CN104161678B - A kind of cosmetics - Google Patents
A kind of cosmetics Download PDFInfo
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- CN104161678B CN104161678B CN201410284294.5A CN201410284294A CN104161678B CN 104161678 B CN104161678 B CN 104161678B CN 201410284294 A CN201410284294 A CN 201410284294A CN 104161678 B CN104161678 B CN 104161678B
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Abstract
The present invention is supplied to a kind of cosmetics, and it contains the compound of formula I of effective dose；Compound of formula I structure is as follows: X is selected from alkali metal.In the cosmetics that the present invention provides, containing effective dose 9,10,12 trihydroxy octadecanoate analog derivatives, this analog derivative has certain antibacterial activity, and to the antibacterial action of some bacterium close to antibiotic activities such as chloramphenicol, uses it for daily cosmetics, can be prevented effectively from or delay the spoilage problems that cosmetics are brought by bacterium, extend commodity shelf life.
Description
Technical field
The present invention relates to a kind of cosmetics.
Background technology
For a long time, dermatology expert, cosmetics expert can effectively maintain mankind's skin striving to find
Skin, or be to treat some dermopathic all kinds of natural materials or Prof. Du Yucang material.Now, make up
Product have had evolved to a relatively flourishing period, various forms, the cosmetics of various function, skin care item
Tinkling of jades meet the eye on every side.In numerous skin care item, containing natural non-stimulated composition, it really is able to effectively maintain skin
The product of the formula of skin composition is always skin care item manufacturing enterprise and skin care item consumer pursued.And energy
Enough actual skin care item meeting this requirement often become expensive luxury goods, it is impossible to most for becoming
The consumer objects of people.
In cosmetics, add antibiotic antiseptic, be to extend the cosmetics shelf-life, increase the effective of shelf life
Method.It is household chemicals preservative, bactericide source by Prof. Du Yucang or natural products extracting directly
Main path, but all there is certain defect in both modes, Prof. Du Yucang household chemicals preservative,
Bactericide, such as imidazolidinyl urea, parabens, often its manufacturing cost is higher, and manufactures
During cause the most serious environmental pollution, the wasting of resources etc..And directly extract from natural products and make
It is generally of stability not good enough for the material of household chemicals preservative, bactericide, water-soluble bad, anti-
The defects such as rotten bactericidal effect is not ideal enough.
Castor oil acid, is that the research of skin now prepared through retrofit by castor oil finds that permeability is best
Natural plants organic acid, be currently used primarily in surfactant, plasticizer, lube oil additive etc..
Yet there are no and castor oil acid and derivative thereof are used for the efficiently fine chemical product aspect such as preservative, bactericide
Research report.
Summary of the invention
It is an object of the invention to provide the cosmetic containing 9,10,12-trihydroxy octadecanoate analog derivative
Product.
Specifically, the invention provides a kind of cosmetics, it contains the compound of formula I of effective dose；Formulas I
Compound structure is as follows:
X is selected from alkali metal.
Further, X is selected from K or Na.
Wherein, compound of formula I accounts for the 1～10% of cosmetics total amount.
Further, compound of formula I accounts for the 1～5% of cosmetics total amount.
Further, compound of formula I accounts for the 3～5% of cosmetics total amount.
Wherein, described cosmetics also include oil phase substrate, consistency modifiers, NMF, emulsifying agent and
Water.
Further, described oil phase substrate is saualane；Described consistency modifiers is glycerin monostearate
And octadecyl alcolol；Described NMF is polyethylene glycol, glycerine and propane diols；Described emulsifying agent is Span-80
And Tween-80.
Further, described cosmetics also include essence, auxiliary anticorrosion agent.
In the cosmetics that the present invention provides, spread out containing the 9 of effective dose, 10,12-trihydroxy stearic acid salts
Biology, this analog derivative has certain antibacterial activity, and to the antibacterial action of some bacterium close to chlorine
The antibiotic activities such as mycin, use it for daily cosmetics, can be prevented effectively from or delay bacterium to cosmetic
The spoilage problems that product bring, extends commodity shelf life.
In some embodiments, one or more compounds of the present invention can be used in conjunction with one another.Also
Optional the compound of the present invention is used in combination with other active agent any, has for preparation anti-
The medicine of bacterium effect or shelf-life longer cosmetics.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the means of this area, not
Depart under the present invention above-mentioned basic fundamental thought premise, it is also possible to make the amendment of other various ways, replace
Change or change.
Below by way of the form of specific embodiment, the foregoing of the present invention is done the most again
Bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to below example.All based on
The technology that foregoing of the present invention is realized belongs to the scope of the present invention.
Accompanying drawing explanation
Fig. 1 bacillus subtilis is 48h growth curve in variable concentrations polyhydroxy sodium ricinoleate
Fig. 2 bacillus subtilis growth curve in variable concentrations polyhydroxy potassium ricinoleate
Detailed description of the invention
The preparation of the stearic salt derivative of embodiment 1 9,10,12-trihydroxy
The ethanol solution of the NaOH (potassium) of equivalent is added drop-wise to polyhydroxy castor oil acid at 80 DEG C
In the solution of ethanol, after being added dropwise to complete, reaction mixture continues stirring 1-1.5h until reactant liquor
PH is that 7. reactant liquors are as cold as room temperature, and decompression removes ethanol, and obtained faint yellow solid is after drying
Sodium (potassium) salt of polyhydroxy castor oil acid, yield > 98%. fusing points: 202-208 DEG C (sylvite and sodium salt
Fusing point is consistent).
1H NMR(400MHz)(DMSO-d6)0.85(t,3H),1.23-1.38(m,24H),1.85(t,
2H), 3.17-3.59 (m, 3H), 4.6 (br, 3H) (sylvite).
1H NMR(400MHz)(DMSO-d6)0.81(t,3H),1.17-1.42(m,24H),1.79(t,
2H), 3.10-3.60 (m, 3H), 4.6 (br, 3H) (sodium salt).
Embodiment 2: the preparation of cosmetics
Preparation condition: by aqueous phase and water-soluble composition (specially Purified Water 500 parts, glycerine 60 parts, the third two
Alcohol 30 parts, polyethylene glycol 30 parts, polyhydroxy ricinate 30 parts, the number of described composition refers to weight
Amount part) be heated to 90 DEG C of sterilizing 20min in a reservoir, then be cooled to 80 DEG C standby；By oil phase and oil soluble
Composition (specially saualane 215 parts, glycerin monostearate 30 parts, octadecyl alcolol 30 parts, span-80
50 parts, tween-80 28 parts, the number of described composition refers to weight portion) be heated with stirring to be completely melt (about
75 DEG C), the mixing speed in oil phase container is modulated 1000r/min, slowly standby aqueous phase is added to oil
In the whirlpool of phase, complete, maintain temperature and mixing speed, emulsify 30min；System temperature is down to 45 DEG C
Adding essence and preservative, Reasonable Speed stirs；System temperature is down to room temperature, ageing；Packaging
Get product.Polyhydroxy ricinate in formula is substituted as a control group with Purified Water equivalent, knot
Fruit display, the product of addition polyhydroxy ricinate finished product is placed does not occurs any change for more than six months
Matter phenomenon, control group then occurred mildew phenomena within six months.
Embodiment 3: the preparation of cosmetics
Preparation condition: by aqueous phase and water-soluble composition (specially Purified Water 500 parts, glycerine 60 parts, the third two
Alcohol 30 parts, polyethylene glycol 30 parts, polyhydroxy ricinate 30 parts, the number of described composition refers to weight
Amount part) be heated to 90 DEG C of sterilizing 20min in a reservoir, then be cooled to 80 DEG C standby；By oil phase and oil soluble
Composition (specially saualane 215 parts, polyhydroxy castor oil acid 30 parts, glycerin monostearate 30 parts,
Octadecyl alcolol 30 parts, span-80 50 parts, tween-80 28 parts, the number of described composition refers to weight portion)
It is heated to being completely melt (about 75 DEG C), the mixing speed in oil phase container is modulated 1000r/min, slowly
Standby aqueous phase is added to the whirlpool of oil phase, complete, maintain temperature and mixing speed, emulsify 30min；
System temperature being down to 45 DEG C and adds essence and preservative, Reasonable Speed stirs；System temperature is dropped
To room temperature, ageing；Packaging gets product.By the polyhydroxy castor oil acid composition in formula respectively with blank,
Purified Water equivalent substitutes as two control groups, prepares cosmetics finished product and compares.Result display formula contains
There is the finished product of polyhydroxy castor oil acid composition, there is the most excellent outward appearance and skin comfort degree.Will formula
In polyhydroxy ricinate with Purified Water equivalent substitute as a control group, result shows, addition is many
The product of hydroxyl ricinate finished product is placed does not occurs any denaturalization phenomenon for more than six months, and control group exists
Mildew phenomena then occurred in six months.
Beneficial effects of the present invention is illustrated below by way of test example.
Test example 1 antibacterial activity is tested
According to antibacterial activity test conventional method and polyhydroxy ricinate (embodiment 1 preparation sylvite or
Sodium salt, below can be called polyhydroxy potassium ricinoleate or polyhydroxy sodium ricinoleate) spy that had
Property, select water as solvent carrier, test polyhydroxy ricinate is to Gram-negative bacteria, leather respectively
The inhibition of Lan Shi positive bacteria.
(1) assay method of antibacterial activity test employing Odontothrips loti minimal inhibitory concentration:
According to the differently configured concentration gradient of antibacterial activity method of testing: 100,50,25,12.5,6.25,3.13,
1.56 (mg/ml) sample solution, and select Gram-negative bacteria, gram-positive bacteria representativeness mushroom: withered
Grass bacillus, staphylococcus aureus, pseudomonas aeruginosa, Escherichia coli, carry out the antibacterial of system
Active testing is tested.
Wherein the test data of polyhydroxy sodium ricinoleate are as follows:
Table 1
Wherein the test data of polyhydroxy potassium ricinoleate are as follows:
Table 2
Note: in table 1,2 "+" represent there is obvious antibacterial activity, "+" the most, activity is the strongest；It is inconspicuous that "-" represents antibacterial activity,
The diameter of inhibition zone in digitized representation sterilization experiment in form, numerical value is the biggest, and bacteriostatic activity is the strongest.
From table 1,2, polyhydroxy sodium ricinoleate to bacillus subtilis, staphylococcus aureus,
Pseudomonas aeruginosa, colibacillary minimal inhibitory concentration is respectively as follows: 1.56,3.13,6.25,50 (mg/ml)；
Polyhydroxy potassium ricinoleate bacillus subtilis, staphylococcus aureus, pseudomonas aeruginosa, large intestine bar
The minimal inhibitory concentration of bacterium is respectively as follows: 1.56,6.25,12.5,50 (mg/ml).
(2) growth curve method measures
Sample concentration is on each impact for examination bacteria growing state and minimal inhibitory concentration thereof:
A, bacillus subtilis 48h growth curve in variable concentrations polyhydroxy sodium ricinoleate: result is shown in
Fig. 1
B, bacillus subtilis growth curve in variable concentrations polyhydroxy potassium ricinoleate: result is shown in figure
2
Result shows: can intuitively reflect that variable concentrations sample is to thalli growth by growth curve of bacteria
The impact of state and minimal inhibitory concentration thereof, along with the increase of sample concentration, curve tends to straight line, to bacterium
Substantially, as above figure can be seen that polyhydroxy sodium ricinoleate and polyhydroxy potassium ricinoleate pair in bulk-growth suppression
Bacillus subtilis minimal inhibitory concentration is 1.56mg/ml, consistent with Odontothrips loti result.
(3) polyhydroxy sodium ricinoleate and polyhydroxy potassium ricinoleate are relative to the titer of antibiotics Chloramphenicol
Measure
With bacillus subtilis and pseudomonas aeruginosa for representing bacterial classification, test sample comparison chloramphenicol ladder
Degree concentration antibiotic property.
Preparation chloromycetin solution concentration is 200,150,100,75,50,37.5,25,18.75,
12.5,9.38,6.25,4.69 (mg/ml), and by the activation bacillus subtilis of 24h, verdigris vacation
Monad is diluted to 107Individual/ml.Take 2ml respectively and add to less than in 50 DEG C of LB culture mediums, every flat board 20ml,
Make the flat board that carries disease germs, be equidistantly placed Oxford cup, and fill sample 200ul, three parallel controls of each bacterium,
Repeat for three times.
Table 3
Average diameter:
Table 4
| Concentration | 200 | 150 | 100 | 75 | 50 | 37.5 | 25 | 18.75 | 12.5 | 9.38 | 6.25 | 4.69 |
| Log concentration | 2.30 | 2.18 | 2 | 1.88 | 1.70 | 1.57 | 1.40 | 1.27 | 1.1 | 0.97 | 0.8 | 0.67 |
| Ko subtilis bar | 1.31 | 1.23 | 1.15 | 1.07 | 0.99 | 0.93 | 0.86 | 0.8 | 0.8 | 0.8 | 0.8 | 0.8 |
| P. aeruginosa | 2.0 | 1.86 | 1.66 | 1.46 | 1.26 | 1.15 | 0.98 | 0.91 | 0.88 | 0.86 | 0.83 | 0.8 |
Chloramphenicol concentration logarithm value and Bacillus subtillis antibacterial circle diameter calibration curve: regression equation:
Y=0.4907x+1.656, R2=0.9964
Chloramphenicol concentration logarithm value and pseudomonas aeruginosa antibacterial circle diameter calibration curve: regression equation:
Y=1.1569x-0.6710, R2=0.9949
If taking concentration is that polyhydroxy sodium ricinoleate during 100mg/ml and polyhydroxy potassium ricinoleate are to withered
Grass bacillus and the antibacterial circle diameter of pseudomonas aeruginosa, can calculating it, to be equivalent to antibiotic chlorine mould
The titer of element is respectively as follows:
Table 5
Result shows: water-soluble sample polyhydroxy castor oil acid sodium salt when concentration is 100mg/ml is to withered grass bud
Spore bacillus and the titer of pseudomonas aeruginosa, be respectively equivalent to chloramphenicol 5.02,111.94 (mg/ml),
Sample polyhydroxy potassium ricinoleate, to bacillus subtilis and the titer of pseudomonas aeruginosa, is respectively equivalent to
Chloramphenicol 1.69,61.66 (mg/ml).
Conclusion: summary test understands, and salt derivative prepared by the present invention possesses certain antibacterial work
Property, wherein, polyhydroxy sodium ricinoleate is to bacillus subtilis, staphylococcus aureus, verdigris vacation list
Born of the same parents bacterium, colibacillary minimal inhibitory concentration is respectively as follows: 1.56,3.13,6.25,50 (mg/ml)；
Polyhydroxy potassium ricinoleate is to bacillus subtilis, staphylococcus aureus, pseudomonas aeruginosa, large intestine
The minimal inhibitory concentration of bacillus is respectively as follows: 1.56,6.25,12.5,50 (mg/ml), and, to certain
The antibacterial activity of a little bacteriums is close to chloramphenicol.
The impact on commodity of test example 2 derivative of the present invention
The design skin care item formula containing polyhydroxy ricinate, calculates polyhydroxy according to formulation Design Principle
The dosage of base ricinate, enumerates formula as follows: saualane 200 parts, white oil 400 parts, firmly
Lipidol 100 parts, glycerin monostearate 50 parts, deionized water 900 parts, glycerine 200 parts, poly-second two
Alcohol (200 gather) 200 parts, polyhydroxy ricinate 40 parts, in above-mentioned data, number refers to weight portion.
Prepare the skin care cream finished product containing polyhydroxy ricinate: 1, by the deionized water in formula,
Glycerine, polyethylene glycol, polyhydroxy ricinate mix, be heated with stirring to 80 DEG C standby；2, Jiang Jiao
Shark alkane, white oil, stearyl alcohol, glycerin monostearate etc. are heated with stirring to be completely melt as clear oil liquid
Body, about 72 DEG C；3, being added slowly to by the aqueous phase in 1 step in the whirlpool of 2 step oil phases, aqueous phase adds
Enter complete, mixing speed is modulated 1000r/min, emulsify 20min；4, system temperature is down to 45 DEG C,
Add appropriate amount of essence and skin-care effect composition；5, continue system temperature is down to normal temperature, bottling, contained
There is the skin care cream finished product of polyhydroxy castor oil acid salt component.Simultaneously with identical formula and process conditions system
For being not added with the skin care cream finished product of polyhydroxy ricinate as comparison.
The skin care cream finished product containing polyhydroxy castor oil acid salt component produced and reference product are placed in often
Temperature natural environment stores more than 3 months, adds polyhydroxy ricinate finished product (experimental group) without rotten
Phenomenon occurs, be not added with skin care cream finished product (control group) of polyhydroxy ricinate then have go mouldy,
The phenomenons such as denseness reduction occur.
Result shows that polyhydroxy ricinate has good antisepsis and sterilization and emulsibility.Although this
The salt derivative antibacterial activity of bright preparation can not surmount antibiotic, but its antibacterial activity can so that its
The Antimicrobial preservative aspect of household chemicals has excellent application prospect.
Claims (8)
1. cosmetics, it is characterised in that: it contains the compound of formula I of effective dose；Compound of formula I structure is as follows:
X is selected from alkali metal.
Cosmetics the most according to claim 1, it is characterised in that: X is selected from K or Na.
Cosmetics the most according to claim 1, it is characterised in that: it is total that compound of formula I accounts for cosmetics
The 1～10% of amount.
Cosmetics the most according to claim 3, it is characterised in that: it is total that compound of formula I accounts for cosmetics
The 1～5% of amount.
Cosmetics the most according to claim 4, it is characterised in that: it is total that compound of formula I accounts for cosmetics
The 3～5% of amount.
Cosmetics the most according to claim 1, it is characterised in that: described cosmetics also include oil
Phase matrix, consistency modifiers, NMF, emulsifying agent and water.
Cosmetics the most according to claim 6, it is characterised in that: described oil phase substrate is saualane；
Described consistency modifiers is glycerin monostearate and octadecyl alcolol；Described NMF is polyethylene glycol, glycerine
And propane diols；Described emulsifying agent is Span-80 and Tween-80.
Cosmetics the most according to claim 6, it is characterised in that: described cosmetics also include perfume (or spice)
Essence, auxiliary anticorrosion agent.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410284294.5A CN104161678B (en) | 2014-06-23 | 2014-06-23 | A kind of cosmetics |
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|---|---|---|---|
| CN201410284294.5A CN104161678B (en) | 2014-06-23 | 2014-06-23 | A kind of cosmetics |
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| CN104161678A CN104161678A (en) | 2014-11-26 |
| CN104161678B true CN104161678B (en) | 2016-08-24 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649578A (en) * | 2002-03-04 | 2005-08-03 | 戴弗根斯公司 | Nematicidal fatty acid and fatty acid ester related compounds |
| KR20060102417A (en) * | 2005-03-23 | 2006-09-27 | 주식회사 코오롱 | Polyacetal resin composition having an excellent heat stability |
-
2014
- 2014-06-23 CN CN201410284294.5A patent/CN104161678B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1649578A (en) * | 2002-03-04 | 2005-08-03 | 戴弗根斯公司 | Nematicidal fatty acid and fatty acid ester related compounds |
| KR20060102417A (en) * | 2005-03-23 | 2006-09-27 | 주식회사 코오롱 | Polyacetal resin composition having an excellent heat stability |
Non-Patent Citations (1)
| Title |
|---|
| 羟基植物油脂肪酸的抗磨规律;胡志孟;《油滑与密封》;20010831(第4期);全文 * |
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