Semen Vaccariae 12 weight portion, Fructus Liquidambaris 3 weight portion, the Radix Linderae 10 weight portion, Fructus Aurantii Immaturus 2 weight portion, Rhizoma Cimicifugae 10 weight portion, Herba Scutellariae Barbatae 5 weight portion, Semen Persicae 14 weight portion, Pericarpium Citri Reticulatae Viride 1 weight portion, Poria 20 weight portion, Radix Codonopsis 1 weight portion, Pheretima 12 weight portion, Pulvis Talci 4 weight portion, Rhizoma Alismatis 18 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make drop pill.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae according to selected parts by weight, Semen Vaccariae, Fructus Liquidambaris, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 90% alcohol reflux of 10 volume times amount, reflux, extract, 3 times at maintenance temperature 78 DEG C, each 4h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Radix Linderae is got, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae according to selected parts by weight, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, mixing, by the water reflux, extract, of 7 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 1h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make drop pill.
Embodiment 8
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 18 weight portion, Herba Epimedii 3 weight portion, Radix Achyranthis Bidentatae 18 weight portion, Semen Vaccariae 2 weight portion, Fructus Liquidambaris 17 weight portion, the Radix Linderae 2 weight portion, Fructus Aurantii Immaturus 14 weight portion, Rhizoma Cimicifugae 1 weight portion, Herba Scutellariae Barbatae 20 weight portion, Semen Persicae 1 weight portion, Pericarpium Citri Reticulatae Viride 14 weight portion, Poria 6 weight portion, Radix Codonopsis 12 weight portion, Pheretima 1 weight portion, Pulvis Talci 18 weight portion, Rhizoma Alismatis 6 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make injection.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae according to selected parts by weight, Semen Vaccariae, Fructus Liquidambaris, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Radix Linderae is got, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae according to selected parts by weight, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) filtered by above-mentioned concentrated solution, dilution, adjust ph, adds customary adjuvant, conveniently technique, makes injection.
Embodiment 9
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 5 weight portion, Herba Epimedii 14 weight portion, Radix Achyranthis Bidentatae 8 weight portion, Semen Vaccariae 10 weight portion, Fructus Liquidambaris 5 weight portion, the Radix Linderae 8 weight portion, Fructus Aurantii Immaturus 4 weight portion, Rhizoma Cimicifugae 8 weight portion, Herba Scutellariae Barbatae 8 weight portion, Semen Persicae 10 weight portion, Pericarpium Citri Reticulatae Viride 3 weight portion, Poria 17 weight portion, Radix Codonopsis 3 weight portion, Pheretima 8 weight portion, Pulvis Talci 8 weight portion, Rhizoma Alismatis 14 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 78% alcohol reflux of 12 volume times amount, reflux, extract, 3 times at maintenance temperature 85 DEG C, each 6h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 9 volume times amount again, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make powder.
Embodiment 10
The crude drug being used for the treatment of prostatitic Chinese medicine composition of the present embodiment consists of: Fructus Rosae Laevigatae 15 weight portion, Herba Epimedii 6 weight portion, Radix Achyranthis Bidentatae 15 weight portion, Semen Vaccariae 4 weight portion, Fructus Liquidambaris 15 weight portion, the Radix Linderae 3 weight portion, Fructus Aurantii Immaturus 10 weight portion, Rhizoma Cimicifugae 3 weight portion, Herba Scutellariae Barbatae 17 weight portion, Semen Persicae 3 weight portion, Pericarpium Citri Reticulatae Viride 9 weight portion, Poria 8 weight portion, Radix Codonopsis 8 weight portion, Pheretima 3 weight portion, Pulvis Talci 15 weight portion, Rhizoma Alismatis 8 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make electuary.Specifically comprise:
(1) Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae according to selected parts by weight, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 10 volume times amount, reflux, extract, 2 times at maintenance temperature 85 DEG C, each 2h, filter and collect filtrate, less than 60 DEG C decompression recycling ethanols, to without alcohol taste, obtain alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 3 times of 10 volume times amount again, each 1.5h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make electuary.
Clinical experiment example
Getting the preparation prepared in embodiments of the invention 1 is the elaboration that example carries out effect, clinical take for honeyed pill, oral, every day 2 times, each serving with 8 ~ 10g, 300 routine prostatitis disease patients are treated, take 50-80 days continuously.Cure 291 examples, clinical effective 300 examples, invalid 0 example, overall cure rate reaches 97%.Follow-up Continuous Tracking follows up a case by regular visits to December, without recurrence.
Model case
Case 1
Lee, 37 years old, man.Suffer from prostatitis and have urine urgency-frequency 3 years more, gargle pain, sexual hypofunction, impotence and premature ejaculation, seek medical advice always take traditional Chinese medicine, Western medicine, but have no improvement.Foretaste this Chinese medicine composition 15 secondary.Take an evident turn for the better after having eaten 5 pairs, then adhere to eating 50 days, all recover normal through examination in hospital urine urgency-frequency impotence and premature ejaculation.Call-on back by phone after having spent 1 year, all indexs are normal, not recurrence.
Case 2
Lee, 41 years old, man.Suffer from prostatitis and have urine urgency-frequency 5 years more, gargle pain, sexual hypofunction, premature ejaculation, seek medical advice always take traditional Chinese medicine, Western medicine, but have no improvement.Foretaste this Chinese medicine composition 10 secondary.Take an evident turn for the better after having eaten 7 days, then adhere to eating 50 days, all recover normal through examination in hospital urine urgency-frequency impotence and premature ejaculation.Call-on back by phone after having spent 1 year, all indexs are normal, not recurrence.
Case 3
Zheng, 55 years old, man.
Case suffers from prostatitis had urine urgency-frequency 4 years more, gargled pain, sexual hypofunction, premature ejaculation, seek medical advice always take traditional Chinese medicine, Western medicine, but have no improvement.Foretaste this Chinese medicine composition 10 secondary.Take an evident turn for the better after having eaten 5 pairs, then adhere to eating 50 days, all recover normal through examination in hospital urine urgency-frequency impotence and premature ejaculation.Call-on back by phone after having spent 1 year, all indexs are normal, not recurrence.
Case 4
Zheng, 42 years old, man.Suffer from prostatitis and have urine urgency-frequency 5 years more, gargle pain, sexual hypofunction, premature ejaculation, seek medical advice always take traditional Chinese medicine, Western medicine, but have no improvement.Foretaste this Chinese medicine composition 10 secondary.Take an evident turn for the better after having eaten 7 days, then adhere to eating 50 days, all recover normal through examination in hospital urine urgency-frequency impotence and premature ejaculation.Call-on back by phone after having spent 1 year, all indexs are normal, not recurrence.
Case 5
Lee, 43 years old, man.Suffer from prostatitis and have urine urgency-frequency 4 years more, gargle pain, sexual hypofunction, premature ejaculation, seek medical advice always take traditional Chinese medicine, Western medicine, but have no improvement.Foretaste this Chinese medicine composition 15 secondary.Take an evident turn for the better after having eaten 5 days, then adhere to eating 60 days, all recover normal through examination in hospital urine urgency-frequency impotence and premature ejaculation.Call-on back by phone after having spent 1 year, all indexs are normal, not recurrence.
Be more than concrete case, when proving that Chinese medicine composition of the present invention is used for the treatment of prostatitis by the multinomial case of reality, good effect, cure rate are up to 97%, and relapse rate is low.It should be noted that, Chinese medicine composition of the present invention all has good therapeutic effect for the prostatitis of each degree, and cure rate is higher.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.

Claims (10)

1. one kind is used for the treatment of prostatitic Chinese medicine composition, it is characterized in that, the crude drug of said composition consists of: Fructus Rosae Laevigatae 2-18 weight portion, Herba Epimedii 3-18 weight portion, Radix Achyranthis Bidentatae 3-18 weight portion, Semen Vaccariae 2-12 weight portion, Fructus Liquidambaris 3-17 weight portion, Radix Linderae 2-10 weight portion, Fructus Aurantii Immaturus 2-14 weight portion, Rhizoma Cimicifugae 1-10 weight portion, Herba Scutellariae Barbatae 5-20 weight portion, Semen Persicae 1-14 weight portion, Pericarpium Citri Reticulatae Viride 1-14 weight portion, Poria 6-20 weight portion, Radix Codonopsis 1-12 weight portion, Pheretima 1-12 weight portion, Pulvis Talci 4-18 weight portion, Rhizoma Alismatis 6-18 weight portion.
2. be used for the treatment of prostatitic Chinese medicine composition as claimed in claim 1, it is characterized in that, the crude drug of said composition consists of: Fructus Rosae Laevigatae 5-15 weight portion, Herba Epimedii 6-14 weight portion, Radix Achyranthis Bidentatae 8-15 weight portion, Semen Vaccariae 4-10 weight portion, Fructus Liquidambaris 5-15 weight portion, Radix Linderae 3-8 weight portion, Fructus Aurantii Immaturus 4-10 weight portion, Rhizoma Cimicifugae 3-8 weight portion, Herba Scutellariae Barbatae 8-17 weight portion, Semen Persicae 3-10 weight portion, Pericarpium Citri Reticulatae Viride 3-9 weight portion, Poria 8-17 weight portion, Radix Codonopsis 3-8 weight portion, Pheretima 3-8 weight portion, Pulvis Talci 8-15 weight portion, Rhizoma Alismatis 8-14 weight portion.
3. be used for the treatment of prostatitic Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, the crude drug of said composition consists of: Fructus Rosae Laevigatae 10 weight portion, Herba Epimedii 8 weight portion, Radix Achyranthis Bidentatae 12 weight portion, Semen Vaccariae 8 weight portion, Fructus Liquidambaris 10 weight portion, the Radix Linderae 6 weight portion, Fructus Aurantii Immaturus 8 weight portion, Rhizoma Cimicifugae 6 weight portion, Herba Scutellariae Barbatae 12 weight portion, Semen Persicae 8 weight portion, Pericarpium Citri Reticulatae Viride 7 weight portion, Poria 12 weight portion, Radix Codonopsis 6 weight portion, Pheretima 6 weight portion, Pulvis Talci 12 weight portion, Rhizoma Alismatis 10 weight portion.
4. add customary adjuvant by the arbitrary described prostatitic Chinese medicine composition selectivity that is used for the treatment of of claim 1-3, conveniently the acceptable clinically preparation made of technique.
5. preparation as claimed in claim 4, is characterized in that, comprise electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
6. prepare a method for the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: get Fructus Rosae Laevigatae, Herba Epimedii, Radix Achyranthis Bidentatae according to selected weight portion, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
7. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
According to selected parts by weight Fructus Rosae Laevigatae, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, remix after pulverizing after mixing or pulverizing respectively, sieve, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
8. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus according to selected parts by weight, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Fructus Rosae Laevigatae is got, Herba Epimedii, Radix Achyranthis Bidentatae, Semen Vaccariae, Fructus Liquidambaris, the Radix Linderae, Fructus Aurantii Immaturus according to selected parts by weight, Rhizoma Cimicifugae, Herba Scutellariae Barbatae, Semen Persicae, Pericarpium Citri Reticulatae Viride, Poria, Radix Codonopsis, Pheretima, Pulvis Talci, and Rhizoma Alismatis, mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
9. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
10. the Chinese medicine composition for preparing of the arbitrary described Chinese medicine composition of claim 1-3 or the arbitrary described method of claim 6-9 is for the preparation of the purposes in treatment prostatitis medicine.
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