CN104147095A - Pediatric expectorant syrup and preparation method thereof - Google Patents
Pediatric expectorant syrup and preparation method thereof Download PDFInfo
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- CN104147095A CN104147095A CN201410399120.3A CN201410399120A CN104147095A CN 104147095 A CN104147095 A CN 104147095A CN 201410399120 A CN201410399120 A CN 201410399120A CN 104147095 A CN104147095 A CN 104147095A
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Abstract
The invention discloses a pediatric expectorant syrup and a preparation method thereof. The syrup is prepared from the following raw materials by weight: 1.0-1.8 parts of carbetapentane citrate, 9.0-130 parts of ephedra, 6-9 parts of ammonium chloride, 380-460 parts of Platycodon grandiflorum, 25-45 parts of carbohydrate, 35-65 parts of sodium benzoate and 3-6 parts of extractum glycyrrhizae liquidum. The benefit effects of the syrup are also reflected in that the syrup conducts comprehensive care and treatment of children from the perspectives of eliminating phlegm and relieving cough and inflammation, and the main ingredients of the syrup are commonly used medicines, highly safe, easy to absorb, and especially suitable for pediatric medication; the syrup does not depress respiratory or cause addiction, has good treatment effect and no adverse reaction, and is convenient for storage and transport; the dosage can be accurately measured according to the age of a child; the raw materials are easily available and low in cost, so as to mitigate burden of the patient; the preparation method is simple in process and easy for production operation; and the syrup has sweet taste, small dosage and can be easily accepted by children. The syrup has the efficacies of relieving cough, calming panting and relieving inflammation, and can be used in the treatment of cough, excessive phlegm, trachitis, disturbance in respiration, pneumonia and emphysema.
Description
Technical field
The invention belongs to medical technical field, relate to a kind of children's syrup and preparation method thereof that eliminates the phlegm.
Background technology
Respiratory system disease is the most common in child.Acute respiratory infection (being mainly upper respiratory tract infection) ratio in the medical number of Pediatric Clinic is the highest; In Hospitalized Children, with pneumonia for the most common.The common symptom of pediatric respiratory system disease is cough, pants and expectoration.Due to children's's anatomical physiology and immune feature, these symptoms, if do not controlled, can promote illness spread and deterioration.Expectorant is the secretions that respiratory tract is produced by bronchus mucus body of gland and goblet cell while having inflammation, can stimulate bronchus sensor to cause cough, and increases the weight of to infect, and even causes dyspnea.Expectorant also claims mucus to actuate medicine, means and can liquefy sputum and promote respiratory mucosa ciliary movement, makes glutinous expectorant be easy to the medicine of expectoration.Children's's internal organs are tender and lovely, and shape gas does not fill, striae of the skin and muscles being loose, susceptible exopathogen.Lung being a delicate viscus, main department is respectful clearly, and position is canopy, has one's ideas straightened out in nose.Exopathogen is attacked people, and lung is first subject to it, clear respectful mistake order, the logical mistake department of falling; Children's's " the spleen tending to insufficiency usually ", current children's indulges and is used to support in addition, throws off restraint food savoury cold drink, deficiency-weakness of spleen-QI, transporting mistake department, the raw wet expectorant of making, internal resistance air flue, therefore exopathogen is attacked lung, expectorant in every many primings, stagnation of Qi and phelgm, declare respectful mistake department, and see cough with copious phlegm, cough up phlegm not well, beat and sneeze watery nasal discharge.The spleen being the source of producing phlegm, the lung being the utensil for storing phlegm, lung spleen is with disease recurrent cough.Give antibiotics and the anti-tussive agents that reduces phlegm, though can alleviate for the moment, yet within phlegm-damp because difficulty is removed, feel again exopathogen, cough recurrence and delay is difficult repeatedly.
7 taste medicines only in the Zhisou San of Cheng Zhongling (< < Medicine Comprehended > >), Herba Schizonepetae, the up sore-throat relieving that can induce sweat of Radix Platycodonis in side, opening lung-energy; Report that Radix Platycodonis can increase bronchial mucosa secretory action, make sputum dilution, be easy to expectoration.The Radix Stemonae, Rhizoma Cynanchi Stauntonii, the descending energy of Radix Asteris lung moistening sending down the abnormal ascending QI, stopping coughing and removing phlegm; Exocarpium Citri Rubrum, Radix Glycyrrhizae and in reduce phlegm, fast diaphragm.All medicines coordinate, and as Cheng Zhongling, say: " gentle peace, cold not hot, both without the excessive anxiety of attack, have greatly and open the gesture that door drives thief.Be fugitive with exopathogen, lung qi is peaceful." Fang Zhongyou take the Radix Stemonae as key medicine, to wind attacking the lung, the itching of the throat person of coughing that chokes, non-this is not understood.Generally speaking, Zhisou San can eliminate the phlegm by lung qi dispersing, again without dispersing too, therefore be called the steady agent in exogenous cough.Have researcher on the basis of Zhisou San, to add Bulbus Fritillariae Cirrhosae, resemble that shellfish is clear and rich reduces phlegm, Vascular aurantii dredging collateral eliminates the phlegm, and Caulis Perillae regulating the flow of QI to ease the stomach increases the merit of its lung qi dispersing.Though add Flos Magnoliae simply, strengthen expelling pathogenic wind and restoring the functions of orifices in face, to separate all diseases of nasal allergy.All medicines share, and make the turbid facilitation of expectorant, and lung qi must be suitable.
Publication number CN 101904850A(application number 201010258583.X) Chinese patent literature discloses a kind of preparation method of medicine and syrup thereof of relieving cough and expelling phlegm, the agent of compound recipe DM Cough is comprised of dextromethorphan hydrobromide, guaifenesin, sucrose, 1,2-PD, benzoic acid, Mentholum, essence, ethanol, caramel color.Publication number CN 1500505A(application number 02138175.5) Chinese patent literature discloses a kind of pharmaceutical composition for the treatment of infantile viral pneumonia, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Radix Peucedani, Bombyx Batryticatus, Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Rhizoma Bistortae, Semen Lepidii (Semen Descurainiae), Cortex Mori ten a herbs, consists of.Granted publication CN 101574425A(application number 200810105789.1) Chinese patent literature disclose a kind of for children's eliminate the phlegm, the preparation method of " child cough granule " of antitussive prescription and this product, it is to retain " XIAOER ZHIKE TANGJIANG " principal agent prescription, be on the basis of Radix Glycyrrhizae fluidextract, Radix Platycodonis fluidextract, ammonium chloride, Pericarpium Citri junoris tincture, starch, dextrin, Icing Sugar, microcrystalline Cellulose, mannitol, carboxymethyl starch sodium, cross-linked carboxymethyl cellulose, select suitable adjuvant to make.
In a word, Chinese and western medical has been obtained good curative effect treatment children's aspect eliminating the phlegm, but also has some problems: at present, Chinese medicine, Western medicine, Chinese patent medicine that the treatment children's that China produces is eliminated the phlegm are a lot.But some curative effect of medication are slow, some medicine children's dysphagias, the drug side effect also having is too large.There is curative effect slowly and the difficult deficiency of taking medicine in Chinese medicine, Chinese patent medicine slow curative effect as same in Fel Serpentis et Bulbus Fritillariae Cirrhosae Liquidus; Western medicine is as mucosolvan, easily addiction.Physiological characteristics for children's " internal organs are tender and lovely " " shape gas does not fill " is unfavorable.The eliminate the phlegm prescription of syrup uniqueness of children's, has brought up its special pharmacology curative effect, is applicable to the development of whole disease; From eliminating the phlegm, the aspect such as cough-relieving, antiinflammatory carries out comprehensive nursing for treating to children's, and this product principal agent composition is conventional Chinese medicine, safety is high, is particularly suitable for pediatric pharmaceuticals; This product does not suppress to breathe in addition, without addiction.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, curative effect fast, taking convenience, portable children's eliminate the phlegm syrup and preparation method thereof.This syrup determined curative effect and having no side effect.
Technical scheme of the present invention is:
Children's's syrup that eliminates the phlegm, in weight portion, its component is: carbetapentane citrate 1.0-1.8 part, ammonium chloride 6-9 part, (preferred, Herba Ephedrae 100-120 part, is more preferably Herba Ephedrae 90-130 part, 110 parts, Herba Ephedrae), Radix Platycodonis 25-45 part, saccharide 380-460 part, sodium benzoate 3-6 part, Radix Glycyrrhizae fluidextract 35-65 part, surplus is water.
In preferred scheme, carbetapentane citrate 1.2-1.6 part, ammonium chloride 6.5-8.5 part, Herba Ephedrae 100-120 part, Radix Platycodonis 30-42 part, saccharide 400-440 part, sodium benzoate 3.5-5.5 part, Radix Glycyrrhizae fluidextract 40-60 part, surplus is water.
Be more preferably, 1.4 parts of carbetapentane citrates, 7 parts of ammonium chloride, 105 parts, Herba Ephedrae, 35 parts of Radix Platycodoniss, 430 parts of saccharides, 4 parts of sodium benzoate, 45 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The preparation method of described syrup is:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 30%-80% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) be 1.8-2.2 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.2-8.5 with alkali.
(3) saccharide first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Preferably be in step (1) ethanol that is 40%-75% by mass concentration.
Preferably be in step (1), evaporation and concentration to volume (by milliliter) be crude drug in whole weight (by gram) 2.0-2.2 doubly.
Preferably be that, in step (2), alkali used is sodium hydroxide, potassium hydroxide or ammonia.
Preferably be in step (2), regulate pH=7.4-8.2.
Preferably be that in step (3), saccharide is selected from sucrose, crystal sugar or maltose.
Be more preferably, in step (1), the ethanol that is 60% by mass concentration.
Be more preferably, evaporation and concentration to volume (by milliliter) is 2.1 times of crude drug in whole weight (by gram) in step (1).
Be more preferably, in step (2), regulate pH=8.0.
The raw materials used effect of the present invention is as follows:
Carbetapentane citrate: conventional its citrate is crystallinity or the graininess powder of white or off-white color; Odorless, bitter in the mouth.Pharmacological action: this product, to the selective inhibitory action of coughing centre, still has slight atropine-like effect and local anesthetic action, heavy dose of have spasmolysis to bronchial smooth muscle, therefore it has central and tip antitussive effect concurrently.Indication: be mainly used in dry cough that upper respiratory tract infection causes and pertussis etc.
Ammonium chloride: be clear crystal or white crystalline powder; Odorless, salty in the mouth, cool; Have draw moist.Due to this product phlegm-dispelling functions a little less than, normal be made into compound preparation use with other eliminating phlegm and stopping cough medicines.Pharmacological action: the vagus nerve of the oral rear stimulation gastric mucosa of this product, cause slight feeling sick, cause to reflexive that trachea and bronchus glandular secretion increases, sputum dilution.Some drugs absorbed into serum is got rid of by respiratory tract, because moisture is taken in the osmotic pressure effect of salt out of, makes sputum dilution, is easy to get rid of.Indication: be applicable to dry cough and glutinous expectorant is difficult for expectoration person.
Sodium benzoate: another name: sodium benzoate is white crystalline powder or granule; Odorless, taste micro-sweet be with salty.Pharmacological action: there is the effect of anti-bacteria and conk.Indication: for the anticorrosive mildewproof of oral liquid preparation, be especially not suitable for the anticorrosion of benzoinated neutrality or alkalescence medicament and food.
Herba Ephedrae: nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return lung, urinary bladder channel.Effect: diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Cure mainly: for anemofrigid cold, uncomfortable in chest breathing with cough, edema due to wind pathogen edema.Honey Herba Ephedrae nourishing the lung to arrest cough, is used for exterior syndrome and separates, asthma and cough.
Radix Platycodonis: nature and flavor: bitter, pungent, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Radix Glycyrrhizae fluidextract is the fluid extract through being processed into by Radix Glycyrrhizae extractum.Radix Glycyrrhizae fluidextract is liquid brown or russet; Taste is sweet, summary is bitter, puckery.Effect: obtundent, normal and preventing phlegm from forming and stopping coughing medicine compatibility application, can alleviate the stimulation to pharyngeal mucosa, and has the gastrointestinal smooth muscular spasm of alleviation and the effect of desoxycortone sample.Cure mainly: for bronchitis, pharyngolaryngitis, bronchial asthma, chronic adrenocortical hypofunction.
The present invention compared with prior art, has the advantages such as curative effect is fast, convenient oral, for children's, eliminates the phlegm a kind of preparation method of desirable syrup is provided.In addition, excellent results of the present invention also shows:
1
,this product curative effect is good, safe and reliable;
2
,storage is convenient, convenient transportation;
3
,can, according to child age, accurately measure institute's taking dose;
4
,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden;
5
,technique is simple, be easy to production operation, and taste is fragrant and sweet, and dose is little, therefore children's is acceptant.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not limited to this.
embodiment 1children's's syrup that eliminates the phlegm, take weight portion (every part is 10g), and its component is: 1.0 parts of carbetapentane citrates, and 6 parts of ammonium chloride, 90 parts, Herba Ephedrae, 25 parts of Radix Platycodoniss, 380 parts of sucrose, 3 parts of sodium benzoate, 35 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The eliminate the phlegm preparation method of syrup of above-mentioned children's:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 30% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 1.8 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.2 with sodium hydroxide.
(3) sucrose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
The instructions of taking of syrup of the present invention: oral, one-year-old to two years old one time 2～3 milliliters, two years old to five years old one time 3～5 milliliters, six years old to 14 years old one time 5～10 milliliters, 3～4 times on the one.
embodiment 2the eliminate the phlegm preparation (every part for 10g) of syrup of children's: 1.8 parts of carbetapentane citrates, 9 parts of ammonium chloride, 130 parts, Herba Ephedrae, 45 parts of Radix Platycodoniss, 460 parts, crystal sugar, 6 parts of sodium benzoate, 65 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The eliminate the phlegm preparation method of syrup of above-mentioned children's:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 80% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.2 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=8.5 with potassium hydroxide.
(3) crystal sugar first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) by carbetapentane citrate, ammonium chloride, sodium benzoate, be dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: xxx, the age: 3 years old; Sex: women; Main suit: cough and expectoration is repeatedly more than January; History of present illness: cough and repeatedly do not heal nearly January, obvious when rising morning and falling asleep, companion's nasal obstruction rhinocnesmus, beats and sneezes watery nasal discharge, and expectoration is glued in vain, and that coughs up is not well, sweating while acting, receiving can dry stool.Successively take amoxicillin, Zithromax, cefaclor, cough and expectoration is showed no improvement.Red tongue, white and thin fur, the little cunning of thready pulse.Auscultation two pulmonary respiration sounds are clear, do not hear and dry moist rale.
Take the present embodiment gained children's syrup that eliminates the phlegm, each 3mL, every day 3 times, takes 3 days, and cough and expectoration obviously alleviates, and beats to sneeze watery nasal discharge and alleviate, and takes 7 days, and any discomfort, does not appear in symptom elimination when patient takes.
embodiment 3the eliminate the phlegm preparation (every part for 50g) of syrup of children's: 1.2 parts of carbetapentane citrates, 6.5 parts of ammonium chloride, 100 parts, Herba Ephedrae, 30 parts of Radix Platycodoniss, 400 parts of maltose, 3.5 parts of sodium benzoate, 40 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The eliminate the phlegm preparation method of syrup of above-mentioned children's:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 40% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.0 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.4 with ammonia.
(3) maltose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: xxx, 5 years old; Male; Cough 4 days.Recurrent cough, monthly 1～3 time, uses antibiotic therapy repeatedly closely over the past half year.Before 4 days, cough rises again, and apasm of coughing stagnation of phlegm, coughs and very draw spit saliva and dyspepsia, swallows red herpes, and constipation takes cefaclor 2 days, and cough is still acute.Red tongue is red, the white greasy micro-Huang of tongue, thready and rolling pulse.Auscultation two pulmonary respiration sounds are slightly thick, even news and rale sound.
Take the present embodiment gained children's syrup that eliminates the phlegm, every day 3 times, each 4mL.Take 2 days, cough alleviates.Take 5 days, symptom is eliminated, and has no adverse reaction.
embodiment 4the eliminate the phlegm preparation (every part for 100g) of syrup of children's: 1.6 parts of carbetapentane citrates, 8.5 parts of ammonium chloride, 120 parts, Herba Ephedrae, 42 parts of Radix Platycodoniss, 440 parts of sucrose, 5.5 parts of sodium benzoate, 60 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The eliminate the phlegm preparation method of syrup of above-mentioned children's:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 75% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.2 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution mixed with Radix Glycyrrhizae fluidextract and regulated, and regulating pH=8.2 with ammonia.
(3) sucrose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
Model case: xxx, the age: 10 years old; Sex: male; Main suit: recurrent cough, expectoration more than 1 year; History of present illness: breast CT is shown " concurrent infection of bronchiectasis ", repeatedly expectorant is cultivated as Pseudomonas aeruginosa.The smelly layering of expectorant, maximum 50ml/d, the heat that occurs together (the highest 38.4 ℃).Uncomfortable in chest, cough repeatedly, coughs the sticky expectorant 20～30mL of yellow green every day, stench many foams, and the even band blood streak, without wire drawing; Cough, expectoration symptom are to rise in night and morning as work, and often suppress awake night.Discuss: patient is juvenile male, repeatedly occur cough, expectoration, the many frowziness of amount of expectoration, stratification, CT points out bronchiectasis, and first diagnosis considers bronchiectasis.
Take the present embodiment gained children's syrup that eliminates the phlegm, each 8mL, every day 3 times, takes 3 days, and cough and expectoration obviously alleviates, uncomfortable in chest alleviating, and expectoration is without the blood streak.Take 6 days, symptom is eliminated, and does not occur any discomfort when patient takes.
embodiment 5the eliminate the phlegm preparation (every part of 20g) of syrup of children's: 1.4 parts of carbetapentane citrates, 7 parts of ammonium chloride, 105 parts, Herba Ephedrae, 35 parts of Radix Platycodoniss, 430 parts of sucrose, 4 parts of sodium benzoate, 45 parts of Radix Glycyrrhizae fluidextract, surplus is water.
The eliminate the phlegm preparation method of syrup of above-mentioned children's:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, the ethanol solvent that is 60% by mass concentration leaches by percolation, and the liquid of must filtering reclaims ethanol, and evaporation and concentration to volume (by milliliter) is 2.1 times of crude drug in whole weight (by gram).
(2) step (1) gained concentrated solution mixed with Radix Glycyrrhizae fluidextract and regulated, and regulating pH=8 with ammonia.
(3) sucrose first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again.
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
test example 1the eliminate the phlegm clinical practice of syrup of embodiment 5 gained children's: in March, 2010-2013 year JIUYUE, in 6 hospitals, screen 180 routine patients, women's 80 examples wherein, male's 100 examples, oldest 11 years old, minimum 16 months, 5.8 years old mean age.During test, this crowd is carried out to Continuous Observation, record symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (as Radix Polygalae, ambroxol, mucosolvan, Fel Serpentis et Bulbus Fritillariae Cirrhosae Liquidus etc.).Using method is: oral, one-year-old to two years old one time 2～3 milliliters, two years old to five years old one time 3～5 milliliters, six years old to 14 years old one time 5～10 milliliters (depending on concrete condition, adjusting to some extent), 3～4 times on the one.Cure: cough and expectoration disappears, the dry moist rale of auscultation disappears.Take a turn for the better: cough and expectoration alleviates, and two pulmonary respiration sounds are clear, and expectorant is few.Do not heal: cough and expectoration symptom and sign have no improvement.Result is as shown in table 1.
Table 1: take 16 months-11 years old expectoration patient treatment result of embodiment 5 product
Therapeutic effect: cure 102 examples (72.9%), 35 examples (25%) that take a turn for the better, invalid 3 examples (2.1%), total effective rate 97.9%.Successful is better than matched group.
The variation of observing experimenter's cough, amount of expectoration, nasal obstruction, dry moist rale during taking is as shown in table 2.
Table 2:
The present invention selects Radix Platycodonis, Herba Ephedrae etc. to carry out compatibility, makes after these drug regimens to produce synergism, and in side, carbetapentane citrate has central and tip antitussive effect concurrently.Sodium benzoate has the effect of anti-bacteria and conk.Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Radix Glycyrrhizae fluidextract is obtundent, with the application of preventing phlegm from forming and stopping coughing medicine compatibility, can alleviate the stimulation to pharyngeal mucosa, and have the gastrointestinal smooth muscular spasm of alleviation and the effect of desoxycortone sample.Ammonium chloride eliminates the phlegm, cough-relieving.Integrative Chinese-Western, all medicines share, and make the turbid facilitation of expectorant, lung qi must be suitable, play altogether eliminate the phlegm, antitussive, anti-inflammatory effect, therefore can obtain good therapeutic effect.Take 3 days, 51% pediatric patient expectoration disappears; Take 5 days, 80% pediatric patient expectoration disappears; Take 8 days, 99% pediatric patient expectoration disappears.In experimental group, take more than 8 days, effective percentage can reach 96%, and matched group is only 78%.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (10)
1. children's's syrup that eliminates the phlegm, is characterized in that, by following raw materials according, is prepared from, and is weight portion: carbetapentane citrate 1.0-1.8 part, ammonium chloride 6-9 part, Herba Ephedrae 90-130 part, Radix Platycodonis 25-45 part, saccharide 380-460 part, sodium benzoate 3-6 part, Radix Glycyrrhizae fluidextract 35-65 part, surplus is water.
2. the children's as claimed in claim 1 syrup that eliminates the phlegm, is characterized in that carbetapentane citrate 1.2-1.6 part, ammonium chloride 6.5-8.5 part, Herba Ephedrae 100-120 part, Radix Platycodonis 30-42 part, saccharide 400-440 part, sodium benzoate 3.5-5.5 part, Radix Glycyrrhizae fluidextract 40-60 part, surplus is water.
3. the children's as claimed in claim 1 syrup that eliminates the phlegm, is characterized in that, 1.4 parts of carbetapentane citrates, and 7 parts of ammonium chloride, 105 parts, Herba Ephedrae, 35 parts of Radix Platycodoniss, 430 parts of saccharides, 4 parts of sodium benzoate, 45 parts of Radix Glycyrrhizae fluidextract, surplus is water.
4. the eliminate the phlegm preparation method of syrup of the children's as described in as arbitrary in claim 1～3, is characterized in that, comprises the following steps:
(1) Radix Platycodonis, Herba Ephedrae are pulverized together rough, with ethanol (mass concentration is 30%-80%) solvent, by percolation, leach, the liquid of must filtering, reclaims ethanol, and evaporation and concentration to volume be crude drug in whole weight 1.8-2.2 doubly;
(2) step (1) gained concentrated solution is mixed with Radix Glycyrrhizae fluidextract, and regulate pH=7.2-8.5 with alkali;
(3) saccharide first adds water boil, dissolving, filtration, and syrup is sneaked in step (2) gained mixed liquor again;
(4) carbetapentane citrate, ammonium chloride, sodium benzoate are dissolved in suitable quantity of water, then mix and add water with step (3) gained, with gauze filtering and get final product.
5. preparation method as claimed in claim 5, is characterized in that, the mass concentration of step (1) ethanol used is that 40%-75%(is preferred, and the mass concentration of ethanol is 60%).
6. preparation method as claimed in claim 5, is characterized in that, step (1) reclaims ethanol, and evaporation and concentration to volume is 2.0-2.2 times (preferred, evaporation and concentration to volume is 2.1 times of crude drug in whole weight) of crude drug in whole weight.
7. preparation method as claimed in claim 5, is characterized in that, in step (2), alkali used is sodium hydroxide, potassium hydroxide or ammonia.
8. preparation method as claimed in claim 5, is characterized in that, regulates pH=7.4-8.2(preferred in step (2), regulates pH=8.0).
9. preparation method as claimed in claim 5, is characterized in that, the saccharide in step (3) is selected from sucrose, crystal sugar or maltose.
10. the application of syrup when treatment children's is eliminated the phlegm of eliminating the phlegm of the children's as described in as arbitrary in claim 1-3.
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| CN201410399120.3A CN104147095A (en) | 2014-08-14 | 2014-08-14 | Pediatric expectorant syrup and preparation method thereof |
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| CN201410399120.3A CN104147095A (en) | 2014-08-14 | 2014-08-14 | Pediatric expectorant syrup and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434789A (en) * | 2014-12-27 | 2015-03-25 | 昆明振华制药厂有限公司 | Preparing method of citron pentoxyverine syrup |
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| CN1650889A (en) * | 2004-11-29 | 2005-08-10 | 俞锋 | Child cough stopping sgrup and its preparation method |
| KR100771399B1 (en) * | 2006-04-26 | 2007-10-30 | 인제대학교 산학협력단 | Composition comprising the seed extract of green tea having antioxidant, anti-inflammatory and anti-arteriosclerosis activity |
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| CN1650889A (en) * | 2004-11-29 | 2005-08-10 | 俞锋 | Child cough stopping sgrup and its preparation method |
| KR100771399B1 (en) * | 2006-04-26 | 2007-10-30 | 인제대학교 산학협력단 | Composition comprising the seed extract of green tea having antioxidant, anti-inflammatory and anti-arteriosclerosis activity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104434789A (en) * | 2014-12-27 | 2015-03-25 | 昆明振华制药厂有限公司 | Preparing method of citron pentoxyverine syrup |
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Application publication date: 20141119 |