CN104225265B - A kind of Traditional Chinese medicine composition for relieving asthenopia - Google Patents
A kind of Traditional Chinese medicine composition for relieving asthenopia Download PDFInfo
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Abstract
The present invention relates to a kind of Traditional Chinese medicine composition for relieving asthenopia, the active principle of this composition is made up of the fruit of Chinese wolfberry or its extract, the stem of noble dendrobium or its extract, chrysanthemum or its extract and the fruit of Chinese magnoliavine or its extract.The Chinese medicine composition can alleviate asthenopia, the beneficial effect that the Chinese medicine composition is acted on human body be single dose it is incomparable.The simple production process of the medicine, be easy to take, it is evident in efficacy, be a kind of preferable to improve the Chinese medicine composition of sleep quality.
Description
Technical field
The invention belongs to the field of Chinese medicines, a kind of Traditional Chinese medicine composition for relieving asthenopia is specifically related to.
Background technology
Asthenopia refers to be engaged near work or study, due to the eye fatigue excessively produced using eyes.This
Disease is often sent out in being engaged in closely fine-limit work, computer work, or in the environment of lighting condition not good (light is excessively bright/excessively dark)
Study works, and with ametropia and physical decline the people such as myopia, long sight, old light.In addition, increase with the age,
Worn with age, liver-kidney deficiency, qi and blood be smooth and a large amount of free radical surpluses etc. in vivo, and asthenopia also occurs.Asthenopia
Symptom has dry and astringent kopiopia, eye, foreign body sensation, eyelid sense of heaviness, blurred vision, photophobia to shed tears, eye distending pain and eye hyperemia etc., sternly
Severe one is it may also occur that headache, dizzy, nauseous, One's spirits are drooping, absent minded, decrease of memory and poor appetite etc. are complete
Body syndrome, small number of patients may occur in which diplopia, stereoscopic vision dysfunction, intraocular pressure rise, corneal injury etc., and teenager can be with
There is myopia or deepen myopic degree.There are glaucoma, eye surface or anterior ocular segment disease patient also to trigger because of the fatigue of eye
Or aggravate original illness in eye.
At present treatment asthenopia medicine in, in, western drug have, but clinical observation find effect be not to manage very much
Think, e.g., most of has been short-term booster action, it is impossible to thoroughly treatment.
The content of the invention
The purpose of the present invention is to provide a kind of Chinese medicine composition for above-mentioned technical problem, and the Chinese medicine composition is with the fruit of Chinese wolfberry
Or its extract, the stem of noble dendrobium or its extract, chrysanthemum or its extract and the fruit of Chinese magnoliavine or its extract are active ingredient, the Chinese medicine group
Compound can alleviate asthenopia by the synergy between active ingredient.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of Traditional Chinese medicine composition for relieving asthenopia, the Chinese medicine composition using the fruit of Chinese wolfberry, the stem of noble dendrobium, chrysanthemum and the fruit of Chinese magnoliavine as
Active ingredient, and constituted according to following portions by weight：1-95 parts of the fruit of Chinese wolfberry, 1-85 parts of the stem of noble dendrobium, 1-80 parts of chrysanthemum and fruit of Chinese magnoliavine 1-
80 parts；It is preferred that the fruit of Chinese wolfberry in the active ingredient of described Traditional Chinese medicine composition for relieving asthenopia, the stem of noble dendrobium, chrysanthemum and the fruit of Chinese magnoliavine
Parts by weight are followed successively by 3-85 parts, 2-70 parts, 3-75 parts and 2-75 parts；Traditional Chinese medicine for relieving vision fatigue described in further preferably
The fruit of Chinese wolfberry, the stem of noble dendrobium, chrysanthemum and the parts by weight of the fruit of Chinese magnoliavine are followed successively by 45-65 parts, 5-15 parts, 5-15 in the active ingredient of composition
Part and 15-25 parts；The fruit of Chinese wolfberry, the stem of noble dendrobium, chrysanthemum in the active ingredient of most preferably described Traditional Chinese medicine composition for relieving asthenopia
60 parts, 10 parts, 10 parts and 20 parts are followed successively by with the parts by weight of the fruit of Chinese magnoliavine.
A kind of Traditional Chinese medicine composition for relieving asthenopia, said composition can also be any one of following combination：
The active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, the 1-85 parts of stems of noble dendrobium, 1-80 parts of chrysanthemums and
The 1-80 portions of fruit ofs Chinese magnoliavine；Or the active ingredient of the Chinese medicine composition is 1-95 parts of the fruit of Chinese wolfberry, 1-85 parts of Herba Dendrobii extracts, 1-80 parts
Chrysanthemum and the 1-80 portions of fruit ofs Chinese magnoliavine；Or the active ingredient of the Chinese medicine composition is 1-95 parts of the fruit of Chinese wolfberry, 1-85 parts of stems of noble dendrobium, 1-80 parts
Chrysanthemum extract and the 1-80 portions of fruit ofs Chinese magnoliavine；Or the active ingredient of the Chinese medicine composition is 1-95 parts of the fruit of Chinese wolfberry, 1-85 parts of stems of noble dendrobium,
1-80 parts of chrysanthemums and 1-80 parts of Schisandra chinens P.Es；
Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-85 parts of Herba Dendrobii extracts, 1-80
Part chrysanthemum and 1-80 parts；Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-85 parts of stems of noble dendrobium, 1-80
Part chrysanthemum extract and 1-80 parts；Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-85 parts of stones
Dry measure used in former times, 1-80 part chrysanthemum and 1-80 parts of Schisandra chinens P.Es；Or the active ingredient of the Chinese medicine composition for 1-95 parts the fruit of Chinese wolfberry, 1-
85 parts of Herba Dendrobii extracts, 1-80 parts of chrysanthemum extracts and the 1-80 portions of fruit ofs Chinese magnoliavine；Or the active ingredient of the Chinese medicine composition is 1-95
The fruit of Chinese wolfberry, 1-85 parts of Herba Dendrobii extracts, 1-80 parts of chrysanthemums and 1-80 parts of Schisandra chinens P.Es of part；Or the Chinese medicine composition has
Imitate the fruit of Chinese wolfberry, the 1-85 parts of stems of noble dendrobium, 1-80 parts of chrysanthemum extracts and 1-80 parts of Schisandra chinens P.Es that composition is 1-95 parts；
Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-85 parts of Herba Dendrobii extracts, 1-80
Part chrysanthemum extract and the 1-80 portions of fruit ofs Chinese magnoliavine；Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-
85 parts of Herba Dendrobii extracts, 1-80 parts of chrysanthemums and 1-80 parts of Schisandra chinens P.Es；Or the active ingredient of the Chinese medicine composition is 1-95
The fruit of Chinese wolfberry, 1-85 parts of Herba Dendrobii extracts, 1-80 parts of chrysanthemum extracts and 1-80 parts of Schisandra chinens P.Es of part；
Or the active ingredient of the Chinese medicine composition for 1-95 parts Fructus lycii P.E, 1-85 parts of Herba Dendrobii extracts, 1-80
Part chrysanthemum extract and 1-80 parts of Schisandra chinens P.Es.
It is preferred that in the active ingredient of the above-mentioned Chinese medicine composition containing extract, the fruit of Chinese wolfberry or its extract, the stem of noble dendrobium or its
The parts by weight of extract, chrysanthemum or its extract and the fruit of Chinese magnoliavine or its extract be followed successively by 3-85 parts, 2-70 parts, 3-75 parts and
2-75 parts.
Above-mentioned Fructus lycii P.E is the extract of fruit of Chinese wolfberry water or organic solvent miscible with water；Herba Dendrobii extract is stone
The extract of dry measure used in former times water or organic solvent miscible with water；Chrysanthemum extract is the extraction of chrysanthemum water or organic solvent miscible with water
Thing；Schisandra chinens P.E is the extract of fruit of Chinese magnoliavine water or organic solvent miscible with water.
Water extract described in technical solution of the present invention is that component carried out into dissolving extraction using water as solvent, concentration and
The extract of formation；The extract of organic solvent miscible with water described in technical solution of the present invention is with water and organic by component
The mixture of solvent is that solvent carries out dissolving extraction, the extract of organic solvent miscible with water formed by concentration.
Above-mentioned organic solvent miscible with water is any one in methanol, ethanol, acetone.
It is above-mentioned obtain extracting method that extract used for decoct extraction, refluxing extraction, soak extraction, ultrasonic extraction or
Any one or a few in seepage pressure effects.
After the extract mixing of Chinese medicine composition or composition described in technical solution of the present invention, add pharmacy and be subjected to
Auxiliary material, clinically-acceptable formulation is made；Described formulation is preparation, Tabules or the capsule formulation of peroral dosage form.
Traditional Chinese medicine composition for relieving asthenopia described in technical solution of the present invention is preparing improvement and is slowing down the blurring of image
Purposes in health medicine.
The fruit of Chinese wolfberry described in technical solution of the present invention is the ripening fruits of matrimony vine of solanaceae plant or lycium barbarum.Described Chinese holly
Matrimony vine includes the either fruit of Chinese wolfberry growth course of fruit of Chinese wolfberry fine powder after Fructus lycii P.E, ground crushing after processing is refined
In various forms.
The stem of noble dendrobium involved by technical solution of the present invention is orchid family Dendrobium, and property slightly sweet flavor is micro- salty, trembles with fear, returns stomach, kidney, lung
Through.Reinforcing stomach reg fluid, nourishing Yin and clearing heat.For impairment of yin body fluid deficiency, dry polydipsia, deficiency of food is retched, after being ill abnormal heat, and mesh is secretly failed to understand.Described
The stem of noble dendrobium includes the dendrobe powder after grinding, other processing for obtaining the Herba Dendrobii extract either stem of noble dendrobium is processed by various techniques
Form.
Chrysanthemum involved by technical solution of the present invention is the perennial herb of composite family, Chrysanthemum in Plant Taxonomy
Plant.Described chrysanthemum includes the chrysanthemum powder after grinding, chrysanthemum extract either chrysanthemum is obtained by the processing of various techniques
Other colored processing forms.
The fruit of Chinese magnoliavine that the present invention relates to is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.This
The fruit of Chinese magnoliavine in invention includes the fruit of Chinese magnoliavine fine powder after grinding, Schisandra chinens P.E is obtained by the processing of various techniques or
It is other processing forms of the fruit of Chinese magnoliavine.
The definition of " collaboration is improved " can be understood as after several medicinal material combinations in the present invention, and its drug effect is relative to exclusive use
When raising；Drug effect is more lasting；Composition produces unexpected effect in new preventing and treating or healthcare field.
Inventor is found by experiment that composition of the invention has the function of alleviating asthenopia.These single doses pass through
After a certain proportion of composition to human body act on beneficial effect be single dose it is incomparable.
The composition of the present invention, can directly pulverize or by this area conventional extraction techniques such as water extraction and alcohol precipitation method or
The Hydrolysis kinetics of ethanol extract from water precipitation as the composition for the treatment of active component.The active component can with it is pharmaceutically acceptable
Carrier or excipient composition various pharmaceutical formulations are made, be such as in how granular tablet, granule, capsule, or oral liquid etc..
According to needs are used, composition of the invention can also be processed into sustained release preparation or quick releasing formulation.Wherein described pharmacy can connect
The carrier or excipient received are selected according to different formulations.These carriers used or excipient are for the common of pharmaceutical field
Technical staff may decide that.
The preparation method of oral liquid, can with but be not only limited to following one kind, after such as active principle is mixed, add water pan-fried
Boil, decoction liquor is filtered, obtain solution, resulting solution is concentrated to give medicinal extract, then gained medicinal extract is dissolved in medicinal extract weight 5-10
The concentration of times weight is in the ethanol water according to weight meter 95%, stirring mixing, quantitative separating obtains oral liquid formulations.
The preparation method of tablet is that active principle mixture sieves, and is crushed, fully in the auxiliary agent conventional with preparing tablet
After well mixed, 40-80 eye mesh screens are crossed, it is by compressing tablet that the direct machine of dry powder is tabletted.
The preparation technology of capsule preparations can be that active principle mixture sieves, in the auxiliary agent conventional with preparing tablet
Crush, be sufficiently mixed it is uniform after, cross 40-80 eye mesh screens, by granulation, dry, fill capsule after the process such as whole grain, polish, packaging, i.e.,
Obtain finished product.
Beneficial effects of the present invention：
In the present invention active ingredient of pharmaceutical composition be the fruit of Chinese wolfberry or its extract, the stem of noble dendrobium or its extract, chrysanthemum or
Its extract and the fruit of Chinese magnoliavine or its extract, the Chinese medicine composition can alleviate asthenopia, and the Chinese medicine composition is made to human body
Beneficial effect be single dose it is incomparable.The simple production process of the medicine, be easy to take, it is evident in efficacy, be a kind of
Preferable Traditional Chinese medicine composition for relieving asthenopia.
Embodiment
With reference to embodiment, the invention will be further described, but protection scope of the present invention not limited to this：
Embodiment 1
Bulk drug is constituted：Fruit of Chinese wolfberry water extract 70g, stem of noble dendrobium water extract 30g, chrysanthemum water extract 60g and the fruit of Chinese magnoliavine
Water extract 60g.
It is prepared by fruit of Chinese wolfberry water extract：The fruit of Chinese wolfberry is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add water inventory
For 8 times of total dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, filters to take filtrate, then add
Enter 6 times of water of total dose, small fire boils state after boiling, maintain liquid level higher than raw material Chinese medicine highly, decoct 2 hours, filtering merges two
Secondary filtrate, through being concentrated under reduced pressure, (pressure 0.06Mpa, 65 DEG C of temperature) to fruit of Chinese wolfberry dry cream is fruit of Chinese wolfberry water extract；
It is prepared by stem of noble dendrobium water extract：The stem of noble dendrobium is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, it is total to add water inventory
8 times of dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, filter to take filtrate, adds total
6 times of water of dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, and filtering merges filters twice
Liquid, through being concentrated under reduced pressure, (pressure 0.06Mpa, 65 DEG C of temperature) to stem of noble dendrobium dry cream is stem of noble dendrobium water extract；
It is prepared by chrysanthemum water extract：Chrysanthemum with water is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, it is total to add water inventory
8 times of dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, filter to take filtrate, adds total
6 times of water of dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, and filtering merges filters twice
Liquid, through being concentrated under reduced pressure, (pressure 0.06Mpa, 65 DEG C of temperature) to chrysanthemum dry cream is chrysanthemum water extract；
It is prepared by fruit of Chinese magnoliavine water extract：The fruit of Chinese magnoliavine is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add water inventory
For 8 times of total dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, filters to take filtrate, then add
Enter 6 times of water of total dose, small fire boils state after boiling, maintain liquid level higher than raw material Chinese medicine highly, decoct 2 hours, filtering merges two
Secondary filtrate, through being concentrated under reduced pressure, (pressure 0.06Mpa, 65 DEG C of temperature) to fruit of Chinese magnoliavine dry cream is fruit of Chinese magnoliavine water extract；
Finally fruit of Chinese wolfberry water extract 70g, stem of noble dendrobium water extract 30g, chrysanthemum water extract 60g and fruit of Chinese magnoliavine water are extracted
Thing 60g is mixed, and is dissolved in the concentration of 5-10 times of weight of water extract gross weight in the ethanol water according to weight meter 95%, to stir
Mixing is mixed, quantitative separating obtains oral liquid formulations.
Embodiment 2
Bulk drug is constituted：Fruit of Chinese wolfberry 70g, stem of noble dendrobium 30g, chrysanthemum 60g and fruit of Chinese magnoliavine 60g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted.
Embodiment 3
Bulk drug is constituted：Fruit of Chinese wolfberry ethanol extract 45g, stem of noble dendrobium ethanol extract 5g, chrysanthemum ethanol extract 5g and five
Taste ethanol extract 15g.
It is prepared by fruit of Chinese wolfberry ethanol extract：The fruit of Chinese wolfberry is used into 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3
Secondary, each 1-3 hours, extract solution is concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion of filtrate
Exchange resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then is used
40%~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Fructus lycii P.E.
It is prepared by stem of noble dendrobium ethanol extract：By the stem of noble dendrobium using 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time, often
Secondary 1-3 hours, extract solution is concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange tree of filtrate
Fat post, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%~
70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Herba Dendrobii extract.
It is prepared by chrysanthemum ethanol extract：By chrysanthemum using 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time, often
Secondary 1-3 hours, extract solution is concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange tree of filtrate
Fat post, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%~
70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains chrysanthemum extract.
It is prepared by schisandra chinensis ethyl hydrate extract：The fruit of Chinese magnoliavine is used into 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3
Secondary, each 1-3 hours, extract solution is concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion of filtrate
Exchange resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then is used
40%~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Schisandra chinens P.E.
By clever fruit of Chinese wolfberry ethanol extract 45g, stem of noble dendrobium ethanol extract 5g, chrysanthemum ethanol extract 5g and fruit of Chinese magnoliavine ethanol
Extract 15g is separately dried, and is ground into fine powder, is sieved, and is mixed, and granulation is tabletted.
Embodiment 4
Bulk drug is constituted：Fruit of Chinese wolfberry 45g, stem of noble dendrobium 5g, chrysanthemum 5g and fruit of Chinese magnoliavine 15g.Foregoing Chinese medicine is dried and crushed into
Fine powder, sieves, and mixes, and granulation is tabletted.
Embodiment 5
Bulk drug is constituted：Fructus lycii P.E 60g, stem of noble dendrobium 10g, chrysanthemum 10g and fruit of Chinese magnoliavine 20g.
The preparation of Fructus lycii P.E：By the fruit of Chinese wolfberry using 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time,
1-3 hours every time, extract solution was concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange of filtrate
Resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%
~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Fructus lycii P.E.
Foregoing Fructus lycii P.E 60g, stem of noble dendrobium 10g, chrysanthemum 10g and fruit of Chinese magnoliavine 20g are ground into fine powder, sieved, is mixed,
The magnesium stearate of gross weight 2% is added, loads capsule.
Embodiment 6
Bulk drug is constituted：Fruit of Chinese wolfberry 60g, stem of noble dendrobium 10g, chrysanthemum 10g and fruit of Chinese magnoliavine 20g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted.
Embodiment 7
Bulk drug is constituted：Fruit of Chinese wolfberry 65g, Herba Dendrobii extract 15g, chrysanthemum extract 15g and fruit of Chinese magnoliavine 25g.
It is prepared by Herba Dendrobii extract：By the stem of noble dendrobium using 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time, each 1-3
Hour, extract solution is concentrated under reduced pressure, centrifuges or filter, and takes clarified solution or filtrate；Clarified solution or the upper anion-exchange resin column of filtrate,
With 40%~70% ethanol elution, eluent is collected；Macroporous resin column on eluent, is first rinsed with water, then with 40%~70%
Ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Herba Dendrobii extract.
It is prepared by chrysanthemum extract：By chrysanthemum using 60% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time, each 1-3
Hour, extract solution is concentrated under reduced pressure, centrifuges or filter, and takes clarified solution or filtrate；Clarified solution or the upper anion-exchange resin column of filtrate,
With 40%~70% ethanol elution, eluent is collected；Macroporous resin column on eluent, is first rinsed with water, then with 40%~70%
Ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains chrysanthemum extract.
Fruit of Chinese wolfberry 65g, Herba Dendrobii extract 15g, chrysanthemum extract 15g and fruit of Chinese magnoliavine 25g are mixed and are broken into fine powder, is sieved,
The magnesium stearate of gross weight 2% is added, loads capsule.
Embodiment 8
Bulk drug is constituted：Fruit of Chinese wolfberry 65g, stem of noble dendrobium 15g, chrysanthemum 15g and fruit of Chinese magnoliavine 25g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted.
Embodiment 9
Bulk drug is constituted：Fructus lycii P.E 85g, Herba Dendrobii extract 70g, chrysanthemum extract 3g and fruit of Chinese magnoliavine 2g.
It is prepared by Fructus lycii P.E：The fruit of Chinese wolfberry is used into 10%~90% ethanol heating and refluxing extraction or ultrasonic extraction 1~3
Secondary, each 1-3 hours, extract solution is concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion of filtrate
Exchange resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then is used
40%~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Fructus lycii P.E.
It is prepared by Herba Dendrobii extract：By the stem of noble dendrobium using 10%~90% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time,
1-3 hours every time, extract solution was concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange of filtrate
Resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%
~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains Herba Dendrobii extract.
It is prepared by chrysanthemum extract：By chrysanthemum using 10%~90% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time,
1-3 hours every time, extract solution was concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange of filtrate
Resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%
~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains chrysanthemum extract.
Fructus lycii P.E 85g, Herba Dendrobii extract 70g, chrysanthemum extract 3g and fruit of Chinese magnoliavine 2g are dried and crushed into fine powder,
Sieving, is mixed, and granulation is tabletted.
Embodiment 10
Bulk drug is constituted：Fruit of Chinese wolfberry 85g, stem of noble dendrobium 70g, chrysanthemum 3g and fruit of Chinese magnoliavine 2g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted.
Embodiment 11
Bulk drug is constituted：Fruit of Chinese wolfberry 3g, stem of noble dendrobium 70g, chrysanthemum extract 75g and fruit of Chinese magnoliavine 2g.
It is prepared by chrysanthemum extract：By chrysanthemum using 10%~90% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time,
1-3 hours every time, extract solution was concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange of filtrate
Resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%
~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains chrysanthemum extract.
Fruit of Chinese wolfberry 3g, stem of noble dendrobium 70g, chrysanthemum extract 75g and fruit of Chinese magnoliavine 2g are mixed and are broken into fine powder, is sieved, gross weight is added
The magnesium stearate of amount 2%, loads capsule.
Embodiment 12
Bulk drug is constituted：Fruit of Chinese wolfberry 3g, stem of noble dendrobium 70g, chrysanthemum 75g and fruit of Chinese magnoliavine 2g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted.
Embodiment 13
Bulk drug is constituted：Fruit of Chinese wolfberry 3g, stem of noble dendrobium 2g, chrysanthemum extract 75g and Schisandra chinens P.E 75g.
It is prepared by chrysanthemum extract：By chrysanthemum using 10%~90% ethanol heating and refluxing extraction or ultrasonic extraction 1~3 time,
1-3 hours every time, extract solution was concentrated under reduced pressure, and centrifuges or filters, and takes clarified solution or filtrate；Clarified solution or the upper anion exchange of filtrate
Resin column, with 40%~70% ethanol elution, collects eluent；Macroporous resin column on eluent, is first rinsed with water, then with 40%
~70% ethanol elution, collects ethanol eluate；Eluent is concentrated under reduced pressure, and dries, obtains chrysanthemum extract.
It is prepared by fruit of Chinese magnoliavine water extract：The fruit of Chinese magnoliavine is soaked 40 minutes, the water surface is higher than raw material Chinese medicine, add water inventory
For 8 times of total dose, small fire boils state after boiling, maintains liquid level higher than raw material Chinese medicine highly, decocts 2 hours, filters to take filtrate, then add
Enter 6 times of water of total dose, small fire boils state after boiling, maintain liquid level higher than raw material Chinese medicine highly, decoct 2 hours, filtering merges two
Secondary filtrate, through being concentrated under reduced pressure, (pressure 0.06Mpa, 65 DEG C of temperature) to fruit of Chinese magnoliavine dry cream is fruit of Chinese magnoliavine water extract.
Fine powder is dried and crushed into after aforementioned component is mixed, is sieved, is mixed, granulation is tabletted.
Embodiment 14
Raw material is constituted：Fruit of Chinese wolfberry 3g, stem of noble dendrobium 2g, chrysanthemum 75g and fruit of Chinese magnoliavine 75g.
Foregoing Chinese medicine is dried and crushed into fine powder, sieved, is mixed, granulation is tabletted
Influence of the Chinese medicine composition of the present invention to SD rat breakup time of tear film is have studied below：
120 SD rats of 5~7 weeks are randomly divided into 4 groups, respectively low dose of Normal group, model control group, Chinese medicine
Amount group and Chinese medicine high dose group.Amino is respectively adopted in the mouse of model control group, Chinese medicine low dose group and Chinese medicine high dose group
Ethyl formate is twilight-sleep, afterwards fixes mouse, pulls open eyelid, the pupil irradiation with cold light lamp just to mouse, and intensity of illumination is
4000Lx, the duration is 4h, repeats 2~5 days, the symptom of conjunctival congestion occurs to mouse.Now mouse dry eye model is set up
Success.
The mouse of Normal group is injected into distilled water daily, the mouse of model group injects distilled water, low dose of Chinese medicine daily
Amount group injects 20g/kg Chinese medicine composition (prepared by embodiment 3) daily, and the mouse of Chinese medicine high dose group injects 40g/kg daily
Chinese medicine composition (prepared by embodiment 3), this experiment administration time be 6 days.
After administration, the mouse of Normal group, model control group, Chinese medicine low dose group and Chinese medicine high dose group is being split
Observed under gap lamp, record its breakup time of tear film, experiment is using blind processing.
Influence of the Chinese medicine composition of the present invention of table 1 to mouse dry eyes
| Project | Breakup time of tear film (s) |
| Normal group | 9.2±0.9 |
| Model control group | 5.1±0.8 |
| Chinese medicine low dose group | 7.9±0.8 |
| Chinese medicine high dose group | 8.2±0.3 |
From table 1 it follows that the mouse of Normal group and the mouse of model control group have in breakup time of tear film
Larger difference, you can perception model is successfully established, from the point of view of the contrast of model group and Chinese medicine group, using in technical solution of the present invention
After drug composition is treated to mouse, the breakup time of tear film of mouse is obviously prolonged, i.e. dry eyes of the technical solution of the present invention to mouse
Possesses certain curative effect.
Clinical observation
1) experimental subjects selected by is all from Yancheng hospital, and the selected objects are provided with following condition：
1) simple eye or binocular vision is respectively less than 5 through logarithmic visual acuity chart inspection；
2) computerized optometry, diopter is -0.5~-3D；
3) amblyopia patient, systemic disease and hereditary myopia are excluded.
2) method of administration and the course for the treatment of：
The oral embodiment of the present invention 1~14 is compareed：The fruit of Chinese wolfberry；Chrysanthemum；The fruit of Chinese wolfberry+chrysanthemum；The fruit of Chinese wolfberry+the stem of noble dendrobium+fruit of Chinese magnoliavine
(1：1：1)；The fruit of Chinese wolfberry+the stem of noble dendrobium+chrysanthemum (1：1：1)
The each 2.5g of oral liquid, 3 times a day；Capsule 3 every time, 3 times a day；The each 3g of tablet, 3 times a day.
With one month for a course for the treatment of, it treats 3 courses for the treatment of.
3) detection method
Selected experimental subjects carries out the inspection such as eyesight, slit-lamp, ophthalmoscope, quick mydriasis computerized optometry, blood before taking
Conventional, routine urianlysis.Take after 3 courses for the treatment of terminate, repeat above-mentioned every check.Respectively to the Syndrome Scale of eye.
4) criterion of asthenopia symptom
Cure：There is integration before taking, without integration after taking；
Improve：There is integration before and after taking, but integration is more than 1 with the integrated value after taking before taking；
It is invalid：Identical or after taking integration is more than the integration before taking before and after taking integration.
Table 2：Visual fatigue symptom criterion (sxemiquantitative integration method)
Wherein, " random thoughts " refer to 1~2 time/2 days, and " when have " refers to 1~3 times/day, and " frequent " refers to >=3 times/day.
5) therapeutic evaluation
Table 3：Clinical observation of the prescription of the present invention to asthenopia symptom
| Composition | Number of cases | Cure | Improve | It is invalid | Total improvement rate |
| Embodiment 1 | 66 | 30 | 28 | 8 | 87.9% |
| Embodiment 2 | 72 | 32 | 30 | 10 | 86.1% |
| Embodiment 3 | 68 | 32 | 28 | 8 | 88.2% |
| Embodiment 4 | 86 | 42 | 32 | 12 | 86.0% |
| Embodiment 5 | 82 | 38 | 30 | 14 | 83.0% |
| Embodiment 6 | 82 | 40 | 29 | 13 | 84.1% |
| Embodiment 7 | 78 | 43 | 24 | 11 | 85.9% |
| Embodiment 8 | 92 | 49 | 29 | 14 | 84.8% |
| Embodiment 9 | 98 | 47 | 35 | 16 | 83.7% |
| Embodiment 10 | 74 | 38 | 23 | 13 | 82.4% |
| Embodiment 11 | 69 | 38 | 18 | 13 | 81.2% |
| Embodiment 12 | 86 | 39 | 31 | 16 | 81.4% |
| Embodiment 13 | 93 | 43 | 35 | 15 | 83.9% |
| Embodiment 14 | 97 | 43 | 38 | 16 | 82.7% |
| The fruit of Chinese wolfberry | 40 | 15 | 10 | 15 | 62.5% |
| Chrysanthemum | 36 | 11 | 10 | 15 | 58.3% |
| The fruit of Chinese wolfberry+chrysanthemum | 42 | 18 | 10 | 14 | 66.7% |
| The fruit of Chinese wolfberry+the stem of noble dendrobium+fruit of Chinese magnoliavine | 46 | 20 | 13 | 13 | 71.7% |
| The fruit of Chinese wolfberry+the stem of noble dendrobium+chrysanthemum | 38 | 13 | 14 | 11 | 71.1% |
From table 3 it is observed that the Chinese medicine composition of technical solution of the present invention is swollen to eye, ophthalmodynia, blurred vision and eye are dry
Puckery have a preferable curative effect, and the beneficial effect that acts on human body of the Chinese medicine composition be single dose it is incomparable.
Claims (8)
1. a kind of Traditional Chinese medicine composition for relieving asthenopia, it is characterised in that：The Chinese medicine composition is with the fruit of Chinese wolfberry, the stem of noble dendrobium, chrysanthemum
It is active ingredient with the fruit of Chinese magnoliavine, and is constituted according to following portions by weight raw material：45-65 parts of the fruit of Chinese wolfberry, 5-15 parts of the stem of noble dendrobium, chrysanthemum 5-
15 parts and 15-25 parts of the fruit of Chinese magnoliavine.
2. Traditional Chinese medicine composition for relieving asthenopia according to claim 1, it is characterised in that：The fruit of Chinese wolfberry, the stem of noble dendrobium, chrysanthemum
60 parts, 10 parts, 10 parts and 20 parts are followed successively by with the parts by weight of the fruit of Chinese magnoliavine.
3. the Traditional Chinese medicine composition for relieving asthenopia described in a kind of claim 1 or 2, it is characterised in that：The fruit of Chinese wolfberry, the stem of noble dendrobium,
At least one of chrysanthemum and the fruit of Chinese magnoliavine are in the form of its extract as active ingredient.
4. Traditional Chinese medicine composition for relieving asthenopia according to claim 3, it is characterised in that：Fructus lycii P.E is Chinese holly
The extract of matrimony vine water or organic solvent miscible with water；Herba Dendrobii extract is carrying for stem of noble dendrobium water or organic solvent miscible with water
Take thing；Chrysanthemum extract is the extract of chrysanthemum water or organic solvent miscible with water；Schisandra chinens P.E be fruit of Chinese magnoliavine water or
The extract of organic solvent miscible with water.
5. Traditional Chinese medicine composition for relieving asthenopia according to claim 4, it is characterised in that：Described is miscible with water
Organic solvent is any one in methanol, ethanol, acetone.
6. Traditional Chinese medicine composition for relieving asthenopia according to claim 4, it is characterised in that：Extracting method carries for decoction
Take, any one or a few in refluxing extraction, soak extraction, ultrasonic extraction or seepage pressure effects.
7. the Traditional Chinese medicine composition for relieving asthenopia according to claim any one of 1-3, it is characterised in that：Described group
After the extract mixing of compound or composition, pharmaceutically acceptable auxiliary material is added, clinically-acceptable formulation is made；Described
Formulation is the preparation of peroral dosage form.
8. the Traditional Chinese medicine composition for relieving asthenopia described in claim any one of 1-3 is preparing improvement and is slowing down the blurring of image
Purposes in health medicine.
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| CN106581291A (en) * | 2016-06-24 | 2017-04-26 | 辽宁省中药研究所 | Tea bag preparation for preventing and/or treating asthenopia and preparing method thereof |
| CN106581290A (en) * | 2016-06-24 | 2017-04-26 | 辽宁省中药研究所 | Chinese magnoliavine fruit decoction for preventing and/or treating vision fatigue and preparation method of decoction |
| CN108567910A (en) * | 2017-03-13 | 2018-09-25 | 陕西新视明医药生物科技有限公司 | The Chinese medicine composition of eye strain is alleviated in a kind of external application |
| CN107096016B (en) * | 2017-06-26 | 2021-04-06 | 蒋广伟 | Dropping liquid for relieving asthenopia |
| CN108338297A (en) * | 2018-01-31 | 2018-07-31 | 佳木斯大学 | A kind of mind-tranquilizing brain-strengthening health beverages and preparation method thereof |
| CN108686037A (en) * | 2018-08-08 | 2018-10-23 | 北京硒哥硒生物科技有限公司 | A kind of pharmaceutical composition of protection eyesight |
| CN116369416A (en) * | 2023-05-06 | 2023-07-04 | 浙江工业大学 | Dendrobium officinale gel soft sweet with function of relieving visual fatigue and preparation method thereof |
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