CN104187171B - A kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma and preparation method - Google Patents
A kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma and preparation method, wherein, feedstuff includes following raw material: Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin, DDGS, dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose, Semen phaseoli radiati powder, enzyme premix material and microelement pre-mix material.The medicine have the advantages that the feed of grass carp of the present invention, by adding Chinese medicine additive, has heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, not only cure rate is high, instant effect, and while detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, difficulty in relapse after healing；The present invention has and is conceived to entirety, emphasizes to regulate allomeric function, improves the premunition of body, and prolonged application is safe and reliable.
Description
Technical field
The present invention relates to technical field of animal, particularly to a kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma
And preparation method.
Background technology
Red skin is again red skin pestilence, wipes skin pestilence.This disease be mostly due to draw in the net operation time or in transit skin be subject to
Wound, antibacterial is invaded mermaid body and causes.This disease is the most visible from early spring to severe winter, but with 6-9 month as onset peak, often with rotten
The gill, hemorrhagic disease are concurrent.Send out disease this with blue or green, grass, Cyprinus carpio more universal.
Symptom: fish body surface local or the hyperemia of big portion, inflammation, scale comes off, especially the brightest with fish body both sides and abdominal part
Aobvious, serious sick fin base portion is congested, and fin ray tip rots, and the crocodile up and down of fish and gill cover part are congested, presents block erythema.
Ctenopharyngodon idellus morbidity is often injured with fish body relevant, is conditioned pathogen.Cause of disease is pseudomonas fluorescens
(Pseudomonas fluorescens), taxonomy belongs to antibacterial territory, Proteobacteria, γ-deformation Gammaproteobacteria, Pseudomonadales,
The Rhodopseudomonas of pseudomonadaceae.Cell is straight bacillus, and size is 0.7-0.8X2.3-2.8 micron, does not produce spore, leather
Blue Albert'stain Albert is negative.There is several polar flagella, motion.Aerobic, carry out strict breathing pattern metabolism, be that final electronics is subject to oxygen
Body.Anaerobic respiration can be carried out for the electron acceptor substituted with nitrate.Chemotrophy heterotrophism, it is not necessary to organic growth factors.Oxygen
Changing enzyme positive, catalase is positive.Can utilize glucose and fructose, some bacterial strain can be from Sucrose synthesis levan, gelatin liquefaction.Raw
Long temperature range 4-37 DEG C, optimum growth temperature is 25-30 DEG C.In DNA, G+C content is 60-61%.It is distributed widely in nature
Boundary, in soil, water, plant and animal activity environment.This bacterium biochemistry ability is enlivened, degradable many artificial-synthetic compounds,
It is commonly used for environmental conservation.The multiple freshwater fishes such as this disease main harm Ctenopharyngodon idellus, Mylopharyngodon piceus, Cyprinus carpio, Megalobrama amblycephala, respectively breed fish in China
Area, has popular throughout the year, especially after fishing for, transporting.When the body surface of fish is intact, pathogen cannot invade fish
Skin.Only make fish body be mechanically damaged when fish because fishing for, transport, putting in a suitable place to breed, or cold injury, or body surface is parasitic and be subject to by parasite
During damage, pathogen just can be taken advantage of a weak point, and causes morbidity.
Fish is slow in action, bradykinesia, weak, peel off and solely swim in the water surface.Body surface local or large-area hemorrhage inflammation, scale
Coming off, particularly fish body both sides and abdominal part is the most obvious.Fin is congested, and afterbody rots, and is formed " moth fin ".Hubei Province up and down of fish and the gill cover
Part is congested, in block erythema.Sometimes the gill cover is rotten goes one piece, in roundlet window-like, blank occurs.Depart from and fin ray at scale
Rotten place often occurs that fish molds is parasitic, increases the weight of patient's condition.Morbidity after a few days will be dead.
Doctor trained in Western medicine preventing and treating Ctenopharyngodon idellus erythroderma is longer for the course for the treatment of, and prevention effect is undesirable, and rear easily recurrence, meanwhile, along with these medicines
A large amount of uses of thing, have remained substantial amounts of drug toxicity in animal body, when people eat these grass carp meats, people in serious threat
The life and health of class.
Chinese medicine, the advantage not only with western modern medicine, also there is western modern medicine and do not have the advantage that, not only cure rate high,
Instant effect, while detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, difficulty in relapse after healing.During China is traditional
Being conceived to entirety during medical applications, emphasize to regulate allomeric function, improve the premunition of body, prolonged application is safe and reliable, because of
This, treatment Ctenopharyngodon idellus erythroderma in terms of serve the most important effect because having drawn from nature, and use there is play
The medical herbs of poison is few, and therefore Chinese herbal medicine can be more safer than Western medicine.
Summary of the invention
The technical problem to be solved is to be to provide one to comprise for preventing and treating the interpolation of Ctenopharyngodon idellus erythroderma Chinese medicine
The functional feed of agent and preparation method.The Chinese medicine additive of the present invention has heat-clearing and toxic substances removing, effect of cooling blood for hemostasis, not only controls
More rate height, instant effect, while detoxicating, relieving inflammation, sterilization, drug residue free, cost price is low, difficulty in relapse after healing；The present invention
Being conceived to entirety, emphasize to regulate allomeric function, improve the premunition of body, prolonged application is safe and reliable.
In order to realize foregoing invention purpose, the invention provides a kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma,
Feedstuff includes following raw material: Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin, DDGS, dried silkworm chrysalis meal, locust
Worm powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose, Semen phaseoli radiati powder, enzyme premix material and microelement pre-mix material.
In described feedstuff, the parts by weight of each raw material are: Semen Maydis 20-55 weight portion, Sorghum vulgare Pers. 10-40 weight portion, Fructus Hordei Vulgaris 30-
60 weight portions, wheat bran 20-40 weight portion, Radix Raphani 10-30 weight portion, Exocarpium Benincasae 15-35 weight portion, Chinese cabbage leaf 20-30 weight portion,
Fructus Citri tangerinae skin 14-30 weight portion, DDGS10-15 weight portion, dried silkworm chrysalis meal 5-20 weight portion, locust powder 5-12 weight portion, bean worm powder 10-
20 weight portions, Pericarppium arachidis hypogaeae 15-25 weight portion, sesame seed meal 30-50 weight portion, egg shell powder 5-10 weight portion, stachyose 1-7 weight
Part, Semen phaseoli radiati powder 10-20 weight portion, enzyme premix material 0.1-0.4 weight portion and microelement pre-mix material 0.1-0.5 weight portion.
Described feedstuff also includes Chinese medicine additive, and in described feedstuff, the parts by weight of each raw material are: Semen Maydis 20-55 weight
Part, Sorghum vulgare Pers. 10-40 weight portion, Fructus Hordei Vulgaris 30-60 weight portion, wheat bran 20-40 weight portion, Radix Raphani 10-30 weight portion, Exocarpium Benincasae 15-35
Weight portion, Chinese cabbage leaf 20-30 weight portion, Fructus Citri tangerinae skin 14-30 weight portion, DDGS10-15 weight portion, dried silkworm chrysalis meal 5-20 weight portion,
Locust powder 5-12 weight portion, bean worm powder 10-20 weight portion, Pericarppium arachidis hypogaeae 15-25 weight portion, sesame seed meal 30-50 weight portion, Ovum crusta Gallus domesticus
Powder 5-10 weight portion, stachyose 1-7 weight portion, Semen phaseoli radiati powder 10-20 weight portion, enzyme premix material 0.1-0.4 weight portion, trace element
Premix material 0.1-0.5 weight portion and Chinese medicine additive 1-5 weight portion.
In described feedstuff, the parts by weight of each raw material are: Semen Maydis 55 weight portion, Sorghum vulgare Pers. 34 weight portion, Fructus Hordei Vulgaris 45 weight
Part, wheat bran 25 weight portion, Radix Raphani 18 weight portion, Exocarpium Benincasae 31 weight portion, Chinese cabbage leaf 27 weight portion, Fructus Citri tangerinae skin 19 weight portion,
DDGS14 weight portion, dried silkworm chrysalis meal 7 weight portion, locust powder 10 weight portion, bean worm powder 19 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, Semen Sesami
The dregs of rice 35 weight portion, egg shell powder 5 weight portion, stachyose 2 weight portion, Semen phaseoli radiati powder 16 weight portion, enzyme premix material 0.2 weight portion, micro-
Trace mineral feed 0.3 weight portion and Chinese medicine additive 4 weight portion.
Described Chinese medicine additive includes following raw medicinal material: Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini,
Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, big blood
Rattan, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae,
Radix Rumicis Japonici and Rhizoma Imperatae.
In described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-
30 weight portions, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, hardship
Ginseng 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25
Weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion,
Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-
25 weight portions, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight
Part, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae
18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
In described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Centipedae 14 weight portion, Herba Lophatheri 22 weight
Part, Fructus Gardeniae 25 weight portion, Rhizoma Coptidis 32 weight portion, Cortex Phellodendri 17 weight portion, Cortex Fraxini 25 weight portion, Radix Sophorae Flavescentis 32 weight portion, Cortex Dictamni
23 weight portions, Flos Lonicerae 7 weight portion, Fructus Forsythiae 31 weight portion, Herba Andrographis 20 weight portion, Folium Isatidis 21 weight portion, Herba Violae 29
Weight portion, Flos Chrysanthemi Indici 19 weight portion, Rhizoma Paridis 5 weight portion, Rhizoma Bistortae 32 weight portion, Herba Houttuyniae 11 weight portion, Caulis Sargentodoxae 30 weight portion,
Herba Patriniae 15 weight portion, Herba Potentillae Discoloris 10 weight portion, Pseudobulbus Cremastrae Seu Pleiones 26 weight portion, Herba Senecionis Scandentis 33 weight portion, Radix Ampelopsis 23 weight portion, the four seasons
Blue or green 27 weight portions, Cortex Moutan 30 weight portion, Radix Rehmanniae 24 weight portion, Radix Arnebiae (Radix Lithospermi) 39 weight portion, Herba Cirsii 18 weight portion, Radix Sanguisorbae 24 weight
Part, Flos Sophorae 37 weight portion, Radix Rumicis Japonici 13 weight portion and Rhizoma Imperatae 25 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step: each component in described Chinese medicine composition be mixed in proportion, puts into pulverizer and carries out pulverizing or directly
Chopping, loads and decocts in container, and the water adding 1-2 times amount makes its submergence medical material, after soaking 10-25 minute, is heated to the 40-that seethes with excitement
After 70 minutes, separating fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, then through filtering
After, take filtrate and abandon filtering residue；
Second step: after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentrating is 80-90% second
Alcohol, is sufficiently mixed uniformly, stands overnight so that it is precipitation, obtains filtrate, precipitate determining alcohol after taking its supernatant liquid filtering next day
Ethanol for 50-60% is cleaned, and collects washing liquid and merges with filtrate, and after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 little
Time, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer and be dried, it is ensured that inlet temperature, at 180 DEG C-200 DEG C, goes out pathogenic wind-warm
Spend 70 DEG C-90 DEG C, be ground into 300 mesh-400 mesh subsequently, it is thus achieved that powder Chinese medicine composition.
In order to preferably realize foregoing invention purpose, the invention provides a kind of feedstuff for preventing and treating Ctenopharyngodon idellus erythroderma
Preparation method, comprises the following steps:
The first step, weigh by ratio of weight and the number of copies Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin,
In 80 after DDGS, dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose and Semen phaseoli radiati powder mix homogeneously
DEG C dry 20min, then puts into pulverizer and carries out Crushing of Ultrafine and cross 2.5mm sieve after pulverizing；
Second step, is mixed in proportion crude drug each in described Chinese medicine additive, carries out charcoal and fries 60-90 minute, adds subsequently
Entering relative to the determining alcohol of mixture quality 4-5 times is 80%-95% ethanol solution, heating and refluxing extraction 1.5-3.0 hour, it is thus achieved that
First extracting solution, filters, it is thus achieved that the first filtrate, it is 80%-95% that filtering residue adds again relative to the determining alcohol of its quality 3-5 times
Ethanol solution, heating and refluxing extraction 1.5 hours, it is thus achieved that the second extracting solution, filter, it is thus achieved that the second filtrate, filtrate is merged,
Concentrating under reduced pressure removes ethanol, it is thus achieved that dry mastic, uses pulverizer to pulverize subsequently, grinding particle size 295-340 mesh, it is thus achieved that powder
Described Chinese medicine additive；
3rd step, Chinese medicine additive, trace element that the fine powder of the pulverizing acquisition first step obtained, second step obtain are pre-
Batch mixing puts in mixer and mixes, and the steam being passed through 94-103 DEG C in feeding modem is modulated 5-12 minute, then exists
Enter extruding puffing granulator at a temperature of 106-113 DEG C and make granule；
4th step, is ground into the powder of 120-160 mesh by enzyme premix material, pours in spraying machine, and in spraying machine, water temperature is 70-
86 DEG C, open spraying machine, enzyme premix material powder spray is obtained particle surface in the 3rd step, cools down after stirring 10-12min, obtain
Obtain described feedstuff.
The medicine have the advantages that the Ctenopharyngodon idellus functional feed of the present invention, by adding Chinese medicine additive, has heat clearing away solution
Poison, effect of cooling blood for hemostasis, not only cure rate is high, instant effect, while detoxicating, relieving inflammation, sterilization, drug residue free, cost price
Lattice are low, difficulty in relapse after healing；The present invention has and is conceived to entirety, emphasizes to regulate allomeric function, improves the premunition of body, long
Phase application safety is reliable.
Detailed description of the invention
The traditional Chinese medical science thinks that disease is body normal physiological function destruction to a certain extent, and the process of disease is exactly that heresy just struggles against
The process striven.In the vital movement of body, on the one hand healthy energy plays its effect maintaining body normal physiological function, separately
On the one hand, body is not being attacked by pathogen, and the two is constantly occurring struggle, the most constantly obtain balance and
Unified, it is ensured that the health of body.Therefore, the generation of disease, it is decided by healthy energy and the result of pathogen both sides struggle.The traditional Chinese medical science is fallen ill
Learn the decisive action both having emphasized body healthy energy in morbidity, be not excluded for again the important function of pathogen, and think that pathogen is necessarily
Under the conditions of can also play conclusive effect.
Therefore, preventing and treating Ctenopharyngodon idellus erythroderma is mainly with heat-clearing and toxic substances removing, and cooling blood for hemostasis is primary treatment principle, it is provided that Yi Zhongyong
In the feedstuff of preventing and treating Ctenopharyngodon idellus erythroderma, it includes that Chinese medicine additive, Chinese medicine additive include following raw medicinal material: Herba Centipedae,
Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni, Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae,
Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, Herba Potentillae Discoloris, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims, Paeonia suffruticosa
Skin, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae, Flos Sophorae, Radix Rumicis Japonici and Rhizoma Imperatae.
Wherein, Herba Centipedae, Herba Lophatheri, Fructus Gardeniae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, Radix Sophorae Flavescentis, Cortex Dictamni clearing away heat-fire, dampness；
Flos Lonicerae, Fructus Forsythiae, Herba Andrographis, Folium Isatidis, Herba Violae, Flos Chrysanthemi Indici, Rhizoma Paridis, Rhizoma Bistortae, Herba Houttuyniae, Caulis Sargentodoxae, Herba Patriniae, turn over white
Grass, Pseudobulbus Cremastrae Seu Pleiones, Herba Senecionis Scandentis, Radix Ampelopsis, Ilex purpurea Hassk.[I.chinensis Sims can heat-clearing and toxic substances removing, removing heat from blood sore；Cortex Moutan, Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Herba Cirsii, Radix Sanguisorbae,
Flos Sophorae, Radix Rumicis Japonici, Rhizoma Imperatae clearing away heat and cooling blood, hemostasis.Complete square while detoxicating, relieving inflammation, sterilization, drug residue free, cost price
Low, difficulty in relapse after healing, it is conceived to entirety, emphasizes to regulate allomeric function, improve the premunition of body, prolonged application safely may be used
Lean on.
The pharmacology of each crude drug is as follows:
Herba Centipedae: pungent, temperature；Return lung, Liver Channel.Clearing the nasal passage, cough-relieving, for headche due to wind-cold, cough with copious phlegm, have a stuffy nose obstructed,
Nasal sinusitis watery nasal discharge.
Herba Lophatheri: nature and flavor, sweet, it is slightly cold；GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.For calentura excessive thirst, red urine
Puckery pouring pain, aphtha of the mouth and tongue.
Fructus Gardeniae: bitter, cold, nontoxic；GUIXIN warp, Liver Channel, lung meridian, stomach warp, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing heat from blood
Removing toxic substances, cooling blood for hemostasis.Calentura is vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, and skin infection swells
Poison, sprains and swells and ache.
Rhizoma Coptidis: bitter, cold, nontoxic；GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function heat clearing and damp drying, eliminating fire and detoxication.For wet
Fullness-oppression in the epigastrium caused by heat is full, vomits acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, is longer than the fire of removing pathogen in the heart stomach, has preventing or arresting vomiting concurrently and disappears the merit of painful abdominal mass, can be used for treating
The prosperous caused dysphoria and insomnia of heart-fire, heat in blood tells nosebleed, conjunctival congestion, toothache, quenches one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus is suppurated.
It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.
Cortex Phellodendri: bitter, cold；Return kidney, bladder warp.Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice,
Leukorrhagia, pyretic stranguria, tinea pedis, flaccidity wards off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For
Hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Cortex Fraxini: bitter in the mouth, cold；Return Liver Channel, gallbladder meridian, large intestine channel.Function heat clearing and damp drying, liver heat removing and eyesight improving, astringent therapy dysentery relieving, leukorrhagia stopping.
For pyretic toxicity dysentery, leukorrhagia pudendal pruritus, liver-heat conjunctival congestion and swelling pain, the raw cataracta of mesh.
Radix Sophorae Flavescentis: bitter in the mouth；Cold in nature.Return liver；Kidney；Large intestine；Small intestine meridian；Bladder；Heart channel；Bladder warp.Main damp-heat dysentery；Hemorrhoidal hamorrhage is just
Blood；Jaundice；Dysuria；Edema；Leukorrhagia；Pudendal pruritus；Scabies；Leprosy；Skin pruritus；Noxious dampness skin infection.
Cortex Dictamni: bitter, salty, cold；Return spleen channel, lung meridian, small intestine meridian, stomach warp, bladder warp.Control all pyretic toxicity wind, aversion to wind, wind
Skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, high fever aversion to cold；Principal solution heat Huang, wine Huang, acute jaundice, yellow, the labor Huang of paddy etc..
Flos Lonicerae: cold in nature, sweet in the mouth；Return lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind, cure mainly swollen
Disease, epidemic febrile disease is completely descended to generate heat, the disease such as pyretic toxicity carbuncle and ulcer and tumor.
Fructus Forsythiae: bitter in the mouth, cold nature；GUIXIN, lung, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis,
Erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm is joined the army, high hot excessive thirst, and coma sends out speckle, pyretic stranguria urine retention.
Herba Andrographis: bitter, cold；GUIXIN, lung, large intestine, bladder warp.Heat-clearing and toxic substances removing, removing heat from blood, detumescence.For cold, fever, throat
Swell and ache, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
Folium Isatidis: bitter, cold；Return liver, the heart, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, popular sexuality
Emit, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spit blood, epistaxis, jaundice, dysentery, sore throat, mouth
Skin ulcer, swollen ulcer drug.
Herba Violae: bitter in the mouth, pungent, cold in nature；GUIXIN, Liver Channel.There is heat-clearing and toxic substances removing, the effect of removing heat from blood detumescence, main popularity
Flu；Upper respiratory tract infection；Tonsillitis；Infectious hepatitis；Enteritis；Dysentery；Nephritis；Parotitis；Conjunctivitis；Acute vermiform appendix
Scorching；Furuncle carbuncle；Scrofula.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent；Return liver, heart channel.Heat-clearing and toxic substances removing.For furuncle carbuncle, conjunctival congestion and swelling pain, have a headache dizzy
Dizzy.
Rhizoma Paridis: slightly poisonous, bitter, cold；Return Liver Channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver is calmed the frightened.For furuncle carbuncle, throat
Swell and ache, venom, fall and flutter the pain of injury, convulsion with spasms.
Rhizoma Bistortae: bitter is cool；Return lung, liver, large intestine channel.Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating.Control calentura infantile convulsion, tetany, broken wound
Wind, carbuncle scrofula, snake bite and insect sting.Control that calentura is frightened jerks, tetanus, bloody dysentery, carbuncle, scrofula.
Herba Houttuyniae: cold nature, bitter in the mouth；Return lung meridian, bladder, large intestine channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung pus
Infections, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.
Caulis Sargentodoxae: bitter in the mouth, property is put down；Return liver, large intestine channel.There is the eliminating carbuncle that relieves internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, master
Controlling acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, injury from falling down etc. is demonstrate,proved.
Herba Patriniae: acrid in the mouth, hardship, is slightly cold；Return liver, stomach, large intestine channel.Function heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, blood stasis dispelling is only
Bitterly, for acute appendicitis, lung abscess high heat, coughing vomiting bloody pus, pyretic toxicity skin ulcer furuncle, furuncle pain is swollen, chest and abdomen pain, appendicitis, and enteritis, dysentery are produced
Rear stomachache, dysmenorrhea.
Herba Potentillae Discoloris: hardship sweet, micro-, flat, nontoxic.Thermal detoxification, cooling blood for hemostasis.For enteritis, bacillary dysentery, amebic dysentery
Disease, spits blood, and epistaxis is had blood in stool, leucorrhea；Wound, carbuncle furuncle and phyma poison are controlled in external.
Pseudobulbus Cremastrae Seu Pleiones: bitter, micro-pungent, cool；Return liver, spleen channel.Heat-clearing and toxic substances removing, dissipating phlegm and resolving masses.For carbuncle furunculosis, scrofula sucutaneous nodule,
Tuberculous lymphadenitis, snake bite and insect sting.
Herba Senecionis Scandentis: cold in nature, bitter in the mouth.Heat-clearing and toxic substances removing；Improving acuity of vision and removing nebula；Killing parasites for relieving itching.Main flow sense；Upper respiratory tract infection；Pneumonia；
Acute tonsillitis；Rib adenitis；Acute enteritis；Bacillary dysentery；Icterohepatitis；Gallbladder exudative dermatitis is scorching；Acute urinary tract infection；Conjunctival congestion and swelling pain nebula
Barrier；Carbuncle furuncle poison；Erysipelas；Eczema；Dry and wet tinea skin ulcer；Trichomonal vaginitis；Burn and scald.
Radix Ampelopsis: bitter, is slightly cold；GUIXIN, stomach warp.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.For carbuncle carbuncle on the back, furuncle, scrofula, extreme misery
Scald.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool.Heat-clearing and toxic substances removing；Promoting tissue regeneration and ulcer healing；Promoting blood circulation and hemostasis.Main cough due to lung-heat；Laryngopharynx swelling and pain；Dysentery；
Diarrhoea；Biliary tract infection；Urinary tract infection；Angina pectoris；Burn and scald；Pyretic toxicity carbuncle；Ulcer of the lower limb；Leprelcosis；Eczema；Freeze
Skin ulcer；Chap；Thromboangiitis obliterans；Traumatic hemorrhage.
Cortex Moutan: bitter in the mouth, pungent, cold nature；GUIXIN, liver, kidney channel.Evil removing gas, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, the logical moon
Warp, disappears and flutters damage blood stasis, reuniting the fractured tendons and bones, and except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour.Nourishing YIN to lower pathogenic fire, solves speckle malicious, throat,
Diuresis stasis.
Radix Rehmanniae: sweet, cold；GUIXIN, liver, kidney channel.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, long muscle.Make
Soup gathers except cold and heat, eliminating impediment.
Radix Arnebiae (Radix Lithospermi): cold in nature is sweet in the mouth, salty；GUIXIN, Liver Channel.Removing heat from blood, invigorates blood circulation, rash of detoxifying.Containing for heat in blood poison, macule purple is black,
Measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Herba Cirsii: sweet, bitter, cold；GUIXIN, Liver Channel.Function cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, just
Blood, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Sanguisorbae: picric acid, cold, nontoxic；Return liver, lung, kidney, large intestine channel.Function cooling blood for hemostasis, heat-clearing and toxic substances removing, sore of subsiding a swelling.With
In haematemesis, spitting of blood, epistaxis, hematuria, having blood in stool, hemorrhoidal bleeding, dysentery, metrorrhagia, leucorrhea with red and white discharge, sore, carbuncle and painful swelling, eczema, pudendal pruritus, extreme misery scalds
Wound, snake bite and insect sting.
Flos Sophorae: bitter in the mouth, cold nature；Return liver, lung, the heart, large intestine channel.There is cooling blood for hemostasis, effect of purging liver-fire；Main hemorrhoidal hamorrhage
Have blood in stool；Hemorrhoid hematochezia；Dysentery；Hematuria；Stranguria with blood；Metrorrhagia；Spit blood；Epistaxis；Liver-heat is had a headache；Conjunctival congestion and swelling pain；Carbuncle skin infection.For just
Blood, hemorrhoidal bleeding, dysentery, metrorrhagia, spit blood, epistaxis, liver-heat conjunctival congestion, dizziness of having a headache.
Radix Rumicis Japonici: bitter；Cold in nature；The heart, liver, large intestine channel.Effect clearing away heat and loosing the bowels, cooling blood for hemostasis, killing parasites for relieving itching.Cure mainly big constipation
Knot, hematemesis and epistaxis, discharging fresh blood stool, hemorrhoidal bleeding, metrorrhagia, scabies, the baldst, ulcerative carbuncle toxic swelling, traumatic injury.
Rhizoma Imperatae: sweet in the mouth, cold in nature；Return lung, stomach, bladder warp.Cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis,
Hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria；Acute nephritis edema.
The invention provides a kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma, feedstuff includes following raw material: Semen Maydis,
Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin, DDGS, dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, Semen Sesami
The dregs of rice, egg shell powder, stachyose, Semen phaseoli radiati powder, enzyme premix material and microelement pre-mix material.
Wherein, in feedstuff, the parts by weight of each raw material are: Semen Maydis 20-55 weight portion, Sorghum vulgare Pers. 10-40 weight portion, Fructus Hordei Vulgaris 30-
60 weight portions, wheat bran 20-40 weight portion, Radix Raphani 10-30 weight portion, Exocarpium Benincasae 15-35 weight portion, Chinese cabbage leaf 20-30 weight portion,
Fructus Citri tangerinae skin 14-30 weight portion, DDGS10-15 weight portion, dried silkworm chrysalis meal 5-20 weight portion, locust powder 5-12 weight portion, bean worm powder 10-
20 weight portions, Pericarppium arachidis hypogaeae 15-25 weight portion, sesame seed meal 30-50 weight portion, egg shell powder 5-10 weight portion, stachyose 1-7 weight
Part, Semen phaseoli radiati powder 10-20 weight portion, enzyme premix material 0.1-0.4 weight portion and microelement pre-mix material 0.1-0.5 weight portion.
Wherein, feedstuff also includes Chinese medicine additive, and in feedstuff, the parts by weight of each raw material are: Semen Maydis 20-55 weight portion,
Sorghum vulgare Pers. 10-40 weight portion, Fructus Hordei Vulgaris 30-60 weight portion, wheat bran 20-40 weight portion, Radix Raphani 10-30 weight portion, Exocarpium Benincasae 15-35 weight
Amount part, Chinese cabbage leaf 20-30 weight portion, Fructus Citri tangerinae skin 14-30 weight portion, DDGS10-15 weight portion, dried silkworm chrysalis meal 5-20 weight portion, locust
Worm powder 5-12 weight portion, bean worm powder 10-20 weight portion, Pericarppium arachidis hypogaeae 15-25 weight portion, sesame seed meal 30-50 weight portion, egg shell powder
5-10 weight portion, stachyose 1-7 weight portion, Semen phaseoli radiati powder 10-20 weight portion, enzyme premix material 0.1-0.4 weight portion, trace element are pre-
Batch mixing 0.1-0.5 weight portion and Chinese medicine additive 1-5 weight portion.
Wherein, in feedstuff, the parts by weight of each raw material are: Semen Maydis 55 weight portion, Sorghum vulgare Pers. 34 weight portion, Fructus Hordei Vulgaris 45 weight
Part, wheat bran 25 weight portion, Radix Raphani 18 weight portion, Exocarpium Benincasae 31 weight portion, Chinese cabbage leaf 27 weight portion, Fructus Citri tangerinae skin 19 weight portion,
DDGS14 weight portion, dried silkworm chrysalis meal 7 weight portion, locust powder 10 weight portion, bean worm powder 19 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, Semen Sesami
The dregs of rice 35 weight portion, egg shell powder 5 weight portion, stachyose 2 weight portion, Semen phaseoli radiati powder 16 weight portion, enzyme premix material 0.2 weight portion, micro-
Trace mineral feed 0.3 weight portion and Chinese medicine additive 4 weight portion.
Wherein, in Chinese medicine additive, the ratio of weight and number of each crude drug is preferably: Herba Centipedae 10-28 weight portion, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle
Leaf 15-30 weight portion, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight
Part, Radix Sophorae Flavescentis 19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis
13-25 weight portion, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight
Measure part, Rhizoma Bistortae 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, turn over
Pennisetum centrasiaticum Tzvel 7-25 weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-
31 weight portions, Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion,
Radix Sanguisorbae 18-35 weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
Wherein, in Chinese medicine additive, the ratio of weight and number of each crude drug can also be preferably: Herba Centipedae 14 weight portion,
Herba Lophatheri 22 weight portion, Fructus Gardeniae 25 weight portion, Rhizoma Coptidis 32 weight portion, Cortex Phellodendri 17 weight portion, Cortex Fraxini 25 weight portion, Radix Sophorae Flavescentis 32 weight
Amount part, Cortex Dictamni 23 weight portion, Flos Lonicerae 7 weight portion, Fructus Forsythiae 31 weight portion, Herba Andrographis 20 weight portion, Folium Isatidis 21 weight portion,
Herba Violae 29 weight portion, Flos Chrysanthemi Indici 19 weight portion, Rhizoma Paridis 5 weight portion, Rhizoma Bistortae 32 weight portion, Herba Houttuyniae 11 weight portion, big blood
Rattan 30 weight portion, Herba Patriniae 15 weight portion, Herba Potentillae Discoloris 10 weight portion, Pseudobulbus Cremastrae Seu Pleiones 26 weight portion, Herba Senecionis Scandentis 33 weight portion, Radix Ampelopsis 23
Weight portion, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portion, Cortex Moutan 30 weight portion, Radix Rehmanniae 24 weight portion, Radix Arnebiae (Radix Lithospermi) 39 weight portion, Herba Cirsii 18 weight
Part, Radix Sanguisorbae 24 weight portion, Flos Sophorae 37 weight portion, Radix Rumicis Japonici 13 weight portion and Rhizoma Imperatae 25 weight portion.
Wherein, the preparation method of Chinese medicine additive comprises the following steps:
The first step: each component in described Chinese medicine composition be mixed in proportion, puts into pulverizer and carries out pulverizing or directly
Chopping, loads and decocts in container, and the water adding 1-2 times amount makes its submergence medical material, after soaking 10-25 minute, is heated to the 40-that seethes with excitement
After 70 minutes, separating fried liquid, medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, then through filtering
After, take filtrate and abandon filtering residue；
Second step: after filtrate cools down, adding relative to the determining alcohol of liquid weight 1-2 times after concentrating is 80-90% second
Alcohol, is sufficiently mixed uniformly, stands overnight so that it is precipitation, obtains filtrate, precipitate determining alcohol after taking its supernatant liquid filtering next day
Ethanol for 50-60% is cleaned, and collects washing liquid and merges with filtrate, and after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 little
Time, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer and be dried, it is ensured that inlet temperature, at 180 DEG C-200 DEG C, goes out pathogenic wind-warm
Spend 70 DEG C-90 DEG C, be ground into 300 mesh-400 mesh subsequently, it is thus achieved that powder Chinese medicine composition.
In order to preferably realize foregoing invention purpose, present invention also offers a kind of feedstuff for preventing and treating Ctenopharyngodon idellus erythroderma
Preparation method, comprise the following steps:
The first step, weigh by ratio of weight and the number of copies Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin,
In 80 after DDGS, dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose, Semen phaseoli radiati powder mix homogeneously
DEG C dry 20min, then puts into pulverizer and carries out Crushing of Ultrafine and cross 2.5mm sieve after pulverizing；
Second step, is mixed in proportion crude drug each in Chinese medicine additive, carries out charcoal and fries 60-90 minute, is subsequently added phase
Determining alcohol for mixture quality 4-5 times is 80%-95% ethanol solution, heating and refluxing extraction 1.5-3.0 hour, it is thus achieved that first
Extracting solution, filters, it is thus achieved that the first filtrate, it is 80%-95% ethanol that filtering residue adds again relative to the determining alcohol of its quality 3-5 times
Solution, heating and refluxing extraction 1.5 hours, it is thus achieved that the second extracting solution, filter, it is thus achieved that the second filtrate, filtrate is merged, decompression
Concentrate and remove ethanol, it is thus achieved that dry mastic, use pulverizer to pulverize subsequently, grinding particle size 295-340 mesh, it is thus achieved that powder described
Chinese medicine additive；
3rd step, Chinese medicine additive, trace element that the fine powder of the pulverizing acquisition first step obtained, second step obtain are pre-
Batch mixing puts in mixer and mixes, and the steam being passed through 94-103 DEG C in feeding modem is modulated 5-12 minute, then exists
Enter extruding puffing granulator at a temperature of 106-113 DEG C and make granule；
4th step, is ground into the powder of 120-160 mesh by enzyme premix material, pours in spraying machine, and in spray, water temperature is 70-
86 DEG C, open spraying machine, enzyme premix material powder spray is obtained particle surface in the 3rd step, cools down after stirring 10-12min, obtain
Obtain described feedstuff.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology hands
Section solves technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Take Herba Centipedae 14g, Herba Lophatheri 22g, Fructus Gardeniae 25g, Rhizoma Coptidis 32g, Cortex Phellodendri 17g, Cortex Fraxini 25g, Radix Sophorae Flavescentis 32g, white
Cortex Dictamni 23g, Flos Lonicerae 7g, Fructus Forsythiae 31g, Herba Andrographis 20g, Folium Isatidis 21g, Herba Violae 29g, Flos Chrysanthemi Indici 19g, Rhizoma Paridis 5g, fist
Ginseng 32g, Herba Houttuyniae 11g, Caulis Sargentodoxae 30g, Herba Patriniae 15g, Herba Potentillae Discoloris 10g, Pseudobulbus Cremastrae Seu Pleiones 26g, Herba Senecionis Scandentis 33g, Radix Ampelopsis 23g, four
Season green grass or young crops 27g, Cortex Moutan 30g, Radix Rehmanniae 24g, Radix Arnebiae (Radix Lithospermi) 39g, Herba Cirsii 18g, Radix Sanguisorbae 24g, Flos Sophorae 37g, Radix Rumicis Japonici 13g and Rhizoma Imperatae
25g。
Preparation method comprises the following steps:
The first step: each component in Chinese medicine additive be mixed in proportion, puts into pulverizer and carries out pulverizing or directly shredding,
Loading and decoct in container, the water adding 2 times amount makes its submergence medical material, after soaking 25 minutes, after being heated to seething with excitement 50 minutes, separates
Fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, then after filtering, take filtrate and abandon filter
Slag；
Second step: after filtrate cools down, adding relative to the determining alcohol of liquid weight 2 times after concentrating is 90% ethanol, fully
Mix homogeneously, stands overnight so that it is precipitation, obtains filtrate after taking its supernatant liquid filtering next day, and precipitate determining alcohol is 60%
Ethanol is cleaned, and collects washing liquid and merges with filtrate, and after ethanol is regained in decompression, dislocation lets cool place, stands 1 hour, makes precipitation complete,
Filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer be dried, it is ensured that inlet temperature at 200 DEG C, leaving air temp 90 DEG C,
It is ground into 400 mesh subsequently, it is thus achieved that powder Chinese medicine additive powder.
Embodiment 2 feedstuff
Embodiments provide a kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma, the weight of each raw material in feedstuff
Amount number is: Semen Maydis 55 weight portion, Sorghum vulgare Pers. 34 weight portion, Fructus Hordei Vulgaris 45 weight portion, wheat bran 25 weight portion, Radix Raphani 18 weight portion, Fructus Benincasae
Skin 31 weight portion, Chinese cabbage leaf 27 weight portion, Fructus Citri tangerinae skin 19 weight portion, DDGS14 weight portion, dried silkworm chrysalis meal 7 weight portion, locust powder 10
Weight portion, bean worm powder 19 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, sesame seed meal 35 weight portion, egg shell powder 5 weight portion, stachyose 2 weight
Amount part, Semen phaseoli radiati powder 16 weight portion, enzyme premix material 0.2 weight portion, microelement pre-mix material 0.3 weight portion and Chinese medicine additive 4 weight
Amount part；Wherein in Chinese medicine additive, the ratio of weight and number of each crude drug is Herba Centipedae 18 weight portion, Herba Lophatheri 25 weight portion, life
Fructus Gardeniae 27 weight portion, Rhizoma Coptidis 34 weight portion, Cortex Phellodendri 16 weight portion, Cortex Fraxini 27 weight portion, Radix Sophorae Flavescentis 19 weight portion, Cortex Dictamni 27 weight
Part, Flos Lonicerae 10 weight portion, Fructus Forsythiae 29 weight portion, Herba Andrographis 17 weight portion, Folium Isatidis 23 weight portion, Herba Violae 33 weight
Part, Flos Chrysanthemi Indici 22 weight portion, Rhizoma Paridis 3 weight portion, Rhizoma Bistortae 26 weight portion, Herba Houttuyniae 15 weight portion, Caulis Sargentodoxae 27 weight portion, Herba Patriniae
Grass 18 weight portions, Herba Potentillae Discoloris 8 weight portion, Pseudobulbus Cremastrae Seu Pleiones 29 weight portion, Herba Senecionis Scandentis 35 weight portion, Radix Ampelopsis 30 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 22
Weight portion, Cortex Moutan 23 weight portion, Radix Rehmanniae 33 weight portion, Radix Arnebiae (Radix Lithospermi) 32 weight portion, Herba Cirsii 14 weight portion, Radix Sanguisorbae 29 weight portion,
Flos Sophorae 39 weight portion, Radix Rumicis Japonici 18 weight portion and Rhizoma Imperatae 33 weight portion.
Its preparation method comprises the following steps:
The first step, weigh by ratio of weight and the number of copies Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin,
In 80 after DDGS, dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose and Semen phaseoli radiati powder mix homogeneously
DEG C dry 20min, then puts into pulverizer and pulverizes, cross 2.5mm sieve after pulverizing；
Second step, is mixed in proportion crude drug each in Chinese medicine additive, carries out charcoal and fries 60-90 minute, is subsequently added phase
Determining alcohol for mixture quality 5 times is 95% ethanol solution, heating and refluxing extraction 3.0 hours, it is thus achieved that the first extracting solution, mistake
Filter, it is thus achieved that the first filtrate, it is 95% ethanol solution that filtering residue adds again relative to the determining alcohol of its quality 4 times, is heated to reflux carrying
Taking 1.5 hours, it is thus achieved that the second extracting solution, filter, it is thus achieved that the second filtrate, merged by filtrate, concentrating under reduced pressure removes ethanol, obtains
Get dry extract body, uses pulverizer to pulverize subsequently, grinding particle size 300 mesh, it is thus achieved that the described Chinese medicine additive of powder；
3rd step, Chinese medicine additive, trace element that the fine powder of the pulverizing acquisition first step obtained, second step obtain are pre-
Batch mixing puts in mixer and mixes, and the steam being passed through 103 DEG C in feeding modem is modulated 8 minutes, then at 113 DEG C
At a temperature of enter extruding puffing granulator make granule；
4th step, is ground into the powder of 160 mesh by enzyme premix material, pours in spraying machine, and in spraying machine, water temperature is 70-86
DEG C, open spraying machine, enzyme premix material powder spray obtained particle surface in the 3rd step, cools down after stirring 10-12min, it is thus achieved that
Described feedstuff.
The toxicity test of Chinese medicine additive:
Take Herba Centipedae 23g, Herba Lophatheri 21g, Fructus Gardeniae 31g, Rhizoma Coptidis 29g, Cortex Phellodendri 18g, Cortex Fraxini 21g, Radix Sophorae Flavescentis 22g, white
Cortex Dictamni 18g, Flos Lonicerae 9g, Fructus Forsythiae 32g, Herba Andrographis 16g, Folium Isatidis 19g, Herba Violae 38g, Flos Chrysanthemi Indici 15g, Rhizoma Paridis 7g, fist
Ginseng 28g, Herba Houttuyniae 13g, Caulis Sargentodoxae 28g, Herba Patriniae 13g, Herba Potentillae Discoloris 9g, Pseudobulbus Cremastrae Seu Pleiones 31g, Herba Senecionis Scandentis 31g, Radix Ampelopsis 28g, the four seasons
Blue or green 25g, Cortex Moutan 19g, Radix Rehmanniae 31g, Radix Arnebiae (Radix Lithospermi) 37g, Herba Cirsii 15g, Radix Sanguisorbae 26g, Flos Sophorae 32g, Radix Rumicis Japonici 14g and Rhizoma Imperatae 19g；
After mix homogeneously, pulverize, the mixture after pulverizing adds the cold water soak 10 hours of 1500g, the boiled rear slow fire boiling of intense fire
2.5 hours, filtering, it is thus achieved that the first filtrate, the cold water adding 1500g in filtering residue decocts 1.5 hours again, filters, it is thus achieved that second
Filtrate, by twice filtrate mixing, is evaporated to the decoct that crude drug concentration is 3g/ml.
Select SD rat, give the soup of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg)
Agent, every day gavage once, continuous 90 days, last be administered latter 24 hours respectively group live and kill 1/2 animal, remaining 1/2 animal continues observation 2
Live after week and kill.Observe the outward appearance of animal, general behavior, food ration, body weight change during test, be administered latter 90 days and drug withdrawal 2 weeks
Carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu,
BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as histopathology.Result of the test
Show: the Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, outward appearance sign, behavioral activity, enter
Appetite and body weight increase change the most without exception；Three dosage groups and matched group hematological examination, blood biochemical analysis, the inspection of urine biochemistry
Look into all between normal range, group without significant difference；Each group main organs histopathological examination shows no obvious abnormalities.These parameters
Drug withdrawal also had no change after 2 weeks.This test dosage is respectively the 180 of clinical medicine dose, 60,20 times, according to test knot
Really the Chinese medicine preparation of the present invention is administered rat at high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) for continuous 90 days
Having no significant effect, without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and prompting is originally
The dose safety of the Chinese medicine preparation clinical practice of invention is higher.
Contrast test
(1) for examination animal
The sick fish made a definite diagnosis from certain Ctenopharyngodon idellus plant of Yancheng of Jiangsu Province randomly selects 600 tail disease fishes as treatment contrast test
Object；From this plant, separately randomly select 600 tail health fishes as prevention contrast test object.
(2) bacterial strain extracts and cultivates:
The sick fish infecting Ctenopharyngodon idellus erythroderma in certain Ctenopharyngodon idellus plant of Yancheng of Jiangsu Province is cutd open inspection, and aseptic collection is died of illness
The internal organs such as the liver of Ctenopharyngodon idellus, gallbladder, spleen are smeared and are inoculated in agar slant, cultivate 24h at 30 DEG C；Take growth bacterium colony smear on inclined-plane,
Gram's method dyes, microscopy.Select colonies typical to be inoculated in meat soup, then after 18h cultivated by 30 DEG C of meat soups, bacterium solution is diluted to
105-106 bacterium/ml is standby.
(3) prevention contrast experiment:
600 tail healthy grass carp of random choose are randomly divided into 3 groups (matched group 1, matched group 2 and embodiment groups), wherein,
Matched group 1 and matched group 2 use tradition feed of grass carp to feed Ctenopharyngodon idellus respectively, and embodiment group uses the feedstuff 1 in embodiment 2 to feed
Ctenopharyngodon idellus, after feeding 5 days, carries out artificial challenge with standby culture to matched group 1 and embodiment group, carries out muscle note under dorsal fin
Penetrating 0.2mL/ tail, observed and recorded respectively organizes sickness rate and the mortality rate of Ctenopharyngodon idellus, and result is as shown in table 1.
Table 1 preventive effect synopsis
Knowable to the data of table 1: the feedstuff that the present invention contains Chinese medicine composition has obvious pre-preventive effect to Ctenopharyngodon idellus erythroderma
Really.
(4) treatment contrast test:
Curative effect determinate standard
Recovery from illness: offer medicine in latter 7 days, Ctenopharyngodon idellus is not dead and transference cure is recovery from illness；
Taking a turn for the better: offer medicine in latter 7 days, Ctenopharyngodon idellus is not dead and symptom alleviates as taking a turn for the better；
Invalid: in offeing medicine latter 7 days, Ctenopharyngodon idellus death is invalid.
The erythroderma Ctenopharyngodon idellus that 600 tails randomly selected are made a definite diagnosis is randomly divided into 3 groups of (treatment by Chinese herbs group, western medicine group, skies
White matched group), treat with different medicines, wherein, treatment by Chinese herbs group selects the Chinese medicine additive of embodiment 1, and dose is every
100kg fish medication 20g, mixes with appropriate adhesive, admixes and make bait feeding in bait, continuously dispensing 7 days, every day 1 time；
Western medicine group selects sulfathiazole, continuously dispensing 7 days, and every day 1 time, within the l days, dosage presses 100kg fish medication 20g medication, with
Appropriate adhesive mixing, admixes and makes bait feeding in bait, and within the 2nd to the 7th day, dosage halves, and external medication is the float of full pond
Bleaching powder (containing 30% effective chlorine) 1mg/kg；Blank group does not feed any medicine.Observed and recorded respectively organizes the cure rate of Ctenopharyngodon idellus, knot
Fruit is as shown in table 2.
Table 2 therapeutic effect synopsis
Knowable to the data of table 2: Chinese medicine composition of the present invention is substantially better than Western medicine to the therapeutic effect of Ctenopharyngodon idellus erythroderma and controls
Treatment group, reduces mortality rate, improves cure rate.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (5)
1. the functional feed being used for preventing and treating Ctenopharyngodon idellus erythroderma, it is characterised in that the weight portion of each raw material in described feedstuff
Number is: Semen Maydis 20-55 weight portion, Sorghum vulgare Pers. 10-40 weight portion, Fructus Hordei Vulgaris 30-60 weight portion, wheat bran 20-40 weight portion, Radix Raphani 10-30
Weight portion, Exocarpium Benincasae 15-35 weight portion, Chinese cabbage leaf 20-30 weight portion, Fructus Citri tangerinae skin 14-30 weight portion, DDGS10-15 weight portion,
Dried silkworm chrysalis meal 5-20 weight portion, locust powder 5-12 weight portion, bean worm powder 10-20 weight portion, Pericarppium arachidis hypogaeae 15-25 weight portion, sesame seed meal
30-50 weight portion, egg shell powder 5-10 weight portion, stachyose 1-7 weight portion, Semen phaseoli radiati powder 10-20 weight portion, enzyme premix material 0.1-
0.4 weight portion, microelement pre-mix material 0.1-0.5 weight portion and Chinese medicine additive 1-5 weight portion；
In described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight
Amount part, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis
19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight
Amount part, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, fist
Ginseng 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25
Weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion,
Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35
Weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
Functional feed for preventing and treating Ctenopharyngodon idellus erythroderma the most according to claim 1, it is characterised in that in described feedstuff
The parts by weight of each raw material are: Semen Maydis 55 weight portion, Sorghum vulgare Pers. 34 weight portion, Fructus Hordei Vulgaris 45 weight portion, wheat bran 25 weight portion, Radix Raphani 18
Weight portion, Exocarpium Benincasae 31 weight portion, Chinese cabbage leaf 27 weight portion, Fructus Citri tangerinae skin 19 weight portion, DDGS14 weight portion, dried silkworm chrysalis meal 7 weight
Part, locust powder 10 weight portion, bean worm powder 19 weight portion, Pericarppium arachidis hypogaeae 16 weight portion, sesame seed meal 35 weight portion, egg shell powder 5 weight
Part, stachyose 2 weight portion, Semen phaseoli radiati powder 16 weight portion, enzyme premix material 0.2 weight portion, microelement pre-mix material 0.3 weight portion and in
Medicine additive 4 weight portion；
In described Chinese medicine additive, the ratio of weight and number of each crude drug is: Herba Centipedae 10-28 weight portion, Herba Lophatheri 15-30 weight
Amount part, Fructus Gardeniae 21-35 weight portion, Rhizoma Coptidis 25-38 weight portion, Cortex Phellodendri 12-23 weight portion, Cortex Fraxini 18-31 weight portion, Radix Sophorae Flavescentis
19-37 weight portion, Cortex Dictamni 15-35 weight portion, Flos Lonicerae 7-16 weight portion, Fructus Forsythiae 23-40 weight portion, Herba Andrographis 13-25 weight
Amount part, Folium Isatidis 14-29 weight portion, Herba Violae 26-42 weight portion, Flos Chrysanthemi Indici 13-29 weight portion, Rhizoma Paridis 3-7 weight portion, fist
Ginseng 19-36 weight portion, Herba Houttuyniae 9-22 weight portion, Caulis Sargentodoxae 20-35 weight portion, Herba Patriniae 13-26 weight portion, Herba Potentillae Discoloris 7-25
Weight portion, Pseudobulbus Cremastrae Seu Pleiones 24-36 weight portion, Herba Senecionis Scandentis 28-39 weight portion, Radix Ampelopsis 21-36 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 18-31 weight portion,
Cortex Moutan 16-34 weight portion, Radix Rehmanniae 19-39 weight portion, Radix Arnebiae (Radix Lithospermi) 21-43 weight portion, Herba Cirsii 13-24 weight portion, Radix Sanguisorbae 18-35
Weight portion, Flos Sophorae 26-42 weight portion, Radix Rumicis Japonici 11-22 weight portion and Rhizoma Imperatae 15-40 weight portion.
Functional feed for preventing and treating Ctenopharyngodon idellus erythroderma the most according to claim 1 and 2, it is characterised in that in described
In medicine additive, the ratio of weight and number of each crude drug is: Herba Centipedae 14 weight portion, Herba Lophatheri 22 weight portion, Fructus Gardeniae 25 weight
Amount part, Rhizoma Coptidis 32 weight portion, Cortex Phellodendri 17 weight portion, Cortex Fraxini 25 weight portion, Radix Sophorae Flavescentis 32 weight portion, Cortex Dictamni 23 weight portion, Radix Ophiopogonis
Spend 7 weight portions, Fructus Forsythiae 31 weight portion, Herba Andrographis 20 weight portion, Folium Isatidis 21 weight portion, Herba Violae 29 weight portion, Flos Chrysanthemi Indici
19 weight portions, Rhizoma Paridis 5 weight portion, Rhizoma Bistortae 32 weight portion, Herba Houttuyniae 11 weight portion, Caulis Sargentodoxae 30 weight portion, Herba Patriniae 15 weight
Part, Herba Potentillae Discoloris 10 weight portion, Pseudobulbus Cremastrae Seu Pleiones 26 weight portion, Herba Senecionis Scandentis 33 weight portion, Radix Ampelopsis 23 weight portion, Ilex purpurea Hassk.[I.chinensis Sims 27 weight portion,
Cortex Moutan 30 weight portion, Radix Rehmanniae 24 weight portion, Radix Arnebiae (Radix Lithospermi) 39 weight portion, Herba Cirsii 18 weight portion, Radix Sanguisorbae 24 weight portion, Flos Sophorae 37 weight
Amount part, Radix Rumicis Japonici 13 weight portion and Rhizoma Imperatae 25 weight portion.
Functional feed for preventing and treating Ctenopharyngodon idellus erythroderma the most according to claim 1 and 2, it is characterised in that in described
The preparation method of medicine additive comprises the following steps:
The first step: each component in described Chinese medicine additive be mixed in proportion, puts into pulverizer and carries out pulverizing or directly shredding,
Loading and decoct in container, the water adding 1-2 times amount makes its submergence medical material, after soaking 10-25 minute, is heated to boiling 40-70 and divides
Zhong Hou, separates fried liquid, and medicinal residues again add water and carry out decocting 2-3 time, separate and collect each fried liquid, then after filtering,
Take filtrate and abandon filtering residue；
Second step: after filtrate cools down, adding relative to the determining alcohol of filtrate weight 1-2 times is 80-90% ethanol, is sufficiently mixed
Uniformly, standing overnight so that it is precipitation, obtain filtrate after taking its supernatant liquid filtering next day, precipitate determining alcohol is 50-60%'s
Ethanol is cleaned, and collects washing liquid and merges with filtrate, and after ethanol is regained in decompression, dislocation lets cool place, stands 0.5-1 hour, makes precipitation
Completely, filter, filtrate low-temperature evaporation, it is thus achieved that paste；
3rd step: paste placed in spray dryer be dried, it is ensured that inlet temperature at 180 DEG C-200 DEG C, leaving air temp 70
DEG C-90 DEG C, it is ground into 300 mesh-400 mesh subsequently, it is thus achieved that powder Chinese medicine additive powder.
The preparation method of the functional feed for preventing and treating Ctenopharyngodon idellus erythroderma the most according to claim 1 and 2, its feature exists
In, comprise the following steps:
The first step, weigh by ratio of weight and the number of copies Semen Maydis, Sorghum vulgare Pers., Fructus Hordei Vulgaris, wheat bran, Radix Raphani, Exocarpium Benincasae, Chinese cabbage leaf, Fructus Citri tangerinae skin, DDGS,
Do in 80 DEG C after dried silkworm chrysalis meal, locust powder, bean worm powder, Pericarppium arachidis hypogaeae, sesame seed meal, egg shell powder, stachyose and Semen phaseoli radiati powder mix homogeneously
Dry 20min, then puts into pulverizer and carries out Crushing of Ultrafine sieve of 2.5mm excessively after pulverizing；
Second step, is mixed in proportion crude drug each in described Chinese medicine additive, carries out charcoal and fries 60-90 minute, is subsequently added phase
Determining alcohol for mixture quality 4-5 times is 80%-95% ethanol solution, heating and refluxing extraction 1.5-3.0 hour, it is thus achieved that first
Extracting solution, filters, it is thus achieved that the first filtrate, it is 80%-95% ethanol that filtering residue adds again relative to the determining alcohol of its quality 3-5 times
Solution, heating and refluxing extraction 1.5 hours, it is thus achieved that the second extracting solution, filter, it is thus achieved that the second filtrate, filtrate is merged, decompression
Concentrate and remove ethanol, it is thus achieved that dry mastic, use pulverizer to pulverize subsequently, grinding particle size 295-340 mesh, it is thus achieved that powder described
Chinese medicine additive；
3rd step, the first step obtained pulverizes the fine powder of acquisition, the Chinese medicine additive of second step acquisition, microelement pre-mix material
Putting in mixer and mix, the steam being passed through 94-103 DEG C in feeding modem is modulated 5-12 minute, then at 106-
Enter extruding puffing granulator at a temperature of 113 DEG C and make granule；
4th step, is ground into the powder of 120-160 mesh by enzyme premix material, pours in spraying machine, and in spraying machine, water temperature is 70-86
DEG C, open spraying machine, enzyme premix material powder spray obtained particle surface in the 3rd step, cools down after stirring 10-12min, it is thus achieved that
Described feedstuff.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410467185.7A CN104187171B (en) | 2014-09-15 | A kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410467185.7A CN104187171B (en) | 2014-09-15 | A kind of functional feed for preventing and treating Ctenopharyngodon idellus erythroderma and preparation method |
Publications (2)
| Publication Number | Publication Date |
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| CN104187171A CN104187171A (en) | 2014-12-10 |
| CN104187171B true CN104187171B (en) | 2017-01-04 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4693897A (en) * | 1984-08-16 | 1987-09-15 | Monell Chemical Senses Center | Stimulation and enhancement of feeding in herbivorous fish |
| CN101564106A (en) * | 2008-04-26 | 2009-10-28 | 王华军 | Preparation method of grass carp feed |
| CN101810261A (en) * | 2010-04-27 | 2010-08-25 | 中山大学 | Grass carp compound feed |
| CN101991005A (en) * | 2009-08-13 | 2011-03-30 | 河南牧鹤(集团)饲料有限公司 | Grass carp feed and processing method thereof |
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4693897A (en) * | 1984-08-16 | 1987-09-15 | Monell Chemical Senses Center | Stimulation and enhancement of feeding in herbivorous fish |
| CN101564106A (en) * | 2008-04-26 | 2009-10-28 | 王华军 | Preparation method of grass carp feed |
| CN101991005A (en) * | 2009-08-13 | 2011-03-30 | 河南牧鹤(集团)饲料有限公司 | Grass carp feed and processing method thereof |
| CN101810261A (en) * | 2010-04-27 | 2010-08-25 | 中山大学 | Grass carp compound feed |
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Inventor after: Ji Guiju Inventor after: Huang He Inventor after: Li Xin Inventor before: Li Huitao Inventor before: Huang He Inventor before: Li Xin |
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Effective date of registration: 20191118 Address after: No.1188 Baicao Road, West Park, hi tech Zone, Chengdu, Sichuan 610097 Patentee after: Chengdu Century Investment Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |