CN104208533A - Drug for treating pustular psoriasis - Google Patents

Abstract

The invention discloses a drug for treating pustular psoriasis. Capsule products are prepared through uniformly mixing the following raw pharmaceutical materials in parts by weight: 28-32g of astragalus root, 28-32g of raw coix seed, 10-14g of phellodendron bark, 28-32g of salvia miltiorrhiza, 28-32g of radix scrophulariae, 8-12g of cortex moutan, 28-32g of rhizoma smilacis glabrae, 8-12g of cassia twig, 6-10g of frankincense, 6-10g of gum myrrh and 8-12g of bupleurum root, then, extracting active ingredients from the traditional Chinese medicines, adding water to decoct for 3 times, decocting for 0.5-1 hour every time, combining decoctions of the three times, filtrating, concentrating into thick paste, of which the relative density at the temperature of 60 DEG C is 1.25-1.3, drying at the temperature of 50-60 DEG C, then, crushing into medicine powder, of which the size is 100 meshes, encapsulating, sterilizing and disinfecting. The weight of the product per capsule is 1.5g. The drug disclosed by the invention has the effects of clearing heat and draining dampness, expelling pus and drawing toxin and lowering turbidity and removing spots, and has the characteristics of fast treatment effect, short treatment course and no side effect during the treatment of pustular psoriasis; after the drug disclosed by the invention is taken orally by 80 patients for 3 treatment courses, 66 patients are cured, the conditions of 10 patients are improved, the treatment for 4 patients is invalid, the effective rate is 95%, and the cure rate is 83%. During medication, no adverse reaction is caused.

Description

A kind of medicine for the treatment of psoriasis pustulosa

Technical field

The present invention relates to one and treat psoriatic medicine, specifically, is a kind of medicine for the treatment of psoriasis pustulosa.

Background technology

Pustular type psoriasis is divided into two types; a kind of is the general hair style of whole body; more rare; etiology unknown; fall ill hurried, the high heat of sustainable a few days tension and relaxation, companion's general malaise, weak and arthroncus; erythema occurs suddenly general send out shallow the aseptic pimple of yellow-white; syringe needle, to foxtail millet grain size, is just small pieces, is fused in " pus lake " later; in several weeks can diffusivity distribution whole body; often there is intertrigo, incrustation in pleat portion, the erythema around pustule is often expanded and is fused into the change of erythroderma sample, the visible pimple of mucosa; lingual surface often has comparatively zanjon stricture of vagina, claims fluted tongue; That the erythra of limit office type is limited to palm and a sufficient sole of the foot, symmetrical.Metacarpus skin lesion onset is in large hypothenar, and later skin lesion gradually expands to the centre of the palm, the back of the hand and finger, and sufficient sole of the foot portion is apt to occur in the middle part of the sole of the foot and inner side, and erythra is that in symmetry erythema, faint yellow syringe needle, to the large pimple of foxtail millet grain, not easily breaks in groups.

Psoriasis pustulosa is also more rare than Folium Styracis Suberifoliae psoriasis pustulosa, and its state of an illness is more serious, and treatment difficulty is also larger.At present, although about the clinical experience to this disease, therapeutic effect report a lot, the scheme that really can reach specially good effect is very not many, and this sick most thorny issue still can recur after treating exactly again, this problem also achieving no breakthrough property progress at present.

Summary of the invention

The invention solves the deficiencies in the prior art, provide the medicine of a kind of short treating period, treatment psoriasis pustulosa evident in efficacy.

Medicine of the present invention is prepared by the crude drug of following ratio of weight and number:

Radix Astragali 28-32 Semen Coicis 28-32 Cortex Phellodendri 10-14 Radix Salviae Miltiorrhizae 28-32

Radix Scrophulariae 28-32 Cortex Moutan 8-12 Rhizoma Smilacis Glabrae 28-32 Ramulus Cinnamomi 8-12

Olibanum 6-10 Myrrha 6-10 Radix Bupleuri 8-12.

The preferred weight mark of described crude drug is:

The Radix Astragali 30 Semen Coicis 30 Cortex Phellodendri 12 Radix Salviae Miltiorrhizae 30

Radix Scrophulariae 30 Cortex Moutan 10 Rhizoma Smilacis Glabrae 30 Ramulus Cinnamomi 10

Olibanum 8 Myrrha 8 Radix Bupleuri 10.

By above-mentioned various Chinese medicine according to after described ratio of weight and number mix homogeneously, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 object medicated powder, in incapsulating, sterilization obtains capsule product.

Chinese traditional treatment psoriasis pustulosa mechanism blood enriching and dryness moistening, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling.The Radix Astragali, Semen Coicis, Rhizoma Smilacis Glabrae QI invigorating dampness removing poison holding in prescription of the present invention, the saturating pus of heat clearing away the turbid descending is monarch; Cortex Phellodendri, Cortex Moutan, Radix Scrophulariae, Radix Salviae Miltiorrhizae removing heat from blood and promoting blood circulation clots absorbing are minister; Olibanum, Myrrha benefiting qi for promoting granulation, detoxification is except pus is for helping; Ramulus Cinnamomi, Radix Bupleuri regulate the flow of vital energy tonifying YANG for making.All medicines share and gather clearing away heat-damp and promoting diuresis altogether, poison holding except pus, the merit of the turbid descending speckle removing.Prescription of the present invention carrys out compatibility for the mechanism of Chinese traditional treatment psoriasis pustulosa, has unique curative effect to treatment psoriasis pustulosa.

For investigating the clinical efficacy of Drug therapy psoriasis pustulosa of the present invention further, 80 routine psoriasis pustulosa patients are selected to carry out clinical observation on the therapeutic effect.

Clinical data:

Select outpatient 80 example, wherein man 50 example, female 30 example, the course of disease 1 year ~ 3 years, 16 ~ 65 years old age.

Diagnostic criteria

Can diagnosis be made according to morbidity history, clinical symptoms, medication treatment history and lab testing:

Limitation psoriasis pustulosa characteristics of incidence:

1, be limited to the palm sole of the foot, there is most faint yellow syringe needle to the large pimple of foxtail millet grain, substrate flushing in be everlasting large hypothenar or sufficient sole of the foot portion in batch;

2, about break through 1 ~ 2 week pustule, incrustation, desquamation.Under squama, there is pimple again later, time light time heavy;

3, consciously to itch or pain.Sometimes also can have low grade fever or general malaise, fingernail is often involved, and in muddy plump, has ridge shape to swell;

4, other positions of patient body Chang Kejian has psoriatic lesion;

5, some patient first sends out in the palm sole of the foot, after repeatedly recurrent exerbation, change a general property person into.

The characteristics of incidence of generalized pustular psoriasis:

1, mostly be acute onset, can within a few days to several weeks pustule general whole body, first have the potential pimple of intensive needle point size, be fused into pus lake very soon;

2, whole body everywhere all can dermexanthesis, but to bend side with pleated portions and extremity be common.Sometimes can there is pimple in nail matrix, and deck is plump muddy;

3, often with high heat, arthralgia and general malaise, routine blood test chemically examines visible Cervical mucus;

4, after pustule dries up, bits of peeling immediately, immediately play new pimple again after scurf comes off; The course of disease again and again can reach the several months or more of a specified duration.

When diagnosing, both differences mainly a general property person with General Symptomies such as heating, general malaises, easy secondary erythroderma etc., and limitation person does not generally have.

Therapeutic Method

Oral medicine of the present invention, one time 5, one day twice, sooner or later each once.

Criterion of therapeutical effect

Clinical recovery: pustule skin lesion all disappears or disappear area >90%;

Effective: pustule skin lesion disappears area 61% ~ 90%;

Progressive: pustule skin lesion disappears area 21% ~ 60%;

Invalid: pustule skin lesion disappears area≤20%.

Therapeutic outcome

80 routine patient's oral administration Drug therapy 3 of the present invention course for the treatment of, cure 66 examples, 10 examples that take a turn for the better, invalid 4 examples, effective percentage 95%, cure rate 83%.Period in a medicine, has no adverse reaction.

Model case

Case one: Bai, female, 56 years old, troop in the main cause both hands palm and left side sole and several erythema basis, foxtail millet grain size, the milky pustule of shallow table, cover dirty Lycoperdon polymorphum Vitt squama crust, companion's pruritus June is remaining went to a doctor on January 25th, 2013.There is the erythema of nail cover size in left foot place before 1 year in patient, covers Lycoperdon polymorphum Vitt squama, companion's pruritus.Go to a doctor in community clinic, give compound fluocinonide tincture one day twice, external " Beijing opera gold " a day twice, external, is interrupted to use being total to more than half a year, bad during state of an illness fashion, poor effect, otherwise foot's skin lesion expanded range, increase to coin size by nail cover size.The both hands palm is new plays portion's egg size erythema, pustule.Several pieces erythema of finger section nail cover size, pustule.Pruritis increases the weight of, modern to our hospital.Have a medical check-up: body temperature 37.2 DEG C, normal face.The no positive sign of cardiopulmonary abdomen.Skin training checks: the swelling of left foot coin large skin lesion flushing, and the shallow table milky pustule trooped in erythema place, covers Lycoperdon polymorphum Vitt scurf; Both hands palm coin great red spot, and intensive milky pustule, finger section nail cover size erythema pustule.Cover dirty Lycoperdon polymorphum Vitt squama crust.Normally, skin elasticity is good, without edema, without subcutaneous nodule, without subcutaneous hemorrhage point, without cicatrix, without lump, without spider angioma and liver palm for both arms and lower limb color and luster.Be diagnosed as palmar and plantar pustula psoriasis.Give psoriasis pustulosa medicine, treatment August after deflorescence, clinical recovery.

Case two: Lee so-and-so, female, 23 years old, main cause right hand metacarpus erythema pustule, squama crust, companion examined more than pain February.After patient's cause in February mop galling palm, the erythema companion squama of nail cover size is played in the centre of the palm, conscious mild pain.Originally do not give and comprehending, personal Piyanping ointment, effect does not show.Otherwise skin lesion expands, and increase to coin size by nail cover size, erythema plays pustule, pain, pruritis increase the weight of.Modern to our hospital.Have a medical check-up: body temperature 37.2 DEG C, normal face.The no positive sign of cardiopulmonary abdomen.Skin training checks: right centre of the palm coin great red spot.The swelling of skin lesion flushing, erythema place is dispersed in several shallow table milky pustule, covers Lycoperdon polymorphum Vitt scurf.Arm color and luster is normal, and skin elasticity is good, without edema, without subcutaneous nodule, without subcutaneous hemorrhage point.Be diagnosed as palmar and plantar pustula psoriasis.Take psoriasis pustulosa medicine March, Schultz-Charlton, clinical recovery.

Case three: Lee so-and-so, man, 70 years old, main cause both hands foot pustule squama was chapped 20 years, increases the weight of May and examines.Patient takes traditional Chinese medicine in 20 years half sole sole of the foot erythema pustule in Xinzhou City institute of traditional Chinese medicine healing.Recurred before 10 years in Taiyuan and the treatment of Xinzhou Army Hospital, effect does not show, skin lesion recurrent exerbation.To our hospital on August 20th, 2011.Have a medical check-up: body temperature 37.2 DEG C, face dolorosa.The no positive sign of cardiopulmonary abdomen.Skin training inspection: the erythema of the both hands palm, the large stretch of flushing swelling in toes portion, erythema basis is played the intensive large pimple of shallow table milky foxtail millet grain and dirty taupe squama crust companion chaps, pain.Finger and toe nail color grey matter is crisp thickly to be covered firmly, is abound with thimble sample pitting.Pus point under two thumb first.Both hands underarm and both legs swelling.Be diagnosed as palmar and plantar pustula psoriasis.Take psoriasis pustulosa medicine 13 months.Deflorescence, clinical recovery.

Case four: Xing so-and-so, man, 32 years old, sole erythema pustule on the left of main cause, squama crust, companion pruritus February is remaining went to a doctor on January 25th, 2013.There is the erythema of nail cover size before patient February without obvious inducement left foot place, cover Lycoperdon polymorphum Vitt squama, companion's pruritus.Go to a doctor in community clinic, give the external of compound fluocinonide tincture, poor effect, on the contrary foot's skin lesion expanded range, and increase to coin size by nail cover size, erythema plays pustule, pruritis increases the weight of.Modern to our hospital.Have a medical check-up: body temperature 37.2 DEG C, normal face.The no positive sign of cardiopulmonary abdomen.Skin training checks: left foot coin great red spot.The swelling of skin lesion flushing, the shallow table milky pustule trooped in erythema place, covers Lycoperdon polymorphum Vitt scurf.Lower limb color and luster is normal, and skin elasticity is good, without edema, without subcutaneous nodule, without subcutaneous hemorrhage point, without cicatrix, without lump, without spider angioma and liver palm.Be diagnosed as sufficient sole of the foot psoriasis pustulosa.Give psoriasis pustulosa medicine, treatment March after deflorescence, clinical recovery.

Case five: Zhang, female, 29 years old, the visible several erythema of sole and two lower limb place, pustule, erosion, desquamation on the left of main cause, conscious pruritus was remaining medical on January 25th, 2013 for January.There is the dried bark of coin size in left foot place before 1 year in patient, black, companion's pruritus.Go to a doctor in community clinic, give compound fluocinonide tincture one day twice, external " Beijing opera gold " one day twice, external, shares more than first quarter moon, bad during state of an illness fashion, poor effect, otherwise foot's skin lesion expanded range, erythema by coin size increase to palm size and the large pimple of foxtail millet grain, pruritis increases the weight of, modern to our hospital.Have a medical check-up: body temperature 37.2 DEG C, normal face.The no positive sign of cardiopulmonary abdomen.Skin training checks: heave Lycoperdon polymorphum Vitt scurf after the visible several erythema of left side sole and two lower limb place, erythema basis play the faint yellow pustule of foxtail millet grain size, part pustule dry crusts, two lower limb color and luster is normal, skin elasticity is good, without edema, without subcutaneous nodule, without subcutaneous hemorrhage point, without cicatrix, without lump, without spider angioma and liver palm.Be diagnosed as Pasfulosis palmaris et plantaris psoriasis.Give psoriasis pustulosa medicine, treatment August after deflorescence, clinical recovery.

Detailed description of the invention

Embodiment 1

Take removing impurity, after the Radix Astragali 28g cleaned up, Semen Coicis 28g, Cortex Phellodendri 10g, Radix Salviae Miltiorrhizae 28g, Radix Scrophulariae 28g, Cortex Moutan 8g, Rhizoma Smilacis Glabrae 28g, Ramulus Cinnamomi 8g, Olibanum 6g, Myrrha 6g, Radix Bupleuri 8g mix homogeneously, extract the active component of Chinese medicine, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 object medicated powder, in incapsulating, sterilization obtains capsule product.This product every is heavy 1.5 grams.

Using method: oral medicine of the present invention, one time 3, one day twice, sooner or later each once.

Embodiment 2

Take removing impurity, after the Radix Astragali 30g cleaned up, Semen Coicis 30g, Cortex Phellodendri 12g, Radix Salviae Miltiorrhizae 30g, Radix Scrophulariae 30g, Cortex Moutan 10g, Rhizoma Smilacis Glabrae 30g, Ramulus Cinnamomi 10g, Olibanum 8g, Myrrha 8g, Radix Bupleuri 10g mix homogeneously, extract the active component of Chinese medicine, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 object medicated powder, in incapsulating, sterilization obtains capsule product.This product every is heavy 1.5 grams.

Using method: oral medicine of the present invention, one time 3, one day twice, sooner or later each once.

Embodiment 3

Take removing impurity, after the Radix Astragali 32g cleaned up, Semen Coicis 32g, Cortex Phellodendri 14g, Radix Salviae Miltiorrhizae 32g, Radix Scrophulariae 32g, Cortex Moutan 12g, Rhizoma Smilacis Glabrae 32g, Ramulus Cinnamomi 12g, Olibanum 10g, Myrrha 10g, Radix Bupleuri 12g mix homogeneously, extract the active component of Chinese medicine, decoct with water 3 times, each 0.5 ~ 1 hour, merge 3 decocting liquids, filter, being condensed into 60 DEG C of relative densities is the thick paste of 1.25 ~ 1.3, after 50 ~ 60 DEG C of dryings, be crushed to 100 object medicated powder, in incapsulating, sterilization obtains capsule product.This product every is heavy 1.5 grams.

Using method: oral medicine of the present invention, one time 3, one day twice, sooner or later each once.

Claims (2)

1. treating a medicine for psoriasis pustulosa, is prepared by the crude drug of following ratio of weight and number:

Radix Astragali 28-32 Semen Coicis 28-32 Cortex Phellodendri 10-14 Radix Salviae Miltiorrhizae 28-32

Radix Scrophulariae 28-32 Cortex Moutan 8-12 Rhizoma Smilacis Glabrae 28-32 Ramulus Cinnamomi 8-12

Olibanum 6-10 Myrrha 6-10 Radix Bupleuri 8-12.

2. treat the medicine of psoriasis pustulosa according to claim 1, wherein the parts by weight of crude drug are:

The Radix Astragali 30 Semen Coicis 30 Cortex Phellodendri 12 Radix Salviae Miltiorrhizae 30

Radix Scrophulariae 30 Cortex Moutan 10 Rhizoma Smilacis Glabrae 30 Ramulus Cinnamomi 10

Olibanum 8 Myrrha 8 Radix Bupleuri 10.