CN104256576B - Functional food capable of regulating blood pressure - Google Patents
Functional food capable of regulating blood pressure Download PDFInfo
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- CN104256576B CN104256576B CN201410320553.5A CN201410320553A CN104256576B CN 104256576 B CN104256576 B CN 104256576B CN 201410320553 A CN201410320553 A CN 201410320553A CN 104256576 B CN104256576 B CN 104256576B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a functional food capable of regulating blood pressure. The functional food is mainly prepared from the following raw materials by weight: 30-50 parts of sophora flower extract, 30-50 parts of semen raphani extract, 5-10 parts of vitamin C and 5-10 parts of calcium lactate. Experiments demonstrate that the functional food formed by mixing the above raw materials has the effects of repairing blood vessels, recovering blood vessel elasticity, expanding smooth muscles of blood-vessel walls, promoting blood circulation, alleviating arterial blood flow pressure, reducing blood pressure, reducing blood lipid and preventing the blood vessels from scleratheroma except for respective effects of the above raw materials. The functional food can well regulate the blood pressure and has no toxic or side effect completely.
Description
Technical field
The present invention relates to field of functional food, particularly a kind of functional food of conditioning blood pressure balance.
Background technology
High blood pressure is chronic cardiovascular diseases common in global range, seriously threatens the health of people.The whole world is about
30% people dies from cardiocerebrovasculaevents events, wherein has 62% palsy event and 49% cardiovascular event to be direct by hypertension
Cause.Once being diagnosed as high blood pressure, then it is lifelong disease, needs continual treatment.High blood pressure is not only by hypertension
Itself cause dizziness, headache, absent minded, the symptom such as emotional instability, if controlling of blood pressure is bad, prolonging over time
It is long, brain, heart, kidney can be affected, the infringement of these internal organs is caused.If with coronary heart disease, hyperlipemia, diabetes, pain
Wind etc. is present jointly, it will cause more adverse consequences.
Population of China Monitoring Data shows that cardiovascular and cerebrovascular death accounts for more than the 40% of total death toll, and wherein hypertension is
The first hazards, in annual 3000000 cardiovascular death, at least half is relevant with hypertension.More than 18 years old adult hypertension of China
Illness rate is 18.8%, estimates that current China there are about 200,000,000 hyperpietics, per 10 adults in just have 2 people with hypertension,
Account for the 1/5 of global hypertension total number of persons.The horizontal crowd of In Prehypertensive accounts for the ratio of total Adult Groups and constantly increases, especially
It is young and middle-aged, has increased to 34% in 2002 from 29% in 1991, be that China's Prevalence of Hypertension is persistently raised and suffered from
The main source that patient's number increases severely.Estimate that China increases 10,000,000 people of hyperpietic every year newly.
As more than 90% hypertension pathogeny is failed to understand, so still difficult at present effect a radical cure but can control, and the pair of related drugs
Effect is big, and drug effect is not also obvious.Medical research is it has been shown that hypertension is had with high salinity in blood, high fat of blood and high blood viscosity
Apparent causal connection, rational diet are advantageous for aided blood pressure-lowering.Normal meals are allocated, and nutrition equilibrium is conducive to controlling blood
Voltage levels, reduce the salinity in blood by the approach of non-drug therapy, and supplementing hyperpietic must nutrition and various
Function factor, the absorption and dilute blood viscosity for delaying fats are all advantageously reduced or effective control blood pressure.
The content of the invention
Present invention seek to address that one of technical problem in prior art problem, for this purpose, the present invention provides a kind of conditioning blood
The functional food of weighing apparatus is flattened, which can repair blood vessel, recover blood vessel elasticity, have expansion of blood vessels wall smooth muscle, promote blood to follow
The effect of ring, make blood flow volume pressure mitigate, blood pressure reduce, while can also reduction blood fat, prevent blood vessel scleratheroma, can
The function of conditioning blood pressure balance is reached well.
In one aspect of the invention, the invention provides a kind of composition, mainly by the raw material system of following parts by weight
Into：Flos Sophorae extract 30-50 parts, radish seed extract 30-50 parts, vitamin C 5-10 parts, calcium lactate 5-10 parts.
In addition, composition according to the above embodiment of the present invention can also have following additional technical characteristic：
In an embodiment of the present invention, composition of the invention further includes the mixed raw material of following parts by weight
Into：45 parts of Flos Sophorae extract, 40 parts of radish seed extract, 5 parts of vitamin C, 10 parts of calcium lactate.
In an embodiment of the present invention, composition of the invention further includes the mixed raw material of following parts by weight
Into：45 parts of Flos Sophorae extract, 45 parts of radish seed extract, 5 parts of vitamin C, 5 parts of calcium lactate.
In an embodiment of the present invention, composition of the invention further includes the mixed raw material of following parts by weight
Into：50 parts of Flos Sophorae extract, 40 parts of radish seed extract, 5 parts of vitamin C, 5 parts of calcium lactate.
In embodiments of the invention, a kind of preparation method of functional food is additionally provided, embodiments in accordance with the present invention,
Its preparation method is as follows：
A. powder raw material that is qualified and configuring by proportioning will be checked to put in mixer, is allowed to stir, and is controlled
Powder raw material water content is 10%～20%, and the parts by weight of these powder raw materials are successively：Flos Sophorae extract 30-50 parts,
Radish seed extract 30-50 parts, vitamin C 5-10 parts, calcium lactate 5-10 parts.
B. the powder raw material for stirring is put in microwave dryer, dries and sterilize；
C. the powder raw material after drying and sterilizing is crushed, sieves, obtain fine powder；
D. functional food is made in fine powder shaping.
Some embodiments of the invention, in above-mentioned preparation method, the moisture of powder raw material described in a steps
Content is 10%-20%.
Some embodiments of the invention, in above-mentioned preparation method, described in the b step, powder raw material is put into micro-
Thickness in ripple drier is 2-2.5cm.
Some embodiments of the invention, in above-mentioned preparation method, powder raw material described in the b step is dried simultaneously
Sterilising temp is 60-80 DEG C, and the time is 4-10 minutes.
Some embodiments of the invention, in above-mentioned preparation method, after the drying of powder raw material described in the b step
Moisture is less than 7%.
Some embodiments of the invention, in above-mentioned preparation method, by the powder after drying and sterilizing in the step c
Shape raw material crosses 100 mesh sieves after being crushed.
Some embodiments of the invention, the functional food in the present invention in capsule, tablet or electuary at least
The form of kind.
Embodiments in accordance with the present invention, the pharmaceutical composition of the present invention can be used for the mediodespidine for nursing one's health hypertensive patient
Weighing apparatus.
Some specific examples of the invention, have carried out function to the functional food of the conditioning blood pressure balance of the present invention
Property experiment, find a kind of functional food of the conditioning blood pressure balance that the present invention is provided to essential hypertension rat model
(SHR) all there is step-down well and the effect of blood pressure is adjusted, long-term taking can reach the purpose of control treatment, at the same time,
A kind of functional food of the conditioning blood pressure balance for also providing to the present invention of the invention has carried out Oral toxicity test, binomial and has caused to dash forward
Become test (PCEMNR number micronucleus test and sperm malformation test) and the security of 30 days feeding trials is commented
Valency is tested and pathologic diagnosis gross anatomy test, and test data does not find that the given the test agent has obvious toxicity to make
With by acute toxicity grading criteria evaluation, the given the test agent belongs to nontoxic level.
In the present invention, in addition to respective effect, after which blends together and to form this food, Jing is tried above-mentioned several raw materials
Checking is bright, can also repair blood vessel with which, recovers blood vessel elasticity, has expansion of blood vessels wall smooth muscle, the work for stimulating circulation
With, make blood flow volume pressure mitigate, blood pressure reduce, while can also reduction blood fat, prevent blood vessel scleratheroma, can be good at
Tune reaches the function of conditioning blood pressure balance, and totally nontoxic side effect.Therefore, this food has conditioning blood pressure balance well
Function, user can be made to adjust blood pressure, reduce using and relying on to depressor, be reduced medicine and make to the poison that body brings is secondary
With.On safety regulation and control blood pressure, this food is that current safety effectively can be by repairing blood vessel, stimulating circulation, reduce blood
Fat etc. come nurse one's health blood pressure balance healthy food.
It should be noted that the medical composition and its use of the present invention is present inventor through arduous creation
Property work and Optimization Work just complete.
The additional aspect and advantage of the present invention will be set forth in part in the description, and partly will become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Description of the drawings
A kind of shadow of the functional food of regulation blood pressure balance that Fig. 1 is provided for the continuous gavage present invention to SHR mouse blood pressures
Ring schematic diagram.
Specific embodiment
Embodiments of the invention are described below in detail.The embodiments described below is exemplary, is only used for explaining this
It is bright, and be not considered as limiting the invention,
A kind of functional food of conditioning blood pressure balance that the present invention is provided, including the mixed raw material of following parts by weight
Into：
30～50 parts of Flos Sophorae extract, 30～50 parts of radish seed extract, 5～10 parts of vitamin C, 5～10 parts of calcium lactate,
Four kinds of raw materials are bought from Beijing Jia Kang sources Chemical Co., Ltd..
Embodiment 1：
A kind of composition is provided, including following parts by weight mixed raw material into：45 parts of Flos Sophorae extract, radish seed carries
Take 40 parts of thing, 5 parts of vitamin C, 10 parts of calcium lactate.
Embodiment 2：
A kind of composition is provided, including following parts by weight mixed raw material into：45 parts of Flos Sophorae extract, radish seed carries
Take 45 parts of thing, 5 parts of vitamin C, 5 parts of calcium lactate.
Embodiment 3：
A kind of composition is provided, including following parts by weight mixed raw material into：50 parts of Flos Sophorae extract, radish seed carries
Take 40 parts of thing, 5 parts of vitamin C, 5 parts of calcium lactate.
Embodiment 4：
A kind of composition is provided, including following parts by weight mixed raw material into：30 parts of Flos Sophorae extract, radish seed carries
Take 50 parts of thing, 10 parts of vitamin C, 10 parts of calcium lactate.
Embodiment 5：
A kind of composition is provided, including following parts by weight mixed raw material into：50 parts of Flos Sophorae extract, radish seed carries
Take 30 parts of thing, 10 parts of vitamin C, 10 parts of calcium lactate.
Preparation method：The invention provides a kind of preparation method of food includes stirring, dry and sterilizing, crush and be molded
Step, it is specific as follows：
Embodiment 6：
45 parts of the Flos Sophorae extract of standard (quality standard, as follows in Q/WHF 0019S-2012), radish will first be met
40 parts of seed extract, 5 parts of vitamin C, in 10 parts of powder raw material (parts by weight) input mixers of calcium lactate, are allowed to stirring equal
It is even, and raw material moisture content is controlled for 10～20%；Again the raw material for mixing uniformly is laid in by the thickness of 2～2.5cm micro-
In ripple drier, under the conditions of 60～80 DEG C of temperature, 4～10 minutes time sterilized and dried, moisture is little after drying
In 7%；Then, the powder raw material after drying and sterilizing is crushed, is sieved, 100 mesh, 80 mesh or 60 mesh when sieving, can be used
Sieve, wherein preferably 100 mesh sieves, obtain fine powder；Finally, require for fine powder raw material to make capsule according to functions of the state food technology,
Or tablet, or electuary, or other kind packaging products.
Embodiment 7：First by 45 parts of standard compliant powder raw material (parts by weight) Flos Sophorae extract, radish seed extract 45
Part, 5 parts of vitamin C, in 5 parts of input mixers of calcium lactate, is allowed to stir, and control raw material moisture content for 10～
20%；Following operation is with embodiment 6.
Embodiment 8：First by 50 parts of standard compliant powder raw material (parts by weight) Flos Sophorae extract, radish seed extract 40
Part, 5 parts of vitamin C, in 5 parts of input mixers of calcium lactate, is allowed to stir, and control raw material moisture content for 10～
20%；Following operation is with embodiment 6.
Embodiment 9：First by 30 parts of standard compliant powder raw material (parts by weight) Flos Sophorae extract, radish seed extract 50
Part, 10 parts of vitamin C, in 10 parts of input mixers of calcium lactate, is allowed to stir, and control raw material moisture content for 10～
20%；Following operation is with embodiment 6.
Embodiment 10：First by 50 parts of standard compliant powder raw material (parts by weight) Flos Sophorae extract, radish seed extract
30 parts, 10 parts of vitamin C, in 10 parts of input mixers of calcium lactate, is allowed to stir, and control raw material moisture content for 10～
20%；Following operation is with embodiment 6.
Functional experiment is tested：
Embodiment 11：A kind of experiment test of the effect for functional food that the present invention is provided
1. materials and methods
1.1 material
Sample：Functional food is balanced by a kind of blood pressure that adjusts that any one of the above embodiment of the present invention 1 to 4 is provided,
There is provided by Kai Ze (Wuhan) health control Co., Ltd, human body recommended amounts are 20mg/ (d kg).
Experimental drug：Captopril (Captopril), from Sigma companies.
Animal used as test：
Essential hypertension rat model (SHR)：Male, 25,10 week old, body weight are 180～220g, by Hubei Province's reality
Animal center offer is provided.Feeding method：Per 5, cage, nursing, freely intakes, and environment temperature is (25 ± 1) DEG C, and relative humidity is
(60 ± 5) %.SHR rats adapted to environment after 7 days, started experiment.
Laboratory apparatus：
RBP-1 type rat blood pressure meters, Chinese-Japanese Friendship Clinic Medical Inst's manufacture；
SL-1001 type electronic balances, Minqiao Precision Scientific Instruments Co., Ltd., Shanghai's manufacture.
1.2 experimental technique
Adapt to, after environment 7d, use RBP-1 by Ministry of Public Health's function of health food detection and 25 SHR rats of assessment technique specification
Type rat blood pressure meter determines blood pressure, according to blood pressure level, SHR rats is randomly divided into five groups, respectively：It is blank control group, low
Dosage group, middle dose group, high dose group and positive controls.A kind of dosage of the functional food for adjusting blood pressure balance is respectively
10th, 20,100mg/kg bw, Jing gavages give a kind of functional food for adjusting blood pressure balance, and blank control group gavage gives
The distilled water of suitable dosage, positive controls gavage give 5mg/kg bw captoprils (Captopril).
1.3 experimental procedure
The invention provides a kind of disposable gavage gives SHR rats a kind of functional food pair for adjusting blood pressure balance
The experimental technique that SHR rat blood pressures affect：SHR rat Jing gavages give distilled water, a kind of of basic, normal, high dosage and adjust blood pressure
The functional food and antihypertensive drugs captopril (Captopril) of balance, when 0,2,4,6,8,10 and 12h after measure gavage
The blood pressure of SHR rats.
The invention provides a kind of continuous gavage gives a kind of functional food for adjusting blood pressure balance of SHR rats to SHR
The experimental technique that rat blood pressure affects：Continuous 20 days timing gavages give SHR rat middle dosages a kind of work(for adjusting blood pressure balance
Energy property food, the blood of SHR rats when respectively at the 0th, 2,4,6,8,10,12,14,16,18 and 20 days 0 and 2h after measure gavage
Pressure.
Present invention also offers a kind of assay method of SHR rat blood pressures：The measure of animal blood pressure is clear-headed, quiet in animal
In the state of carry out, rat-tail set is positioned over into the root of rat-tail, each measurement interval regular hour, recorded heart rate change≤10
The reading of continuous three to five times of secondary/min, blood pressure≤6mmHg/min, averages.
1.4 data statistics processing methods
Variance analysis is carried out to data using SAS statistical softwares, the comparison between business group is carried out with Q inspections.
2 experimental results
A kind of functional food of regulation blood pressure balance that 2.1 present invention are provided gives mode pair by disposable gavage
The impact of SHR rat blood pressures is shown in Table 1.As a result show, the blood pressure of all dosage group SHR rats is decreased obviously, drop in blood pressure
Amplitude increases with the dosage of gavage and increases.During gavage 2h, drop in blood pressure amplitude reaches maximum, then slowly gos up.Q is examined
Test result to show, gavage is given in a kind of functional food for adjusting blood pressure balance, and the blood pressure level of high dose group SHR rat exists
2 after gavage, 4,6h when be substantially less than blank control group (P ＜ 0.05), wherein after high dose group gavage during 2h, drop in blood pressure amplitude
It is same as captopril (Captopril) group.
1 disposable gavage of table gives a kind of impact of functional food for adjusting blood pressure balance to SHR rat blood pressures
(mean ± standard deviation, mmHg)
Jing one-way analysis of variances between a SHR rat level Four, during test the 2nd, 4h, F values are respectively 8.23 and 8.10, P ＜
0.001；
Jing one-way analysis of variances between b SHR rat level Four, during test the 6th, 8h, F values are respectively 5.53 and 7.12, P ＜
0.01；
* Q inspections, compare with SHR control groups that there were significant differences, P ＜ 0.05.
A kind of functional food of regulation blood pressure balance that 2.2 present invention are provided gives experimental technique pair by continuous gavage
The impact of SHR rat blood pressures：On the basis of the test of disposable gavage, continuous gavage test is carried out, investigate a kind of regulation blood pressure
Impact of the functional food of balance to SHR mouse blood pressures and fluctuation of blood pressure situation.Continuous gavage gives a kind of blood pressure that adjusts and balances
Impact of the functional food to SHR rat blood pressures it is as shown in Figure 1.
As shown in Figure 1, Jing gavages give a kind of functional food 2h of regulation blood pressure balance of 90mg/kg bw dosage,
The drop in blood pressure of SHR rats 20mmHg or so, with the time lengthening of gavage, is slowly increased with the difference of control group, explanation
A kind of functional food for adjusting blood pressure balance of long-term taking does not only have obvious hypotensive effect and is depressured stable.Continuous gavage
After 8d, the initial value of SHR rat blood pressures starts slowly to decline, and have dropped 13.5mmHg after 20d, illustrates that long-term taking can reach control
The effect for the treatment of.
3. functional experiment result
Each experimental data with reference to more than, inventor draw to draw a conclusion, are filled with 10,20,100mg/kg bw dosage respectively
Stomach gives SHR rats a kind of functional food for adjusting blood pressure balance, is decreased obviously SHR rat blood pressures, drop in blood pressure width
Spend with the dosage increase of gavage and increase.During gavage 2h, drop in blood pressure amplitude reaches maximum, is 14,19 and respectively
After 30mmHg, 2h, blood pressure slowly gos up, and recovers to original level to 10h.The antihypertensive effect and Kato of 100mg/kg bw dosage
Puli (Captopril) group is suitable.Continuous gavage 20d gives SHR rat middle dosages (90mg/kg bw) a kind of regulation mediodespidine
During the functional food of weighing apparatus, SHR rat blood pressure smooth decreasings, after 8d, the initial value of SHR rat blood pressures starts slowly to decline, 20d
After have dropped 13.5mmHg.
It is demonstrated experimentally that the functional food of a kind of regulation blood pressure balance that the present invention is provided have in vivo step-down well and
The effect of blood pressure is adjusted, long-term taking can reach the purpose of control treatment.
Safety assessment is tested
Present invention also offers a kind of assessment experiment, by acute toxicity test in mice, mouse bone marrow cells are thermophilic
Polychromatic erythrocytes number micronucleus test, mouse inbred strain, 30 days feeding trials and hematological examination result are tested and dynamic
A kind of security performance of functional food that thing pathologic diagnosis are provided to the present invention is evaluated.
Embodiment 12：
Acute toxicity test in mice
Test method：
SPF level Kunming mouse acute oral toxicity tests to two kinds of sexes, method are pressed《Health food is checked and is evaluated
Technical specification》The toxicology method of inspection of 2003 editions, gavage 20g/kg BW is (equivalent to crowd recommended intake 0.02g/ twice
1000 times of kg BW), mouse test the results are shown in Table 2 within the observation period of 14 days.
A kind of functional food for adjusting blood pressure balance of table 2 is to acute toxicity test in mice result
Experimental data shows that two groups of animals do not observe Novel presentation, has no animal poisoning symptom and dead in two weeks
It is raw.By acute toxicity grading criteria evaluation, the given the test agent belongs to nontoxic level.
Embodiment 13：
Binomial mutagenicity test
PCEMNR number micronucleus test
Test method：
SPF level Kunming mouse Polychromatic erythrocyte number micronucleus tests to two kinds of sexes, method are pressed《Health food
Inspection and assessment technique specification》The toxicology method of inspection of 2003 editions, the results are shown in Table 3.
A kind of functional food for adjusting blood pressure balance of table 3 is to PCEMNR number micronucleus test result
Note：Compare * * P ＜ 0.01 with negative control group
Compare with negative control group, positive controls male and female micronuclei in mice rate there were significant differences property (＜ 0.01), and it is tested
The each dosage group male and female micronuclei in mice rate of sample is compared with negative control group, difference that there are no significant (P ＞ 0.05), and normal
In the range of, show the given the test agent bone marrow micronucleus test result for feminine gender.Mouse inbred strain
Test method：
To SPF level Kunming mouse sperm malformation tests, method is pressed《Health food is checked and assessment technique specification》2003
The toxicology method of inspection of version, the results are shown in Table 4.
A kind of functional food for adjusting blood pressure balance of table 4 is to mouse inbred strain result
Note：Compare * * P ＜ 0.01 with negative control group
Result of the test shows, compares with negative control group that positive controls mouse sperm deformity rate has significant difference (P
0.01), and each dosage group mouse sperm deformity rate of given the test agent is compared ＜ with negative control group, difference that there are no significant (P ＞
0.05), show the given the test agent sperm malformation test result for feminine gender.
Embodiment 14：
30 days feeding trials
Test method：
30 days feeding trials of SPF levels Wistar rat to two kinds of sexes, method are pressed《Health food is checked and assessment technique
Specification》The toxicology method of inspection of 2003 editions, the impact to rat body weight, food-intake, food utilization the results are shown in Table 5-7.
A kind of impact (mean ± standard deviation) of the functional food for adjusting blood pressure balance of table 5 to rat body weight
A kind of impact (mean ± standard deviation) of the functional food for adjusting blood pressure balance of table 6 to rats eating amount
A kind of impact (mean ± standard deviation) of the functional food for adjusting blood pressure balance of table 7 to rat chow utilization rate
Result of the test shows, in process of the test animal without death, hair is normal, behavior expression without exception.Given the test agent is each
There are no significant (P ＞ 0.05) to rat body weight, food-intake, food utilization and negative control group comparing difference for dosage group.
Embodiment 15：
Hematological examination result is tested
Impact to rat blood routine examination, the impact to rat leukocyte classification, the shadow to rat blood biochemical analysis
Ring result and be shown in Table 8-10 respectively.
A kind of impact of the functional food for adjusting blood pressure balance of table 8 to rat blood routine examination result
(mean ± standard deviation)
The impact (mean ± standard deviation) that a kind of functional food for adjusting blood pressure balance of table 9 is classified to rat leukocyte
A kind of impact of the functional food for adjusting blood pressure balance of table 10 to rat blood biochemical analysis
(mean ± standard deviation)
Continued
As seen from Table 8, each dosage group of given the test agent is compared result of the test with negative control group, there are no significant difference (P
＞ 0.05), and in range of normal value.As seen from Table 9, each dosage group of given the test agent is compared with negative control group, equal nothing
Significant difference (P ＞ 0.05), and in range of normal value.As seen from Table 10, each dosage group rat blood serum of given the test agent
The measurement result of ALT, AST, BUN, CRE, GLU, TRI, CHO, ALB, TP is compared with negative control group, there are no significant difference (P
＞ 0.05), and in range of normal value.
Embodiment 16：
Pathologic diagnosis gross anatomy:
The heart of the female male rat of each test dose group, liver,spleen,kidney, stomach and intestine compare with Normal group its appearance color and
Organ size is normal, be showed no substantially ooze out, hyperplasia, oedema, the pathology such as atrophy.Finding under mirror：
High dose group is compared with normal group：As a result, in the range of normal morphology, have no that obvious Poisoning pathological change changes,
Wherein：Liver：Lobuli hepatis structure is normal, and liver cell is arranged in radioactivity, and the visible slight cloudy swelling of minority liver cell section is (normal right
According to group 5 and high dose group 2), sinus hepaticus has no that obvious inflammatory cell invades profit, and the accidental inflammatory cell of portal area minority animal is invaded
Profit, (control group 4 and high dose group 3), caused by sample toxicity is used in non-experiment.Kidney：The partially visible glomerulus of cortex renis and
Closely, distal vessels, even dyeing；Have no obvious pathological change.Stomach and intestine：Under mucous membrane, mucous membrane, muscle layer, placenta percreta be showed no inflammatory
Cell invasion and hemorrhagic focus, it is viscous to touch complete.Spleen：3, control group spleen extravasated blood, mild inflammatory cell invasion 3, high dose group spleen
Extravasated blood and mild inflammatory cell invasion are each 2, remaining to have no that other abnormal pathologics change.Each experimental data, inventor with reference to more than
Draw to draw a conclusion, a kind of functional food of regulation blood pressure balance that the present invention is provided is a kind of food of safety non-toxic, both
Can play a part of to adjust blood pressure balance, be safety non-toxic again to hypertensive patient.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that not
These embodiments can be carried out with various changes, modification, replacement and modification in the case of the principle and objective that depart from the present invention, this
The scope of invention is limited by claim and its equivalent.
Claims (8)
1. the functional food that a kind of conditioning blood pressure is balanced, it is characterised in that by Flos Sophorae extract, radish seed extract, dimension life
Plain C, calcium lactate mixed raw material are into the raw material mixed weight number is：Flos Sophorae extract 30-50 parts, radish seed extract
30-50 parts, vitamin C 5-10 parts, calcium lactate 5-10 parts.
2. the functional food that conditioning blood pressure according to claim 1 is balanced, it is characterised in that by following parts by weight
Mixed raw material into：45 parts of Flos Sophorae extract, 40 parts of radish seed extract, 5 parts of vitamin C, 10 parts of calcium lactate.
3. the functional food for being balanced according to the arbitrary described conditioning blood pressure of claim 1 to 2, it is characterised in that the function
Property food in capsule, tablet or electuary at least one form.
4. it is a kind of conditioning blood pressure balance functional food preparation method, it is characterised in that prepare through the following steps：
A. powder raw material that is qualified and configuring by proportioning will be checked to put in mixer, is allowed to stir, and is controlled powdery
Raw material moisture content is 10%～20%, and the weight proportion number of these powder raw materials is successively：Flos Sophorae extract 30-50 parts,
Radish seed extract 30-50 parts, vitamin C 5-10 parts, calcium lactate 5-10 parts；
B. the powder raw material for stirring is put in microwave dryer, dries and sterilize；
C. the powder raw material after drying and sterilizing is crushed, sieves, obtain fine powder；
D. functional food is made in fine powder shaping.
5. it is according to claim 4 conditioning blood pressure balance functional food preparation method, it is characterised in that the b
Powder raw material described in step is put into the thickness in microwave dryer for 2-2.5cm.
6. it is according to claim 4 conditioning blood pressure balance functional food preparation method, it is characterised in that the b
Simultaneously sterilising temp is 60-80 DEG C to the drying of powder raw material described in step, and the time is 4-10 minutes.
7. it is according to claim 4 conditioning blood pressure balance functional food preparation method, it is characterised in that the b
After the drying of powder raw material described in step, moisture is less than 7%.
8. the preparation method of the functional food of conditioning blood sugar according to claim 4 balance, it is characterised in that the c
100 mesh sieves are crossed by the drying and after the powder raw material after sterilizing is crushed in step.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1792247A (en) * | 2005-12-27 | 2006-06-28 | 武汉哈福科技有限公司 | Health-care food with functions of anti-senium and cosmetic |
| KR100618146B1 (en) * | 2004-11-22 | 2006-08-31 | 정재희 | Nutrition reinforced soybean paste and manufacturing method of it |
| CN101062081A (en) * | 2006-04-25 | 2007-10-31 | 长春英联生物技术有限公司 | Dispersing tablets for reducing dizzy feeling and pressure and the preparing method thereof |
| CN102266407A (en) * | 2011-08-05 | 2011-12-07 | 李运伦 | Traditional Chinese medicinal composition for treating hypertension and preparation method thereof |
| CN103828981A (en) * | 2014-02-23 | 2014-06-04 | 廖少波 | Hemp tea |
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2014
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100618146B1 (en) * | 2004-11-22 | 2006-08-31 | 정재희 | Nutrition reinforced soybean paste and manufacturing method of it |
| CN1792247A (en) * | 2005-12-27 | 2006-06-28 | 武汉哈福科技有限公司 | Health-care food with functions of anti-senium and cosmetic |
| CN101062081A (en) * | 2006-04-25 | 2007-10-31 | 长春英联生物技术有限公司 | Dispersing tablets for reducing dizzy feeling and pressure and the preparing method thereof |
| CN102266407A (en) * | 2011-08-05 | 2011-12-07 | 李运伦 | Traditional Chinese medicinal composition for treating hypertension and preparation method thereof |
| CN103828981A (en) * | 2014-02-23 | 2014-06-04 | 廖少波 | Hemp tea |
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