CN104056006A

CN104056006A - Drug for treatment of chronic bronchitis and preparation method thereof

Info

Publication number: CN104056006A
Application number: CN201410279205.8A
Authority: CN
Inventors: 宋克垣
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-23
Filing date: 2014-06-23
Publication date: 2014-09-24

Abstract

The invention discloses a drug for treatment of chronic bronchitis and a preparation method thereof. The drug is prepared mainly from Aconitum carmichaelii, radix rehmanniae, Radix Rehmanniae Preparata, Chinese yam, herba epimedii, fructus psoraleae, dodder and dried tangerine peel according to certain weight ratio. The drug provided by the invention has the functions of clearing away heat and toxic materials, regulating qi-flowing and strengthening spleen, removing dampness and reducing phlegm, and can reach the effects of quick effect, short course of treatment and no recurrence when used for treatment of chronic bronchitis.

Description

A kind of medicine for the treatment of chronic bronchitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic bronchitis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Chronic bronchitis refers to the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Chronic bronchitis main cause is that the repeated infection of virus and antibacterial has formed bronchial chronic nonspecific inflammation.When mercury dropped, respiratory tract small blood vessel spasm ischemia, defense function are easy to cause a disease while decline; The chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes bronchospasm, mucosa variation, ciliary movement reduction, the favourable infection of mucus secretion increasing; Irritated factor also has certain relation.At present, because Western medicine cannot effectively be treated chronic bronchitis, and long-term taking Western medicine has more side effect, and therefore, people exist very large demand to the Chinese medicine of effective treatment chronic bronchitis.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment chronic bronchitis, thereby has completed the present invention.

Object of the present invention is just to provide a kind of composition of medicine that can effectively treat chronic bronchitis.

Another object of the present invention has just been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae, Radix Taraxaci medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of chronic bronchitis.Wherein selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia ， Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid, controls calentura excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis, sends out speckle dermexanthesis.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor, enters liver, kidney channel, has YIN nourishing, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, waist knee flaccidity, and chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia, quenches one's thirst, frequency of micturition, deafness, blurred vision.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, there is spleen invigorating, tonifying the lung, reinforces the kidney, and the function of benefit essence, controls diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quenches one's thirst, seminal emission, leukorrhagia, frequent micturition.Selecting Herba Epimedii is that temperature, enters liver, kidney channel, has kidney invigorating and YANG supporting because of its property acrid-sweet flavor, and the function of expelling wind and removing dampness is controlled sexual impotence erectile problem, dribbling urination, and muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, four feet are meciless.Select Fructus Psoraleae to be because its nature and flavor are pungent, temperature, enters kidney channel, has the function of reinforcing the kidney and supporting YANG, controls the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, and spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed, external curing vitiligo.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Selecting Pericarpium Citri Reticulatae is that temperature, returns lung, spleen channel, has regulating qi-flowing for strengthening spleen because of its nature and flavor hardship, pungent, and the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Radix Taraxaci for the dry root of Herba Taraxaci, is sent out root to get before spring and summer is bloomed or while just having bloomed, removes earth, dries; Slightly be coniform, bending, long 4-10cm, surperficial sepia, shrinkage, root head has the young pilose antler of brown or yellow-white, or has come off.Select Radix Taraxaci to be because its property bitter but sweet flavor is cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.

Detailed description of the invention

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Radix Aconiti Lateralis Preparata 140-160 gram of Radix Rehmanniae 140-160 gram of Radix Rehmanniae Preparata 140-160 gram

Rhizoma Dioscoreae 440-460 gram of Herba Epimedii 140-160 gram of Fructus Psoraleae 140-160 gram

Semen Cuscutae 140-160 gram of Pericarpium Citri Reticulatae 290-310 gram of Radix Taraxaci 190-210 gram.

Preferable amount is

150 grams of 150 grams of Radix Rehmanniae Preparata of 150 grams of Radix Rehmanniae of Radix Aconiti Lateralis Preparata

150 grams of 150 grams of Fructus Psoraleaes of 450 grams of Herba Epimedii of Rhizoma Dioscoreae

200 grams of 300 grams of Radix Taraxacis of 150 grams of Pericarpium Citri Reticulataes of Semen Cuscutae.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries;

2, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;

3, Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;

4, Rhizoma Dioscoreae: choose clean impurity, be soaked in water softening to Rhizoma Dioscoreae central part till, pull out slightly and dry in the air, section is dried or is dried;

5, Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;

6, Fructus Psoraleae: the clean impurity of winnowing with a dustpan, clean, dry;

7, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

8, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash, soften, shredding, dries or cold drying, sieve dedust bits;

9, Radix Taraxaci: choose decontamination, clean earth, cutting, dries.

Two, preparation

1, the Radix Aconiti Lateralis Preparata of described weight, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae, Radix Taraxaci medicine are pulverized, mixing and stirring, grinds to form fine powder altogether, crosses 200 order dusting covers.

2, Mel is tempered to the tender honey of making 110 DEG C-115 DEG C with slow fire, filter skimming.

3, by the spice ratio of 1:1 by weight of grinding as fine powder, add mixing system in Mel to stick together, then rubbing pill, every ball is containing 1 gram of pure medicine.

4, in process for preparation, for preventing that pill from adhering to instrument, can smear a small amount of pill oil, the preparation of pill oil: add Mel with vegetable oil and prepare, its preparation weight ratio is 4:1 or 5:1.

Medicine of the present invention has heat-clearing and toxic substances removing, regulating qi-flowing for strengthening spleen, and effect of drying dampness to eliminate phlegm, treatment chronic bronchitis instant effect, short treating period, do not recur.

Further set forth below the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 1.5 grams/kg, and normal amount is 0.76 gram/kg, and administering mode is administration by gavage administration, every day twice, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 37 examples for medical treatment.

2, diagnostic criteria

Chronic bronchitis clinical manifestation

(1) cough: the cough increasing the weight of for a long time, repeatedly, is gradually the outstanding behaviours of primary disease.The lighter is only in winter-spring season morbidity, and especially with the most obvious before and after getting up early morning, daytime, cough was less.Summer and autumn, cough alleviates.Patient with severe symptoms the four seasons all cough, Winter-Spring aggravation, day and night cough, sooner or later particularly violent.

(2) expectoration: the general expectorant mucus cystose that is white in color, rise more morning, often because sticky being difficult for brings up.Infect or catch cold after symptom aggravate rapidly, amount of expectoration increases, viscosity increases, or is yellow purulent sputum or with panting.Accidental cause play is coughed and sputum mixed with blood.

3, Therapeutic Method

Select above-mentioned pill, take to patient, each serving using 4 balls, every day, early, middle and late respectively clothes 1 time, 7 days was a course for the treatment of, took continuously 3 courses for the treatment of.

4, efficacy assessment standard

Effective: chronic bronchitis is eliminated, observe after half a year without recurrence;

Take a turn for the better: chronic bronchitis shape is clearly better;

Invalid: symptom, without improvement, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy chronic bronchitis patient 37 examples of the present invention, effective 34 examples of result, obvious effective rate is 94.59%, 2 examples that take a turn for the better, and improvement rate is 5.41%, invalid 1 example, total effective rate is 97.30%.

Claims

1. a medicine for the treatment of chronic bronchitis, is characterized in that: it is to be made up of the crude drug in following weight range:

2. medicine according to claim 1, wherein the consumption of each crude drug is:

3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section, dries;

(2) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cuts sheet, dry, and sieve removes chip;

(3) Radix Rehmanniae Preparata: select clean Radix Rehmanniae Preparata;

(4) Rhizoma Dioscoreae: choose clean impurity, be soaked in water softening to Rhizoma Dioscoreae central part till, pull out slightly and dry in the air, section is dried or is dried;

(5) Herba Epimedii: choose clean impurity, destemming, shredding, sieve removes chip;

(6) Fructus Psoraleae: the clean impurity of winnowing with a dustpan, clean, dry;

(7) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

(8) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash, soften, shredding, dries or cold drying, sieve dedust bits;

(9) Radix Taraxaci: choose decontamination, clean earth, cutting, dries;

(2) preparation

(1) Radix Aconiti Lateralis Preparata of described weight, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae, Radix Taraxaci medicine are pulverized, mixing and stirring, grinds to form fine powder altogether, crosses 200 order dusting covers;

(2) Mel is tempered to the tender honey of making 110 DEG C-115 DEG C with slow fire, filter skimming;

(3) by the spice ratio of 1:1 by weight of grinding as fine powder, add mixing system in Mel to stick together, then rubbing pill, every ball is containing 1 gram of pure medicine;

(4) in process for preparation, for preventing that pill from adhering to instrument, can smear a small amount of pill oil, the preparation of pill oil: add Mel with vegetable oil and prepare, its preparation weight ratio is 4:1 or 5:1.