CN104173594A - Chinese herbal medicine patch package for treating ascites due to cirrhosis and umbilical patch thereof - Google Patents
Chinese herbal medicine patch package for treating ascites due to cirrhosis and umbilical patch thereof Download PDFInfo
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Abstract
The invention provides a Chinese herbal medicine patch package for treating ascites due to cirrhosis and an umbilical patch thereof, and aims at overcoming the problems that the Western medicine is not ideal in treatment effect on liver ascites and a plurality of side effects are caused by long-term treatment. According to the technical scheme, the Chinese herbal medicine patch package for treating ascites due to cirrhosis comprises the following components by weight: 4-6g of rheum officinale, 4-5g of mirabilite, 3-5g of semen pharbitidis, 3-5g of fennel, 3-4g of agilawood and 2-3g of borneol. The preparation method comprises the following steps: 1, weighing the rheum officinale, the mirabilite, the semen pharbitidis, the fennel, the agilawood and the borneol for later use according to the weight of the formula components; 2, cleaning the Chinese herbal medicines, drying, crushing and screening by a 100-mesh sieve; and 3, taking a filter paper bag of which the area is 6cm*6cm and the thickness is 0.3on, enclosing 8g of mixed powder into each bag, and sealing and packaging by using an aluminum-plastic composite film bag after conventional sterilization. The Chinese herbal medicine patch package also comprises a permeation enhancer for wetting the patch package. The Chinese herbal medicine patch package is reasonable in formula, easy to prepare, low in cost, and convenient to use, and has good clinical and social value, and the clinical curative effect and the safety are fully validated.
Description
Technical field
The present invention relates to medicine, particularly a kind of Chinese herbal medicine patch bag and umbilicus note agent (the relieving distension umbilicus that claims again to relieve oedema or abdominal distension through diuresis or purgation pastes) thereof for the treatment of cirrhotic ascites.
Background technology
Cirrhotic ascites is commonly called as hepatic ascites, occurs hypofunction of liver when liver cirrhosis, and causes portal hypertension, splenomegaly, and intestinal to protein and vitamin malabsorption and leak out protein liquid, has formed ascites symptoms; Cirrhotic ascites is that liver is transferred to an important symbol losing the compensatory phase by the compensatory phase, once there is ascites in liver cirrhosis patient, and prognosis mala, within 2 years, survival rate is lower than 50 ﹪; Its evolution process is both relevant, also relevant with individual immunity state with the development of liver basis disease itself; Ascites forms mechanism for the excessive retention of sodium water, relevant with abdominal cavity factor and systemic factor, common because have:
1, portal venous pressure increases, and abdominal viscera vascular bed hydrostatic pressing increases, and tissue fluid resorption is received and reduced and the abdominal cavity of bleeding;
2, hypoalbuminemia causes plasma colloid osmotic pressure reduction, and blood constituent exosmoses;
3, lymph fluid generates too much;
4, Secondary cases aldosterone increases and causes kidney sodium and heavily absorb increase;
5, the heavily absorption that antidiuretic hormone secretion too much causes water increases;
Above-mentioned various factors is given priority in ascites formation and sustained period role, and wherein hepatic insufficiency and portal hypertension run through whole process; Before ascites occurs, most patient often has abdominal distention, and abdominal tympanites shape, as frog abdomen, patient's difficulty in walking, occurs that orthopnea and umbilical hernia, part patient are with breast water then; The anemia that blood biochemistry checking can have weight not wait, when hypersplenism, hemocyte and platelet count reduce, transaminase often has gently, moderate increases; Archon ratio is inverted, and hepatic fibrosis index obviously raises; Ascites inspection mostly is and spills liquid.
The Therapeutic Method doctor trained in Western medicine of Refractory ascites resulted from hepatocirrhosis is divided into following six aspects:
1, the treatment of protopathy; 2, internal medicine conservative treatment; 3, Therapeutic paracentesis repeatedly; 4, interventional therapy, as bypass (TIPS) in jugular vein door body liver; 5, surgical operation therapy; 6, liver transplantation, but curative effect is all dissatisfied.
The oral drugs of western medical treatment ascites mostly are diuretic, diuresis can reduce blood volume, alleviate surrounding tissue and internal organs edema, diuretic can make swelling of the feet, lower limb is swollen disappears, but without obvious effect, and the life-time service of diuretic can produce very large side effect to dead space water such as ascites, hydrothorax and pericardial effusions:
1, too urgent too quickly diuresis easily causes dehydration and electrolyte disturbance, and diuresis excessively can cause Hypovolemia, low blood sodium, hypokalemia, hypomagnesemia and hypochloremic alkalosis;
2, ototoxicity, show as dizzy, tinnitus, auditory dysesthesia, temporary deafness;
3, gastrointestinal reaction, can cause nauseating, vomiting, epigastric discomfort and diarrhoea, heavy dose can cause gastrointestinal hemorrhage;
4, hyperuricemia, this medicine and uric acid are all by the excretion of kidney organic acid movement system, and competing property suppresses, and long-term prescription can reduce urate excretion and cause hyperuricemia; Use frequently diuretic can cause vicious cycle, that patient can occur is weak, the soreness of waist, feel sick and the symptom such as diuresis is invalid.
Doctor trained in Western medicine is abdominal paracentesis extraction hydrops repeatedly:
1, can cause hydrops produce speed faster, after general 3 days, hydrops can be met again, approximately 50% patient 7-10 days hydrops can increase to the level before tapping, 97% case hydrops within January can meet again before level;
2, make to lose a large amount of albumen in patient body and cause hypoproteinemia, thereby it is poorer to cause hydrops to produce faster general status, becomes thin, dyscrasia further increases the weight of;
3, increase infection chance, can form empyema, pneumothorax, bronchopleural fistula;
Thereby 4, cause pleuroperitoneum adhesion to form " encapsulated effusion ", patient occurs cough, breathes hard, chest pain further increases the weight of, and respiratory function is poorer, makes to treat more difficult.
Doctor trained in Western medicine intracavitary administration medicine:
1, can make that feeling sick appears in patient, the untoward reaction such as vomiting, weak, chest pain, stomachache, fever, shiver with cold, leukopenia.
Ascites doctor trained in Western medicine conventional treatments is more harm than good, and namely toxic and side effects is huge, and curative effect is very micro-, the actual slight illness that often can't resolve patient, consequently patient's general status is poorer, and quality of life declines, dyscrasia increases the weight of, and life is more critically ill, finally loses the chance of " for a long time with tumor existence ".
The Therapeutic Principle of Chinese traditional treatment edema is: negative and positive and controlling, YANG edema mainly control with diaphoresis, diuresis, should lung spleen invigorating, water is wet stop up contain can take the circumstances into consideration provisional attack by, always taking eliminating evil as main; YIN edema is mainly controlled with warming YANG and invigorating QI, spleen invigorating, kidney tonifying, reinforcing the heart, double diuresis, always help gasification for controlling with righting, deficiency and excess the person of opinion, reinforcement and elimination in combination, the two large method for the treatment of of using diaphoresis, diuresis dialectically, motherland's medical science thinks that cirrhotic ascites belongs to the category such as " tympanites ", " dropsy ", " Aranea legendary venomous insect ", is one of " wind, labor, drum, diaphragm " four large pertinacious diseases; The traditional Chinese medical science thinks that the formation of primary disease is mainly that liver,spleen,kidney three is dirty impaired due to various factors, the liver failing to maintain the normal flow of QI, and dysfunction of the spleen in transportation, kidney loses to be opened entirely, causes gas, blood, the water stasis of blood and amasss in abdomen and form; Its pathogenic characteristic is deficiency in origin and excess in superficiality; Just, be stagnation of liver-QI with deficiency of the spleen, retention of dampness due to stagnation of QI mid-term, involve in kidney late period, if water damp poison is strongly fragrant, heat-transformation is disturbed and the mind, priming liver-wind, sudden raw coma, the crisis such as hemorrhage; This disease belongs to difficult critical illness, depends merely on a kind of therapy and is difficult to gather effect, often needs Comprehensive Treatment; Because primary disease is the card of deficiency in origin and excess in superficiality, giving consideration to both the incidental and fundamental is worked as in treatment, except tonifying speen and tonifying kidney, blood stasis dispelling softening the hard mass, also needs " symptomatic treatment in acute condition ", the method that adopts purging FU-organs the turbid descending, circulation of qi promoting to relieve oedema or abdominal distension through diuresis or purgation; This navel patch, just based on above-mentioned theory, on reference to a large amount of evidence-based medicine EBM data bases, develops by clinical repeatedly practising, through clinical application, evident in efficacy, can accelerate ascites and disappear, and reduces complication, obviously shortens patient's time of hospitalization.
Summary of the invention
For present stage, the therapeutic effect of western medical treatment hepatic ascites existence is undesirable, and many side-effect problems of causing of prolonged application diuretic or surgical intervention, the invention provides a kind of Chinese medicine formula for overcoming the defect of prior art, can effectively solve western medical treatment hepatic ascites effect undesirable, the problems such as side effect is many, and prescription science, preparation is simple, easy to use, effect stability can prolonged application.
The technical scheme of dealing with problems is:
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 4-6g, Natrii Sulfas 4-5g, Semen Pharbitidis 3-5g, Fructus Foeniculi 3-5g, Lignum Aquilariae Resinatum 3-4g, Borneolum Syntheticum 2-3g medicine, its preparation method is:
Step 1, to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
A umbilicus note agent for the treatment of cirrhotic ascites, forms by Chinese herbal medicine patch bag with for the transdermal enhancer of moistening this patch bag.
Transdermal enhancer is 0.5% laurocapram solution preferably.
When the present invention uses, aluminum-plastic composite membrane bag is torn, taking-up patch wraps in transdermal enhancer and soaks into, stick in SHENQUE acupoint, the property of medicine enters human body by sticking SHENQUE acupoint, can continue in a long time release with constant speed, and Clinical efficacy and safety is fully verified, said preparation cost is low, preparation is simple, easy to use, has well clinical and social value.
Detailed description of the invention
Below in conjunction with embodiment, the content of invention is described in detail:
Embodiment 1
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 6g, Natrii Sulfas 5g, Semen Pharbitidis 4g, Fructus Foeniculi 4g, Lignum Aquilariae Resinatum 3g, Borneolum Syntheticum 2g, its preparation method is:
Step 1, first to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
Embodiment 2
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 5g, Natrii Sulfas 4.5g, Semen Pharbitidis 4g, Fructus Foeniculi 4g, Lignum Aquilariae Resinatum 3.5g, Borneolum Syntheticum 2.5g, its preparation method is:
Step 1, first to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
Embodiment 3
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 5g, Natrii Sulfas 5g, Semen Pharbitidis 3g, Fructus Foeniculi 3g, Lignum Aquilariae Resinatum 3g, Borneolum Syntheticum 2g, its preparation method is:
Step 1, first to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
Embodiment 4
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 6g, Natrii Sulfas 5g, Semen Pharbitidis 5g, Fructus Foeniculi 5g, Lignum Aquilariae Resinatum 4g, Borneolum Syntheticum 3g, its preparation method is:
Step 1, first to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
Embodiment 5
A kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites: be made up of Radix Et Rhizoma Rhei 4g, Natrii Sulfas 4g, Semen Pharbitidis 3g, Fructus Foeniculi 3g, Lignum Aquilariae Resinatum 3g, Borneolum Syntheticum 2g, its preparation method is:
Step 1, first to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and close with aluminum-plastic composite membrane bag after routine disinfection, and package is dressed up finished product.
Embodiment 6
A kind of umbilicus note agent for the treatment of cirrhotic ascites: by treating the Chinese herbal medicine patch bag of cirrhotic ascites and forming for the transdermal enhancer of moistening this Chinese herbal medicine patch bag,
Chinese herbal medicine patch bag: by Radix Et Rhizoma Rhei 4-6g, Natrii Sulfas 4-5g, Semen Pharbitidis 3-5g, Fructus Foeniculi 3-5g, Lignum Aquilariae Resinatum 3-4g, Borneolum Syntheticum 2-3g ingredients.
Embodiment 7
A kind of umbilicus note agent for the treatment of cirrhotic ascites: by treating the Chinese herbal medicine patch bag of cirrhotic ascites and forming for the transdermal enhancer of moistening this Chinese herbal medicine patch bag,
Chinese herbal medicine patch bag: by Radix Et Rhizoma Rhei 4-6g, Natrii Sulfas 4-5g, Semen Pharbitidis 3-5g, Fructus Foeniculi 3-5g, Lignum Aquilariae Resinatum 3-4g, Borneolum Syntheticum 2-3g; Ingredients;
Transdermal enhancer is: 0.5% laurocapram solution.
Embodiment 8
A kind of umbilicus note agent for the treatment of cirrhotic ascites: by treating the Chinese herbal medicine patch bag of cirrhotic ascites and forming for the transdermal enhancer of moistening this Chinese herbal medicine patch bag,
Chinese herbal medicine patch bag: by Radix Et Rhizoma Rhei 5g, Natrii Sulfas 4.5g, Semen Pharbitidis 4g, Fructus Foeniculi 4g, Lignum Aquilariae Resinatum 3.5g, Borneolum Syntheticum 2.5g ingredients;
Transdermal enhancer is: 0.5% laurocapram solution.
Medicine used in the present invention:
Radix Et Rhizoma Rhei
Nature and flavor: hardship, cold;
Gui Jing: spleen, stomach, large intestine, liver, pericardium channel;
Effect: attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances;
Cure mainly: dysuria, edema abdominal distention, excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, haematemesis, spitting of blood, epistaxis, have blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scald.
Natrii Sulfas
Nature and flavor: salty, bitter, cold;
Gui Jing: return stomach warp, lung meridian, spleen channel, kidney channel, small intestine meridian, tri-jiao channel, large intestine channel;
Function: purging heat to relax the bowels, moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat;
Cure mainly: for excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swell and ache, external treatment acute mastitis, swelling and pain of hemorrhoid; External hot compress, antiinflammatory goes to swell.
Semen Pharbitidis
Nature and flavor: cold in nature, bitter in the mouth is pungent, poisonous;
Gui Jing: lung, kidney, large intestine, small intestine meridian;
Function: drink is washed in removing water retention by purgation relieving constipation, expectorant, parasite killing is attacked long-pending;
Cure mainly: for edema distension, constipation and anuresis, phlegm retention gather, QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation, ascarid, taeniasis; Join Radix Et Rhizoma Rhei, Semen Pharbitidis is walked edema caused by disorder of QI partially, and Radix Et Rhizoma Rhei is walked blood system partially, and two medicines are 5, the one wet knots of stopping up of water of controlling edema caused by disorder of QI mutually, and one to control the excess pathogen knot of blood system stagnant, and Xiang Jiwei use is rushed down purgation power very high, and have and lead wet diuretic, the pyretic toxicity of having loose bowels, removing mass leads to stagnant merit; Join the Radix Aucklandiae, Semen Pharbitidis obtains the Radix Aucklandiae makes gas capable, and the Radix Aucklandiae can anti-Semen Pharbitidis bitter cold injure one's stomach again, and Papillary, can be used for fluid-retention stagnating in the interior, breast abdomen hydrops, and enlarged abdomen distension, the diseases such as dysuria, joins Fructus Foeniculi, specially enters the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels with detumescence, and the merit of hernia is treated in pain relieving.
Fructus Foeniculi
Nature and flavor: acrid in the mouth, warm in nature;
Gui Jing: return liver,kidney,spleen, stomach warp;
Function: dispersing cold for relieving pain, relieving QI stagnancy in the stomach;
Cure mainly: colic of cold type is suffered from abdominal pain and the testis swelling and hanging down of either of the testes swells and ache, the every and same use of warm liver promoting the circulation of QI to relieve pain medicine, relieving QI stagnancy in the stomach: can control cold syndrome of the stomach distending pain, the diseases such as lack of appetite vomiting.
Lignum Aquilariae Resinatum
Nature and flavor: arduous, temperature;
Gui Jing: enter kidney, spleen, stomach warp;
Function: sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI;
Cure mainly: the pungent loose temperature of Lignum Aquilariae Resinatum is logical, its gas fragrance, kind in breast abdomen YIN-cold, the merit of promoting the circulation of QI to relieve pain is rather good; There is warming spleen and stomach for dispelling cold, the merit of stopping nausea and vomiting by lowering the adverse flow of QI; The kidney warming improving inspiration by invigorating kidney-QI, lowering the adverse QI to relieve asthma, with controlling below element deficiency and cold, the dyspnea due to deficiency of failure of the kidney in receiving QI, with controlling upper excess and lower deficiency, accumulation and obstruction of sputum, cough and asthma.
This navel patch adopts Chinese medicine application medication, as the doctor Wu Shi of Qing Dynasty machine described in << Li Yue Pianwen, Rhymed Discourse for Topical Remedies >>: " reason of external treatment is the reason for the treatment of by oral administration of medicines; the medicine of external treatment that is the medicine for the treatment of by oral administration of medicines ", under in side, Radix Et Rhizoma Rhei purging FU-organs rushes down, push away Chen Zhixin, cleansing gastrointestinal retention, make heresy that water is wet under stool, is monarch drug; Natrii Sulfas, Semen Pharbitidis removing water retention by purgation, just, the merit that helps Radix Et Rhizoma Rhei removing water retention by purgation is ministerial drug to tonneau two; Lignum Aquilariae Resinatum relieving distension by promoting circulation of QI, make the capable water of gas capable, Fructus Foeniculi dispersing cold for relieving pain, regulating the flow of Qi and the middle Jiao, prevent the overweight taste that injure of cold and cool medicine, is adjuvant drug altogether; The pungent perfume (or spice) of Borneolum Syntheticum is walked to alter, and inducting the medicines into affected channel, for making medicine; Monarch, minister, help, make respectively to take charge of to some extent, coordinate mutually again to reach harmony by mutual collocation; Through sticking SHENQUE acupoint, guide drugs penetrates to absorb from skin and plays a role on the one hand, on the other hand by stimulating acupoint, thereby and news act on liver,spleen,kidney from meridians and play and adjust three dirty functions, performance tonneau two just, effect of the relieving distension of relieving oedema or abdominal distension through diuresis or purgation.
Four, clinical practice situation
We paste and have carried out clinical application research by GCP standard the relieving distension umbilicus of relieving oedema or abdominal distension through diuresis or purgation in recent years:
1.1 case standards
1., have chronic hepatopathy or a liver cirrhosis medical history selected case meets " liver cirrhosis combination of Chinese and Western medicine diagnosis and treatment project (draft) " [2] that digestive system disease Professional Committee of CAIM (Chinese Association Of Integrative Medicine) revises in Chongqing for 2003 and determines clinical criteria:; 2., clinical manifestation: abdominal part distension, the sign of ascites positive, or with abdominal wall varicosis, spleen enlargement, spider angioma, liver palm; 3., synthetic, the reserve function Indexes Abnormality of lab testing liver; 4., abdominal part color ultrasound examination prompting liver cirrhosis, portal hypertension, have seroperitoneum; 5., child pugh classification B level, C level.
Chinese medical discrimination belongs to stagnation of liver-QI with deficiency of the spleen, the syndrome of blockade of dampness due to qi stagnation of tympanites; Get rid of and merge liver failure, hepatocarcinoma, hepatorenal syndrome, digestive tract hemorrhage and severe cardiac, lung, brain, kidney Disease.
1.2 physical data
Qualified 80 routine patients are divided into treatment group and each 40 examples of matched group at random;
In treatment group, male 24 examples, female's 16 examples; Year at age (46.6 ± 4.8); The course of disease (11.2 ± 3.5) year; Wherein hbv-liver cirrhosis patient 34 examples, hepatitis C liver cirrhosis patient 5 examples, alcoholic cirrhosis patient 1 example; Child pugh classification B level 33 examples, C level 7 examples.
In matched group, male 25 examples, female's 15 examples; Year at age (47.2 ± 5.1); The course of disease (12.2 ± 4.0) year; Wherein hbv-liver cirrhosis patient 33 examples, hepatitis C liver cirrhosis patient 5 examples, alcoholic cirrhosis patient 2 examples; Child pugh classification B level 34 examples, C level 6 examples.
Two groups of physical data are learned processing by statistics, and difference not statistically significant (P > 0.05), has comparability.
1.3 Therapeutic Method
1.3.1 matched group: 1., give the conventional hepatoprotective of doctor trained in Western medicine, support and symptomatic treatment; If 2. hbv-liver cirrhosis, gives Entecavir antiviral therapy (0.5mg, every day 1 time, oral); If 3. ALB is lower than 28g/L person, give venoclysis 20% human albumin 50ml, 2 times weekly, in the time that ALB rises to 28g/L, human albumin stops using; If 4. the seroperitoneum degree of depth is greater than 10cm person and gives ascites ultra-filtration Concentration and reinfusion treatment 1 time, treating 8 weeks is 1 course for the treatment of.
1.3.2 treatment group: on the basis of above treatment, add with the relieving distension umbilicus subsides of relieving oedema or abdominal distension through diuresis or purgation, SHENQUE acupoint local skin, with after the sterilization of An Er iodine, is sticked to the relieving distension umbilicus of relieving oedema or abdominal distension through diuresis or purgation and pastes, immobilization with adhesive tape, 24h changes dressings 1 time, and treating 8 weeks is 1 course for the treatment of.
1.4 efficacy assessment standards:
General curative effect evaluation, " Ascites Complicating Liver Cirrhosis Efficacy of Traditional Chinese Medicine criterion draft " (trying) [3] and Child-pugh scoring grade scale [4] with reference to the Dalian meeting revision of in August, 1993 China's Chinese medicine and pharmacy meeting internal medicine hepatopathy Professional Committee are formulated following standard: 1. effective: the course for the treatment of is while end, ascites disappears completely, cardinal symptom, sign are eliminated substantially, and appetite and general status are good; It is normal that liver complex functionality index (PA, ALB, CHE, TC) is recovered; Child-pugh classification integration reduces more than 3 points; 2. take a turn for the better: the course for the treatment of, while end, the ascites degree of depth reduced more than 50%, and cardinal symptom, sign alleviate, appetite and general status improve; Liver complex functionality index (PA, ALB, CHE, TC) takes a turn for the better; Child-pugh classification integration reduces 1-2 and divides; 3. invalid: when finish the course for the treatment of, not reach improvement standard or deterioration person.
1.5 statistical methods: application SPSS13.0 statistical software, first sample data is carried out to test of normality and homogeneity test of variance, data are with mean ± standard deviation
represent, enumeration data adopts chi-square criterion, and measurement data adopts t inspection, and ranked data adopt Ridit to analyze, and have statistical significance taking P<0.05 as difference.
2 results
2.1 general curative effects are relatively in table 1
Table 1 liang group general curative effect comparative example (%)
Note: 1) with the comparison of matched group total effective rate, P<0.05
2.2 ascites curative effect comparisons, in table 2
Before and after table 2 liang group treatment, color ultrasound is measured ascites depth ratio
Note: 1) with before treatment compare P<0.05,2) and relatively P<0.05 of matched group
2.3 major complications incidence rate comparisons, in table 3
Table 3 liang group patient's major complications incidence rate comparison [n (%)]
Note: 1) with relatively P < 0.05 of matched group
2.4 hospital stayss and ascites ultra-filtration treatment number of times are relatively in table 4
Table 4 liang group length of patient stay and the comparison of ascites ultra-filtration treatment number of times
Note: 1) with relatively P < 0.05 of matched group
2.5 untoward reaction are observed: during two groups of patient treatments, obvious adverse reaction does not all occur.
3 discuss according to the clinical manifestation of cirrhotic ascites, primary disease can belong to the traditional Chinese medical science " tympanites " category, the traditional Chinese medical science thinks that primary disease is that liver spleen kidney is all hindered, the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, kidney mistake is opened entire, gas, blood, water are handed over resistance, stop in poly-abdomen due to, be the disease of deficiency in origin and excess in superficiality, treating both the principal and secondary aspects of a disease is worked as in treatment, and this navel patch is the method for symptomatic treatment in acute condition; According to clinical research results suggest, for Decompensated Cirrhosis Patients, on the basis of doctor trained in Western medicine routine treatment, add with the relieving distension umbilicus subsides of relieving oedema or abdominal distension through diuresis or purgation, can significantly improve the curative effect of doctor trained in Western medicine routine treatment for ascites, reduce the complication such as upper gastrointestinal hemorrhage, hepatic encephalopathy, infection, for improving patients ' life quality, to extend life cycle significant; This navel patch is safe and reliable, and application is convenient, and clinical expansion has a extensive future.
Model case
Patient king so-and-so, female, 51 years old, peasant.
Patient was chief complaint by my section of clinic income with " enlarged abdomen distension 2 years repeatedly, increases the weight of 15 days " on March 3rd, 2011.Patient previously has hepatitis C, liver cirrhosis medical history.While being admitted to hospital, disease is seen: god is clear, and spirit is poor, enlarged abdomen distension, poor appetite, weak, xerostomia, two just still can, sleep is felt unwell, body of the tongue is light red, tongue is slightly thick in vain, stringy and thready pulse.Chemical examination liver function: ALT40U/L, AST43U/L, ALB33.0g/L, TBIL28umol/L, TBA80.4umol/L; CA-125:554U/ml.Abdominal part color ultrasound: meet liver cirrhosis ultrasonogram and change, portal hypertension, gallbladder wall edema, splenomegaly, a large amount of ascites.The tcm diagnosis of being admitted to hospital: tympanites, syndrome of blockade of dampness due to qi stagnation; Western medicine diagnose: liver cirrhosis activeness is lost compensatory and ascites.Treat the relieving distension umbilicus of relieving oedema or abdominal distension through diuresis or purgation and paste and liver-protecting medicine, patient's symptom and sign alleviates gradually; Check color ultrasound prompting on June 4 ascites obviously alleviates, a small amount of hydrothorax in x-ray rabat prompting right side; Check on April 6 color ultrasound has no ascites, clinical cure.
2. patient Zhang, man, 61 years old, peasant.
Patient was chief complaint by my section of clinic income with " enlarged abdomen distension shows effect 3 years repeatedly, increases the weight of to accompany right flank portion pain 10 days " on March 19th, 2014.Patient previously has hbv-liver cirrhosis medical history.While being admitted to hospital, disease is seen: mind is clear, spirit poor, enlarged abdomen distension, right flank distending pain, poor appetite, weak, xerostomia, two just still can, sleep is felt unwell, dark tongue quality is slightly red, tongue is greasy in vain, stringy and rolling pulse.Chemical examination liver function: ALT382U/L AST103U/L TBIL17.5umol/L GGT382U/L ALP453U/L, ALB26.8g/L; Color ultrasound examination: liver cirrhosis companion diffusivity hyperplastic nodule, splenomegaly, a large amount of ascites.The tcm diagnosis of being admitted to hospital: tympanites; Western medicine diagnose: hbv-liver cirrhosis activeness is lost compensatory phase ascites.Treat the relieving distension umbilicus of relieving oedema or abdominal distension through diuresis or purgation and paste and liver-protecting medicine, patient's symptom alleviates gradually; Check on May 3 color ultrasound prompting ascites disappears, and lab testing liver function is shown: ALT38U/L AST453U/L TBIL19.5umol/L GGT62U/L ALP86U/L, ALB33.8g/L; Clinical cure.
In sum
This navel patch bases oneself upon motherland's theory of medicine, adopt Chinese medicine application medication, stick SHENQUE acupoint by medicine, guide drugs penetrates to absorb from skin and plays a role on the one hand, pass through on the other hand stimulating acupoint, and thereby news act on liver,spleen,kidney from meridians and play and adjust three dirty functions, performance tonneau two just, effect of the relieving distension of relieving oedema or abdominal distension through diuresis or purgation; And can continue in a long time release with constant speed by sticking medicine, curative effect is lasting; Simultaneously formulation of drug monarch, minister, help, make respectively to take charge of to some extent, coordinate mutually again to reach harmony by mutual collocation, Clinical efficacy and safety is fully verified; Said preparation preparation is simple, and cost is lower, easy to use, is conducive to clinical expansion; Coordinate the method treatment hepatic ascites such as acupoint application of Chinese herb, umbilicus treatment, coloclysis, moxibustion to have the effect of collaborative effect simultaneously, have well clinical and social value.
Claims (6)
1. a Chinese herbal medicine patch bag for the treatment of cirrhotic ascites, is characterized in that: be made up of Radix Et Rhizoma Rhei 4-6 g, Natrii Sulfas 4-5g, Semen Pharbitidis 3-5g, Fructus Foeniculi 3-5g, Lignum Aquilariae Resinatum 3-4g, Borneolum Syntheticum 2-3g medicine, its preparation method is:
Step 1, to take Radix Et Rhizoma Rhei, Natrii Sulfas, Semen Pharbitidis, Fructus Foeniculi, Lignum Aquilariae Resinatum, Borneolum Syntheticum by the amount of recipe ingredient for subsequent use;
Step 2, got component is carried out to pre-treatment: medical material is cleaned, and drying and crushing, crosses 100 mesh sieves;
Step 3, take area and be 6cmX6cm, the thickness filter paper bag that is 0.3on, in each bag, pack above-mentioned mixed powder 8g into, and become finished product with aluminum-plastic composite membrane bag hermetic package after routine disinfection.
2. a kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites according to claim 1, is characterized in that: be made up of Radix Et Rhizoma Rhei 5g, Natrii Sulfas 4.5g, Semen Pharbitidis 4g, Fructus Foeniculi 4g, Lignum Aquilariae Resinatum 3.5g, Borneolum Syntheticum 2.5g.
3. a kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites according to claim 1, is characterized in that: be made up of Radix Et Rhizoma Rhei 6g, Natrii Sulfas 5g, Semen Pharbitidis 5g, Fructus Foeniculi 5g, Lignum Aquilariae Resinatum 4g, Borneolum Syntheticum 3g.
4. a kind of Chinese herbal medicine patch bag for the treatment of cirrhotic ascites according to claim 1, is characterized in that: be made up of Radix Et Rhizoma Rhei 4g, Natrii Sulfas 4g, Semen Pharbitidis 3g, Fructus Foeniculi 3g, Lignum Aquilariae Resinatum 3g, Borneolum Syntheticum 2g.
5. a umbilicus note agent for the treatment of cirrhotic ascites, is characterized in that: treated the Chinese herbal medicine patch bag of cirrhotic ascites and formed for the transdermal enhancer of moistening this Chinese herbal medicine patch bag by a kind of described in claim 1 or 2 or 3 or 4.
6. a kind of umbilicus note agent for the treatment of cirrhotic ascites according to claim 5, is characterized in that: transdermal enhancer is 0.5% laurocapram solution.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107648408A (en) * | 2017-08-03 | 2018-02-02 | 陕西中医肝肾病医院 | A kind of paste preparation and preparation method for treating hepatic sclerosis |
CN108066706A (en) * | 2018-01-09 | 2018-05-25 | 党中勤 | A kind of Chinese medicine removing jaundice for treating icteric hepatitis sticks agent |
CN112618625A (en) * | 2021-01-18 | 2021-04-09 | 广州中医药大学第一附属医院 | A Chinese medicinal composition and its preparation method |
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CN1915345A (en) * | 2005-08-19 | 2007-02-21 | 上海中医药大学附属曙光医院 | External preparation of Chinese traditional medicine for improving ascites due to cirrhosis, and preparation method |
CN101129943A (en) * | 2007-08-28 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating cirrhosis after hepatitis |
CN102327589A (en) * | 2011-09-29 | 2012-01-25 | 沈庆利 | Pill for treating hepatitis |
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2014
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1915345A (en) * | 2005-08-19 | 2007-02-21 | 上海中医药大学附属曙光医院 | External preparation of Chinese traditional medicine for improving ascites due to cirrhosis, and preparation method |
CN101129943A (en) * | 2007-08-28 | 2008-02-27 | 尹克山 | Traditional Chinese medicine for treating cirrhosis after hepatitis |
CN102327589A (en) * | 2011-09-29 | 2012-01-25 | 沈庆利 | Pill for treating hepatitis |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107648408A (en) * | 2017-08-03 | 2018-02-02 | 陕西中医肝肾病医院 | A kind of paste preparation and preparation method for treating hepatic sclerosis |
CN108066706A (en) * | 2018-01-09 | 2018-05-25 | 党中勤 | A kind of Chinese medicine removing jaundice for treating icteric hepatitis sticks agent |
CN112618625A (en) * | 2021-01-18 | 2021-04-09 | 广州中医药大学第一附属医院 | A Chinese medicinal composition and its preparation method |
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