CN104181311B - A kind of thrombus elasticity testing device - Google Patents
A kind of thrombus elasticity testing device Download PDFInfo
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- CN104181311B CN104181311B CN201410417792.2A CN201410417792A CN104181311B CN 104181311 B CN104181311 B CN 104181311B CN 201410417792 A CN201410417792 A CN 201410417792A CN 104181311 B CN104181311 B CN 104181311B
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
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Abstract
The saucer unit that the invention discloses a kind of thrombus elasticity testing device, comprise back up pad, be arranged at measuring unit in described back up pad and driver element, be connected with described driver element, described measuring unit comprises pedestal, rotation section, rotating shaft and hairspring.Thrombus elasticity testing device provided by the invention, carries out rule concussion in conjunction with saucer unit to the blood sample surveyed in cup by driver element, with physiological environment thrombotic in analogue body, thus ensures test result accurately and reliably; The rotating shaft of point and the structure of hairspring is bored by adopting in measuring unit, while guarantee restoring force, the friction produced during the measuring unit that both fallen sharply concussion, substantially increase again the shock resistance of package unit, Measurement reliability is higher; Adopt optical lever measuring mechanism, effectively increase measurement resolution and the sensitivity of thrombus elastic force, measuring accuracy is significantly improved; Loading and the feel trim actuator of surveying cup make more convenient operation reliable.
Description
Technical field
The present invention relates to clinical coagulation analysis technical field, particularly a kind of thrombus elasticity testing device.
Background technology
Blood coagulation and blood clotting, refer to that blood is become the process of the gel state that can not flow by the liquid condition flowed, be the important step of physiological haemostasis, to be exactly that soluble fibrin in blood plasma is former become insoluble fibrinous process for the essence of blood clotting.Thrombelastogram instrument is used for clinical examination, it is one of important tool detecting blood coagulation, existing thrombus elasticity testing device complex structure, data processing stability that is loaded down with trivial details, measuring accuracy is not high, therefore, be necessary to research and develop a kind of thrombus elasticity testing device, to meet the requirement that clinical Hemostasis examination is now analyzed.
Summary of the invention
For the weak point existed in above-mentioned technology, the invention provides a kind of rational in infrastructure, simple operation, measuring accuracy thrombus elasticity testing device accurately and reliably.
The technical solution used in the present invention is: a kind of thrombus elasticity testing device, is characterized in that, comprising: back up pad, be provided with bulge loop, and the center place of described bulge loop offers annular distance, and the circumference both sides of described bulge loop offer guide rod hole, measuring unit, it comprises: pedestal, it is anchored on described bulge loop, described pedestal offers upper through hole and the lower through-hole of the setting of upper and lower co-axially align, axle holder is equipped with in described upper through hole, the inner tip of described upper axle holder is provided with adjustment cap, the inside of described upper axle holder is also provided with axillare, compression spring is provided with between described adjustment cap and described upper axillare, the inner bottom of described upper axle holder is fastened with upper baffle ring, lower shaft holder is equipped with in described lower through-hole, lower baffle ring and lower axillare is coaxially fastened with from top to bottom successively in described lower shaft holder, the side end face of described pedestal is provided with and measures position, described measurement position laser instrument and position transducer have been arranged side by side, rotation section, its center place offers center pit, upper through hole and the lower through-hole of described center pit and described pedestal are coaxially arranged, the top of described rotation section is fastened with one end of hairspring, the other end of described hairspring is anchored on the side end face of described pedestal, and the bottom of described rotation section is fastened with probe, and described probe runs through described annular distance coaxially, described rotation section is also provided with minute surface, and described minute surface and described measurement position are oppositely arranged, rotating shaft, it is placed in the center pit of described rotation section coaxially, and the top of described rotating shaft is provided with pivot, and described upper pivot and described upper axillare offset, and the bottom of described rotating shaft is provided with lower pivot, and described lower pivot and described lower axillare offset, driver element, it comprises the rolling bearing being placed on described bulge loop outside, the change be fastenedly connected on described rolling bearing, the driving mechanism that drives described change to rotate, described change is fixed with the one end of the guide rod running through described guide rod hole, the other end of described guide rod is provided with the saucer unit that can move up and down along described guide rod, is coaxially equipped with survey cup in described saucer unit.
Preferably, the bottom of described back up pad is fastened with set casing, the inner tip of described set casing is fastened with back-up ring, the bottom face of described back-up ring is provided with the ring that is coaxially affixed up and down and moves back a glass ring, the outer wall side of described set casing offers moves back a glass groove, described ring is provided with driving lever, move back described in described driving lever is placed in glass groove, described moving back between the top end face of glass ring and the bottom face of described set casing is provided with lower stage clip, the opposite side of described set casing outer wall is provided with guide pole, described guide pole and described driving lever are symmetricly set in described ring both sides, described probe coaxially runs through described back-up ring from top to bottom successively, ring and move back a glass ring.
Preferably, described saucer unit comprises glass stand, the cup chamber be arranged in described glass stand, be arranged at collet bottom described glass stand, the center of described collet is equipped with moves back a glass bar, described move back glass bar top and described cup chamber bottom upper surface bonded to each other, be provided with stage clip between the upper surface of described collet and described lower surface of moving back glass bar.
Preferably, described back up pad is provided with fixed block, described driving mechanism comprises drive motor, by the Slave Block of described cam driven transmission, one end of fork of being connected with described Slave Block, the other end of described fork is anchored on described change, the middle part of described fork is fastened with one end of extension spring, and the other end and the described fixed block of described extension spring are fastenedly connected.
Preferably, the bottom of described rotating shaft offers annular groove, is equipped with ring set in described annular groove, and the upper surface of described ring set and the end face of described rotation section fit.
Preferably, the top of described rotating shaft is provided with upper retaining surface, when described rotating shaft moves to extreme position, described upper baffle ring realizes spacing to described upper retaining surface, the bottom of described rotating shaft is provided with lower retaining surface, and when described rotating shaft is displaced downwardly to extreme position, described lower baffle ring realizes spacing to described lower retaining surface.
Preferably, the side end face of described rotation section is provided with set screw, described set screw realizes radial location to described rotating shaft.
Preferably, the lower surface of described upper axillare and center, the upper surface place of described lower axillare all offer ball recess, and described ball recess and described upper pivot and described lower pivot match.
The present invention compared with prior art, its beneficial effect is: thrombus elasticity testing device provided by the invention, in conjunction with saucer unit, rule concussion is carried out to the blood sample surveyed in cup by driver element, with physiological environment thrombotic in analogue body, thus ensure test result accurately and reliably; The rotating shaft of point and the structure of hairspring is bored by adopting in measuring unit, while guarantee restoring force, the friction produced during the measuring unit that both fallen sharply concussion, substantially increase again the shock resistance of package unit, Measurement reliability is higher; Adopt optical lever measuring mechanism, effectively increase measurement resolution and the sensitivity of thrombus elastic force, measuring accuracy is significantly improved; Loading and the feel trim actuator of surveying cup make more convenient operation reliable; This apparatus structure is simple and practical, simple operation, data processing fast, the requirement that clinical Hemostasis examination now analyzes can be met, there is good application value.
Accompanying drawing explanation
Fig. 1 is the structural representation of thrombus elasticity testing device of the present invention;
Fig. 2 is the schematic diagram that cooperatively interacts of saucer unit of the present invention and described survey cup;
Fig. 3 is the structural representation of measuring unit of the present invention;
Fig. 4 is the cut-open view of measuring unit of the present invention;
Fig. 5 is the part A cut-open view in Fig. 4 of the present invention;
Fig. 6 is the part B cut-open view in Fig. 4 of the present invention;
Fig. 7 is the structural representation of pedestal of the present invention;
Fig. 8 is the structural representation of rotating shaft of the present invention;
Fig. 9 is the structural representation of driver element of the present invention;
Figure 10 is the structural representation of back up pad of the present invention;
In figure: 100 measuring units; 101 adjustment caps; Axle holder on 102; 103 compression springs; Axillare on 104; 105 upper baffle rings; 106 pedestals; Through hole on 1061; 1062 lower through-holes; 1063 measure position; 107 rotating shafts; Pivot on 1071; 1072 times pivots; 1073 annular grooves; 1074 upper retaining surfaces; 1075 lower retaining surfaces; 108 hairsprings; 109 set screw; 110 minute surfaces; 111 ring sets; 112 lower baffle rings; 113 times axillares; 114 lower shaft holders; 115 rotation sections; 116 probes; 117 back-up rings; 118 driving levers; 119 guide poles; 120 rings; 121 move back a glass ring; 122 times stage clips; 123 set casings; 1231 move back a glass groove; 124 laser instruments; 125 position transducers; 200 saucer unit; 201 glass stands; 202 glasss of chambeies; 203 collets; 204 move back a glass bar; 205 stage clips; 300 survey cup; 301 glasss of heads; 302 glasss of bodies; 400 driver elements; 401 cams; 402 Slave Blocks; 403 forks; 404 drive motor; 405 changes; 406 guide rods; 407 rolling bearings; 408 extension springs; 500 back up pads; 501 fixed blocks; 502 guide rod holes; 503 bulge loops; 504 annular distances.
Embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail, can implement according to this with reference to instructions word to make those skilled in the art.
As shown in Figure 1, the invention provides a kind of thrombus elasticity testing device, comprising:
Back up pad 500 (as shown in Figure 10), is provided with bulge loop 503, and the center place of described bulge loop 503 offers annular distance 504, and the circumference both sides of described bulge loop 503 offer guide rod hole 502, and described back up pad 500 is also provided with fixed block 501;
Measuring unit 100 (as seen in figures 3-6), it comprises:
Pedestal 106 (as shown in Figure 7), its by screw fastening on described bulge loop 503, described pedestal 106 offers upper through hole 1061 and the lower through-hole 1062 of the setting of upper and lower co-axially align, axle holder 102 is equipped with in described upper through hole 1061, the inner tip of described upper axle holder 102 is provided with adjustment cap 101, the inside of described upper axle holder 102 is also provided with axillare 104, compression spring 103 is provided with between described adjustment cap 101 and described upper axillare 104, the inner bottom of described upper axle holder 102 is fastened with upper baffle ring 105, lower shaft holder 114 is equipped with in described lower through-hole 1062, lower baffle ring 112 and lower axillare 113 is coaxially fastened with from top to bottom successively in described lower shaft holder 114, the lower surface of described upper axillare 104 and center, the upper surface place of described lower axillare 113 all offer ball recess, the side end face of described pedestal 106 is provided with and measures position 1063, described measurement position 1063 is arranged side by side laser instrument 124 and position transducer 125,
Rotation section 115, its center place offers center pit, upper through hole 1061 and the lower through-hole 1062 of described center pit and described pedestal 106 are coaxially arranged, the top of described rotation section 115 is fastened with one end of hairspring 108, the other end of described hairspring 108 is anchored on the side end face of described pedestal 106, the bottom of described rotation section 115 is fastened with probe 116, described probe 116 runs through described annular distance 504 coaxially, described rotation section 115 is also provided with minute surface 110, and described minute surface 110 is oppositely arranged with described measurement position 1063;
Rotating shaft 107 (as shown in Figure 8), it is placed in the center pit of described rotation section 115 coaxially, the top of described rotating shaft 107 is provided with pivot 1071, described upper pivot 1071 offsets with described upper axillare 104, the bottom of described rotating shaft 107 is provided with lower pivot 1072, described lower pivot 1072 offsets with described lower axillare 113, described ball recess and described upper pivot 1071 and described lower pivot 1072 match, the bottom of described rotating shaft 107 offers annular groove 1073, ring set 111 is equipped with in described annular groove 1073, the upper surface of described ring set 111 and the end face of described rotation section 115 fit, during original state, initial alignment is carried out by ring set 111 countershaft 107 and rotation section 115, the top of described rotating shaft 107 is provided with upper retaining surface 1074, when described rotating shaft 107 moves to extreme position, described upper baffle ring 105 realizes spacing to described upper retaining surface 1074, the bottom of described rotating shaft 107 is provided with lower retaining surface 1075, when described rotating shaft 107 is displaced downwardly to extreme position, described lower baffle ring 112 realizes spacing to described lower retaining surface 1075, the side end face of described rotation section 115 is provided with set screw 109, described set screw 109 realizes radial location to described rotating shaft 107,
Set casing 123, it is by the bottom of screw fastening in described back up pad 500, the inner tip of described set casing 123 is fastened with back-up ring 117, the bottom face of described back-up ring 117 is provided with the ring 120 that is coaxially affixed up and down and moves back glass ring 121, the outer wall side of described set casing 123 offers moves back glass groove 1231, described ring 120 is provided with driving lever 118, move back described in described driving lever 118 is placed in glass groove 1231, described moving back between the top end face of glass ring 121 and the bottom face of described set casing 123 is provided with lower stage clip 122, the opposite side of described set casing 123 outer wall is provided with guide pole 119, described guide pole 119 and described driving lever 118 are symmetricly set in described ring 120 both sides, described probe 116 coaxially runs through described back-up ring 117 from top to bottom successively, ring 120 and move back glass ring 121,
Driver element 400 (as shown in Figure 9), it comprises the rolling bearing 407 being placed on described bulge loop 503 outside, be fastenedly connected the change 405 on described rolling bearing 407, drive the driving mechanism that described change 405 is rotated, described driving mechanism comprises drive motor 404, the Slave Block 402 of transmission is driven by described cam 401, the one end of the fork 403 be connected with described Slave Block 402, the other end of described fork 403 is anchored on described change 405, the middle part of described fork 403 is fastened with one end of extension spring 408, the other end and the described fixed block 501 of described extension spring 408 are fastenedly connected, described change 405 is fixed with the one end of the guide rod 406 running through described guide rod hole 502, the other end of described guide rod 406 is provided with the saucer unit 200 that can move up and down along described guide rod 406, described saucer unit 200 comprises glass stand 201, be arranged at the cup chamber 202 in described glass stand 201, be arranged at the collet 203 bottom described glass stand 201, the center of described collet 203 is equipped with moves back glass bar 204, described move back glass bar 204 top and described cup chamber 202 bottom upper surface bonded to each other, stage clip 205 is provided with between the upper surface of described collet 203 and described lower surface of moving back glass bar 204, coaxially be equipped with in described cup chamber 202 and survey cup 300, described survey cup 300 comprises cup 301 and cup body 302.
The concrete use procedure of this proving installation is as follows:
The blood sample of collection is placed in and surveys cup 300, the survey cup 300 that blood sample is housed is placed in glass chamber 202 (as shown in Figure 2), and move up being equipped with the glass stand 201 surveying cup 300 along guide rod 406, and be close to set casing 123 bottom, hand push moves back glass bar 204 and moves upward to make probe 116 to insert completely to survey in cup cup 301, move down to make upper axillare 104 by rotating adjustment cap 101, thus the pretightning force of adjustment rotating shaft 107 axis, start drive motor 404, cam 401 rotates under the effect of driving shaft, and drive fork 403 reciprocally swinging, thus change 405 is swung thereupon, glass stand 201 is finally made to shake according to predetermined rule, with physiological environment thrombotic in analogue body,
Now, probe 116 carries out the detection of thrombus elastic force to the blood sample surveyed in cup 300, drives rotation section 115 constant velocity rotation, make the minute surface 110 also constant velocity rotation be arranged on rotation section 115 while probe 116 swings; Meanwhile, laser instrument 124 is made to send laser by controlling primary controller (not shown), laser reflects (order of reflection foundation measuring accuracy requirement setting through minute surface 110, order of reflection is more, and precision is higher, and structure is also more complicated), reflected light is received by position transducer 125, detect the rotation angle of probe 116 according to this, data processor extrapolates the change figure of thrombus elastic force according to rotation angle, thus the thrombus force variation in the test blood clotting fibrinolytic process of sensitivity;
Be completed, by driving lever 118 along moving back glass groove 1231 slide downward, so that the cup 301 that blood sample is housed is separated with probe 116, move back glass bar 204 by hand propelled more up to move, so that the cup body 302 be placed in glass chamber 202 is popped up, after hand release, move back glass bar 204 and reset under stage clip 205 acts on.
Thrombus elasticity testing device provided by the invention, carries out rule concussion in conjunction with saucer unit 200 to the blood sample surveyed in cup 300 by driver element 400, with physiological environment thrombotic in analogue body, thus ensures test result accurately and reliably; The rotating shaft 107 of point and the structure of hairspring 108 is bored by adopting in measuring unit 100, while guarantee restoring force, the friction produced during the measuring unit that both fallen sharply concussion, substantially increase again the shock resistance of package unit, Measurement reliability is higher; Adopt optical lever measuring mechanism, effectively increase measurement resolution and the sensitivity of thrombus elastic force, measuring accuracy is significantly improved; Loading and the feel trim actuator of surveying cup 300 make more convenient operation reliable; This apparatus structure is simple and practical, simple operation, data processing fast, the requirement that clinical Hemostasis examination now analyzes can be met, there is good application value.
In the present embodiment, " top " " upper end " mentioned defines according to common meaning, such as, the definition of the direction of reference to gravitational, the direction of gravity is downwards, and contrary direction is top, similarly up be top or top.
Although embodiment of the present invention are open as above, but it is not limited in listed in instructions and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend described.
Claims (8)
1. a thrombus elasticity testing device, comprise driver element, it comprises the rolling bearing being placed on bulge loop outside, the change be fastenedly connected on described rolling bearing, the driving mechanism that drives described change to rotate, described change is fixed with the one end of the guide rod running through guide rod hole, the other end of described guide rod is provided with the saucer unit that can move up and down along described guide rod, coaxially be equipped with survey cup in described saucer unit, it is characterized in that, described thrombus elasticity testing device also comprises:
Back up pad, is provided with bulge loop, and the center place of described bulge loop offers annular distance, and the circumference both sides of described bulge loop offer guide rod hole;
Measuring unit, it comprises:
Pedestal, it is anchored on described bulge loop, described pedestal offers upper through hole and the lower through-hole of the setting of upper and lower co-axially align, axle holder is equipped with in described upper through hole, the inner tip of described upper axle holder is provided with adjustment cap, the inside of described upper axle holder is also provided with axillare, compression spring is provided with between described adjustment cap and described upper axillare, the inner bottom of described upper axle holder is fastened with upper baffle ring, lower shaft holder is equipped with in described lower through-hole, lower baffle ring and lower axillare is coaxially fastened with from top to bottom successively in described lower shaft holder, the side end face of described pedestal is provided with and measures position, described measurement position laser instrument and position transducer have been arranged side by side,
Rotation section, its center place offers center pit, upper through hole and the lower through-hole of described center pit and described pedestal are coaxially arranged, the top of described rotation section is fastened with one end of hairspring, the other end of described hairspring is anchored on the side end face of described pedestal, and the bottom of described rotation section is fastened with probe, and described probe runs through described annular distance coaxially, described rotation section is also provided with minute surface, and described minute surface and described measurement position are oppositely arranged;
Rotating shaft, it is placed in the center pit of described rotation section coaxially, and the top of described rotating shaft is provided with pivot, and described upper pivot and described upper axillare offset, and the bottom of described rotating shaft is provided with lower pivot, and described lower pivot and described lower axillare offset.
2. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, the bottom of described back up pad is fastened with set casing, the inner tip of described set casing is fastened with back-up ring, the bottom face of described back-up ring is provided with the ring that is coaxially affixed up and down and moves back a glass ring, the outer wall side of described set casing offers moves back a glass groove, described ring is provided with driving lever, move back described in described driving lever is placed in glass groove, described moving back between the top end face of glass ring and the bottom face of described set casing is provided with lower stage clip, the opposite side of described set casing outer wall is provided with guide pole, described guide pole and described driving lever are symmetricly set in described ring both sides, described probe coaxially runs through described back-up ring from top to bottom successively, ring and move back a glass ring.
3. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, described saucer unit comprises glass stand, the cup chamber be arranged in described glass stand, be arranged at collet bottom described glass stand, the center of described collet is equipped with moves back a glass bar, described move back glass bar top and described cup chamber bottom upper surface bonded to each other, be provided with stage clip between the upper surface of described collet and described lower surface of moving back glass bar.
4. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, described back up pad is provided with fixed block, described driving mechanism comprises drive motor, by the Slave Block of cam driven transmission, one end of fork of being connected with described Slave Block, the other end of described fork is anchored on described change, the middle part of described fork is fastened with one end of extension spring, and the other end and the described fixed block of described extension spring are fastenedly connected.
5. thrombus elasticity testing device as claimed in claim 4, it is characterized in that, the bottom of described rotating shaft offers annular groove, is equipped with ring set in described annular groove, and the upper surface of described ring set and the end face of described rotation section fit.
6. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, the top of described rotating shaft is provided with upper retaining surface, when described rotating shaft moves to extreme position, described upper baffle ring realizes spacing to described upper retaining surface, the bottom of described rotating shaft is provided with lower retaining surface, and when described rotating shaft is displaced downwardly to extreme position, described lower baffle ring realizes spacing to described lower retaining surface.
7. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, the side end face of described rotation section is provided with set screw, and described set screw realizes radial location to described rotating shaft.
8. thrombus elasticity testing device as claimed in claim 1, it is characterized in that, the lower surface of described upper axillare and center, the upper surface place of described lower axillare all offer ball recess, and described ball recess and described upper pivot and described lower pivot match.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410417792.2A CN104181311B (en) | 2014-08-22 | 2014-08-22 | A kind of thrombus elasticity testing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410417792.2A CN104181311B (en) | 2014-08-22 | 2014-08-22 | A kind of thrombus elasticity testing device |
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| CN104181311A CN104181311A (en) | 2014-12-03 |
| CN104181311B true CN104181311B (en) | 2016-02-03 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107525915A (en) * | 2016-06-21 | 2017-12-29 | 北京航空航天大学 | A kind of thrombelastogram instrument |
| CN107525915B (en) * | 2016-06-21 | 2019-10-18 | 北京航空航天大学 | A kind of thrombelastogram instrument |
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