CN104174058A - VHP sterilization device and method - Google Patents
VHP sterilization device and method Download PDFInfo
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- CN104174058A CN104174058A CN201410449682.4A CN201410449682A CN104174058A CN 104174058 A CN104174058 A CN 104174058A CN 201410449682 A CN201410449682 A CN 201410449682A CN 104174058 A CN104174058 A CN 104174058A
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Abstract
The invention discloses a VHP sterilization device and method. The sterilization device is arranged between a material area and a sterile area, and comprises an air source, a hydrogen peroxide storage device, a sterilization chamber, a dehumidification pipeline, a sterilization pipeline, a vent line and an air exhaust pipeline, wherein the dehumidification pipeline is connected with the air source and the sterilization chamber; the sterilization pipeline is connected with the air source, the hydrogen peroxide storage device and the sterilization chamber; the vent line is connected with the sterile area and the sterilization chamber; and the air exhaust pipeline is connected with the material area and the sterilization chamber. The sterilization method utilizing the sterilization device comprises three steps of dehumidifying, sterilizing and venting. Compared with the prior art, the scheme disclosed by the invention has the advantages that vapor hydrogen peroxide serves as a sterilizing medium, dehumidification, sterilization and ventilation are performed due to reasonable pipeline arrangement, and the sterilization effect and safety are effectively improved.
Description
Technical field
The present invention relates to sterilizing installation field, particularly a kind of VHP bactericidal unit and method.
Background technology
Traditional toilet's air sterilization technology mainly adopts ozone or formaldehyde to carry out disinfection or sterilizing, but the development along with aseptic medicine production, more and more higher to production environment and safety, environmental requirement, the negative effect that formaldehyde fumigation brings more and more draws attention, and formaldehyde easily condenses and adsorbs in disinfecting process, produce residually in a large number, people stay in the environment of residues of formaldehyde very large to human health damage for a long time, and bactericidal effect is undesirable.Therefore, this technology can not meet medical production field for the requirement of sterilizing.
Summary of the invention
The invention provides a kind of VHP bactericidal unit and method, in order to solve, in prior art, have the problem that bactericidal effect is poor, safety is low.
The invention provides a kind of VHP bactericidal unit, be arranged between material district and aseptic area, described bactericidal unit comprises source of the gas, hydrogen peroxide bin, sterilization chamber, dehumidifying pipeline, sterilizing pipeline, air pipeline and air draft pipeline, described dehumidifying pipeline connects source of the gas and sterilization chamber, described sterilizing pipeline connects source of the gas, hydrogen peroxide bin and sterilization chamber, described air pipeline connects aseptic area and sterilization chamber, described air draft pipeline junctional complex material district and sterilization chamber;
During dehumidifying, described sterilizing pipeline and air pipeline are closed, and described dehumidifying pipeline and air draft pipeline are opened, and the air in source of the gas to be via the dehumidifying pipeline laggard sterilization chamber that enters that dehumidifies, and are expelled to material district via described air draft pipeline;
During sterilizing, described dehumidifying pipeline and air pipeline are closed, and described sterilizing pipeline and air draft pipeline are opened, and the hydrogen peroxide in the air in source of the gas and hydrogen peroxide bin generates after vaporized hydrogen peroxide via sterilizing pipeline, enter sterilization chamber, and be expelled to material district via described air draft pipeline;
During ventilation, described dehumidifying pipeline and sterilizing pipeline are closed, and described air pipeline and air draft pipeline are opened, and the filtrated air in aseptic area enters sterilization chamber via air pipeline, and is expelled to material district via described air draft pipeline.
Further, described dehumidifying pipeline comprises the first valve and dehumidifier, and described source of the gas is connected sterilization chamber by described the first valve with dehumidifier successively.
Further, described sterilizing pipeline comprises VHP generator, the second valve, dosing pump, the 3rd valve, described source of the gas connects the air-in of VHP generator by the second valve, described hydrogen peroxide bin is connected the hydrogen oxide input port of VHP generator successively with the 3rd valve by dosing pump, the delivery outlet of described VHP generator connects sterilization chamber.
Further, between described source of the gas and the air-in of VHP generator, be also provided with pre-heater.
Further, described air pipeline comprises the 4th valve, ventilation blower fan and ventilation filter, and described aseptic area is connected sterilization chamber by described the 4th valve, ventilation blower fan with ventilation filter successively.
Further, described air draft pipeline comprises the 5th valve, exhaust fan and exhaust-air filter, and described sterilization chamber is connected material district by described the 5th valve, exhaust-air filter successively with exhaust fan.
Further, described exhaust-air filter comprises drainage screen and is coated in the manganese dioxide powder on described drainage screen.
Further, this sterilization chamber comprises the openable hatch door of two fans, two described fan hatch doors are respectively used to be communicated with material district and sterilization chamber and aseptic area and sterilization chamber after opening, and described hatch door comprises a body and doorframe, on doorframe, be provided with groove with the cooperation place of door body, in this groove, be provided with jacking mechanism and sealing ring, described sealing ring is arranged at the notch of groove, when described door body is closed, described sealing ring ejects to groove outside under jacking mechanism effect, combines closely with door body.
The present invention also provides a kind of VHP sterilizing methods, comprises the following steps:
Dehumidifying, open dehumidifying pipeline and air draft pipeline, close sterilizing pipeline and air pipeline, after the air of low dew point is dehumidified via dehumidifying pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline, so that the humiture in sterilization chamber and pressure reach preset value;
Sterilizing, opens sterilizing pipeline and air draft pipeline, closes dehumidifying pipeline and air pipeline, and air and hydrogen peroxide are generated after vaporized hydrogen peroxide via sterilizing pipeline, sends into sterilization chamber, and is expelled to material district via described air draft pipeline;
Ventilate, open air pipeline and air draft pipeline, close dehumidifying pipeline and sterilizing pipeline, the filtrated air in aseptic area is sent into sterilization chamber via air pipeline, and be expelled to material district via described air draft pipeline, until the concentrations of vapor hydrogen peroxide in described sterilization chamber is lower than preset concentration.
Further, the persistent period of described sterilization steps is 60～90 minutes.
The present invention adopts vaporized hydrogen peroxide as sterile medium, by rational line arrangement, dehumidifies, sterilizing and ventilation, has effectively improved sterilization effect and safety.In addition, in air draft pipeline, adopted the exhaust gas purification mode of catalysis type, by apply manganese dioxide powder on drainage screen, can be decomposed into environment is not had to influential water and oxygen so that the vaporized hydrogen peroxide of discharging reacts with it, prevented from polluting.
Accompanying drawing explanation
The structural representation of a kind of VHP bactericidal unit that Fig. 1 provides for the embodiment of the present invention one;
Fig. 2 is the hatch door structural representation of sterilization chamber in the embodiment of the present invention one;
The schematic flow sheet of a kind of VHP sterilizing methods that Fig. 3 provides for the embodiment of the present invention one;
The piping arrangement of a kind of VHP bactericidal unit that Fig. 4 provides for the embodiment of the present invention two.
The specific embodiment
Below in conjunction with Figure of description, the embodiment of the present invention is described in further detail.
Embodiment mono-
A kind of VHP bactericidal unit that the embodiment of the present invention one provides, is arranged between material district and aseptic area.Aseptic area refers to the region that needs to carry out sterile working, and in this region, necessary maintenance personnel and relative article, in aseptic condition, therefore must carry out disinfection by bactericidal unit when article are sent into aseptic area by material district.During use, operator will need the article of sterilizing to put into bactericidal unit in material district one side, carry out after sterilization treatment, by aseptic area one side-draw, are gone out in order to use in aseptic area.
The concrete structure of this bactericidal unit as shown in Figure 1, comprises source of the gas 1, hydrogen peroxide bin 2, sterilization chamber 3, dehumidifying pipeline 4, sterilizing pipeline 5, air pipeline 6 and air draft pipeline 7.Dehumidifying pipeline 4 connects source of the gas 1 and sterilization chamber 3, and described sterilizing pipeline 5 connects source of the gas 1, hydrogen peroxide bin 2 and sterilization chamber 3, and described air pipeline 6 connects aseptic area A and sterilization chamber 3, and described air draft pipeline 7 connects material district B and sterilization chamber 3.
Above-mentioned several pipeline is provided with corresponding valve, by valve, is carried out the unlatching of control piper or is closed.In the course of the work, this bactericidal unit comprises following several duty:
One, except wet condition
In when dehumidifying, described sterilizing pipeline 5 and air pipeline 6 are closed, and described dehumidifying pipeline 4 and air draft pipeline 7 are opened, and the air in source of the gas 1, via the dehumidifying pipeline 4 laggard sterilization chamber 3 that enters that dehumidifies, is then expelled to material district B via described air draft pipeline 7.
Two, sterilizing state
When sterilizing, described dehumidifying pipeline 4 and air pipeline 6 are closed, described sterilizing pipeline 5 and air draft pipeline 7 are opened, hydrogen peroxide in air in source of the gas 1 and hydrogen peroxide bin 2 generates after vaporized hydrogen peroxide via sterilizing pipeline, enter sterilization chamber 3, then via described air draft pipeline 7, be expelled to material district B.
Three, ventilation state
When ventilating, described dehumidifying pipeline 4 and sterilizing pipeline 5 are closed, and described air pipeline 6 and air draft pipeline 7 are opened, and the filtrated air in the A of aseptic area enters sterilization chamber 3 via air pipeline 6, then via described air draft pipeline 7, is expelled to material district B.
Wherein, described dehumidifying pipeline 4 comprises the first valve and dehumidifier, and described source of the gas is connected sterilization chamber by described the first valve with dehumidifier successively.
Described sterilizing pipeline 5 comprises VHP generator, the second valve, dosing pump, the 3rd valve, described source of the gas connects the air-in of VHP generator by the second valve, described hydrogen peroxide bin is connected the hydrogen oxide input port of VHP generator successively with the 3rd valve by dosing pump, the delivery outlet of described VHP generator connects sterilization chamber.In addition, between described source of the gas and the air-in of VHP generator, be also provided with pre-heater, for preheating entering the air of VHP generator, to improve the production efficiency of vaporized hydrogen peroxide.
Described air pipeline 6 comprises the 4th valve, ventilation blower fan and ventilation filter, and described aseptic area is connected sterilization chamber by described the 4th valve, ventilation blower fan with ventilation filter successively.
Described air draft pipeline 7 comprises the 5th valve, exhaust fan and exhaust-air filter, and described sterilization chamber is connected material district by described the 5th valve, exhaust-air filter successively with exhaust fan.Wherein, exhaust-air filter comprises drainage screen and is coated in the manganese dioxide powder on described drainage screen, by apply manganese dioxide powder on drainage screen, and can be so that the vaporized hydrogen peroxide of discharging reacts with it, be decomposed into environment is not had to influential water and oxygen, prevent from polluting.
This sterilization chamber 3 comprises the openable hatch door 8 of two fans, and two described fan hatch doors are respectively used to be communicated with material district and sterilization chamber and aseptic area and sterilization chamber after opening, and article can be sent into by material district, and have aseptic area to take out.The concrete structure of hatch door can adopt structure as shown in Figure 2, comprise a body 81 and doorframe 82, on doorframe, be provided with groove 83 with the cooperation place of door body, in this groove 83, be provided with jacking mechanism and sealing ring 85, described sealing ring 85 is arranged at the notch place of groove 83, when described door body is closed, described sealing ring 85 ejects to groove outside under jacking mechanism effect, combines closely with door body.
When practical application, above-mentioned jacking mechanism can adopt the mechanism of pneumatic type.Because sealing ring 85 is arranged at the notch of groove 83, make inside grooves can form a cavity 86, jacking mechanism can be a gas passage 87 and for controlling the valve of this gas passage, gas passage is communicated with the cavity 86 in source of the gas and groove, in the time of need to holding out against, by source of the gas via gas passage to 86 input Compressed Gas in cavity so that sealing ring 85 is ejected under the effect of Compressed Gas, reach sealing effectiveness.
In conjunction with above-mentioned bactericidal unit, the embodiment of the present invention one also provides a kind of VHP sterilizing methods, comprises step as shown in Figure 3:
Step 301, dehumidifying.
Open dehumidifying pipeline and air draft pipeline, close sterilizing pipeline and air pipeline, after the air of low dew point is dehumidified via dehumidifying pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline, so that the humiture in sterilization chamber and pressure reach preset value.In the present embodiment, by dew point for-22 air heat to 30 degree centigrade and dehumidify after send into sterilization chamber, to reach good effect on moisture extraction.
Step 302, sterilizing.
Open sterilizing pipeline and air draft pipeline, close dehumidifying pipeline and air pipeline, air and hydrogen peroxide are generated after vaporized hydrogen peroxide via sterilizing pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline.
The persistent period of this step is 60～90 minutes, can obtain good sterilization effect.
Step 303, ventilates.
Open air pipeline and air draft pipeline, close dehumidifying pipeline and sterilizing pipeline, filtrated air in aseptic area is sent into sterilization chamber via air pipeline, and be expelled to material district via described air draft pipeline, until the concentrations of vapor hydrogen peroxide in described sterilization chamber is lower than preset concentration.In general pharmaceutical industry, the general preset concentration of setting is 1PPM.
Embodiment bis-
A kind of VHP bactericidal unit that the embodiment of the present invention two provides, the pipeline arranging structure of this bactericidal unit as shown in Figure 4.
Dehumidifying pipeline 4 shares a source of the gas 1 with sterilizing pipeline 5, by this source of the gas, provides compressed air.Dehumidifying pipeline 4 comprises the first valve 41 and dehumidifier 42, and source of the gas 1 is connected sterilization chamber 3 by described the first valve 41 with dehumidifier 42 successively.Sterilizing pipeline 5 comprises VHP generator 55, pre-heater 51, the second valve 52, dosing pump 53 and the 3rd valve 54, described source of the gas is complied with the air-in that connects VHP generators 55 for 1 time by pre-heater 51, the second valve 52, described hydrogen peroxide bin 2 is connected the hydrogen oxide input port of VHP generator 55 by dosing pump 53 successively with the 3rd valve 54, the delivery outlet of described VHP generator 55 connects sterilization chamber 3.Air pipeline 6 comprises the 4th valve 61, ventilation blower fan 62 and ventilation filter 63, and described aseptic area A is connected sterilization chamber 3 by described the 4th valve 61, ventilation blower fan 62 with ventilation filter 63 successively.Described air draft pipeline 7 comprises the 5th valve 71, exhaust fan 72 and exhaust-air filter 73, and described sterilization chamber is connected material district B by described the 5th valve 71, exhaust-air filter 73 successively with exhaust fan 72.
Specific works principle while adopting this bactericidal unit to carry out sterilizing is as follows:
The article that need sterilizing are put into after sterilization chamber, first dehumidify.
When dehumidifying, open the first valve 41 and the 5th valve 71, close the second valve 51, the 3rd valve 54 and the 4th valve 61, described sterilizing pipeline 5 and air pipeline 6 are closed, described dehumidifying pipeline 4 and air draft pipeline 7 are opened.After the air of low dew point is dehumidified via dehumidifying pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline, so that the humiture in sterilization chamber and pressure reach preset value.
Complete after dehumidifying, then carry out sterilizing.
When sterilizing, open the second valve 51, the 3rd valve and the 5th valve 71, close the first valve 41 and the 4th valve 61, described dehumidifying pipeline 4 and air pipeline 6 are closed, described sterilizing pipeline 5 and air draft pipeline 7 are opened.Air and hydrogen peroxide are generated after vaporized hydrogen peroxide via sterilizing pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline, now article have completed sterilizing.
After sterilizing completes, then ventilate.
When ventilating, open the 4th valve 61 and the 5th valve 71, close the first valve 41, the second valve 51 and the 3rd valve 54, make to dehumidify pipeline 4 and sterilizing pipeline 5 are closed, and described air pipeline 6 and air draft pipeline 7 are opened.Filtrated air in aseptic area is sent into sterilization chamber via air pipeline, and be expelled to material district via described air draft pipeline, until the concentrations of vapor hydrogen peroxide in described sterilization chamber is lower than preset concentration.Now, the air in sterilization chamber has been replaced into the air in aseptic area, can open the hatch door of aseptic area one side, takes out article.
Obviously, those skilled in the art can carry out various changes and modification and not depart from the spirit and scope of the present invention the present invention.Like this, if within of the present invention these are revised and modification belongs to the scope of the claims in the present invention and equivalent technologies thereof, the present invention is also intended to comprise these changes and modification interior.
Claims (10)
1. a VHP bactericidal unit, be arranged between material district and aseptic area, it is characterized in that, described bactericidal unit comprises source of the gas, hydrogen peroxide bin, sterilization chamber, dehumidifying pipeline, sterilizing pipeline, air pipeline and air draft pipeline, described dehumidifying pipeline connects source of the gas and sterilization chamber, described sterilizing pipeline connects source of the gas, hydrogen peroxide bin and sterilization chamber, and described air pipeline connects aseptic area and sterilization chamber, described air draft pipeline junctional complex material district and sterilization chamber;
During dehumidifying, described sterilizing pipeline and air pipeline are closed, and described dehumidifying pipeline and air draft pipeline are opened, and the air in source of the gas to be via the dehumidifying pipeline laggard sterilization chamber that enters that dehumidifies, and are expelled to material district via described air draft pipeline;
During sterilizing, described dehumidifying pipeline and air pipeline are closed, and described sterilizing pipeline and air draft pipeline are opened, and the hydrogen peroxide in the air in source of the gas and hydrogen peroxide bin generates after vaporized hydrogen peroxide via sterilizing pipeline, enter sterilization chamber, and be expelled to material district via described air draft pipeline;
During ventilation, described dehumidifying pipeline and sterilizing pipeline are closed, and described air pipeline and air draft pipeline are opened, and the filtrated air in aseptic area enters sterilization chamber via air pipeline, and is expelled to material district via described air draft pipeline.
2. VHP bactericidal unit according to claim 1, is characterized in that, described dehumidifying pipeline comprises the first valve and dehumidifier, and described source of the gas is connected sterilization chamber by described the first valve with dehumidifier successively.
3. VHP bactericidal unit according to claim 1, it is characterized in that, described sterilizing pipeline comprises VHP generator, the second valve, dosing pump, the 3rd valve, described source of the gas connects the air-in of VHP generator by the second valve, described hydrogen peroxide bin is connected the hydrogen oxide input port of VHP generator successively with the 3rd valve by dosing pump, the delivery outlet of described VHP generator connects sterilization chamber.
4. VHP bactericidal unit according to claim 3, is characterized in that, between described source of the gas and the air-in of VHP generator, is also provided with pre-heater.
5. VHP bactericidal unit according to claim 1, is characterized in that, described air pipeline comprises the 4th valve, ventilation blower fan and ventilation filter, and described aseptic area is connected sterilization chamber by described the 4th valve, ventilation blower fan with ventilation filter successively.
6. VHP bactericidal unit according to claim 1, is characterized in that, described air draft pipeline comprises the 5th valve, exhaust fan and exhaust-air filter, and described sterilization chamber is connected material district by described the 5th valve, exhaust-air filter successively with exhaust fan.
7. VHP bactericidal unit according to claim 6, is characterized in that, described exhaust-air filter comprises drainage screen and is coated in the manganese dioxide powder on described drainage screen.
8. VHP bactericidal unit according to claim 1, it is characterized in that, this sterilization chamber comprises the openable hatch door of two fans, after two described fan hatch doors are opened, be respectively used to be communicated with material district and sterilization chamber and aseptic area and sterilization chamber, described hatch door comprises a body and doorframe, on doorframe, be provided with groove with the cooperation place of door body, in this groove, be provided with jacking mechanism and sealing ring, described sealing ring is arranged at the notch of groove, when described door body is closed, described sealing ring ejects to groove outside under jacking mechanism effect, combines closely with door body.
9. a VHP sterilizing methods, is characterized in that, comprises the following steps:
Dehumidifying, open dehumidifying pipeline and air draft pipeline, close sterilizing pipeline and air pipeline, after the air of low dew point is dehumidified via dehumidifying pipeline, send into sterilization chamber, and be expelled to material district via described air draft pipeline, so that the humiture in sterilization chamber and pressure reach preset value;
Sterilizing, opens sterilizing pipeline and air draft pipeline, closes dehumidifying pipeline and air pipeline, and air and hydrogen peroxide are generated after vaporized hydrogen peroxide via sterilizing pipeline, sends into sterilization chamber, and is expelled to material district via described air draft pipeline;
Ventilate, open air pipeline and air draft pipeline, close dehumidifying pipeline and sterilizing pipeline, the filtrated air in aseptic area is sent into sterilization chamber via air pipeline, and be expelled to material district via described air draft pipeline, until the concentrations of vapor hydrogen peroxide in described sterilization chamber is lower than preset concentration.
10. VHP sterilizing methods according to claim 9, is characterized in that, the persistent period of described sterilization steps is 60～90 minutes.
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Cited By (5)
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| CN110461371A (en) * | 2017-03-27 | 2019-11-15 | 里珍纳龙药品有限公司 | Sterilizing methods |
| CN110585908A (en) * | 2019-09-18 | 2019-12-20 | 无锡零界净化设备股份有限公司 | Catalytic decomposition filter paper and filter for VHP (very high molecular weight) sterilization device |
| CN111254053A (en) * | 2019-12-31 | 2020-06-09 | 浙江泰林医学工程有限公司 | Hydrogen peroxide instantaneous sterilization device and sterilization method |
| CN111426022A (en) * | 2020-04-02 | 2020-07-17 | 克莱门特捷联制冷设备(上海)有限公司 | Disinfection and sterilization device and disinfection and sterilization method for air conditioning unit |
| CN112400084A (en) * | 2018-06-11 | 2021-02-23 | 杜斯米特有限公司 | Technique for denaturing small biological objects in a building |
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| CN102350003B (en) * | 2011-10-28 | 2014-03-19 | 成都老肯科技股份有限公司 | Hydrogen peroxide low-temperature sterilizing equipment and use method thereof |
| CN202314532U (en) * | 2011-11-25 | 2012-07-11 | 四川汇宇制药有限公司 | Hydrogen peroxide sterilization device |
| CN202440293U (en) * | 2011-11-25 | 2012-09-19 | 四川汇宇制药有限公司 | Isolator air treatment system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110461371A (en) * | 2017-03-27 | 2019-11-15 | 里珍纳龙药品有限公司 | Sterilizing methods |
| US10905786B2 (en) | 2017-03-27 | 2021-02-02 | Regeneron Pharmaceuticals, Inc. | Sterilisation method |
| US10918754B2 (en) | 2017-03-27 | 2021-02-16 | Regeneron Pharmaceuticals, Inc. | Sterilisation method |
| CN110461371B (en) * | 2017-03-27 | 2022-03-18 | 里珍纳龙药品有限公司 | Sterilization method |
| CN112400084A (en) * | 2018-06-11 | 2021-02-23 | 杜斯米特有限公司 | Technique for denaturing small biological objects in a building |
| US11193679B2 (en) | 2018-06-11 | 2021-12-07 | Dusmit Ltd | Technique for denaturing of small organic items in premises |
| CN112400084B (en) * | 2018-06-11 | 2022-04-12 | 杜斯米特有限公司 | Technique for denaturing small biological objects in a building |
| CN110585908A (en) * | 2019-09-18 | 2019-12-20 | 无锡零界净化设备股份有限公司 | Catalytic decomposition filter paper and filter for VHP (very high molecular weight) sterilization device |
| CN111254053A (en) * | 2019-12-31 | 2020-06-09 | 浙江泰林医学工程有限公司 | Hydrogen peroxide instantaneous sterilization device and sterilization method |
| CN111254053B (en) * | 2019-12-31 | 2023-06-02 | 浙江泰林医学工程有限公司 | Hydrogen peroxide instantaneous sterilization device and sterilization method |
| CN111426022A (en) * | 2020-04-02 | 2020-07-17 | 克莱门特捷联制冷设备(上海)有限公司 | Disinfection and sterilization device and disinfection and sterilization method for air conditioning unit |
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| CN104174058B (en) | 2017-04-12 |
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