CN104055708B - Anti-inflammatory cosmetic composition and preparation method thereof - Google Patents
Anti-inflammatory cosmetic composition and preparation method thereof Download PDFInfo
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- CN104055708B CN104055708B CN201410319713.4A CN201410319713A CN104055708B CN 104055708 B CN104055708 B CN 104055708B CN 201410319713 A CN201410319713 A CN 201410319713A CN 104055708 B CN104055708 B CN 104055708B
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 41
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims description 9
- 241000544066 Stevia Species 0.000 claims abstract description 22
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims abstract description 22
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- 239000003963 antioxidant agent Substances 0.000 claims abstract description 6
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 5
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- 239000000377 silicon dioxide Substances 0.000 claims abstract description 4
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- 238000003756 stirring Methods 0.000 claims description 12
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- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 2
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 2
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- 229940057910 shea butter Drugs 0.000 claims description 2
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 2
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- 229930003799 tocopherol Natural products 0.000 claims description 2
- 235000010384 tocopherol Nutrition 0.000 claims description 2
- 239000011732 tocopherol Substances 0.000 claims description 2
- 125000002640 tocopherol group Chemical group 0.000 claims description 2
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- 229940084106 spermaceti Drugs 0.000 claims 1
- 239000012177 spermaceti Substances 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 abstract description 7
- 239000000419 plant extract Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract 4
- 239000011259 mixed solution Substances 0.000 abstract 2
- 239000003906 humectant Substances 0.000 abstract 1
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- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
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- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
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- 230000003796 beauty Effects 0.000 description 1
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an anti-inflammatory cosmetic composition. The anti-inflammatory cosmetic composition comprises, by weight, 1-15 parts of plant extracts, 2.55-7 parts of emulsifying agents, 4-26 parts of emollient, 2.5-20 parts of humectant, 0.1-0.3 part of dipotassium glycyrrhizinate, 0.1-2 parts of silica, 0.03-0.07 part of potassium hydroxide, 0.1-0.2 part of a thickening agent, 0.05-2 parts of antioxidants, 0.201-1.01 parts of preservatives and 40-75 parts of water. The plant extracts are mixed solutions of stevia extracting solutions and palm leaf extracting solutions. The mixed solutions of the stevia extracting solutions and the palm leaf extracting solutions are applied to anti-inflammatory cosmetics, so that the dermatitis is effectively prevented and treated.
Description
Technical field
The present invention relates to cosmetic field, more particularly to a kind of cosmetic composition with anti-inflammatory properties and its preparation
Method.
Background technology
Cosmetics are the methods to smear, to spray or other are similar to, and impose on any position of human body surface (skin, nail, mouth
Lip, the ripe film in oral cavity etc.), to reach cleaning, to eliminate bad smell, skin care, beauty treatment and the product modifying purpose.
With social progress, the continuous improvement of working environment, increasing people can under comfortable air conditioner surroundings work
Make.However, being easy in air-conditioned room grow substantial amounts of bacterium.Wherein legionella pneumophilia is the pneumonia sense being active in air-conditioned room
Dye bacterium, it has the infection of unknown cause to skin, causes the inflammation of skin, makes skin the symptoms such as erythema, itch.This will
Have influence on the external image of people, the normal life of people can be had influence on what is more.
With the development of cosmetics industry, natural plant kind product due to using safety, action temperature and, effect obvious
The advantages of and welcome.Obtain the plant extracts containing active ingredient generally by corresponding processing, and be added to cosmetic
In product.
At present, anti-inflammatory cosmetics antiphlogistic effects on the market are inconspicuous, and easily cause allergic phenomena.Therefore, what selects
Plant plant, and being applied in cosmetics of its safety is reached more preferable antiphlogistic effects, be problem demanding prompt solution.
Content of the invention
Based on this, it is an object of the invention to provide a kind of anti-inflammatory cosmetic composition.
Concrete technical scheme is as follows：
A kind of anti-inflammatory cosmetic composition it is characterised in that by weight, including following components：
Wherein, described plant extraction liquid is the mixed liquor of stevia rebaudianum extract and palm leaf extract.
Wherein in an embodiment, the weight portion of described plant extraction liquid is 5～12 parts；Described stevia rebaudianum extract and palm fibre
The weight part ratio of palmitic acid leaf extract is (0.5～10)：(0.5～10).
Wherein in an embodiment, the weight part ratio of described stevia rebaudianum extract and palm leaf extract is (2～10)：(2
～10).
Wherein in an embodiment, described thickener is Carbomer；Described antioxidant is tocopherol.
Wherein in an embodiment, described emulsifying agent is (1～3) for weight part ratio：(1～3)：(0.5～3)：(0.05
～2) cetostearyl alcohol olive oleate/sorb smooth olive oleate, the smooth palmitate/mountain of cetanol palmitate/sorb
Pears smooth olive oleate, cetostearyl alcohol and stearic mixing.
Wherein in an embodiment, described emollient is (1～5) for weight part ratio：(0.5～5)：(0.5～5)：(1
～5)：(0.5～5)：The shea butter of (0.5～2), olive oil, caprylic/capric triglyceride, saualane, ring five poly dimethyl
Siloxanes and the mixing of dimethyl silicone polymer.
Wherein in an embodiment, described NMF is (1～10) for weight part ratio：(1～10)：(0.1～3)：
The mixing of the glycerine of (0.01～0.1), butanediol, trehalose and Sodium Hyaluronate.
Wherein in an embodiment, described preservative is (0.2～1) for weight part ratio：The benzene oxygen of (0.001～0.01)
Ethanol and the mixing of methylisothiazolinone.
The stevia rebaudianum extract of the present invention and palm leaf extract can be by conventional alcohol extracting method preparations, with this to greatest extent
Ensure the anti-inflammatory efficacy of two kinds of extracts, preferably following extracting method：The plant (stevia rebaudianum or palma) being dried is added to matter
Amount ratio is in 85% ethanol, carrying out extracting 4～8h under backflow and dipping.Subsequently, with filter cloth, extract is filtered, then
Centrifugation obtains plant (stevia rebaudianum or palma) extract.
The preparation method of above-mentioned anti-inflammatory cosmetic composition, comprises the steps：
(1) emollient, emulsifying agent and antioxidant are put into oil phase pot, be heated to 70～85 DEG C, wait all components to melt
After be incubated, obtain final product A phase；
(2) NMF, silica, thickener, dipotassium glycyrrhizinate and water are put into emulsification pot, be heated to 70～85 DEG C, insulation
15～30 minutes, obtain final product B phase；
(3) by the emulsification pot of A phase suction step (2) in step (1), homogeneous 3～15 minutes, stir speed (S.S.) is 2000
～4000rpm, then insulated and stirred 15～45 minutes, stir speed (S.S.) is 20～40rpm；
(4) emulsion in step (3) is cooled to 40～45 DEG C, adds NaOH, stir；
(5) add plant extraction liquid and preservative, stir, obtain anti-inflammatory cosmetic composition.
Stevia rebaudianum is this ratio subgenus herbaceos perennial of composite family, also known as STEVIA REBAUDIANA.Stevia rebaudianum original producton location is in South America Paraguay
Oman that northeast is connected with Brazilian border is visitd in mountain range.The existing ground such as Beijing, Hebei, Shaanxi, Jiangsu, Fujian, Hunan, Yunnan is equal
Introduce a fine variety.Legionella pneumophilia can cause the baffled skin infection under air conditioner surroundings, and stevia extract has suppression to legionella pneumophilia
System, adding stevia extract in the anti-inflammatory cosmetic composition of the present invention plays the role of to prevent well and prevents and treats dermatitis.
Palma is the leaf of palm.Palm also known as Tang palm fibre, Chinese fan palm fibre, spelling palm fibre, are the green arbor of Palmae Trachycarpus length,
It originates in Chinese Central-South mountain region, is palm the most cold-resistant, and in addition to China, many countries introduce a fine variety in the world.Palma extracts
Thing also has suppression to legionella pneumophilia, in the anti-inflammatory cosmetic composition of the present invention add palm leaf extract have pre- well
Effect that is anti-and preventing and treating dermatitis.
The dipotassium glycyrrhizinate adding in the anti-inflammatory cosmetic composition of the present invention has excellent anti-inflammatory antiallergic effect, can
With in and/or lower cosmetics noxious material, prevent allergic reaction, with emollient, NMF share can accelerate skin to them
Absorption and synergy.
The emollient energy moistening skin that adds in the anti-inflammatory cosmetic composition of the present invention, greasy skin, protection and soft
Change skin, and the moisture time of staying in skin can be improved；The effect of NMF is to form thin film in skin surface, will
Moisture content is sealed in prevent water part from evaporating in skin, and without prejudice to skin is for the absorption of in the air moisture content simultaneously, thus keeping skin
The suitable humidity of skin.
The following component title that the application occurs is INCI (International Nomenclaure Cosmetic
Ingredient, that is, international cosmetic raw material name) defined title：The cetostearyl alcohol olive oleate/smooth olive of sorb
Oleate, the smooth olive oleate of the smooth palmitate/sorb of cetanol palmitate/sorb and caprylic/capric triglyceride.
Advantages of the present invention is as follows：
Compared with prior art, the anti-inflammatory cosmetic composition of the present invention can effectively prevent and prevent and treat dermatitis.
Specific embodiment
With reference to specific embodiment, technical scheme is described further.
Stevia rebaudianum extract and the preparation of palm leaf extract：
The stevia rebaudianum being dried is added in the ethanol that mass ratio is 85%, carries out extracting 6h under backflow and dipping.Subsequently,
With filter cloth, extract is filtered, then under rotating speed 3000r/min, centrifugation 30 minutes, that is, obtain stevia rebaudianum extract.
The palma being dried is added in the ethanol that mass ratio is 85%, carries out extracting 6h under backflow and dipping.With
Afterwards, with filter cloth, extract is filtered, then under rotating speed 3000r/min, centrifugation 30 minutes, that is, obtain palma and extract
Liquid.
The formula of the anti-inflammatory cosmetic composition of embodiment 1-3 and comparative example 1-3 is shown in Table 1.
Table 1
The formula of the anti-inflammatory cosmetic composition of embodiment 4-6 and comparative example 4-6 is shown in Table 2.
Table 2
The formula of the anti-inflammatory cosmetic composition of embodiment 7-9 and comparative example 7-9 is shown in Table 3.
Table 3
The formula of the anti-inflammatory cosmetic composition of embodiment 10-12 and comparative example 10-12 is shown in Table 4.
Table 4
The cosmetics that above-described embodiment and comparative example are obtained, continuously try out 30 days through 100 personnel of 20～50 years old respectively,
The antiphlogistic effects of obtained cosmetics in the various embodiments described above are evaluated in comparative analysis.Wherein, described antiphlogistic effects be erythema,
The improvement situation of itch, fash, eczema etc., the results are shown in Table 5.
Table 5
The cosmetic composition of above-described embodiment 1-12 and comparative example 1-12 all do not find during on probation excitant and
Allergic phenomena.
As known from Table 5：In embodiment each product to the improvement degree of erythema, itch, fash, eczema etc. substantially than control group
In each product improvement degree will height；And the weight portion of stevia rebaudianum extract and palm leaf extract is bigger, improvement degree is higher,
When the mixed liquor weight portion of stevia rebaudianum extract and palm leaf extract is 5～12, the cost performance highest of product.
The cosmetic composition of above-described embodiment 1-12 and comparative example 1-12 is obtained by following preparation method：
(1) above-mentioned A phase component is put into oil phase pot, be heated to 75 DEG C, heat preservation for standby use after waiting all components to melt；
(2) above-mentioned B phase component is put into emulsification pot, be heated to 80 DEG C, be incubated 20 minutes；
(3) by step 1) in A phase suction step 2) emulsification pot in, 5 points of homogeneous (homogeneous stir speed (S.S.) be 3000rpm)
Insulated and stirred (stir speed (S.S.) is 30rpm) 25 minutes after clock；
(4) emulsion in step (3) is cooled to 40 DEG C, adds above-mentioned C phase component, stir；
(5) add D phase and E phase component, stir, obtain the cosmetics of anti-inflammatory composition.
Embodiment described above only have expressed the several embodiments of the present invention, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, some deformation can also be made and improve, these broadly fall into the guarantor of the present invention
Shield scope.Therefore, the protection domain of patent of the present invention should be defined by claims.
Claims (8)
1. a kind of anti-inflammatory cosmetic composition it is characterised in that by weight, including following components：
Plant extraction liquid
Emulsifying agent 2.55-7 part
Emollient
NMF 2.5-20 part
Dipotassium glycyrrhizinate
Silica
Potassium hydroxide
Thickener
Antioxidant
Preservative
Water
Wherein, described plant extraction liquid is mixed liquor, described stevia rebaudianum extract and the palm fibre of stevia rebaudianum extract and palm leaf extract
The weight part ratio of palmitic acid leaf extract isDescribed stevia rebaudianum extract and the preparation method of palm leaf extract
As follows：The stevia rebaudianum being dried or palma are added in the ethanol that mass ratio is 85%, are extracted under backflow and dippingWith filter cloth, extract is filtered, after centrifugation, obtain final product.
2. according to claim 1 anti-inflammatory cosmetic composition it is characterised in that described stevia rebaudianum extract and palma extract
The weight part ratio of liquid is
3. according to claim 1 or anti-inflammatory cosmetic composition described in 2 any one it is characterised in that described thickener is card ripple
Nurse；Described antioxidant is tocopherol.
4. according to claim 1 or anti-inflammatory cosmetic composition described in 2 any one it is characterised in that described emulsifying agent is weight
Part ratio is Cetostearyl alcohol olive oleate/sorb smooth olive oleate, spermaceti
The smooth olive oleate of the smooth palmitate/sorb of alcohol palmitate/sorb, cetostearyl alcohol and stearic mixing.
5. according to claim 1 or anti-inflammatory cosmetic composition described in 2 any one it is characterised in that described emollient is weight
Part ratio is Shea butter, olive oil, caprylic/capric sweet
Oily three esters, saualane,
Ring five dimethyl silicone polymer and the mixing of dimethyl silicone polymer.
6. according to claim 1 or anti-inflammatory cosmetic composition described in 2 any one it is characterised in that described NMF is weight
Part ratio is Glycerine, the mixing of butanediol, trehalose and Sodium Hyaluronate.
7. according to claim 1 or anti-inflammatory cosmetic composition described in 2 any one it is characterised in that described preservative is weight
Part ratio is Phenoxyethanol and methylisothiazolinone mixing.
8. a kind of preparation method of anti-inflammatory cosmetic composition described in any one of claim 1-7 is it is characterised in that include following
Step：(1) emollient, emulsifying agent and antioxidant are put into oil phase pot, be heated toProtect after melting Deng all components
Temperature, obtains final product A phase；(2) NMF, silica, thickener, dipotassium glycyrrhizinate and water are put into emulsification pot, be heated toProtect
TemperatureObtain final product B phase；(3) by the emulsification pot of A phase suction step (2) in step (1), homogeneousStir
Mixing speed isThen insulated and stirredStir speed (S.S.) is(4) by step (3)
Emulsion be cooled toAdd potassium hydroxide, stir；(5) add plant extraction liquid and preservative, stir,
Obtain anti-inflammatory cosmetic composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410319713.4A CN104055708B (en) | 2014-07-07 | 2014-07-07 | Anti-inflammatory cosmetic composition and preparation method thereof |
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| CN201410319713.4A CN104055708B (en) | 2014-07-07 | 2014-07-07 | Anti-inflammatory cosmetic composition and preparation method thereof |
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| CN105816395A (en) * | 2016-05-25 | 2016-08-03 | 广州丹奇日用化工厂有限公司 | Oil-control anti-acne cosmetic containing enoki mushroom extract and preparation method of oil-control anti-acne cosmetic |
| CN106726987A (en) * | 2016-12-28 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of inhibiting bacteria and diminishing inflammation composition and its application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101048201A (en) * | 2004-10-25 | 2007-10-03 | 科蒂·普雷斯蒂奇·兰开斯特集团有限公司 | Moisture-regulating cosmetic |
| CN103040680A (en) * | 2012-12-06 | 2013-04-17 | 郭民召 | Composite of acne curing cream and beauty liquid |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08325156A (en) * | 1995-06-01 | 1996-12-10 | Ichimaru Pharcos Co Ltd | Skin preparation for external use, drink and food product containing steviol glycoside |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101048201A (en) * | 2004-10-25 | 2007-10-03 | 科蒂·普雷斯蒂奇·兰开斯特集团有限公司 | Moisture-regulating cosmetic |
| CN103040680A (en) * | 2012-12-06 | 2013-04-17 | 郭民召 | Composite of acne curing cream and beauty liquid |
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