CN104013685A - Traditional Chinese medicine prescription for treating liver and gallbladder damp-heat type jaundice - Google Patents
Traditional Chinese medicine prescription for treating liver and gallbladder damp-heat type jaundice Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine prescription for treating liver and gallbladder damp-heat type jaundice. The traditional Chinese medicine prescription is characterized in that the prescription is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20-40 parts of Hypericum japonicum, 10-20 parts of isatis root, 10-20 parts of white paeony root, 5-15 parts of scutellaria baicalensis, 10-20 parts of abrus cantoniensis hance, 10-20 parts of oriental wormwood, 5-10 parts of radix bupleuri, 5-10 parts of liquorice, 20-40 parts of whitebackleaf root, 5-15 parts of plantain herb and 5-15 parts of radix achyranthis bidentatae. According to the theory of traditional Chinese medicine, the effects of clearing away heat and eliminating dampness and strengthening the spleen and stomach are taken as the treatment principle aiming at pathogenesis of jaundice, and the traditional Chinese medicine prescription has an obvious curative effect on treatment of the liver and gallbladder damp-heat type jaundice, has the effects of treating both symptoms and root causes and strengthening the health and cultivating the essence and has the advantages of wide drug source, low cost, small toxic and side effects and the like.
Description
Technical field:
The present invention relates to Chinese medicine technical field, particularly a kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice.
Background technology:
Syndrome of dampness-heat of liver and gallbladder is the disease of retention of damp-heat in the interior hepato-biliary function due to not normal.Often raw in wet because experiencing damp and hot heresy or insufficiency of the spleen water, with the passing of time heat-transformation, or the sweet plump taste of long-term surfeit is raw wetly helps heat, affects due to hepato-biliary function.Due to the damp and hot heresy of impression, or be addicted to drink, surfeit delicious food is pungent, and wine is raw damp and hot, or transporting and transforming function of the spleen and stomach is not normal, and endogenous damp formation, accumulates and heat-transformation, checks liver and gall and forms.True card, internal organs are with sick, and disease located in liver, gallbladder, often relate to taste.Be more common in the illness such as acute icterohepatitis type hepatitis, gallbladder and bile duct inflammation, cholelithiasis.
Summary of the invention:
The present invention is exactly in order to overcome deficiency of the prior art, according to theory of Chinese medical science, pathogeny for jaundice, take clearing away heat and eliminating dampness, invigorating the spleen and regulating the stomach is Therapeutic Principle, providing a kind of has for treatment liver gallbladder damp-heat type jaundice, curative effect obviously, treating both the principal and secondary aspects of a disease, vital base and primordial QI consolidating, and the Chinese medicinal formulae that medicine source is wide, cost is low, toxic and side effects is little.
The invention provides following technical scheme:
A kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: Herba Hyperici Japonici 20-40 part, Radix Isatidis 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Scutellariae 5-15 part, Herba Abri 10-20 part, Herba Artemisiae Scopariae 10-20 part, Radix Bupleuri 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Malloti Apelitae 20-40 part, Herba Plantaginis 5-15 part, Radix Achyranthis Bidentatae 5-15 part.
Formula optimization is:
30 parts of Herba Hyperici Japonici, 15 parts of Radix Isatidis, 12 parts of the Radix Paeoniae Albas, 9 parts of Radix Scutellariaes, 12 parts of Herba Abris, 12 parts of Herba Artemisiae Scopariaes, 6 parts of Radix Bupleuri, 6 parts, Radix Glycyrrhizae, 30 parts of Radix Malloti Apelitaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Achyranthis Bidentataes.
Preparation method with take explanation:
Get by weight ratio above-mentioned raw material of Chinese medicine, soak with ethanol with 95% is after 72 hours, go supernatant to reclaim after ethanol standby, after last medicinal residues are decocted to 3 times, gained decoction liquor is mixed with supernatant, atomization drying then, in the dry thing of gained, add pharmaceutics in typical additives can make any common formulations.
Take every day 3 times, the 6-8 hour of being at every turn separated by, is containing 5 grams of crude drugs in dosage form each serving dose.Serveing on 1 week is a course for the treatment of.
Form being described in detail as follows of raw material of Chinese medicine of the present invention:
Herba Hyperici Japonici: sweet in the mouth, micro-hardship, cold nature.Return liver, spleen channel.There is heat-clearing and toxic substances removing, dampness removing jaundice eliminating, the effects such as detumescence dissipating blood stasis.Be usually used in jaundice due to damp-heat, acute appendicitis, conjunctival congestion and swelling pain, hot carbuncle toxin; Closely be useful on acute, chronic hepatitis, early stage liver cirrhosis, hepatalgia, appendicitis, mastitis, the diseases such as pulmonary abscess.Research shows: this product, to illness such as acute icteric and non-icterohepatitis, delay property and chronic hepatitiss, all has compared with significant curative effect.After medication, liver function, subjective symptoms and sign have clear improvement.Herba Hyperici Japonici all has inhibitory action in various degree to staphylococcus aureus, streptococcus, bacillus tuberculosis bovis, streptococcus pneumoniae, hog cholera bacillus.To isolated rabbit intestinal, the visible rhythmicity of Herba Hyperici Japonici fluid extract low concentration is shunk and is strengthened, and spastic contraction appears in high concentration.To Bufo siccus heart, suppress after first excited during low concentration, there is cardiac muscle fiber vibration and cause heart beating and stop in high concentration.Sanguis Canitis is pressed slightly and declined.
Radix Isatidis: bitter in the mouth, cold in nature.GUIXIN, stomach warp.There is heat-clearing and toxic substances removing, the effects such as removing heat from blood sore-throat relieving.Be usually used in maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, the diseases such as carbuncle.Radix Isatidis clinically clearing away heat and cooling blood, antiviral antibacterial action is obvious, and consumption is large, can be rated as Chinese patent medicine.Result of study shows, Radix Isatidis has the pyrogen effect that can cause fervescence in significant removing body, and separation has obtained this active substance.The effect of bringing down a fever of Radix Isatidis is by killing pathogen such as virus and bacteria in body, removes factors such as causing the peroxy radical of fever and pyrogen and realize.The in the situation that of low grade fever, take the Chinese patent medicines such as Radix Isatidis, not only can effectively bring down a fever, meanwhile, can also promote the rehabilitation of health and the enhancing of immunity resistance.Early stage application coordinates anti symptom treatment simultaneously, can greatly improve therapeutic effect.
The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, is slightly cold, and has blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.The effects such as astringing YIN to stop sweating, are applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, are with inferior disease.In this product, contained paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose; Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.In addition, research shows: the Radix Paeoniae Alba has potentiation to the phagocytic function of macrophage.
Radix Scutellariae: bitter in the mouth, cold in nature, can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.That this product also has is antibacterial, antifungal, antiviral, antiinflammatory antiallergic action, antiplatelet aggregation, blood fat reducing, can reduce liver T-CHOL, free cholesterol and content of triglyceride, protect the liver, function of gallbladder promoting, antioxidation, the effect such as anticancer.
Herba Abri: sweet and slightly bitter taste, cool in nature, return liver, gallbladder, stomach warp.There is clearing away heat-damp and promoting diuresis, the effects such as eliminating stasis to stop pain.Be usually used in icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, the diseases such as mastalgia.In this product, the thick Saponin of contained Herba Abri has protection effect to hepatic injury.In addition, also has strong effect.
Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: the pharmaceutical researches such as jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis have function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory; blood fat reducing; the effects such as coronary dilating, this is that western medicine extracts the research that Herba Artemisiae Scopariae composition is worked it out, the how bad judgement of effect in clinical practice certainly.Chen Su toxicity is that maincenter suppresses, show as drowsy, sialorrhea etc.Herba Artemisiae Scopariae consumption is excessive causes dizziness, feel sick, and diarrhoea, epigastric discomfort, acute Bile duct injury, also has ARR report, but the Herba Artemisiae Scopariae of therapeutic dose generally can not caused serious damaging action.Herba Artemisiae Scopariae has significant hepatoprotective effect, to first, and hepatitis B, icterohepatitis, has significant curative effect.There is function of gallbladder promoting, promote bile secretion, the effect that in increase bile, cholic acid and bilirubin are discharged. can increase heart coronary flow, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.
Radix Bupleuri: bitter in the mouth, cold nature.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, the effects such as yang invigorating.Be usually used in cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, the diseases such as proctoptosis.The effective ingredient of this product: volatile oil (eugenol, acid, r-undecanoic acid lactone and to methoxybenzene diketone), saikoside (sapogenin A).Effect: heating due to typhoid fever, paratyphoid fever vaccine, escherichia coli liquid, fermented milk, yeast etc. is had to trivial solution heat effect; And can make animal normal body temperature decline.Saikosaponin decoct 2g/kg is to rabbit gavage, to all having obvious refrigeration function with the heating that vaccine and temperature thorn cause; Antiinflammatory, effective ingredient: saponin.Effect: swollen and desmoplastic inflammation all has inhibitory action to ankle joint due to multiple proinflammatory agent.Saikoside 300 mg/kg lumbar injections, can suppress the rat paw edema that carrageenin, 5-hydroxy tryptamine, histamine cause, suppress rat granuloma swollen, can make adrenal gland loose simultaneously, atrophy of thymus gland; Inflammation-inhibiting is organized histamine release and leukoplania; Promote immunity function, effective ingredient: Bupleurum chinense polysaccharide.Effect: phagocytic function strengthens, Natural killer activity strengthens, and improves special viral antibody titre, improves lymphocyte and turns core rate, improves skin delayed hypersensitivity reaction; Anti-liver injury, injection of Radix Bupleuri (concentration 1: a 1) 1 ml/ subcutaneous injection can significantly reduce the rat blood serum GPT rising that carbon tetrachloride causes for continuous 5 days, hepatocellular degeneration and necrosis also obviously alleviate, and in hepatocyte, glycogen and rna content also approach normal; Antiradiation injury, a Bupleurum chinense polysaccharide 5 mg/ lumbar injection, can improve the survival rate of irradiating mice, in mouse chest cell 3H-TdR mix increase, accelerate the release of thymocyte cell simultaneously, make again skin in blood plasma simultaneously.Matter ketone content increases, and after adrenalectomize, no longer includes these performances, therefore think to realize by adrenal cortex.In addition, external have an anti-tubercle bacillus effect.
Radix Glycyrrhizae: sweet in the mouth, property is flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effects such as coordinating the actions of various ingredients in a prescription.Be usually used in weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Glycyrrhizin or its calcium salt have stronger Detoxication, and diphtheria toxin, diphtherotoxin, tetanus toxin are had to stronger Detoxication, for some anaphylaxis illness, zoopery hepatitis, tetrodotoxin, TTX and snake venom, also have Detoxication.Its Detoxication mechanism may be many-sided, and by precipitation, absorption and the combination of physics, chemical mode, strengthening the removing toxic substances function of liver and the hydrolyzate glucuronic acid of glycyrrhizin is also the effective ingredient of Detoxication.In addition, enoxolone is to the granuloma induced by implantation of cotton pellets of rat, formaldehyde edema, and tuberculin reaction, subcutaneous granulation capsule inflammation all have inhibitory action.Ammonium glycyrrhizinate, Monosodium glycyrrhetin can effectively affect the phase of oozing out and the proliferative phase of subcutaneous granulation capsule inflammation, and its action intensity is weaker than or close to cortisone.The antiinflammatory action of the various preparations of glycyrrhizic acid, higher with the activity of succinate, but toxicity is also large.
Radix Malloti Apelitae: mildly bitter flavor; Puckery; Property is put down.Return spleen; Kidney; Urinary bladder channel.There is heat clearing away; Damp eliminating; Astringent therapy; The effects such as repercussive.Be usually used in hepatitis intestinal scorching; Stranguria with turbid discharge; Leukorrhagia; Proctoptosis; Uterine prolapse; Hepatosplenomegaly; The diseases such as osteopatia sprain.Research shows: in this product, contained ursolic acid has the various biological effects such as calmness, antiinflammatory, antibacterial, anti-diabetic, antiulcer, reduction blood glucose, and ursolic acid also has obvious anti-oxidation function.Ursolic acid clinical manifestation have significantly and rapidly reduce glutamate pyruvate transaminase, serum transaminase, the effect of the yellow cellulitis that disappears, appetite stimulator, fibrosis and recovery liver function, there is the feature of instant effect, short treating period, effect stability.
Herba Plantaginis: sweet in the mouth, cold in nature.Return liver, kidney, lung, small intestine meridian.There is clearing away heat and promoting diuresis, eliminate the phlegm, removing heat from blood, the diseases such as removing toxic substances.Be usually used in edema oliguria, the puckery pain of pyretic stranguria, heat-damp in summer dysentery, phlegm-heat cough, hematemesis and epistaxis, the diseases such as carbuncle sore tumefacting virus.In this product, contained oleanolic acid can alleviate hepatic injury: oleanolic acid is pentacyclic triterpenoid, and the rat acute and chronic liver injury that carbon tetrachloride is caused has obvious protective effect.After treatment, the mitochondrion of enlargement and the rough endoplasmic reticulum of expansion are restored.Also can make acute and Hepatocellular ballooning, necrosis and inflammatory reaction chronic hepatic injury obviously alleviate.In liver, triglyceride is accumulated minimizing, and glycogen amount increases; Reduce serum glutamic pyruvic transminase active: oleanolic acid all has obvious effect of reducing enzyme levels to acute, chronic hepatitis and liver cirrhosis animal; Reduce serum r-globulin, and alleviate consistent with the relevant inflammatory reaction of liver of histological observation finding; Promote hepatocellular regeneration: oleanolic acid can impel the karyokinesis phase number showed increased of rat residual liver, regeneration degree is higher than matched group, and prompting has the effect that promotes cell regeneration; Reduce the cruel propylhomoserin level of rats with liver cirrhosis brain homogenate: because the cruel propylhomoserin level of brain homogenate obviously declines, can suppress the generation of false neurotransmitter, therefore be conducive to the control of hepatic encephalopathy; Suppress hepatic fibroplasia: the rat of the hepatic fibrosis for the treatment of through oleanolic acid, hepatic fibroplasia is serious also obviously to be alleviated, and liver collagen content reduces, and prompting has the effect that prevents and treats liver cirrhosis; Oleanolic acid has obvious inhibitory action to mouse monokaryon mononuclear phagocyte system, macrophage phagocytic function and experimental arthritis, but different in nature humoral immune function and antigen binding cell are had to impact.Strengthen immunity and suppress S180 tumor strain growth; Chromosome damage is had to protective effect, experimental atherosclerosis is had to preventive effect, also can correct Proteometabolism obstacle.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat.Return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, the effects such as conducting blood to flow downwards.Be usually used in soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, the diseases such as dizziness due to hyperactivity of liver-YANG.Experiment shows: in this product, contained ecdysterone has stronger protein synthesis facilitation.The centrifugal analysis of sucrose density sample degree shows, administration blood RNA contrasts blood, and to have the casting mold of 2 times active, and the protein synthesis effect of prompting ecdysterone is at least with promoting the synthetic effect of m mono-RNA.From newborn male mice, give continuously ecdysterone in the time of 60 days, its body weight gain is very fast, and Liver and kidney protein synthesis level also increases, the hyperfunction performance of the visible hepatocyte function of hepatic tissue inspection.In addition, also there is the effects such as anti-inflammatory and antalgic.
The present invention is according to theory of Chinese medical science, pathogeny for jaundice, take clearing away heat and eliminating dampness, invigorating the spleen and regulating the stomach is Therapeutic Principle, for treatment liver gallbladder damp-heat type jaundice have curative effect obviously, treating both the principal and secondary aspects of a disease, vital base and primordial QI consolidating, and the advantage such as medicine source is wide, cost is low, toxic and side effects is little.
The specific embodiment:
Embodiment 1:
A kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: 30 parts of Herba Hyperici Japonici, 15 parts of Radix Isatidis, 12 parts of the Radix Paeoniae Albas, 9 parts of Radix Scutellariaes, 12 parts of Herba Abris, 12 parts of Herba Artemisiae Scopariaes, 6 parts of Radix Bupleuri, 6 parts, Radix Glycyrrhizae, 30 parts of Radix Malloti Apelitaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Achyranthis Bidentataes.
Embodiment 2:
A kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: 25 parts of Herba Hyperici Japonici, 15 parts of Radix Isatidis, 10 parts of the Radix Paeoniae Albas, 6 parts of Radix Scutellariaes, 10 parts of Herba Abris, 10 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 8 parts, Radix Glycyrrhizae, 25 parts of Radix Malloti Apelitaes, 8 parts of Herba Plantaginiss, 8 parts of Radix Achyranthis Bidentataes.
Embodiment 3:
A kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: 40 parts of Herba Hyperici Japonici, 20 parts of Radix Isatidis, 20 parts of the Radix Paeoniae Albas, 15 parts of Radix Scutellariaes, 20 parts of Herba Abris, 20 parts of Herba Artemisiae Scopariaes, 10 parts of Radix Bupleuri, 10 parts, Radix Glycyrrhizae, 35 parts of Radix Malloti Apelitaes, 15 parts of Herba Plantaginiss, 15 parts of Radix Achyranthis Bidentataes.
Embodiment 1-3 all adopts following preparation method and instructions of taking:
Get by weight ratio above-mentioned raw material of Chinese medicine, soak with ethanol with 95% is after 72 hours, go supernatant to reclaim after ethanol standby, after last medicinal residues are decocted to 3 times, gained decoction liquor is mixed with supernatant, atomization drying then, in the dry thing of gained, add pharmaceutics in typical additives can make any common formulations.
Take every day 3 times, the 6-8 hour of being at every turn separated by, is containing 5 grams of crude drugs in dosage form each serving dose.Serveing on 1 week is a course for the treatment of.
Claims (2)
1. a Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: Herba Hyperici Japonici 20-40 part, Radix Isatidis 10-20 part, Radix Paeoniae Alba 10-20 part, Radix Scutellariae 5-15 part, Herba Abri 10-20 part, Herba Artemisiae Scopariae 10-20 part, Radix Bupleuri 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Malloti Apelitae 20-40 part, Herba Plantaginis 5-15 part, Radix Achyranthis Bidentatae 5-15 part.
2. according to a kind of Chinese medicinal formulae for the treatment of liver gallbladder damp-heat type jaundice described in claim 1, it is characterized in that being made by the raw material of Chinese medicine of following composition by weight: 30 parts of Herba Hyperici Japonici, 15 parts of Radix Isatidis, 12 parts of the Radix Paeoniae Albas, 9 parts of Radix Scutellariaes, 12 parts of Herba Abris, 12 parts of Herba Artemisiae Scopariaes, 6 parts of Radix Bupleuri, 6 parts, Radix Glycyrrhizae, 30 parts of Radix Malloti Apelitaes, 10 parts of Herba Plantaginiss, 10 parts of Radix Achyranthis Bidentataes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383153A (en) * | 2014-11-19 | 2015-03-04 | 安庆市延龄堂肝病研究所 | Traditional Chinese medicine for treating biliary cirrhosis and preparation method thereof |
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| CN103845429A (en) * | 2014-03-02 | 2014-06-11 | 马青 | Traditional Chinese medicine for treating chronic hepatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103845429A (en) * | 2014-03-02 | 2014-06-11 | 马青 | Traditional Chinese medicine for treating chronic hepatitis |
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| 宋鹭冰: "《病因病机学》", 31 January 1987, 人民卫生出版社 * |
| 聂晶等: "《肝病验方400首》", 31 January 2002, 上海中医药大学出版社 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383153A (en) * | 2014-11-19 | 2015-03-04 | 安庆市延龄堂肝病研究所 | Traditional Chinese medicine for treating biliary cirrhosis and preparation method thereof |
| CN104383153B (en) * | 2014-11-19 | 2018-05-01 | 安庆市延龄堂肝病研究所 | A kind of Chinese medicine for treating biliary cirrhosis and preparation method thereof |
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Application publication date: 20140903 |