CN104623360A - Traditional Chinese medicine for treating chronic nephritis - Google Patents

Abstract

The invention relates to the field of applications of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating chronic nephritis. The traditional Chinese medicine for treating chronic nephritis is prepared from astragalus membranaceus, Chinese yam, radix rehmanniae preparata, wolfberry, periostracum cicada, fructus forsythia, herba leonuri, schisandra chinensis, rosa laevigata michx and lalang grass rhizome as a main composition; corresponding addition and reduction are carried out according to the change of the disease and accompanied symptoms; fructus forsythia and astragalus membranaceus are added for patients with an exogenous fever; crinis carbonisatus and rubia cordifolia are added for patients with hematuria or occult blood; poria cocos and semen plantaginis are added for patients with obvious edema; pinellia ternata and ginger are added for patients with pernicious vomiting; cassia twig and monkshood are added for patients with cold chills; morinda officinalis and loranthus parasiticus are added for patients with mild lumbago discomfort; salviae miltiorrhizae and lycopus lucidus are added for patients with blood stasis; and rhubarb is added for patients with constipation. The traditional Chinese medicine is simple to prepare, convenient to take, good in absorption effect, long in medicine effect lasting time, stable and significant in curative effect, high in safety, free of toxic or side effect, and low in production cost, and can be taken for a long period of time; timely relieving of symptoms of patients is facilitated; and the radical treatment effect is reached.

Description

A kind of Chinese medicine for the treatment of chronic nephritis

(1) technical field

The present invention relates to application in TCM field, particularly a kind of Chinese medicine for the treatment of chronic nephritis.

(2) background technology

Chronic glomerulonephritis is called for short chronic nephritis, mean that albuminuria, hematuria, hypertension, edema are basic clinical, mode of onset is had nothing in common with each other, protracted inflammation; pathological changes is slowly in progress; can have renal hypofunction in various degree, has renal function exacerbation tendency and the one group of glomerulopathy developing into chronic renal failure the most at last.Due to histological type and the stadium difference of this group disease, main clinical manifestation can be different.Disease indicia is in variation.Chronic nephritis can betide any age, but based on Yong adult, male is common.It is most that onset is slow, hidden attacks.Clinical manifestation is multiformity, and albuminuria, hematuria, hypertension, edema are its basic clinical, can have renal hypofunction in various degree, heavy time light during the state of an illness, delay, gradually develops into chronic renal failure.Lab testing mostly is slightly urinates exception, and urine protein is everlasting 1 ~ 3g/d, and urinary sediment microscopy erythrocyte can increase, visible cast.Blood pressure can normally or slightly raise.Normal renal function or slightly impaired (creatinine clearance rate declines or slight azotemia); this situation sustainable several years; even many decades, renal function runs down and occurs corresponding clinical manifestation (as anemia, blood pressure increase), enters uremia.

Chronic glomerulonephritis is very common in clinical conditions, and treat thorny, patient needs Long-term taking medicine, Chang Yin renal hypofunction in various degree and cause uremia, and the traditional Chinese medical science is many carries out Coryza Treated by Syndrome Differentiation from being invaded by exogenous pathogen, stagnation of phlegm-damp, deficiency of spleen and stomach etc.; This disease symptoms shows as that the face puffiness of the eyes, the few many foams of urine amount or hematuria, the soreness of waist are weak, poor appetite lack of appetite more, and light red tongue tongue is white thick greasy, rolling pulse or slow and unable, how with hypertension.As controlling of blood pressure is bad, renal function exacerbation is very fast, and prognosis is poor.In addition, some patients because infecting, tired of acute attack, or with the hurried deterioration of the state of an illness after nephrotoxic drugs, through removing inducement in time and after suitably treating, the state of an illness can to a certain degree be alleviated, but also may enter irreversible chronic renal failure therefrom.Most patients with chronic glomerulonephritis renal function is chronic progressive infringement, histological type is determine that the key factor of renal function progress speed is (as mesangial capillary glomerulonephritis makes fast progress, membranous nephropathy progress is normal slower), but also to whether rational therapy is relevant, at present, for its albuminuria, there is no effective Therapeutic Method, the Drug therapys such as western medical treatment many employings adrenocortical hormone or immunosuppressant, not only weak effect, and side effect is large, causes patient body weak, easy diseases caused by exogenous pathogenic factor, form vicious cycle on the contrary.The long-term High-grade Proteinuria of patient very easily develops into chronic renal failure, finally causes systemic organs's exhaustion.This kind of patient often shows as deficiency of spleen and stomach, simultaneously many because of recurrences such as diseases caused by exogenous pathogenic factor or increase the weight of again, often doublely holds damp or the obstructed performance of stasis blocking under the arm.Giving consideration to both the incidental and fundamental is difficult to during treatment, and the many diseases of this kind of patient are weak for a long time, both can not highly mend, also can not diuretic too impairment of YIN, Chinese medicine of the prior art is difficult to the therapeutic effect reaching expection, medicine conventional clinically has Caps Bailing, JINSHUIBAO etc., and medicine is simple, and costly, often there are the side effect such as dyspepsia, treatment time is long, weak effect, adds great misery to patient.

(3) summary of the invention

The present invention, in order to make up the deficiencies in the prior art, provides and a kind ofly prepares a kind of Chinese medicine for the treatment of chronic nephritis simple, evident in efficacy.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for chronic nephritis, be made up of following raw material:

The Radix Astragali 60 grams, Rhizoma Dioscoreae 60 grams, 15 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, Periostracum Cicadae 10 grams, Fructus Forsythiae 15 grams, Herba Leonuri 30 grams, Fructus Schisandrae Chinensis 10 grams, Fructus Rosae Laevigatae 10 grams, Rhizoma Imperatae 20 grams are main formula, mainly according to the change of disease and double disease number and add and subtract accordingly: the obvious person of heating diseases caused by exogenous pathogenic factor, adds Fructus Forsythiae 15 grams, Radix Scutellariae 10 grams; Hematuria obviously or the person that has occult blood, adds Crinis Carbonisatus 15 grams, 15 grams, Radix Rubiae; The obvious person of edema adds 15 grams, Poria, Semen Plantaginis 30 grams; Pernicious vomiting person adds the Rhizoma Pinelliae 15 grams, 10 grams, Rhizoma Zingiberis Recens; The fear of cold person that is afraid of cold adds Ramulus Cinnamomi 10 grams, Radix Aconiti Lateralis Preparata gram; Soreness of waist discomfort person adds Radix Morindae Officinalis 15 grams, Herba Taxilli 15 grams; Blood stasis person adds Radix Salviae Miltiorrhizae 30 grams, Herba Lycopi 30 grams; Constipation person adds Radix Et Rhizoma Rhei 10 grams.

The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:

The Radix Astragali: sweet in the mouth slightly warm in nature.Return lung, spleen, liver, kidney channel.Polishing consolidating superficial resistance, holder skin ulcer granulation promoting.Cure mainly the empty spontaneous perspiration of body, chronic diarrhea, proctoptosis, uterine prolapse, chronic nephritis, body is impractical swollen, chronic ulcer, open sore part disunion of a specified duration; The life Radix Astragali, has effect of benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting, is applicable to spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle and does not burst or burst and the disease such as not hold back for a long time.

Rhizoma Dioscoreae: sweet in the mouth, property is put down; Return lung, spleen, kidney channel.Spleen reinforcing; Support lung; Reinforce the kidney; Benefit essence.Main diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula.1. invigorating spleen and reinforcing stomach is aid digestion, is conducive to taste digestive and absorptive functions, is the product of the medicine-food two-purpose of flat tonifying the spleen and stomach simply.No matter spleen sun loses or deficiency of stomach-YIN, all edible.Often clinically drink together with controlling weakness of the spleen and stomach with gastrointestinal, lack of appetite body is tired, the disease such as to have loose bowels; 2. the strong body of kidney nourishing and replenishing vital essence, the effect of kidney nourishing and replenishing vital essence.The diseases such as deficiency of the kidney seminal emission generally, many, the frequent micturition of women leucorrhea, all can take it; 3. reduce blood glucose, have and fall hypoglycemic effect, can be used for treating diabetes, is the dietetic therapy good merchantable brand of diabetes patient; 4. life lengthening, effectively stops blood fat in the precipitation of blood vessel wall, prevention cardiovascular diseases.Obtain the mind calming and mentality promoting, effect of life lengthening.

Radix Rehmanniae Preparata: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Fructus Lycii: the flat sweet in the mouth of Fructus Lycii, enter liver, kidney channel, there is effect of replenishing YIN and blood, nourishing the liver and kidney, replenishing vital essence to improve eyesight, be usually used in treating that Liver and kidney is deficient, the disease such as soreness of the waist and knees, dizziness, tinnitus, seminal emission caused by asthenia of essence and blood, to deficiency of the liver and kindey, essence and blood can not on disease curative effects such as, visual deterioration dim-sighted in the eyes caused by order of helping especially good.Modern pharmacological research shows, Fructus Lycii contains the composition such as carotene, betanin, vitamin A, vitamin B1, vitamin B2, vitamin C and calcium, phosphorus, ferrum, there is the effect strengthening leukocyte activity, suppress fat deposition, promotion hepatocyte new life in hepatocyte, evident in efficacy to chronic hepatitis, central serous chorioretinopathy, optic atrophy etc., also can blood pressure lowering, blood sugar lowering, blood fat reducing.

Periostracum Cicadae: Periostracum Cicadae sweet in the mouth, pungent, micro-salty, cool in nature; Return lung, Liver Channel; Light pulvis refrigerans, can rise and can fall; There is dispelling wind and heat pathogens, rash sore-throat relieving, improving acuity of vision and removing nebula, the effect of expellingging wind and relieving convulsion; Cure mainly anemopyretic cold, cough, dizzy, measles without adequate eruption, pharyngalgia hoarseness, cataract, pruritus before wind, pediatric epilepsy scared, night cry, tetanus.

Fructus Forsythiae: attribute: bitter, is slightly cold.Return lung, the heart, gallbladder meridian.Fructus Forsythiae has broad-spectrum antibacterial action, has very strong inhibitory action to staphylococcus aureus, Hayes dysentery bacterium, has certain inhibitory action to other pathogenic bacterium, influenza virus, fungus.There is antiinflammatory action.Oleanolic acid contained by this product has heart tonifying, diuresis and hypotensive activity, and Citrin can reduce vascular permeability and fragility, prevents haemolysis.Decoct has the town effect of telling, anti-liver injury effect.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease is from the beginning of, puckery pain of pyretic stranguria etc.

Herba Leonuri: promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing, is mainly used in the stagnant disease of gynecological's stasis of blood, cures mainly menoxenia, dysmenorrhea, and for edema, dysuria, can also be used for traumatic injury sore swollen toxin.

Fructus Schisandrae Chinensis: sweet in the mouth, acid, warm in nature.Energy supplementing QI for promoting the production of body fluid, the kidney invigorating is nourished heart, and restrains astringent or styptic treatment for spontaneous sweating.For deficiency of vital energy Tianjin wound, the tired hyperhidrosis of body, cardiopalmus of losing heart; Breathing with cough caused by insufficiency of lung-QI or deficiency of both the lung and kidney, or breath with cough with the passing of time, lung qi consumption wound; Insufficiency of heart-YIN, severe palpitation, insomnia forgetfulness; Instability of kidney QI, seminal emission, frequent micturition, or asthenia of both the spleen and kidney, incessant chronic diarrhea.

Fructus Rosae Laevigatae: reinforcing the kidney and controlling nocturnal emission, reducing urination and antidiarrheal.Control spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery, the deficiency of the lung is breathed with cough, spontaneous sweating, bleeding not during menses.

Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.

Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, for hygropyrexia, heat-damp in summer, vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Crinis Carbonisatus: for haematemesis, spitting of blood, hematuria, have blood in stool, epistaxis, dysentery, stranguria with blood, traumatic hemorrhage and the card such as woman uterine bleeding and dysuria.

Radix Rubiae: removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulates the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.

Poria: promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming, for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Semen Plantaginis: clearing away heat and promoting diuresis is treating stranguria, eliminating dampness by diuresis antidiarrheal, improving eyesight, eliminates the phlegm.For the puckery pain of pyretic stranguria, edema distension, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.

The Rhizoma Pinelliae: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.

Rhizoma Zingiberis Recens: induce sweat cold expelling, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, removing toxic substances.Anemofrigid cold, taste sympotoms caused by cold factors, gastrofrigid vomiting, lung cold cough, solving toxin of fish and crab.

Ramulus Cinnamomi: relieving the exterior syndrome by diaphoresis, dispersing cold for relieving pain, activating YANG and prormoting functioning of QI.For anemofrigid cold, all pain diseases of congealing cold with blood stasis, phlegm retention, syndrome of water-retention, cardiopalmus.

Radix Aconiti Lateralis Preparata: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, dispersing cold for relieving pain.For YANG-depletion collapse, cold extremities faint pulse, deficiency of heart-YANG, obstruction of qi in the chest and cardialgia, deficiency and coldness is vomited and diarrhoea, coldness and pain in the epigastrium, kidney yang deficiency, sexual impotence cold womb, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.

Radix Morindae Officinalis: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.

Herba Taxilli: have wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, the effect of antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia is through many, and blood leaking in gestation, frequent fetal movement, has a dizzy spell.

Radix Salviae Miltiorrhizae: root is used as medicine, containing TANSHINONES, is robustness emmenagogue, has blood stasis dispelling, tissue regeneration promoting, invigorates blood circulation, the effectiveness such as regulating menstruation, is gynecological's key medicine, cures mainly metrorrhagia, menoxenia, blood stasis, stomachache, dysmenorrhoea, amenorrhea, mausoleum pain.Good result is had to treatment coronary heart disease.In addition also control the weak insomnia of nerve, arthralgia, anemia, mastitis, lymphadenitis, arthritis, furuncle pain is swollen, erysipelas, acute, chronic hepatitis, nephritis, traumatic injury, advanced schistosomiasis hepatosplenomegaly, epilepsy.External can wash dermatitis rhus again.

Herba Lycopi: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.

Radix Et Rhizoma Rhei: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances; Hemostasis by removing blood stasis.

Chinese medicine of the present invention is Chinese herbs decoction, after above-mentioned raw materials is made Chinese herbs decoction in conventional manner, regularly, quantitatively takes.

The present invention prepares simply, not only can thoroughly effect a radical cure chronic nephritis, and each organ of energy across-the-board regulation human body, and giving consideration to both the incidental and fundamental, even reinforcing-reducing method, and the patient that may be used for Long-term Hormone, reduce the side effect of hormone.Can long-term taking, taking convenience, good absorbing effect, duration of efficacy is long, and stable curative effect, significantly, safety is high, without any side effects, and production cost is low, is conducive to sufferer and alleviates condition of illness in time, and reaches the therapeutic effect of thoroughly curing.

(4) detailed description of the invention

Embodiment 1:

Get the Radix Astragali 60 grams, Rhizoma Dioscoreae 60 grams, 15 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, Periostracum Cicadae 10 grams, Fructus Forsythiae 15 grams, Herba Leonuri 30 grams, Fructus Schisandrae Chinensis 10 grams, Fructus Rosae Laevigatae 10 grams, Rhizoma Imperatae 20 grams be main formula, mainly according to the change of disease and double disease number and add and subtract accordingly: the obvious person of heating diseases caused by exogenous pathogenic factor, adds Fructus Forsythiae 15 grams, Radix Scutellariae 10 grams; Hematuria obviously or the person that has occult blood, adds Crinis Carbonisatus 15 grams, 15 grams, Radix Rubiae; The obvious person of edema adds 15 grams, Poria, Semen Plantaginis 30 grams; Pernicious vomiting person adds the Rhizoma Pinelliae 15 grams, 10 grams, Rhizoma Zingiberis Recens; The fear of cold person that is afraid of cold adds Ramulus Cinnamomi 10 grams, Radix Aconiti Lateralis Preparata gram; Soreness of waist discomfort person adds Radix Morindae Officinalis 15 grams, Herba Taxilli 15 grams; Blood stasis person adds Radix Salviae Miltiorrhizae 30 grams, Herba Lycopi 30 grams; Constipation person adds Radix Et Rhizoma Rhei 10 grams; Above-mentioned raw materials is made decoct in conventional manner.Usage and dosage: oral, three times on the one, each potion, every agent 100 ~ 150 milliliters, one after each meal.

Clinical case:

Example 1: patient, man, 42 years old, the two lower limbs edema recurrent exerbation of cause 4 months, increase the weight of companion's facial edema 7 days to go to a doctor, disease sees face, the puffiness of the eyes, two lower limb pitting edema; urine amount slightly reduces; many foams, and poor appetite is weak, and spirit is poor; begin because symptom was not slightly paid attention to, modern because of edema obviously the double face puffiness of the eyes examine.Light red tongue, tongue is thick in vain, and arteries and veins is string slightly.Blood pressure: 140/100mmHg.Routine urinalysis shows: albumen 3+; 24h urine protein quantitation: 4g/L.Dialectical: deficiency of spleen and stomach, damp are contained partially.Method for the treatment of: tonifying speen and tonifying kidney, inducing diuresis to remove edema.Prescription: the Radix Astragali 60 grams, Rhizoma Dioscoreae 60 grams, 15 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, Periostracum Cicadae 10 grams, Fructus Forsythiae 15 grams, Herba Leonuri 30 grams, Fructus Schisandrae Chinensis 10 grams, Fructus Rosae Laevigatae 10 grams, Rhizoma Imperatae 20 grams.Drug administration checks routine urinalysis after January normal, transference cure.

Example 2: patient, man, 23 years old, examines over 1 year because finding that urine protein is abnormal.Patient's 1 year cause is had a medical check-up and is found urine protein 2+, once at the People's Hospital's hospitalization, is diagnosed as chronic glomerulonephritis, and gives the hormone therapies such as prednisone, but Relapse rate, and time have two lower limbs edema, modernly measure many foams less and examine because of two lower limbs edema, urine.Patient's disease sees spiritlessness and weakness, poor appetite lack of appetite, soreness of the waist and knees, the many foams of urine, and amount is few, and large constipation, two lower limb pitting edema, red tongue tongue is greasy in vain, stringy pulse.Dialectical: deficiency of spleen and stomach, damp are contained partially.Method for the treatment of: tonifying speen and tonifying kidney, inducing diuresis to remove edema.Prescription: the Radix Astragali 60 grams, Rhizoma Dioscoreae 60 grams, 15 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, Periostracum Cicadae 10 grams, Fructus Forsythiae 15 grams, Herba Leonuri 30 grams, Fructus Schisandrae Chinensis 10 grams, Fructus Rosae Laevigatae 10 grams, Rhizoma Imperatae 20 grams, Radix Morindae Officinalis 10 grams, Herba Taxilli 15 grams.After drug administration first quarter moon, symptom obviously alleviates, and checks routine urinalysis normal after March.

Claims (1)

1. treat the Chinese medicine of chronic nephritis for one kind, it is characterized by, be made up of the raw material of following parts by weight: the Radix Astragali 60 grams, Rhizoma Dioscoreae 60 grams, 15 grams, Radix Rehmanniae Preparata, Fructus Lycii 15 grams, Periostracum Cicadae 10 grams, Fructus Forsythiae 15 grams, Herba Leonuri 30 grams, Fructus Schisandrae Chinensis 10 grams, Fructus Rosae Laevigatae 10 grams, Rhizoma Imperatae 20 grams are main formula, mainly according to the change of disease and double disease number and add and subtract accordingly: the obvious person of heating diseases caused by exogenous pathogenic factor, adds Fructus Forsythiae 15 grams, Radix Scutellariae 10 grams; Hematuria obviously or the person that has occult blood, adds Crinis Carbonisatus 15 grams, 15 grams, Radix Rubiae; The obvious person of edema adds 15 grams, Poria, Semen Plantaginis 30 grams; Pernicious vomiting person adds the Rhizoma Pinelliae 15 grams, 10 grams, Rhizoma Zingiberis Recens; The fear of cold person that is afraid of cold adds Ramulus Cinnamomi 10 grams, Radix Aconiti Lateralis Preparata gram; Soreness of waist discomfort person adds Radix Morindae Officinalis 15 grams, Herba Taxilli 15 grams; Blood stasis person adds Radix Salviae Miltiorrhizae 30 grams, Herba Lycopi 30 grams; Constipation person adds Radix Et Rhizoma Rhei 10 grams.