CN104230955A - 一种对羟基青霉素v酸及其盐的制备方法 - Google Patents
一种对羟基青霉素v酸及其盐的制备方法 Download PDFInfo
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- CN104230955A CN104230955A CN201310238004.9A CN201310238004A CN104230955A CN 104230955 A CN104230955 A CN 104230955A CN 201310238004 A CN201310238004 A CN 201310238004A CN 104230955 A CN104230955 A CN 104230955A
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- penicillin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/60—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
- C07D499/12—Acylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310238004.9A CN104230955B (zh) | 2013-06-17 | 2013-06-17 | 一种对羟基青霉素v酸及其盐的制备方法 |
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CN201310238004.9A CN104230955B (zh) | 2013-06-17 | 2013-06-17 | 一种对羟基青霉素v酸及其盐的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104230955A true CN104230955A (zh) | 2014-12-24 |
CN104230955B CN104230955B (zh) | 2016-06-22 |
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CN201310238004.9A Active CN104230955B (zh) | 2013-06-17 | 2013-06-17 | 一种对羟基青霉素v酸及其盐的制备方法 |
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CN (1) | CN104230955B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111272916A (zh) * | 2020-03-30 | 2020-06-12 | 河北华北制药华恒药业有限公司 | 一种青霉素v酸含量的检测方法 |
CN115894522A (zh) * | 2022-12-30 | 2023-04-04 | 海南医学院 | 一种含三氮唑青霉素分子的合成方法及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0523585A2 (en) * | 1991-07-15 | 1993-01-20 | BIOCHEMIE Gesellschaft m.b.H. | Improvements in or relating to beta lactam production |
CN1982315A (zh) * | 2005-12-14 | 2007-06-20 | 陈舒明 | 一种合成头孢克洛的方法 |
CN102161667A (zh) * | 2011-05-05 | 2011-08-24 | 苏州二叶制药有限公司 | 磺苄西林钠及注射用磺苄西林钠 |
CN102268016A (zh) * | 2011-03-28 | 2011-12-07 | 哈药集团制药总厂 | 一种阿莫西林钠的制备方法 |
CN103319502A (zh) * | 2013-04-24 | 2013-09-25 | 济南康和医药科技有限公司 | 一种磺苄西林钠的制备方法 |
-
2013
- 2013-06-17 CN CN201310238004.9A patent/CN104230955B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0523585A2 (en) * | 1991-07-15 | 1993-01-20 | BIOCHEMIE Gesellschaft m.b.H. | Improvements in or relating to beta lactam production |
CN1982315A (zh) * | 2005-12-14 | 2007-06-20 | 陈舒明 | 一种合成头孢克洛的方法 |
CN102268016A (zh) * | 2011-03-28 | 2011-12-07 | 哈药集团制药总厂 | 一种阿莫西林钠的制备方法 |
CN102161667A (zh) * | 2011-05-05 | 2011-08-24 | 苏州二叶制药有限公司 | 磺苄西林钠及注射用磺苄西林钠 |
CN103319502A (zh) * | 2013-04-24 | 2013-09-25 | 济南康和医药科技有限公司 | 一种磺苄西林钠的制备方法 |
Non-Patent Citations (1)
Title |
---|
刘长鹰 等: ""一种头孢丙烯一水合物的制备方法"", 《现代化工》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111272916A (zh) * | 2020-03-30 | 2020-06-12 | 河北华北制药华恒药业有限公司 | 一种青霉素v酸含量的检测方法 |
CN115894522A (zh) * | 2022-12-30 | 2023-04-04 | 海南医学院 | 一种含三氮唑青霉素分子的合成方法及其应用 |
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CN104230955B (zh) | 2016-06-22 |
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Inventor after: Zhu Xiuliang Inventor after: Jia Bo Inventor after: Qiu Zhaolai Inventor after: Gu Mingxia Inventor after: Liu Heqin Inventor after: Hu Junping Inventor after: Feng Yubin Inventor after: Lu Xiaohan Inventor after: Zhu Shiqing Inventor after: Wang Yajuan Inventor after: Zhang Lirong Inventor after: Guo Dong Inventor before: Zhu Xiuliang Inventor before: Gu Mingxia Inventor before: Liu Heqin Inventor before: Hu Junping Inventor before: Feng Yubin Inventor before: Lu Xiaohan Inventor before: Zhu Shiqing Inventor before: Wang Yajuan Inventor before: Zhang Lirong Inventor before: Guo Dong |
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