CN104147312A - Traditional Chinese medicine preparation for treating male infertility - Google Patents
Traditional Chinese medicine preparation for treating male infertility Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating male infertility. The traditional Chinese medicine preparation comprises the selected raw medicinal materials by weight: 20-30 g of radix morindae officinalis, 10-20 g of eucommia bark, 10-20 g of medlar, 10-20 g of fructus rubi, 10-20 g of radix achyranthis, 10-20 g of Chinese yam, 10-20 g of semen cuscutae, 10-20 g of acorus calamus, 8-12 g of herba epimedii, 8-15 g of mulberry, 8-12 g of human hair, 8-12 g of walnut meat, 8-12 g of prunella vulgaris, 8-12 g of radix scrophulariae, 8-12 g of cibotium barometz, 8-12 g of cynomorium songaricum, and 8-12 g of fructus forsythiae. The drugs are in excellent compatibility to together play the efficacies of strengthening body resistance to culture essence, tonifying qi and invigorating kidney, replenishing essence and enriching blood, and promoting blood circulation to remove blood stasis; after being taken, the traditional Chinese medicine preparation can effectively improve a body nutritional status, improves the body quality and ability, has good effectiveness on increasing the man sperm quantity and quality, has the advantages of definite curative effect, convenient taking, low price, no side effect and high cure rate, and is worth of clinical promotion and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, is a kind of Chinese medicine preparation that can treat male infertility.
Background technology
Male infertility refer to due to male factor cause sterile, generally living together after marriage, within 2 years, do not take above any contraceptives and the wife's side is conceived, be called infertility.Incidence rate is 10% left and right, and wherein single wife's side factor that belongs to is about 60%, and simple bridegroom's or husband's side factor is about 40%, and men and women total approximately 10%.
Male infertility, according to clinical manifestation, is divided into normal two classes of sexual dysfunction and sexual function, and the latter can be further divided into azoospermia, oligospermatism according to semen analysis result, and azoospermia, asthenospermia disease and sperm count normality are sterile.Along with the develop rapidly of people to the raising of human reproduction's problem understanding and andrology research, the discovery rate of male sterility progressively increased, and had caused andrology worker's great attention in recent years.
The current treatment for male infertility, the low hypogonadism disease of the long-acting testosterone enanthatas treatment promoting sexual gland hormone of the general application of all treatments of doctor trained in Western medicine, Treatment of Hyperprolactinemia with Bromocriptine: Analysis, clomiphene treatment oligospermatism and HCG and HMG share the low disease for the treatment of promoting sexual gland hormone, also take individually test-tube mode, but Western medicine exists curative effect slow mostly, treatment cycle is long, side effect is larger, easily recurrence, easily produce the defect of drug resistance, artificial insemination somewhat expensive and cure rate are lower, cannot generally be suitable for.
Summary of the invention
The invention solves at present in the defect and the deficiency that exist aspect treatment male infertility, provide a kind of determined curative effect, cheap, cure rate is high and the Chinese medicine preparation that has no side effect.
The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of male infertility, it is characterized in that, and described Chinese medicine preparation is comprised of the raw material of following weight portion:
20-30 gram of halberd, Cortex Eucommiae 10-20 gram of bar, Fructus Lycii 10-20 gram, Fructus Rubi 10-20 gram, Radix Achyranthis Bidentatae 10-20 gram, Rhizoma Dioscoreae 10-20 gram, Semen Cuscutae 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Herba Epimedii 8-12 gram, Fructus Mori 8-15 gram, Crinis Carbonisatus 8-12 gram, Semen Juglandis 8-12 gram, Spica Prunellae 8-12 gram, Radix Scrophulariae 8-12 gram, Rhizoma Cibotii 8-12 gram, Herba Cynomorii 8-12 gram, Fructus Forsythiae 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is comprised of the raw material of following weight portion:
20 grams of halberds of bar, 10 grams of the Cortexs Eucommiae, 10 grams of Fructus Lyciis, 10 grams of Fructus Rubies, 10 grams of Radix Achyranthis Bidentataes, 10 grams of Rhizoma Dioscoreaes, 10 grams of Semen Cuscutae, 10 grams of Rhizoma Acori Gramineis, 8 grams of Herba Epimedii, 8 grams, Fructus Mori, 8 grams of Crinis Carbonisatus, 8 grams of Semen Juglandis, 8 grams of Spica Prunellaes, 8 grams of Radix Scrophulariae, 8 grams of Rhizoma Cibotii, 8 grams of Herba Cynomoriis, 8 grams of Fructus Forsythiaes.
As this kind of prioritization scheme:
Described Chinese medicine preparation is comprised of the raw material of following weight portion:
25 grams of halberds of bar, 15 grams of the Cortexs Eucommiae, 15 grams of Fructus Lyciis, 15 grams of Fructus Rubies, 15 grams of Radix Achyranthis Bidentataes, 15 grams of Rhizoma Dioscoreaes, 15 grams of Semen Cuscutae, 15 grams of Rhizoma Acori Gramineis, 10 grams of Herba Epimedii, 12 grams, Fructus Mori, 10 grams of Crinis Carbonisatus, 10 grams of Semen Juglandis, 10 grams of Spica Prunellaes, 10 grams of Radix Scrophulariae, 10 grams of Rhizoma Cibotii, 10 grams of Herba Cynomoriis, 10 grams of Fructus Forsythiaes.
As this kind of prioritization scheme:
Described Chinese medicine preparation is comprised of the raw material of following weight portion:
30 grams of halberds of bar, 20 grams of the Cortexs Eucommiae, 20 grams of Fructus Lyciis, 20 grams of Fructus Rubies, 20 grams of Radix Achyranthis Bidentataes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Semen Cuscutae, 20 grams of Rhizoma Acori Gramineis, 12 grams of Herba Epimedii, 15 grams, Fructus Mori, 12 grams of Crinis Carbonisatus, 12 grams of Semen Juglandis, 12 grams of Spica Prunellaes, 12 grams of Radix Scrophulariae, 12 grams of Rhizoma Cibotii, 12 grams of Herba Cynomoriis, 12 grams of Fructus Forsythiaes.
The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, according to the method for the fried Chinese medicine of tradition, get its medicine juice, 1 dose of every day, add clear water 400ml, soak 30 minutes, first boil with high heat rear use taking liquid 150ml at a simmer; Take again medicinal liquid 150ml.By 2 liquid medicine mixings, minute morning, late 2 decoction being taken warmly.30 days be 1 course for the treatment of 1 dose of every day.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Bar halberd, acrid in the mouth, hardship, cold in nature; Return kidney, urinary bladder channel.There is clearing away heat-damp and promoting diuresis, the effect of dispelling wind for relieving itching.
The Cortex Eucommiae, sweet in the mouth, warm in nature; Return liver, kidney channel.There is the liver and the kidney tonifying, the effect of bone and muscle strengthening.
Fructus Lycii, sweet in the mouth, property is flat; Return liver, kidney channel.There is nourishing the liver and kidney, the effect of replenishing vital essence to improve eyesight.
Fructus Rubi, sweet in the mouth, acid, slightly warm in nature; Return liver, kidney channel.There is wind-expelling pain-stopping, improving acuity of vision and removing nebula, the effect of stomach function regulating preventing or arresting vomiting.
Radix Achyranthis Bidentatae, bitter in the mouth, acid, property is flat; Return liver, kidney channel.There is blood circulation promoting and blood stasis dispelling, the liver and the kidney tonifying, bone and muscle strengthening, relieving stranguria by diuresis, the effect of conducting blood to flow downwards.
Rhizoma Dioscoreae, sweet in the mouth, property is flat; Return spleen, lung, kidney channel.There is supplementing QI and nourishing YIN, the effect of spleen reinforcing lung kidney.
Semen Cuscutae, sweet in the mouth, warm in nature; Return kidney,liver,spleen warp.The effect with nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive improving eyesight, antidiarrheal.
Rhizoma Acori Graminei, acrid in the mouth, warm in nature; GUIXIN, stomach warp.Having eliminates the phlegm has one's ideas straightened out, removing dampness appetizing, the effect of the mind calming and mentality promoting.
Herba Epimedii, acrid in the mouth, sweet, warm in nature; Return liver, kidney channel.There is kidney invigorating and YANG supporting, expelling wind and removing dampness, the effect of bone and muscle strengthening.
Fructus Mori, sweet in the mouth, acid, cold in nature; GUIXIN, liver, kidney channel.There is the YIN nourishing of enriching blood, the effect of promoting the production of body fluid and moisturizing.
Crinis Carbonisatus, bitter in the mouth, puckery, property is flat; Return liver, stomach, kidney channel.There is hemostasia and dissipation blood stasis, the effect of diuresis granulation promoting.
Semen Juglandis, sweet in the mouth, warm in nature; Return kidney, lung, large intestine channel.There is tonifying the kidney to consolidate the essence, warming the lung Dingchuan, the effect of loosening bowel to relieve constipation.
Spica Prunellae, acrid in the mouth, hardship, cold in nature; Return liver, gallbladder meridian.There is the improving eyesight of relieving inflammation or internal heat, the effect of mass dissipating and swelling eliminating.
Radix Scrophulariae, bitter in the mouth, salty, cold nature; GUIXIN, lung, stomach, kidney channel.There is clearing away heat and cooling blood, the effect of eliminating fire and detoxication.
Rhizoma Cibotii, bitter in the mouth, sweet, warm in nature; Return liver, kidney channel.There is the liver and the kidney tonifying, the effect of the strong ridge of strong waist.
Herba Cynomorii, sweet in the mouth, warm in nature.Return kidney, large intestine channel.There is tonifying YANG and mend essence, moistening dryness for relaxing bowels, the effect of bone strengthening nourishing muscle and tendon.
Fructus Forsythiae, bitter in the mouth, cold nature; Return lung, the heart, gallbladder meridian.There is heat-clearing and toxic substances removing, the effect of eliminating carbuncle eliminating stagnation.
The traditional Chinese medical science thinks, the related cause of disease of male infertility is more, interrelate also more complicated, but mainly should be conceived to the dirty function of kidney,liver,spleen three, and it is newly of a specified duration to note examining in detail its state of an illness between its cause of disease, and the deficiency and excess of essence, gas, blood is attached most importance to.Therefore the treatment aspect of primary disease is main mainly with conditioning kidney, liver, the dirty function of board three, should support emphatically essence, logical essence and adjust Reproductive Performance, make its essence prosperous, be proficient in, men and women reach agreement essence, normally join to form and breed, the dirty benefit that focuses on to kidney,liver,spleen, for damp and hot heresy clear profit in addition, to the stasis of blood, to answer promoting flow of QI and blood removing blood stasis be principle for the treatment of in stagnant resembling.
In Chinese medicine preparation of the present invention, bar halberd, Spica Prunellae, Fructus Forsythiae, Radix Scrophulariae, collocation can clearing away heat and cooling blood, eliminating fire and detoxication; The Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Dioscoreae, Semen Cuscutae, Herba Epimedii, Rhizoma Cibotii, Crinis Carbonisatus collocation have the liver and the kidney tonifying, bone and muscle strengthening, expelling wind and removing dampness, the effect of blood circulation promoting and blood stasis dispelling; Semen Juglandis, Fructus Lycii can tonifying the kidney to consolidate the essence, supplementing QI and nourishing YIN; Fructus Rubi, Rhizoma Acori Graminei can be whetted the appetite in removing dampness, the mind calming and mentality promoting; Fructus Mori, Herba Cynomorii can tonifying YANG be mended essence, the YIN nourishing of enriching blood, the body resistance strengthening and constitution consolidating.All medicine compatibilities are superior, play altogether the body resistance strengthening and constitution consolidating, vital energy benefiting and the kidney invigorating, replenishing essence is enriched blood, and the merit of blood circulation promoting and blood stasis dispelling can effectively be improved body nutriture after taking, improve organism quality and ability, to improving mankind spermatozoon quality and quantity, there is good effectiveness, have advantages of determined curative effect, taking convenience, cheap, have no side effect and cure rate high, clinic promotion and application.
For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 40 routine male infertility patients to carry out clinical trial, minimum 24 years old of age, maximum 45 years old; Medical history is the shortest 2 years, the longest 10 years; Primary sterility 31 examples in 40 routine patients, secondary sterility 9 examples, all patients' lover is all no abnormal through in many ways checking.
Diagnostic criteria:
With reference to < < new Chinese medicine guideline of clinical investigations > > relevant criterion, work out, 1, the couple at child-bearing age normally lives together more than 2 years after marriage, both sides all do not take any contraceptives and wife's side unpregnancy, and obstacle is bred and bridegroom's or husband's side dysspermatism causes sterile person without any in the wife's side on inspection; 2, semen efamination for less, azoospermia person: (1) semen volume≤1ml; (2) sperm concentration < 20 * 10～9/L; (3) a level < 25% or a+b < 50%; (4) motility rate < 60%.
Criterion of therapeutical effect:
Cure: seminal fluid routine examination (sperm concentration > 20 * 10～9/L after taking medicine; Motility rate > 60%) indices recovers normal or the wife's side is conceived, clinical symptom disappearance.
Take a turn for the better: after taking medicine, seminal fluid routine examination indices does not promote > 50%, clinical symptom disappearance before taking medicine.
Invalid: symptom after taking medicine sign and semen efamination are without improving or improving not obvious.
Therapeutic Method:
Treatment group is taken Chinese medicine preparation of the present invention, according to the method for the fried Chinese medicine of tradition, gets its medicine juice, 1 dose of every day, adds clear water 400ml, soaks 30 minutes, first boils with high heat rear use taking liquid 150ml at a simmer; Take again medicinal liquid 150ml.By 2 liquid medicine mixings, minute morning, late 2 decoction being taken warmly.30 days be 1 course for the treatment of 1 dose of every day.Check seminal fluid routine a course for the treatment of one time, dynamically to observe its curative effect.Period in a medicine is given up smoking, is not indulged in excessive drinking, and avoids using the disadvantageous medicine of sperm and food, without hot water bathing, for a long time not by bike, wears underwear loose, good permeability, avoids work in hot environment as far as possible, does not contact radiation, noxious substance, notes keeping oneself clean.
Efficacy result:
After treatment, in 40 routine patients, cure 26 examples, account for 65%; Wherein conceived 21 examples in the wife's side, account for 52.5%, and 10 examples that take a turn for the better, account for 25%; Invalid 4 examples, account for 10%, and total effective rate is 90%.In curing example, what treatment time was the shortest is two months, and what treatment time was the longest is 11 months.Detailed results is in Table 1.
Table 1: efficacy result statistical table after treatment
| Total number of cases | Cure (%) | Take a turn for the better (%) | Invalid (%) | Total effective rate (%) |
| 40 | 26(65.0) | 10(25.0) | 4(10.0) | 90.0 |
Untoward reaction comparison:
During treating, all there is not obvious adverse reaction in all patients.
Result shows, Chinese medicine preparation of the present invention can effectively regulate organism quality, improves sperm quality, be used for the treatment of male infertility have determined curative effect, cheap, have no side effect, the high advantages such as recurrence that are difficult for of cure rate, clinic is applied.
The specific embodiment
Embodiment 1: a kind of Chinese medicine preparation for the treatment of male infertility, choose 20 grams of halberds of bar, 10 grams of the Cortexs Eucommiae, 10 grams of Fructus Lyciis, 10 grams of Fructus Rubies, 10 grams of Radix Achyranthis Bidentataes, 10 grams of Rhizoma Dioscoreaes, 10 grams of Semen Cuscutae, 10 grams of Rhizoma Acori Gramineis, 8 grams of Herba Epimedii, 8 grams, Fructus Mori, 8 grams of Crinis Carbonisatus, 8 grams of Semen Juglandis, 8 grams of Spica Prunellaes, 8 grams of Radix Scrophulariae, 8 grams of Rhizoma Cibotii, 8 grams of Herba Cynomoriis, 8 grams of Fructus Forsythiaes.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of male infertility, choose 25 grams of halberds of bar, 15 grams of the Cortexs Eucommiae, 15 grams of Fructus Lyciis, 15 grams of Fructus Rubies, 15 grams of Radix Achyranthis Bidentataes, 15 grams of Rhizoma Dioscoreaes, 15 grams of Semen Cuscutae, 15 grams of Rhizoma Acori Gramineis, 10 grams of Herba Epimedii, 12 grams, Fructus Mori, 10 grams of Crinis Carbonisatus, 10 grams of Semen Juglandis, 10 grams of Spica Prunellaes, 10 grams of Radix Scrophulariae, 10 grams of Rhizoma Cibotii, 10 grams of Herba Cynomoriis, 10 grams of Fructus Forsythiaes.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of male infertility, choose 30 grams of halberds of bar, 20 grams of the Cortexs Eucommiae, 20 grams of Fructus Lyciis, 20 grams of Fructus Rubies, 20 grams of Radix Achyranthis Bidentataes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Semen Cuscutae, 20 grams of Rhizoma Acori Gramineis, 12 grams of Herba Epimedii, 15 grams, Fructus Mori, 12 grams of Crinis Carbonisatus, 12 grams of Semen Juglandis, 12 grams of Spica Prunellaes, 12 grams of Radix Scrophulariae, 12 grams of Rhizoma Cibotii, 12 grams of Herba Cynomoriis, 12 grams of Fructus Forsythiaes.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:
Case 1
Permitted certain, man, 36 years old.Patient's 3 years unpregnancies always of marrying, the wife's side checks without abnormality, is bridegroom's or husband's side infertility on inspection, and once medication treatment was 1 year, and effect is undesirable, slowly unpregnancy.After being introduced, take medicine of the present invention and treat, before taking medicine, check and show: patient's soreness of the waist and knees, dizzy weak, pale white complexion, extremities being not warm, libido is indifferent, sexual impotence, deep,thready and forceless pulse, pale tongue, white and thin fur.Seminal fluid chemical examination is shown: sperm count is few, and activity ratio is low, a little less than energy.Take medicine of the present invention after 1 course for the treatment of, patient sign obviously improves, and complexion greatly takes a turn for the better, and seminal fluid chemical examination is shown: sperm count rises to 25.0 * 109/L, sperm motility 55%, energy a level 10%, b level 20%, c level 25%.Continue to take 1 course for the treatment of, patient's libido strengthens, and without sexual impotence outbreak, its spouse is conceived, rear natural labor one son.
Case 2
Zhao, man, 35 years old.Patient 2 years is after marriage sterile, and the wife's side is normal through in many ways checking, patient takes medicine and one do not improve every year, after being introduced, takes medicine of the present invention and treats.Before treatment, the dim red tongue of patient's tongue is white, stringy pulse, seminal fluid routine examination: semen volume 1.5ml, sperm count 5 * 109/L, motility rate 20.1%, a level 5.06%, b level 9.5%, liquefying time 30 minutes, eupyrene sperm number 10%.Take Drug therapy of the present invention after 1 course for the treatment of, tongue is light red by dim red stain, and tongue is white, stringy pulse, and seminal fluid routine examination shows: semen volume 2ml, sperm count 20 * 10～9/L, motility rate 43%, a level 15.06%, b level 14.5%; Continue to take 2 half courses for the treatment of, light red tongue, white and thin fur, wiry forceful pulse.Seminal fluid routine examination shows: semen volume 3ml, and sperm count 67 * 10～9/L, motility rate 67%, a level 29.1%, b level 24.6%, semen efamination is normal; Continue to take the course for the treatment of half, patient wife is conceived, next year natural labor one girl baby.
Case 3
Grandson, man, 27 years old.4 years after marriage unpregnancies always, couple's sexual life is normal, and its wife's reproductive function is normal.Once in many hospital admissions, poor effect.Take after being introduced medicine of the present invention and treat, before treatment, patient presents giddy, weak, and waist is ached, pale tongue white and thin fur, the symptoms such as stringy pulse, seminal fluid routine examination shows: semen volume is normal, sperm concentration 3.51 * 109/L, survival rate 24.3%, a level 5.06%, b level 12.5%.Take medicine of the present invention after 3 courses for the treatment of, all diseases of patient's readme all disappear, and the mental status is good, semen efamination: semen volume, liquefying time are normal, sperm concentration 61.2 * 109/L, sperm survival rate 73.12%, a level 21.06%, b level 34.5%.After January, wife patient is conceived, next year natural labor one son.
Claims (4)
1. a Chinese medicine preparation for the treatment of male infertility, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:
20-30 gram of halberd, Cortex Eucommiae 10-20 gram of bar, Fructus Lycii 10-20 gram, Fructus Rubi 10-20 gram, Radix Achyranthis Bidentatae 10-20 gram, Rhizoma Dioscoreae 10-20 gram, Semen Cuscutae 10-20 gram, Rhizoma Acori Graminei 10-20 gram, Herba Epimedii 8-12 gram, Fructus Mori 8-15 gram, Crinis Carbonisatus 8-12 gram, Semen Juglandis 8-12 gram, Spica Prunellae 8-12 gram, Radix Scrophulariae 8-12 gram, Rhizoma Cibotii 8-12 gram, Herba Cynomorii 8-12 gram, Fructus Forsythiae 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
20 grams of halberds of bar, 10 grams of the Cortexs Eucommiae, 10 grams of Fructus Lyciis, 10 grams of Fructus Rubies, 10 grams of Radix Achyranthis Bidentataes, 10 grams of Rhizoma Dioscoreaes, 10 grams of Semen Cuscutae, 10 grams of Rhizoma Acori Gramineis, 8 grams of Herba Epimedii, 8 grams, Fructus Mori, 8 grams of Crinis Carbonisatus, 8 grams of Semen Juglandis, 8 grams of Spica Prunellaes, 8 grams of Radix Scrophulariae, 8 grams of Rhizoma Cibotii, 8 grams of Herba Cynomoriis, 8 grams of Fructus Forsythiaes.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
25 grams of halberds of bar, 15 grams of the Cortexs Eucommiae, 15 grams of Fructus Lyciis, 15 grams of Fructus Rubies, 15 grams of Radix Achyranthis Bidentataes, 15 grams of Rhizoma Dioscoreaes, 15 grams of Semen Cuscutae, 15 grams of Rhizoma Acori Gramineis, 10 grams of Herba Epimedii, 12 grams, Fructus Mori, 10 grams of Crinis Carbonisatus, 10 grams of Semen Juglandis, 10 grams of Spica Prunellaes, 10 grams of Radix Scrophulariae, 10 grams of Rhizoma Cibotii, 10 grams of Herba Cynomoriis, 10 grams of Fructus Forsythiaes.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the raw material of following weight portion:
30 grams of halberds of bar, 20 grams of the Cortexs Eucommiae, 20 grams of Fructus Lyciis, 20 grams of Fructus Rubies, 20 grams of Radix Achyranthis Bidentataes, 20 grams of Rhizoma Dioscoreaes, 20 grams of Semen Cuscutae, 20 grams of Rhizoma Acori Gramineis, 12 grams of Herba Epimedii, 15 grams, Fructus Mori, 12 grams of Crinis Carbonisatus, 12 grams of Semen Juglandis, 12 grams of Spica Prunellaes, 12 grams of Radix Scrophulariae, 12 grams of Rhizoma Cibotii, 12 grams of Herba Cynomoriis, 12 grams of Fructus Forsythiaes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109453306A (en) * | 2018-12-27 | 2019-03-12 | 同溢堂药业有限公司 | A kind of drug and preparation method thereof for treating male sterility |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772158A (en) * | 2005-05-26 | 2006-05-17 | 李琦白 | Chinese medicine prepn for treating azoospermatism |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772158A (en) * | 2005-05-26 | 2006-05-17 | 李琦白 | Chinese medicine prepn for treating azoospermatism |
Non-Patent Citations (1)
| Title |
|---|
| 陈必军: "调肝论治男性不育", 《广州中医药大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453306A (en) * | 2018-12-27 | 2019-03-12 | 同溢堂药业有限公司 | A kind of drug and preparation method thereof for treating male sterility |
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Inventor after: Du Zhaojin Inventor before: Zhang Chuanying Inventor before: Wang Weiyou |
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| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20171110 Address after: 266000 Shandong province Qingdao City Rail Road No. 10 Applicant after: Du Zhaojin Address before: 262200 Zhucheng people's Hospital, 59 South Outer Ring Road, Zhucheng, Shandong Applicant before: Zhang Chuanying |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180209 Termination date: 20210817 |