A kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof.
Background technology
Diabetes are a kind of common endocrinopathyes, absolute shortage or the relative deficiency due to insulin in body, or the quality of insulin own and other reasons cause it can not normally bring into play physiological action, and a kind of syndrome taking carbohydrate metabolism as main saccharide, lipid, protein three large substance metabolism disorders causing.Clinical manifestation is polyuria, polydipsia, polyphagia, becomes thin, i.e. " three-many-one-little " symptom.
The traditional Chinese medical science thinks, diabetes are mainly that the five internal organs are weak due to the plain body deficiency of YIN, multiple because of eating and drinking without temperance, surfeit delicious food, and disorder of emotion, labor is wanted excessively, and causes deficiency of kidney-YIN, lung dryness of the stomach heat; Pathogenesis emphasis is that the deficiency of YIN is scorching, and taking the deficiency of YIN as this, scorching is mark; With the passing of time disease prolongs, deficiency of YIN affecting YANG, deficiency in both YIN and YANG.
The drug main of the diabetes for the treatment of treatment at present will be divided three classes, the one, with euglycemic agent, sulphanylureas, biguanides and alpha-glucosidase inhibitor are main Western medicine preparation, the advantage of this class medicine is that blood sugar lowering is rapid, effect is remarkable, but side effect is obvious, and oral drugs are unsuitable for hepatic and kidney function obstacle patient use mostly, and can cause patient's medicine secondary failure; The 2nd, the pharmaceutical preparation of Chinese medicine and western medicine combination, contains western medicine composition in such medicine, and hepatic and renal function is existed to side effect, and long-term taking is larger to health harm; The 3rd, pure Chinese medicinal preparation, such medicine is less to the side effect of human body, can entirety improve patient's symptom, but have some pure Chinese medicinal preparation onsets slower, and action effect is not remarkable.
Summary of the invention
The object of the invention is for overcoming above-mentioned the deficiencies in the prior art, provides a kind of good effect, Chinese medicine composition of the treatment diabetes of safe without toxic side effect and preparation method thereof.
For achieving the above object, the present invention adopts following technical proposals:
Treat a Chinese medicine composition for diabetes, made by the crude drug of following weight portion:
Radix Astragali 25-35 part, Radix Paeoniae Alba 20-30 part, Rhizoma Anemarrhenae 15-20 part, Poria 12-16 part, Rhizoma Polygonati 12-16 part, Radix Ophiopogonis 5-10 part, Herba Sedi 5-10 part, Herba Euphorbiae Humifusae 5-10 part, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 5-10 part, Flos Campsis 5-10 part, Caulis Bambusae In Taenia 5-10 part, Dens Draconis 4-8 part, Rabdosia rubescens 4-8 part, Yunnan Caulis Spatholobi 3-6 part, Radix Glycyrrhizae 8-10 part.
The Chinese medicine composition for the treatment of diabetes of the present invention, preferred prescription is:
30 parts of the Radixs Astragali, 25 parts of the Radix Paeoniae Albas, 18 parts of the Rhizoma Anemarrhenaes, 14 parts, Poria, 14 parts of Rhizoma Polygonatis, 8 parts of Radix Ophiopogonis, 8 parts of Herba Sedis, 8 parts of Herba Euphorbiae Humifusaes, 6 parts of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), 6 parts of Flos Campsiss, 6 parts of Caulis Bambusae In Taenia, 6 parts of Dens Draconiss, 6 parts of Rabdosia rubescens, 5 parts of Yunnan Caulis Spatholobis, 9 parts, Radix Glycyrrhizae.
Formula of the present invention is according to China's theory of TCM, in conjunction with inventor's clinical research for many years, the refined diagnosis technology of macroscopical determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of Chinese medicine and modern medicine apply in clinical experimentation, draw through proved recipe.According to theory of Chinese medical science, for the pathogeny of diabetes, carry out dialectical composition of prescription, base oneself upon " deficiency syndrome ", tonify deficiency consolidates, to reach the object for the treatment of both the principal and secondary aspects of a disease.
In medicament composing prescription, the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Poria, Rhizoma Polygonati, Radix Ophiopogonis, Herba Sedi, Herba Euphorbiae Humifusae, Flos Campsis, Caulis Bambusae In Taenia, Rabdosia rubescens, Yunnan Caulis Spatholobi, Radix Glycyrrhizae 13 taste medical materials are the kind that " Chinese Pharmacopoeia " 2010 version () is recorded, and its quality all meets every regulation relevant under each kind item; Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Dens Draconis 2 taste medicines are the kind that " genuine medicinal materials figure allusion quotation " (Fujian science tech publishing house) records, and its quality all meets every regulation relevant under each kind item.
Wherein, the Radix Astragali: have strengthening the body resistance, effect of invigorating the spleen and replenishing QI, contains the Multiple components such as polysaccharide, glycosides, flavone and trace element in the Radix Astragali, all has effect widely to human endocrine system, nervous system.
The Radix Paeoniae Alba: there is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, effect of suppressing liver-YANG.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
The Rhizoma Anemarrhenae: there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, restlessness of asrhenia type and insomnia.
Poria: sweet in the mouth, light is flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.
Rhizoma Polygonati: sweet in the mouth is flat.Return spleen, lung, kidney channel.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, early whitening of beard and hair, interior-heat is quenched one's thirst.
Radix Ophiopogonis: there is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Herba Sedi: sweet in the mouth, light is cool.Return liver, gallbladder, small intestine meridian.There is dampness removing jaundice eliminating, effect of heat-clearing and toxic substances removing.For jaundice due to damp-heat, dysuria, carbuncle skin infection.
Herba Euphorbiae Humifusae: there is heat-clearing and toxic substances removing, cooling blood for hemostasis, effect of dampness removing jaundice eliminating.For dysentery, have loose bowels, spitting of blood, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle, jaundice due to damp-heat.
Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): cool in nature, sweet in the mouth, pungent.Have promoting blood flow to regulate menstruation, effect of dissipating blood stasis hemostasis, for diseases such as hypertension, menoxenia, bones and muscles injury.
Flos Campsis: sweet in the mouth, acid, cold.Return liver, pericardium channel.There is promoting blood circulation to restore menstrual flow, effect of cooling blood, expelling wind.For menoxenia, amenorrhea and mass in the abdomen, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
Caulis Bambusae In Taenia: sweet, be slightly cold.Return lung, stomach, the heart, gallbladder meridian.There is removing heat-phlegm, relieving restlessness, effect of preventing or arresting vomiting.For phlegm-heat cough, gallbladder fire is held expectorant under the arm, palpitate with fear not peaceful, and vexed insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Dens Draconis: cool in nature, sweet in the mouth, puckery.There is the relieving convulsion effect of calming the nerves, for diseases such as palpitation and being susceptible to fright, vexed, insomnia and dreamful sleeps.
Rabdosia rubescens: bitter in the mouth, sweet, is slightly cold.Return lung, stomach, Liver Channel.There is heat-clearing and toxic substances removing, effect of promoting blood circulation and stopping pain.
Yunnan Caulis Spatholobi: there is blood circulation promoting and enriching, menstruction regulating and pain relieving, effect of channels sootheing and network vessel quickening.For menoxenia, dysmenorrhea, paralysis and numbness, rheumatic arthralgia, deficient qi and blood.
Radix Glycyrrhizae: there is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.
In medicament composing prescription of the present invention, each drug component is through dialectical compatibility, in drug action, assistant helps mutually, with heat clearing away QI invigorating, nourishing kidney spleen invigorating is the rule for the treatment of, acts on the organs such as spleen, liver, kidney, endocrine regulation, repair and activate pancreas cell, saccharide, lipid and protein metabolism in body are tending towards normally, fundamentally treat diabetes and the multiple complication being caused by diabetes.
Chinese medicine composition of the present invention can adopt following methods preparation:
(1) take each Chinese medicinal components by parts by weight in prescription, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Flos Campsis, Dens Draconis 3 taste medicines be dry, pulverize, cross 200-300 mesh sieve, obtain medicinal powder, for subsequent use;
(2) Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Poria, Rhizoma Polygonati, Radix Ophiopogonis, Herba Sedi, Herba Euphorbiae Humifusae, Caulis Bambusae In Taenia, Rabdosia rubescens, Yunnan Caulis Spatholobi, Radix Glycyrrhizae 12 taste medicines are mixed, decocting boils 2 times, and the water that adds for the first time 8-10 doubly to measure decocts 2-4 hour; The water that adds for the second time 6-8 doubly to measure, decocts 1-2 hour, merges the decoction liquor of twice and filters, and filtrate decompression is concentrated, and while being concentrated into 50 DEG C, recording relative density is 1.2-1.3, obtains extractum;
(3) extractum that medicinal powder step (1) being obtained and step (2) obtain mixes, dry, to obtain final product.
The Chinese medicine composition for the treatment of diabetes of the present invention can be made the medically dosage form of accreditation according to a conventional method, as capsule, tablet or granule.
Beneficial effect of the present invention:
(1) Chinese medicine composition for the treatment of diabetes of the present invention is pure Chinese medicinal preparation, the diabetes that caused is had to significant curative effect, without obvious toxic-side effects by endocrine disturbance; The medicine that has overcome traditional treatment diabetes uses antidiabetic drug and insulin in a large number, and cost is higher, the problem that life-time service is larger to human body side effect;
(2) instant effect, determined curative effect, medicine source is extensive, with low cost;
(3) effective percentage is up to 94%, and complication rate is little, treating both the principal and secondary aspects of a disease, and long-term effect is good.
Detailed description of the invention
Below by instantiation, the present invention will be further elaborated, should be noted that following explanation is only in order to explain the present invention, not limits its content.
1 one kinds of embodiment treat the Chinese medicine composition of diabetes
30 kilograms of [prescription] Radixs Astragali, 25 kilograms of the Radix Paeoniae Albas, 18 kilograms of the Rhizoma Anemarrhenaes, 14 kilograms, Poria, 14 kilograms of Rhizoma Polygonatis, 8 kilograms of Radix Ophiopogonis, 8 kilograms of Herba Sedis, 8 kilograms of Herba Euphorbiae Humifusaes, 6 kilograms of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), 6 kilograms of Flos Campsiss, 6 kilograms of Caulis Bambusae In Taenia, 6 kilograms of Dens Draconiss, 6 kilograms of Rabdosia rubescens, 5 kilograms of Yunnan Caulis Spatholobis, 9 kilograms, Radix Glycyrrhizae.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Flos Campsis, Dens Draconis 3 taste medicines be dry, pulverize, and crosses 300 mesh sieves, obtains medicinal powder, for subsequent use;
(2) Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Poria, Rhizoma Polygonati, Radix Ophiopogonis, Herba Sedi, Herba Euphorbiae Humifusae, Caulis Bambusae In Taenia, Rabdosia rubescens, Yunnan Caulis Spatholobi, Radix Glycyrrhizae 12 taste medicines are mixed, decocting boils 2 times, adds for the first time the water of 9 times of amounts (ml/g), decocts 3 hours; Add for the second time the water of 7 times of amounts (ml/g), decoct 1.5 hours, merge the decoction liquor of twice and filter, filtrate decompression is concentrated, and while being concentrated into 50 DEG C, recording relative density is 1.25, obtains extractum;
(3) extractum that medicinal powder step (1) being obtained and step (2) obtain mixes, and 70 DEG C are dried 4 hours, obtain final product.
The Chinese medicine composition of the present embodiment can be made the medically capsule of accreditation according to a conventional method, and the specification of capsule is 0.3g/ grain, and usage and dosage is: every day 2 times, each 4.
The Chinese medicine composition of 2 one kinds of diabetes of embodiment
25 kilograms of [prescription] Radixs Astragali, 30 kilograms of the Radix Paeoniae Albas, 15 kilograms of the Rhizoma Anemarrhenaes, 16 kilograms, Poria, 12 kilograms of Rhizoma Polygonatis, 10 kilograms of Radix Ophiopogonis, 5 kilograms of Herba Sedis, 10 kilograms of Herba Euphorbiae Humifusaes, 5 kilograms of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), 10 kilograms of Flos Campsiss, 5 kilograms of Caulis Bambusae In Taenia, 8 kilograms of Dens Draconiss, 4 kilograms of Rabdosia rubescens, 6 kilograms of Yunnan Caulis Spatholobis, 8 kilograms, Radix Glycyrrhizae.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Flos Campsis, Dens Draconis 3 taste medicines be dry, pulverize, and crosses 300 mesh sieves, obtains medicinal powder, for subsequent use;
(2) Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Poria, Rhizoma Polygonati, Radix Ophiopogonis, Herba Sedi, Herba Euphorbiae Humifusae, Caulis Bambusae In Taenia, Rabdosia rubescens, Yunnan Caulis Spatholobi, Radix Glycyrrhizae 12 taste medicines are mixed, decocting boils 2 times, adds for the first time the water of 8 times of amounts (ml/g), decocts 4 hours; Add for the second time the water of 8 times of amounts (ml/g), decoct 1 hour, merge the decoction liquor of twice and filter, filtrate decompression is concentrated, and while being concentrated into 50 DEG C, recording relative density is 1.2, obtains extractum;
(3) extractum that medicinal powder step (1) being obtained and step (2) obtain mixes, and 70 DEG C are dried 4 hours, obtain final product.
The Chinese medicine composition of the present embodiment can be made the medically capsule of accreditation according to a conventional method, and the specification of capsule is 0.3g/ grain, and usage and dosage is: every day 2 times, each 4.
3 one kinds of embodiment treat the Chinese medicine composition of diabetes
35 kilograms of [prescription] Radixs Astragali, 20 kilograms of the Radix Paeoniae Albas, 20 kilograms of the Rhizoma Anemarrhenaes, 12 kilograms, Poria, 16 kilograms of Rhizoma Polygonatis, 5 kilograms of Radix Ophiopogonis, 10 kilograms of Herba Sedis, 5 kilograms of Herba Euphorbiae Humifusaes, 10 kilograms of Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), 5 kilograms of Flos Campsiss, 10 kilograms of Caulis Bambusae In Taenia, 4 kilograms of Dens Draconiss, 8 kilograms of Rabdosia rubescens, 3 kilograms of Yunnan Caulis Spatholobis, 10 kilograms, Radix Glycyrrhizae.
[method for making] (1) takes each Chinese medicinal components by parts by weight in prescription, and Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), Flos Campsis, Dens Draconis 3 taste medicines be dry, pulverize, and crosses 300 mesh sieves, obtains medicinal powder, for subsequent use;
(2) Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Poria, Rhizoma Polygonati, Radix Ophiopogonis, Herba Sedi, Herba Euphorbiae Humifusae, Caulis Bambusae In Taenia, Rabdosia rubescens, Yunnan Caulis Spatholobi, Radix Glycyrrhizae 12 taste medicines are mixed, decocting boils 2 times, adds for the first time the water of 10 times of amounts (ml/g), decocts 2 hours; Add for the second time the water of 6 times of amounts (ml/g), decoct 2 hours, merge the decoction liquor of twice and filter, filtrate decompression is concentrated, and while being concentrated into 50 DEG C, recording relative density is 1.3, obtains extractum;
(3) extractum that medicinal powder step (1) being obtained and step (2) obtain mixes, and 70 DEG C are dried 4 hours, obtain final product.
The Chinese medicine composition of the present embodiment can be made the medically capsule of accreditation according to a conventional method, and the specification of capsule is 0.3g/ grain, and usage and dosage is: every day 2 times, each 4.
Clinical data
One, physical data:
Case-data is selected from June, 2009-2013 inpatient 240 examples in year May, is divided at random test group 120 examples, wherein male's 60 examples, women's 60 examples; Matched group 120 examples, wherein male's 60 examples, women's 60 examples.Test group and matched group age, men and women's ratio and coincident with severity degree of condition had comparability through X 2 test no significant difference (P > 0.05) at 35~65 years old.Two, diagnostic criteria and criterion of therapeutical effect:
(1) diagnostic criteria: according to WHO diabetes diagnosis Standard Selection case, be type ii diabetes patient, and meet the dialectical standard of deficiency of both QI and YIN disease in " guideline of clinical investigations of new Chinese medicine treatment diabetes (diabetes) ".
(2) curative effect determinate standard
Curative effect determinate standard in " guideline of clinical investigations of new Chinese medicine treatment diabetes (diabetes) " formulated according to Ministry of Public Health is judged.
1. effective: to treat blood glucose numerical value after two months and treat front decline more than 30%;
2. effective: to treat blood glucose numerical value after two months and treat front decline 29-10%;
3. invalid: to treat after two months blood glucose numerical value and treat front unchanged or decline below 10%.
Three, clinical trial method:
(1) dosage regimen
Test group is taken capsule prepared by the embodiment of the present invention 1, oral, every day 2 times, each 4; Matched group is taken XIAOKE JIANGTANG JIAONANG (Guangxi Tian Pharmaceutical Co., Ltd, the accurate word of traditional Chinese medicines: Z20083229), oral, every day 3 times, each 3; Test group and matched group drug treatment are 60 days.
(2) observation index
Fasting glucose and after the meal 2 hours blood glucoses.
Four, clinical treatment result
The therapeutic effect of test group and matched group is in table 1.Result shows, the clinical obvious effective rate of test group is 70.8%, and total effective rate is 94.0%, is better than matched group.Show Chinese medicine composition determined curative effect of the present invention.Treatment before and after test group and matched group blood
The variation of sugar numerical value is in table 2.
Table 1. test group and the comparison of matched group curative effect
Blood glucose change in value before and after table 2 treatment (mmol/L,
)
Note: fasting glucose numerical value with treatment before compared with,
*p < 0.01; 2h-plasma glucose numerical value with treatment before compared with,
* △p < 0.01.