CN104258294A

CN104258294A - Bone-strengthening powder

Info

Publication number: CN104258294A
Application number: CN201410534530.4A
Authority: CN
Inventors: 不公告发明人
Original assignee: Qingdao Huaren Technology Incubator Co Ltd
Current assignee: Qingdao Huaren Technology Incubator Co Ltd
Priority date: 2014-10-11
Filing date: 2014-10-11
Publication date: 2015-01-07

Abstract

The invention provides bone-strengthening powder. The bone-strengthening powder comprises Chinese medicinal raw materials such as dodder seed, eucommia bark, fortune's drynaria rhizome, morinda root, antler, prepared rehmannia root, twotoothed achyranthes root, papermulberry fruit, Chinese taxillus herb, solomonseal rhizome, manyprickle acanthopanax, tuber fleeceflower stem, spikemoss, turmeric, mountain spicy fruit, siegesbeckia herb, acanthopanax root bark, Chinese yam, sargentgloryvine stem, ciliate bugle herb, aleppo avens, white cardamon fruit, hempleaf negundo chastetree leaf, common gendarussa herb and paleaceous knotweed rhizome. The bone-strengthening powder can improve general symptoms, can eliminate pain of patients, can increase the bone mineral density, lays emphasis on the holism concept and overcomes the defect that the compliance of the patients is limited due to the fact that Western medicines are few in active ingredient, limited in absorption, poor in curative effect, expensive, too heavy in economic burden if being taken for a long time and obvious in adverse reaction.

Description

Bone-strengthening powder

Technical field

The present invention relates to health product technology field, particularly relate to a kind of bone-strengthening powder for protect against osteoporosis.

Background technology

Osteoporosis is one of orthopaedics commonly encountered diseases, finally causes bone strength to reduce because bone amount reduces, thus causes osteodynia even deformity and the clinical disease of fracturing.This disease is apt to occur in old people, and China sickness rate women reaches 90.48%, and male reaches 60.72%.Be a kind of with overall pain, back dull pain sense is the disease of main clinical manifestation, and its pain be persistence, and from light to heavy, pain on motion increases the weight of, and microtrauma easily causes fracturing.Its pathogenesis is by various factors, and most important several factor mostly is: endocrine, nutrition, immunity, heredity, expense osteoporosis etc.Insecondary osteoporosis is mostly because activity minimizing, alcoholism, hepatopathy, weightlessness, gonad endocrine function is not enough etc. caused.What the application discussed is primary osteoporosis.

Primary osteoporosis comprises postmenopausal osteoporosis and senile osteoporosis two kinds.It is reported, the prevalence of the osteoporosis in women that China different regions 50 years old are later is 25.0% ~ 51.2%, and postmenopausal women's prevalence is 48%.Osteoporosis and fracture after osteoporosis have become the serious threat to China senior health and fitness.

Osteoporosis forms existing bone resorption and enlivens, and also has bone formation low, and western medicine has the calcium preparation of Primary Care and calcium absorption enhancer to support one's family D; Bone resorption inhibitor and bone formation-promoter.One side old people often gastrointestinal function lowly can not tolerate multi-medicament, and multi-medicament has increased the weight of again the Liver and kidney burden of old people on the other hand.

Chinese medicine thinks that osteoporosis belongs to " osteomyelitis " category.Huangdi's Internal Classics day: " kidney storing essence, main bone, raw marrow ", " controlling withers solely get sun bright ", describes osteoporosis and kidney taste are in close relations.The kidney being the origin of congenital constitution, and kidney essense abundance then bone is foster to some extent, if suffer from a deficiency of the kidney, bone marrow loses and fills; The spleen being the foundation of acquired constitution, the riveting of QI and blood biochemistry, the vital essence of kidney depends on the nourishing of essence of water and grain; The strong fortune of temper, then biochemical active, and congenital essence-QI of supplementing nutrition.If dysfunction of the spleen in transportation, then biochemical passive, deficiency of kidney-essence, bone is become homeless foster, fragile unable, causes osteoporosis.

Chinese medicine primary osteoporosis has obvious advantage, can General Symptoms be improved, eliminate patient suffering, can bone density be improved again, more holistic idea simultaneously, overcome the active component of Western medicine existence very little, absorb limited, curative effect is not good enough, expensive, long-term taking financial burden is overweight, there is obvious adverse reaction, thus limits the defect of the compliance of patient.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of bone-strengthening powder, it can improve General Symptoms, eliminates patient suffering, can improve bone density again, more holistic idea simultaneously, overcome the active component of Western medicine existence very little, absorb limited, curative effect is not good enough, expensive, long-term taking financial burden is overweight, there is obvious adverse reaction, thus limits the defect of the compliance of patient.

For solving the problems of the technologies described above, the invention provides a kind of bone-strengthening powder, its Chinese medicine crude drug comprises Semen Cuscutae, the Cortex Eucommiae, Rhizoma Drynariae, Radix Morindae Officinalis, Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Fructus Broussonetiae, Herba Taxilli, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Caulis Polygoni Multiflori, Herba Selaginellae, Rhizoma Curcumae Longae, Fructus Litseae, Herba Siegesbeckiae, Cortex Acanthopancis, Rhizoma Dioscoreae, Caulis Sargentodoxae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Radix seu Herba Gei aleppici, Fructus Amomi Rotundus, Folium Viticis Negundo, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and Rhizoma Polygoni Paleachi.

Wherein, in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 25g ~ 35g, Cortex Eucommiae 30g ~ 40g, Rhizoma Drynariae 50g ~ 60g, Radix Morindae Officinalis 25g ~ 35g, Cornu Cervi Pantotrichum 30g ~ 40g, Radix Rehmanniae Preparata 20g ~ 30g, Radix Achyranthis Bidentatae 35g ~ 45g, Fructus Broussonetiae 20g ~ 30g, Herba Taxilli 25g ~ 35g, Rhizoma Polygonati 30g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Caulis Polygoni Multiflori 20g ~ 30g, Herba Selaginellae 25g ~ 35g, Rhizoma Curcumae Longae 30g ~ 40g, Fructus Litseae 15g ~ 25g, Herba Siegesbeckiae 20g ~ 30g, Cortex Acanthopancis 30g ~ 40g, Rhizoma Dioscoreae 30g ~ 40g, Caulis Sargentodoxae 25g ~ 35g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 25g, Radix seu Herba Gei aleppici 25g ~ 35g, Fructus Amomi Rotundus 20g ~ 30g, Folium Viticis Negundo 25g ~ 35g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 40g and Rhizoma Polygoni Paleachi 20g ~ 30g.

Wherein, in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g ~ 35g, Cortex Eucommiae 35g ~ 40g, Rhizoma Drynariae 55g ~ 60g, Radix Morindae Officinalis 30g ~ 35g, Cornu Cervi Pantotrichum 35g ~ 40g, Radix Rehmanniae Preparata 25g ~ 30g, Radix Achyranthis Bidentatae 40g ~ 45g, Fructus Broussonetiae 25g ~ 30g, Herba Taxilli 30g ~ 35g, Rhizoma Polygonati 35g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 30g ~ 35g, Caulis Polygoni Multiflori 20g ~ 25g, Herba Selaginellae 25g ~ 30g, Rhizoma Curcumae Longae 30g ~ 35g, Fructus Litseae 15g ~ 20g, Herba Siegesbeckiae 20g ~ 25g, Cortex Acanthopancis 30g ~ 35g, Rhizoma Dioscoreae 30g ~ 35g, Caulis Sargentodoxae 25g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 20g, Radix seu Herba Gei aleppici 25g ~ 30g, Fructus Amomi Rotundus 20g ~ 25g, Folium Viticis Negundo 25g ~ 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 35g and Rhizoma Polygoni Paleachi 20g ~ 25g.

Wherein, in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g, Cortex Eucommiae 35g, Rhizoma Drynariae 55g, Radix Morindae Officinalis 30g, Cornu Cervi Pantotrichum 35g, Radix Rehmanniae Preparata 25g, Radix Achyranthis Bidentatae 40g, Fructus Broussonetiae 25g, Herba Taxilli 30g, Rhizoma Polygonati 35g, Radix Et Caulis Acanthopanacis Senticosi 30g, Caulis Polygoni Multiflori 25g, Herba Selaginellae 30g, Rhizoma Curcumae Longae 35g, Fructus Litseae 20g, Herba Siegesbeckiae 25g, Cortex Acanthopancis 35g, Rhizoma Dioscoreae 35g, Caulis Sargentodoxae 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20g, Radix seu Herba Gei aleppici 30g, Fructus Amomi Rotundus 25g, Folium Viticis Negundo 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 35g and Rhizoma Polygoni Paleachi 25g.

Present invention also offers the preparation method of above-mentioned bone-strengthening powder:

The first step, Semen Cuscutae, the Cortex Eucommiae, Rhizoma Drynariae, Cornu Cervi Pantotrichum, Radix Achyranthis Bidentatae, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Fructus Litseae, Herba Siegesbeckiae, Cortex Acanthopancis, Rhizoma Dioscoreae, Folium Viticis Negundo, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and Rhizoma Polygoni Paleachi are mixed according to above-mentioned weight, stir, mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 50 DEG C ~ 60 DEG C, sealing immersion 5 ~ 10 days, boil 1 hour ~ 3 hours subsequently, leave standstill 12 hours, filter, the filtrate obtained is concentrated into removes all Chinese liquor, pulverize and drying, obtain the first powder, filtering residue is for subsequent use;

Second step, by remaining components by above-mentioned weight mixing, obtains mixture, this mixture of every 300g, adds 1L ~ 2L water, heating decoction 3 hours ~ 5 hours, decoction liquor is filtered, the filtering residue that filtering residue obtains with the first step mixes, and the filtering residue of every 300g mixing adds 1L ~ 2L water, heating decoction 2 hours ~ 4 hours, decoction liquor is filtered, filtrate after filtering is concentrated into all water of removal, pulverizes sick dry, obtain the second powder;

3rd step, by the first powder and the mixing of the second powder, gets 500g mixed-powder, adds 100g starch, 5g edible essence, 5g sucrose, mix homogeneously, obtain bone-strengthening powder.

Beneficial effect of the present invention:

Bone-strengthening powder provided by the invention can improve General Symptoms, eliminate patient suffering, can bone density be improved again, simultaneously more holistic idea, overcome the active component of Western medicine existence very little, absorb limited, curative effect is not good enough, expensive, and long-term taking financial burden is overweight, there is obvious adverse reaction, thus limit the defect of the compliance of patient.

Detailed description of the invention

Primary disease is the disease of deficiency in origin and excess in superficiality, namely to suffer from a deficiency of the kidney, simultaneously with the disease that many void of the time of insufficiency of the spleen, deficiency of the liver, blood stasis are become silted up more.Says in " Plain Questions six saves state of internal organs opinion ": " also, its Hua Fa, it fills at bone smart part for kidney person, the dominator of storing essence ".In " not occupying collection ": " lumbago as all belongs to and suffering from a deficiency of the kidney, and waist flaccidity is weak, physical tiredness, foot knees soreness; arteries and veins is large or thin, and pain also indistinctly and not very, is that it is waited also " all illustrates deficiency of kidney essence, can not the raw marrow of main bone, bone loses to moisten and supports and cause ache of the spinal column, and because it is empty pain, therefore pain gesture is indistinct, is continuous without cease; Essence house god, essence declines, refreshing weak and cause spiritlessness and weakness; Essence void then can not activating QI, and agitate blood vessels unable, QI and blood is not all right, numbness resistance meridians and cause lumbar and back pain.

Modern study also confirms, the pathomechanism of kidney weak osteoporosis is deficiency of kidney-essence, and bone marrow, brains lose supports, and shows that the regulation and control of hypothalamic-pituitary-target gland axis are not normal, comprises the cytokine of inferior colliculus cerebral tissue and the exception of signal transduction pathway thereof.

The spleen and stomach provide the material basis of the acquired, main limb muscle.Middle gas is impaired, then received, the malfunction of transporting, defeated cloth, and qi-blood-body fluid the source of vital function is not enough, be difficult supplement nutrition the five internal organs, operation vim and vigour, so that muscles and bones lose support, articular instability, wasting, limbs flaccidity weak need not, flaccidity of a specified duration must cause bone without used, and then causes osteoporosis.Because old people's body function fails, the empty gas of body is weak, is subject to exopathogen invasion and attack, causes disorder of QI movement, in the deficiency of vital energy unable promotion blood arteries and veins, makes blockage of main and collateral channels, QI and blood smooth, therefore while all void of old people's spleen kidney, often with the existence of blood stasis.It is main etiology and pathogenesis that primary osteoporosis removes void, and blood stasis and congestion are also its Important cause of diseases, and the even more important pathology of congestion.Also there is certain associating in deficiency of the liver and osteoporosis.Blood stored in the liver, kidney storing essence.The biochemistry of blood, depends on the gasification of essence in kidney; Essence in kidney fill Sheng, also depend on the nourishing of blood.Essence also often influences each other with the pathological changes of blood.As deficiency of the kidney, deficiency of liver-blood can be caused; Otherwise deficiency of liver-blood, also can cause deficiency of the kidney, deficiency of the kidney then marrow is empty, and skeleton is deficient, and forms osteoporosis.

Theoretical based on above-mentioned Chinese traditional treatment, the present invention is based on the kidney invigorating, be aided with and fill blood, adjust liver spleen, heavy promoting blood circulation, dredging meridian and relieving pain is principle, there is provided a kind of bone-strengthening powder, its Chinese medicine crude drug comprises Semen Cuscutae, the Cortex Eucommiae, Rhizoma Drynariae, Radix Morindae Officinalis, Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Fructus Broussonetiae, Herba Taxilli, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Caulis Polygoni Multiflori, Herba Selaginellae, Rhizoma Curcumae Longae, Fructus Litseae, Herba Siegesbeckiae, Cortex Acanthopancis, Rhizoma Dioscoreae, Caulis Sargentodoxae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Radix seu Herba Gei aleppici, Fructus Amomi Rotundus, Folium Viticis Negundo, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and Rhizoma Polygoni Paleachi.

Further, the raw material of Chinese medicine medicine of described bone-strengthening powder is only made up of said components.

In described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 25g ~ 35g, Cortex Eucommiae 30g ~ 40g, Rhizoma Drynariae 50g ~ 60g, Radix Morindae Officinalis 25g ~ 35g, Cornu Cervi Pantotrichum 30g ~ 40g, Radix Rehmanniae Preparata 20g ~ 30g, Radix Achyranthis Bidentatae 35g ~ 45g, Fructus Broussonetiae 20g ~ 30g, Herba Taxilli 25g ~ 35g, Rhizoma Polygonati 30g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Caulis Polygoni Multiflori 20g ~ 30g, Herba Selaginellae 25g ~ 35g, Rhizoma Curcumae Longae 30g ~ 40g, Fructus Litseae 15g ~ 25g, Herba Siegesbeckiae 20g ~ 30g, Cortex Acanthopancis 30g ~ 40g, Rhizoma Dioscoreae 30g ~ 40g, Caulis Sargentodoxae 25g ~ 35g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 25g, Radix seu Herba Gei aleppici 25g ~ 35g, Fructus Amomi Rotundus 20g ~ 30g, Folium Viticis Negundo 25g ~ 35g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 40g and Rhizoma Polygoni Paleachi 20g ~ 30g.

Further, in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g ~ 35g, Cortex Eucommiae 35g ~ 40g, Rhizoma Drynariae 55g ~ 60g, Radix Morindae Officinalis 30g ~ 35g, Cornu Cervi Pantotrichum 35g ~ 40g, Radix Rehmanniae Preparata 25g ~ 30g, Radix Achyranthis Bidentatae 40g ~ 45g, Fructus Broussonetiae 25g ~ 30g, Herba Taxilli 30g ~ 35g, Rhizoma Polygonati 35g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 30g ~ 35g, Caulis Polygoni Multiflori 20g ~ 25g, Herba Selaginellae 25g ~ 30g, Rhizoma Curcumae Longae 30g ~ 35g, Fructus Litseae 15g ~ 20g, Herba Siegesbeckiae 20g ~ 25g, Cortex Acanthopancis 30g ~ 35g, Rhizoma Dioscoreae 30g ~ 35g, Caulis Sargentodoxae 25g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 20g, Radix seu Herba Gei aleppici 25g ~ 30g, Fructus Amomi Rotundus 20g ~ 25g, Folium Viticis Negundo 25g ~ 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 35g and Rhizoma Polygoni Paleachi 20g ~ 25g.

Most preferably, in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g, Cortex Eucommiae 35g, Rhizoma Drynariae 55g, Radix Morindae Officinalis 30g, Cornu Cervi Pantotrichum 35g, Radix Rehmanniae Preparata 25g, Radix Achyranthis Bidentatae 40g, Fructus Broussonetiae 25g, Herba Taxilli 30g, Rhizoma Polygonati 35g, Radix Et Caulis Acanthopanacis Senticosi 30g, Caulis Polygoni Multiflori 25g, Herba Selaginellae 30g, Rhizoma Curcumae Longae 35g, Fructus Litseae 20g, Herba Siegesbeckiae 25g, Cortex Acanthopancis 35g, Rhizoma Dioscoreae 35g, Caulis Sargentodoxae 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20g, Radix seu Herba Gei aleppici 30g, Fructus Amomi Rotundus 25g, Folium Viticis Negundo 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 35g and Rhizoma Polygoni Paleachi 25g.

The pharmacology of described each crude drug is as follows:

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the cards such as aqueous-grainy diarrhea.

The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature, enters liver, kidney channel, has blood pressure lowering, invigorating the liver and kidney, bone and muscle strengthening, the effect of antiabortive gas, for caused by liver and kidney deficiency, card see dizzy, soreness of waist and knee joint, muscles and bones flaccidity are weak; Instability of kidney QI, frequent micturition or dripping urination, uncontrolled urination are itched, sexual impotence, anemia of pregnant woman are weak, frequent fetal movement or waist pendant pain; The cards such as chronic joint diseases, bone tuberculosis, dysmenorrhea, dysfunctional uterine bleeding, chronic pelvic inflammatory disease, the leaf of the Cortex Eucommiae and skin contain the nutritional labelings such as protein, fat, vitamin and mineral.

Rhizoma Drynariae: bitter in the mouth, warm in nature, enter liver, kidney channel, there is invigorating the kidney and strengthening the bones, continuous effect of hindering pain relieving, for soreness of waist and knee joint of suffering from a deficiency of the kidney, flaccidity and weakness of the lower limbs, the hepatic and renal YIN deficiency, empty positive rising and the deafness and tinnitus that causes, odontoseisis pain or gingival hemorrhage, asthenia of both the spleen and kidney and cause the cards such as chronic diarrhea chronic dysentery.

Radix Morindae Officinalis: acrid in the mouth, sweet, slightly warm in nature, enters liver, kidney channel, has the effect of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, and for impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen cold type of pain, cold womb is infertile, the cards such as the muscles and bones flaccidity caused by deficiency of the liver and kindey is soft, chills and pain of the waist and kness.

Cornu Cervi Pantotrichum: sweet in the mouth, salty, warm in nature, return kidney, Liver Channel, there is invigorating kidney-YANG, mend marrow, bone and muscle strengthening, adjust punching to appoint, effect of holder sore, cures mainly cards such as suffering from a deficiency of the kidney, dizzy, deaf, order is dark, sexual impotence, spermatorrhea, cold womb are infertile, weakness and emaciation, Mental fatigue, fear of cold, spinal column cold type of pain, muscles and bones flaccidity are soft, bleeding not during menses, carbuncle of yin nature are not held back and prolonged illness is deficient.

Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has YIN nourishing of enriching blood, and beneficial essence fills out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney the cards such as dyspnea with rapid and short breath.

Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is put down, and enters liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite that (blood) is descending, effect of inducing diuresis for treating stranguria syndrome, treatment soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal abdominal pain due to blood stasis, lump in the abdomen, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, the cards such as laryngopharynx swelling and pain.

Fructus Broussonetiae: sweet in the mouth, cold in nature, return liver, kidney channel, there is the kidney invigorating liver heat removing, effect of improving eyesight diuresis, cure mainly deficiency of the liver and kindey, soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, have a dizzy spell, the card such as edema distension.

Herba Taxilli: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, have the effect of invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, for the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood void is lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, has enriching qi and yin, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched

Caulis Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, numbness of the skin, rheumatic arthralgia, the cards such as wind skin ulcer scabies.

Herba Selaginellae: latin name Selaginellae Herba is the dry herb of Spikemoss plant Herba Selaginellae or Selaginella pulvinata, acrid in the mouth, and property is put down, and returns liver, heart channel, there is effect of promoting blood circulation to restore menstrual flow, for amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.

Rhizoma Curcumae Longae: latin name curcumae longae rhizoma, bitter in the mouth, pungent, warm in nature, enter Liver Channel, there is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia, twinge for the breast side of body, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, the cards such as tumbling and swelling

Fructus Litseae: warm in nature, acrid in the mouth, returns spleen, stomach, kidney, urinary bladder channel, has warming spleen and stomach for dispelling cold, effect of promoting the circulation of QI to relieve pain, and for cold syndrome of the stomach vomiting, coldness and pain in the epigastrium, colic of cold type is suffered from abdominal pain, the cards such as stagnancy of cold-damp.

Herba Siegesbeckiae: latin name Siegesbeckiae Herba, taste is cold, pungent, bitter, returns Liver Channel, kidney channel, has wind-damp dispelling, sharp joint, effect of removing toxic substances, cures mainly that rheumatic arthralgia, muscles and bones are unable, the card such as soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.

Cortex Acanthopancis: be the root bark of studies on plants of Acanthopanax Miq. in Araliaceae acanthopanax gracilistylus and Acanthopanax sessiliflorus(Rupr.et Maxim.) Seem., acrid in the mouth, hardship, warm in nature, return liver, kidney, there is wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; To invigorate blood circulation effect of arteries and veins, cure mainly anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination such as to be itched at the card.

Rhizoma Dioscoreae: latin name dioscoreae rhizoma, sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.

Caulis Sargentodoxae: latin name Sargentodoxae Caulis, bitter in the mouth, property is put down, and returns liver, large intestine channel, has the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.

Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): latin name Ajugae Herba is hardship, cold in nature, returns lung meridian, has effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, cures mainly laryngopharynx swelling and pain, lung-heat hemoptysis, the cards such as traumatic injury pain.

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is put down, and return liver, spleen, lung meridian, have analgesia, blood pressure lowering, regulating menstruation, effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison is controlled in external, the cards such as traumatic injury.

Fructus Amomi Rotundus: acrid in the mouth, warm in nature, return lung, spleen, stomach warp, have removing dampness circulation of qi promoting, warming middle-JIAO to arrest vomiting, effect of appetite-stimulating indigestion-relieving, cures mainly retention of damp leading to blockage of QI, incoordination between the spleen and stomach, distension and fullness in the abdomen, anorexia, hygropyrexia from the beginning of, uncomfortable in chest not hungry, gastrofrigid vomiting, food stagnation such as not to disappear at the card.

Folium Viticis Negundo: latin name Viticis NegundoFolium, acrid in the mouth; Bitter; Property is put down, and returns lung meridian, has removing dampness of inducing sweat, eliminating phlegm and relieving asthma; Removing toxic substances, expelling pathogenic wind from the body surface, dehumidifying, parasite killing, effect of pain relieving, cures mainly Common Cold, cough, asthma; Stomachache; Stomachache; Heat-damp in summer dysentery; Beriberi swelling; Rubella pruritus; Tinea pedis; Acute mastitis swells and ache; The cards such as snake bite and insect sting.

Herba Gendarussae (Caulis et Folium Gendarussae vulgaris): acrid in the mouth, bitter, property is put down, and has wind-damp dispelling, dissipating blood stasis blood, effect of reuniting the fractured tendons and bones, cures mainly rheumatic arthralgia, dysmenorrhea, traumatic injury, fracture card of Denging.

Rhizoma Polygoni Paleachi: be the rhizome of Polygonaceae arsesmart Rhizoma Polygoni Paleachi, bitter in the mouth, pungent, cold in nature, there is dissipating blood stasis hemostasis, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, removing toxic substances, effect of dampness removing, cures mainly traumatic injury, traumatic hemorrhage, spits blood, hemoptysis, metrorrhagia, chronic gastritis, stomach, duodenal ulcer, food stagnation is stagnated, dysentery, enteritis, edema, sore, venom, the cards such as burning hot wound.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 bone-strengthening powder 1

By Semen Cuscutae 30g, Cortex Eucommiae 35g, Rhizoma Drynariae 55g, Cornu Cervi Pantotrichum 35g, Radix Achyranthis Bidentatae 40g, Rhizoma Polygonati 35g, Radix Et Caulis Acanthopanacis Senticosi 30g, Fructus Litseae 20g, Herba Siegesbeckiae 25g, Cortex Acanthopancis 35g, Rhizoma Dioscoreae 35g, Folium Viticis Negundo 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 35g and Rhizoma Polygoni Paleachi 25g mixes, stir, the mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 60 DEG C, sealing immersion 10 days, boil 2 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and drying, obtain the first powder, filtering residue is for subsequent use, by Radix Morindae Officinalis 30g, Radix Rehmanniae Preparata 25g, Fructus Broussonetiae 25g, Herba Taxilli 30g, Caulis Polygoni Multiflori 25g, Herba Selaginellae 30g, Rhizoma Curcumae Longae 35g, Caulis Sargentodoxae 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20g, Radix seu Herba Gei aleppici 30g, Fructus Amomi Rotundus 25g mixes, obtain mixture, this mixture of every 300g, adds 2L water, heating decoction 4 hours, decoction liquor is filtered, and the filtering residue that filtering residue obtains with the first step mixes, and the filtering residue of every 300g mixing adds 2L water, heating decoction 3 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into all water of removal, pulverizes sick dry, obtain the second powder, by the first powder and the mixing of the second powder, get 500g mixed-powder, add 100g starch, 5g edible essence, 5g sucrose, mix homogeneously, obtains bone-strengthening powder.

Embodiment 2 bone-strengthening powder 2

By Semen Cuscutae 35g, Cortex Eucommiae 40g, Rhizoma Drynariae 60g, Cornu Cervi Pantotrichum 40g, Radix Achyranthis Bidentatae 45g, Rhizoma Polygonati 40g, Radix Et Caulis Acanthopanacis Senticosi 35g, Fructus Litseae 20g, Herba Siegesbeckiae 25g, Cortex Acanthopancis 35g, Rhizoma Dioscoreae 35g, Folium Viticis Negundo 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 35g and Rhizoma Polygoni Paleachi 25g mixes, stir, the mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 60 DEG C, sealing immersion 10 days, boil 2 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and drying, obtain the first powder, filtering residue is for subsequent use, by Radix Morindae Officinalis 35g, Radix Rehmanniae Preparata 30g, Fructus Broussonetiae 30g, Herba Taxilli 35g, Caulis Polygoni Multiflori 25g, Herba Selaginellae 30g, Rhizoma Curcumae Longae 35g, Caulis Sargentodoxae 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20g, Radix seu Herba Gei aleppici 30g, Fructus Amomi Rotundus 25g mixes, obtain mixture, this mixture of every 300g, adds 2L water, heating decoction 4 hours, decoction liquor is filtered, and the filtering residue that filtering residue obtains with the first step mixes, and the filtering residue of every 300g mixing adds 2L water, heating decoction 3 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into all water of removal, pulverizes sick dry, obtain the second powder, by the first powder and the mixing of the second powder, get 500g mixed-powder, add 100g starch, 5g edible essence, 5g sucrose, mix homogeneously, obtains bone-strengthening powder.

Embodiment 3 bone-strengthening powder 3

By Semen Cuscutae 30g, Cortex Eucommiae 35g, Rhizoma Drynariae 55g, Cornu Cervi Pantotrichum 35g, Radix Achyranthis Bidentatae 40g, Rhizoma Polygonati 35g, Radix Et Caulis Acanthopanacis Senticosi 30g, Fructus Litseae 15g, Herba Siegesbeckiae 20g, Cortex Acanthopancis 30g, Rhizoma Dioscoreae 30g, Folium Viticis Negundo 25g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g and Rhizoma Polygoni Paleachi 20g mixes, stir, the mixture after mix homogeneously is put into the Chinese liquor that alcoholic strength is 60 DEG C, sealing immersion 10 days, boil 2 hours subsequently, leave standstill 12 hours, filter, the filtrate of acquisition is concentrated into removes all Chinese liquor, pulverize and drying, obtain the first powder, filtering residue is for subsequent use, by Radix Morindae Officinalis 30g, Radix Rehmanniae Preparata 25g, Fructus Broussonetiae 25g, Herba Taxilli 30g, Caulis Polygoni Multiflori 20g, Herba Selaginellae 25g, Rhizoma Curcumae Longae 30g, Caulis Sargentodoxae 25g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g, Radix seu Herba Gei aleppici 25g, Fructus Amomi Rotundus 20g mixes, obtain mixture, this mixture of every 300g, adds 2L water, heating decoction 4 hours, decoction liquor is filtered, and the filtering residue that filtering residue obtains with the first step mixes, and the filtering residue of every 300g mixing adds 2L water, heating decoction 3 hours, decoction liquor is filtered, and the filtrate after filtering is concentrated into all water of removal, pulverizes sick dry, obtain the second powder, by the first powder and the mixing of the second powder, get 500g mixed-powder, add 100g starch, 5g edible essence, 5g sucrose, mix homogeneously, obtains bone-strengthening powder.

Embodiment 4 toxicology test

Acute toxicity test: cleaning grade male and female mice is divided into administration group and matched group at random, the maximum administration concentration of administration group feed, 2.5g crude drug/ml, 90ml/kg, matched group feed disinfectant, 90ml/kg, divide equally three administrations feedwater, within every 4 hours, be administered once, normal breeding observing one week.During administration feedwater, each group mice behavioral activity is normal, has no movable and reduces, rolls up, the phenomenon such as Folium Pini, and nose, eye, oral cavity have no secretions, none dead mouse.The maximum dosage of mice is 225g crude drug/kg body weight, is 252 times of clinical application according to the weight.The above results shows, when the maximum dosage of mice is 225g crude drug/kg, drug regimen of the present invention has no acute toxic reaction.

Long term toxicity test: observe the continuous gavage of drug regimen of the present invention 180 days body weight on rat, hematological indices, serological biochemical markers and Main Organ Coefficients and histological impact.Cleaning grade male and female rat is divided into large, medium and small administration group and Normal group at random.Large, medium and small administration group dosage is respectively 56,28,14g crude drug/kg/d, be respectively 62 times of clinical application, 31 times, 15.5 times.Continuous oral administration 180 days.Experimental result shows, during administration, the behavior of each group rat outward appearance, body weight, food-intake are all normal, has no movable and reduces, rolls up, the phenomenon such as Folium Pini, and nose, eye, oral cavity have no secretions; When routine blood test [RBC, HGB, HCT, PLT, WBC and classification (LYM, MID, GRA) thereof], blood coagulation, (CT) is all normal.Biochemical indicator: comprise liver function (AST, ALT), renal function (BUN, Crea), alkali phosphatase (ALP), total serum protein (TP), albumin (ALB) and cholesterol (TC), blood glucose (GLU), 90 days upon administration, 180 days compared with corresponding matched group, all within the scope of normal variation, have no significant change.Rat administration histoorgan (heart, liver,kidney,spleen, lung, adrenal gland, thymus, testis, epididymis, uterus and ovary, brain, stomach, pancreas, thyroid) organ index of two weeks after 90,180 days and after drug withdrawal, visual inspection and Histological section check and are showed no obvious pathological change.The above results shows, drug regimen 56g crude drug of the present invention/kg, 28g crude drug/kg and 14g crude drug/kg successive administration has no overt toxicity reaction for 6 months.

Embodiment 5 animal experiment

Experimental animal

Wistar rat, male, body weight (230 ± 20) g, cleaning grade.

Pharmaceutical preparation

Bone-strengthening powder prepared by embodiment 1; XIANLING GUBAO JIAONANG, Guizhou Tongjitang Pharmaceutical Co., Ltd, lot number: 080611; Retinoic acid, Beijing Ding Guo Bioisystech Co., Ltd, lot number: 081102; Serum calcium (Ca) test kit, Changchun Hui Li Bioisystech Co., Ltd, lot number: 2009003; Serum Calcium Phosphorus (P) test kit, Changchun Hui Li Bioisystech Co., Ltd, lot number: 2009006; Alkali phosphatase (ALP) test kit, Changchun Hui Li Bioisystech Co., Ltd, lot number: 2009005.

Instrument

Direct digital radiograph system (DR); 2700 type biochemistry analyzer.

Modeling

After male Wistar rat adapts to 1 week, gavage is to retinoic acid 80mgkg ^-1d ^-1, continuous 14d, Normal group gavage is to equivalent distilled water.

Grouping and administration

80 male Wistar rats are divided at random Normal group, model group, positive controls (XIANLING GUBAO JIAONANG, 1gkg ^-1d ^-1) and bone-strengthening powder group (16kg ^-1d ^-1).Except Normal group, all the other respectively organize equal modeling.Simultaneously, bone-strengthening powder is dissolved in water and according to dosage gavages by bone-strengthening powder group in modeling.Normal group gavages same volume distilled water, 1 time/d.After gavaging retinoic acid 14d, stop filling with retinoic acid, administration group continues to gavage the male strong osseous granules of compound recipe Du, and model control group gavages same volume distilled water, puts to death rat to draw materials detection to the 30th day.

Observation index

(1) blood serum sample detects: after treatment terminates, and ventral aorta blood sampling separation of serum, measures blood calcium (Ca), phosphorus (P), alkali phosphatase (ALP) with automatic biochemistry analyzer.(2) bone weight in wet base, dry weight: peel off rat two femurs, remove the soft tissue of attachment, a left side then femur claims its weight in wet base, then dries 8h at 120 DEG C, takes out and claims its dry weight.The right side then femur is immersed in normal saline after taking out, and-20 DEG C of preservations, measure for DR.(3) bone density and fracture rates: application DR to the right side then femur carry out picture-taking, adopt specialized image analysis software Imag-Pro Plus6.0 to rat respectively organize the right side then femur picture analyze, the density of the right then femur of indirect determination and fracture rates.

Statistical method

Adopt SPSS11.0 systems soft ware process data, measurement data represents with (x ± s), compares employing one factor analysis of variance between group, and enumeration data adopts χ ²inspection, P < 0.05 has statistical significance for difference.

Result

On the impact of left femur weight in wet base and dry weight, the results are shown in Table 1.

Table 1 is on the impact of rats with left femur weight in wet base and dry weight

Group	Dosage (g/kg)	Weight in wet base (g)	Dry weight (g)
				Normal group	-	0.9325±0.0751	0.4758±0.0735
Model group	-	0.9512±0.0411	0.4591±0.0639
				Positive group	1	0.9075±0.0704	0.5017±0.0838

Bone-strengthening powder group

18

0.9453±0.0677

0.4892±0.0573

As known from Table 1, model group, bone-strengthening powder group left femur weight in wet base and dry weight compare with Normal group, the equal not statistically significant of difference (P > 0.05), and prompting osteoporosis rat left femur weight in wet base and dry weight are without significant change.

On the impact of femoral bmd on the right side of rat, the results are shown in Table 2.

Table 2 is on the impact of femoral bmd on the right side of rat

Group	Dosage (g/kg)	Density (pixel)
			Normal group	-	121.48±19.09
Model group	-	90.85±17.73
			Positive group	1	111.71±17.42
Bone-strengthening powder group	18	116.37±10.65

As known from Table 2, and Normal group compares, and on the right side of model group rats, femoral bmd reduces, and difference has statistical significance (P < 0.05), and hints model copies successfully; Compare with model group, on the right side of bone-strengthening powder group, femoral bmd raises (P < 0.05).

On the impact of rat blood calcium (Ca), phosphorus (P), alkali phosphatase (ALP), the results are shown in Table 3.

Table 3 is on the impact of rat blood calcium (Ca), phosphorus (P), alkali phosphatase (ALP)

Group	Dosage (g/kg)	Ca(mmol/L)	P(mmol/L)	ALP(U/L)
					Normal group	-	4.13±1.23	2.53±0.78	123.35±17.82
Model group	-	2.61±0.88	1.76±0.51	120.62±16.16
					Positive group	1	3.55±0.73	2.43±0.61	122.17±13.69
Bone-strengthening powder group	18	3.72±0.81	2.39±0.56	123.17±15.29

As can be seen from Table 3, and Normal group compares, and model group rats Ca, P level reduces, and difference has statistical significance (P < 0.05 or P < 0.01), and hints model copies successfully; Compare with model group, bone-strengthening powder group blood Ca, P level raises, and difference has statistical significance (P < 0.05).

On the impact of rat fracture rates, the results are shown in Table 4.

Table 4 is on the impact of rat fracture rates

Group	Dosage (g/kg)	Fracture number of animals (only)	Fracture rates (%)
				Normal group	-	0	0
Model group	-	16	80％
				Positive group	1	7	35％
Bone-strengthening powder group	18	2	10％

Table 4 can be found out, in experiment, model group rats femur significantly can see callus parcel femur after taking out, carry out also can seeing in femur callus having obvious fracture line after DR takes the photograph sheet, model group fracture rates is 80%, the fracture rates of bone-strengthening powder group is 10%, two groups are compared, and difference has statistical significance (P < 0.05).

Embodiment 6 clinical data

Physical data

Senile osteoporosis patient 126 example that the court accepts for medical treatment above-mentioned period, wherein man 69 example, female 57 example; Year at age 58 ~ 74 (65.9 ± 12.3).Patient all meets the Criteria of Osteoporosis of WHO formulation in 1994.Patient all took the medicine such as glucocorticoid and gonadal hormone in the recent period.Get rid of the patient suffering from cardio-pulmonary function exception, hepatic and renal function exception, hematopathy, hyperparathyroidism, diabetes, mental sickness.Senile osteoporosis patient is divided into 2 groups at random, the oral calcium of 63 routine patient is matched group, the oral calcitriol Combined with Calcium of 63 routine patient is observation group, the ordinary circumstance (age, sex etc.) of 2 groups of patients there are no significant difference (P > 0.05), has comparability.

Method

Administrated method

The oral calcium tablet of matched group (medicine is called D-Cal sheet, ounce pharmaceutical Co. Ltd of the U.S. produce, 750mg/ sheet), 1 piece/times, 1 time/d, the course for the treatment of 1a.Bone-strengthening powder prepared by the oral embodiment 1 of control group, can be dissolved in wet suit use, each 50g, every day 3 times, the course for the treatment of 1a.

The assay method of bone density

The mensuration of bone density uses DPX type dual energy X-ray absorptiometry detector (production of Lunar company of the U.S.).Operation is carried out in strict accordance with description, and the detection position of bone density is the lumbar vertebra L of patient _2-4position, side and neck of femur.

The assay method of skeleton metabolism

People's bone alkaline phosphatase and people's TRAP 5b all adopt ELISA method to detect, and test kit is R & D company of the U.S. and produces, and the CV in criticizing and between criticizing is less than 5%.Operation is carried out in strict accordance with test kit description.

Observation index

Bone density situation (vertebra L _2-4position, side bone density, femoral neck bone density), skeleton metabolism (people's bone alkaline phosphatase, people's TRAP 5b).

Statistical procedures

Result

Bone density situation before and after 2 groups of patient treatments compares, and the results are shown in Table 5.

After treatment, the L of matched group patient _2-4the bone density of position, side and neck of femur all raises, but there are no significant difference (P > 0.05).The L of observation group patient _2-4the bone density of position, side and neck of femur all obviously raises (P < 0.05).The L of observation group patient _2-4the bone density of position, side and neck of femur all apparently higher than matched group (P < 0.05), in table 5.

L before and after table 52 groups of patient treatments _2-4(g/cm is compared with the bone density situation of neck of femur in position, side ²)

Skeleton metabolism before and after 2 groups of patient treatments compares, and the results are shown in Table 6.

After treatment, people's bone alkaline phosphatase and people's TRAP 5b of matched group patient all raise, but there are no significant difference (P > 0.05).People's bone alkaline phosphatase and people's TRAP 5b of observation group patient all obviously decline (P < 0.05).People's bone alkaline phosphatase of observation group patient and people's TRAP 5b are all starkly lower than matched group (P < 0.05).

Skeleton metabolism before and after table 62 groups of patient treatments compares (IU/L)

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. a bone-strengthening powder, is characterized in that: raw material of Chinese medicine medicated bag draws together Semen Cuscutae, the Cortex Eucommiae, Rhizoma Drynariae, Radix Morindae Officinalis, Cornu Cervi Pantotrichum, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Fructus Broussonetiae, Herba Taxilli, Rhizoma Polygonati, Radix Et Caulis Acanthopanacis Senticosi, Caulis Polygoni Multiflori, Herba Selaginellae, Rhizoma Curcumae Longae, Fructus Litseae, Herba Siegesbeckiae, Cortex Acanthopancis, Rhizoma Dioscoreae, Caulis Sargentodoxae, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Radix seu Herba Gei aleppici, Fructus Amomi Rotundus, Folium Viticis Negundo, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) and Rhizoma Polygoni Paleachi.

2. bone-strengthening powder as claimed in claim 1, it is characterized in that: in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 25g ~ 35g, Cortex Eucommiae 30g ~ 40g, Rhizoma Drynariae 50g ~ 60g, Radix Morindae Officinalis 25g ~ 35g, Cornu Cervi Pantotrichum 30g ~ 40g, Radix Rehmanniae Preparata 20g ~ 30g, Radix Achyranthis Bidentatae 35g ~ 45g, Fructus Broussonetiae 20g ~ 30g, Herba Taxilli 25g ~ 35g, Rhizoma Polygonati 30g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 25g ~ 35g, Caulis Polygoni Multiflori 20g ~ 30g, Herba Selaginellae 25g ~ 35g, Rhizoma Curcumae Longae 30g ~ 40g, Fructus Litseae 15g ~ 25g, Herba Siegesbeckiae 20g ~ 30g, Cortex Acanthopancis 30g ~ 40g, Rhizoma Dioscoreae 30g ~ 40g, Caulis Sargentodoxae 25g ~ 35g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 25g, Radix seu Herba Gei aleppici 25g ~ 35g, Fructus Amomi Rotundus 20g ~ 30g, Folium Viticis Negundo 25g ~ 35g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 40g and Rhizoma Polygoni Paleachi 20g ~ 30g.

3. bone-strengthening powder as claimed in claim 1 or 2, it is characterized in that: in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g ~ 35g, Cortex Eucommiae 35g ~ 40g, Rhizoma Drynariae 55g ~ 60g, Radix Morindae Officinalis 30g ~ 35g, Cornu Cervi Pantotrichum 35g ~ 40g, Radix Rehmanniae Preparata 25g ~ 30g, Radix Achyranthis Bidentatae 40g ~ 45g, Fructus Broussonetiae 25g ~ 30g, Herba Taxilli 30g ~ 35g, Rhizoma Polygonati 35g ~ 40g, Radix Et Caulis Acanthopanacis Senticosi 30g ~ 35g, Caulis Polygoni Multiflori 20g ~ 25g, Herba Selaginellae 25g ~ 30g, Rhizoma Curcumae Longae 30g ~ 35g, Fructus Litseae 15g ~ 20g, Herba Siegesbeckiae 20g ~ 25g, Cortex Acanthopancis 30g ~ 35g, Rhizoma Dioscoreae 30g ~ 35g, Caulis Sargentodoxae 25g ~ 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 15g ~ 20g, Radix seu Herba Gei aleppici 25g ~ 30g, Fructus Amomi Rotundus 20g ~ 25g, Folium Viticis Negundo 25g ~ 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 30g ~ 35g and Rhizoma Polygoni Paleachi 20g ~ 25g.

4. the bone-strengthening powder as described in claims 1 to 3, is characterized in that: in described raw material of Chinese medicine medicine, the weight of each component is respectively Semen Cuscutae 30g, Cortex Eucommiae 35g, Rhizoma Drynariae 55g, Radix Morindae Officinalis 30g, Cornu Cervi Pantotrichum 35g, Radix Rehmanniae Preparata 25g, Radix Achyranthis Bidentatae 40g, Fructus Broussonetiae 25g, Herba Taxilli 30g, Rhizoma Polygonati 35g, Radix Et Caulis Acanthopanacis Senticosi 30g, Caulis Polygoni Multiflori 25g, Herba Selaginellae 30g, Rhizoma Curcumae Longae 35g, Fructus Litseae 20g, Herba Siegesbeckiae 25g, Cortex Acanthopancis 35g, Rhizoma Dioscoreae 35g, Caulis Sargentodoxae 30g, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 20g, Radix seu Herba Gei aleppici 30g, Fructus Amomi Rotundus 25g, Folium Viticis Negundo 30g, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 35g and Rhizoma Polygoni Paleachi 25g.

5. the preparation method of bone-strengthening powder described in claim 1-4, is characterized in that, comprising: