CN103933453A - Medicine composition for treating dyspepsia-induced damp stagnation - Google Patents
Medicine composition for treating dyspepsia-induced damp stagnation Download PDFInfo
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Abstract
The invention provides a medicine composition for treating dyspepsia-induced damp stagnation. The medicine composition is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 8-10 parts of agastache stems, 8-10 parts of orange fruit, 8-10 parts of officinal magnolia bark, 8-10 parts of dried tangerine peel, 6-8 parts of amomum tsaoko, 8-10 parts of poria cocos, 8-10 parts of almonds, 12-15 parts of medicated leaven, 8-10 parts of rice sprouts, 8-10 parts of malt, 8-10 parts of hawthorn, 15-18 parts of radish seed and 8-10 parts of areca peel. The invention also provides a preparation method of the medicine composition. The composition has the beneficial effects that the medicines are clear in functions and supplement each other; the medicine composition has good treatment effects on dyspepsia-induced damp stagnation, can effectively alleviate or eliminate dyspepsia-induced damp stagnation induced qi ascending and descending dysfunction, abdominal fullness and distention and distending pains, putrid belching and acid regurgitation, vomiting and anorexia, smelly and dirty diarrhea and other symptoms, has better curative effects than classic indigestion removing prescription digestant pills and provides a new choice for clinical medicines.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of food stagnation damp-stagnancy.
Background technology
In Chinese medicine, there is " six climate exopathogens " cause of disease to say, " six climate exopathogens " claim again " six evils ", be wind, cold, summer-heat, wet, dry, fiery six kinds of pathogenic heresies, wind, cold, summer-heat, wet, dry, the wind in non-the Nature of fighting, tremble with fear, summer-heat, wet, dry, fiery, but human body suffer from these six kinds to the Nature apoplexy, cold, summer-heat, the similar or similar paathogenic factor of wet, dry, fiery feature, then there is corresponding sufferer.If " damp " is for suffering from, just can produce non-cold non-thermal, as smoked as steam, though symptoms such as sweating symptom is puzzled, extremity are sleepy, pain of joint muscle, or gastral cavity abdomen discomfort due to fullness, dysuria, inappetence, stool are not well or the symptom such as diarrhea with loose stool.Because damp pathogen being heavy and turbid in nature, viscous, become under, damp being a kind of YIN pathogen again, damage yang-energy, check mechanism of qi, so not only symptom and the syndrome of initiation and these feature similarities, and its treatment also can embody these features, for example damp pathogen being sticky and stagnant in nature, easily and other virulence factors (as " heat " heresy) be bonded together and deadlocked touching, be difficult to speed and control.
Affection of exogenous damp, diseases caused by exogenous pathogenic factor hygropyrexia (damp and warm pathogens agglomerating close), among the people being commonly called as again made hygropyrexia flu or damp and hot flu, and its morbidity, makes people's general weakness, heaviness of the head and fatigue of the body, and gastral cavity abdomen painful abdominal mass is vexed, and inappetence is extremely felt bad, cannot work and study, live also influenced.This " hygropyrexia flu " responds well to treatment very micro-by general Western medicine coldrex, even if current commercially available some Chinese Patent Medicines, its effect is also not remarkable.Therefore the Chinese medicine composition, urgently a kind ofly take effect rapidly, therapeutic effect being good.
Summary of the invention
The object of the present invention is to provide the pharmaceutical composition of a kind of onset treatment food stagnation damp-stagnancy rapid, evident in efficacy.Another object of the present invention is to provide preparation method and the purposes of this pharmaceutical composition.
The invention provides a kind of pharmaceutical composition for the treatment of food stagnation damp-stagnancy, it is the preparation being prepared from by the crude drug of following weight proportion:
8～10 parts, Herba Pogostemonis stalk, 8～10 parts of Fructus Aurantiis, 8～10 parts of Cortex Magnoliae Officinalis, 8～10 parts of Pericarpium Citri Reticulataes, 6～8 parts of Fructus Tsaokos, 8～10 parts, Poria, 8～10 parts, Semen Armeniacae Amarum, 12～15 parts of Massa Medicata Fermentata, 8～10 parts of Fructus Setariae Germinatuss, 8～10 parts, Fructus Hordei Germinatus, 8～10 parts of Fructus Crataegis, 15～18 parts of Semen Raphanis, 8～10 parts of Pericarpium Arecae.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
10 parts, Herba Pogostemonis stalk, 10 parts of Fructus Aurantiis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Fructus Tsaokos, 10 parts, Poria, 10 parts, Semen Armeniacae Amarum, 12 parts of Massa Medicata Fermentata, 10 parts of Fructus Setariae Germinatuss, 10 parts, Fructus Hordei Germinatus, 10 parts of Fructus Crataegis, 18 parts of Semen Raphanis, 10 parts of Pericarpium Arecae.
Further, described Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Crataegi, Semen Raphani are parched medicinal material.
Wherein, described pharmaceutical composition be by the medicated powder of the crude drug of described weight proportion or the water of crude drug or/and ethanol extraction is active component, add the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from.
Wherein, described preparation is oral formulations.
Further, described oral agents is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
The present invention also provides the preparation method of aforementioned pharmaceutical compositions, and it comprises the steps:
(1) by described weight proportion weighting raw materials;
(2) by the water of the medicated powder of crude drug or crude drug or/and ethanol extraction, add pharmaceutically can with adjuvant or complementary composition be prepared into conventional formulation.
The present invention also provides the purposes of aforementioned pharmaceutical compositions in the medicine of preparation treatment food stagnation damp-stagnancy.
Further, described medicine is ascending or descending movement of vital Qi mistake department due to treatment food stagnation damp-stagnancy, gastral cavity abdomen feeling of fullness distending pain, and belching and acid regurgitation, food is disliked in vomiting, or loose stool and diarrhea is smelly dirty, greasy fur on tongue or rotten greasy, forceful pulse or the medicine of sliding.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, to this doctor trained in Western medicine cannot cognitive cannot explain orally more cannot diagnosis and treatment sufferer recuperate under medical treatment, can obtain the splendid therapeutic effect that green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, prescription of the present invention is just being followed this principle.
Prescription of the present invention is taking the Massa Medicata Fermentata of being good at the various food stagnations of food stagnation removing as monarch drug, is good at the Fructus Crataegi of food stagnation removing meat food stagnation, the paddy Fructus Hordei Germinatus of being good at food stagnation removing paddy wheat food stagnation, the Semen Raphani of being good at food stagnation removing vegetables and fruits food stagnation relieving distension and makes left hall ministerial drug and appoint, and assists monarch drug to strengthen drug effect; This four taste also can help Massa Medicata Fermentata exploitation gastric qi, removes from another point of view gastral cavity abdomen feeling of fullness distending pain, belching and acid regurgitation, vomiting evil food, the smelly dirty symptom of loose stool and diarrhea.Pathogenesis is food stagnation damp-stagnancy, need send Herba Pogostemonis, Fructus Tsaoko removing dampness by means of aromatics, and Herba Pogostemonis obstructs with it, more can wide gastral cavity abdomen solution damp-stagnancy, then send Poria, Pericarpium Arecae dampness removing, be all right hall ministerial drug with Herba Pogostemonis Fructus Tsaoko.Fructus Aurantii, Cortex Magnoliae Officinalis, Pericarpium Citri Reticulatae three tastes are arrogated to oneself circulation of qi promoting promoting the circulation of QI machine, both can help row aqueous vapor, annoyingly again push away bent short, bristly hair or beard bud Fu, help it to help digestion long-pending, therefore use adjuvant drug as.Semen Armeniacae Amarum simply, above can dispersing and lowering lung-QI, the tonneau road (wet by the dirty common transporting of lung spleen kidney three) that wets, under can dredge intestine moistening internal organs, logical dirty just help digestion long-pending, therefore for making medicine, assistant manager's three warmers ascending or descending movement of vital Qi, separate altogether food stagnation damp-stagnancy with prodrug, ascending or descending movement of vital Qi mistake department, gastral cavity abdomen feeling of fullness distending pain, belching and acid regurgitation, food is disliked in vomiting, or the smelly dirty pathology machine pivot of loose stool and diarrhea, and curative effect is better than classical food stagnation removing prescription lenitive pill.
Below respectively organize flavour of a drug post clearly demarcated, complement each other, there is good therapeutic effect for food stagnation damp-stagnancy, can effectively alleviate or eliminate ascending or descending movement of vital Qi mistake department due to food stagnation damp-stagnancy, gastral cavity abdomen feeling of fullness distending pain, belching and acid regurgitation, food is disliked in vomiting, loose stool and diarrhea is smelly dirtyly waits card, and curative effect is better than classical food stagnation removing side lenitive pill, for clinical application provides a kind of new selection.
Detailed description of the invention
The preparation of embodiment 1 pharmaceutical composition of the present invention
Get Herba Pogostemonis stalk 10g, Fructus Aurantii 10g, Cortex Magnoliae Officinalis 10g, Pericarpium Citri Reticulatae 10g, Fructus Tsaoko 8g, Poria 10g, Semen Armeniacae Amarum 10g, Massa Medicata Fermentata 12g, Fructus Setariae Germinatus (parched) 10g, Fructus Hordei Germinatus (parched) 10g, Fructus Crataegi (parched) 10g, Semen Raphani (parched) 18g, Pericarpium Arecae 10g.Each flavour of a drug take according to quantity, add decocting and be adjusted to slow fire to boiling, after approximately 8 minutes to 10 minutes, collect decocting liquid; Medicinal residues decoct with water 2 times again, merge decocting liquid each time, obtain decoction.
The preparation of embodiment 2 pharmaceutical compositions of the present invention
Get Herba Pogostemonis stalk 8g, Fructus Aurantii 8g, Cortex Magnoliae Officinalis 8g, Pericarpium Citri Reticulatae 8g, Fructus Tsaoko 6g, Poria 8g, Semen Armeniacae Amarum 8g, Massa Medicata Fermentata 15g, Fructus Setariae Germinatus (parched) 8g, Fructus Hordei Germinatus (parched) 8g, Fructus Crataegi (parched) 8g, Semen Raphani (parched) 15g, Pericarpium Arecae 8g.First, with after 95%v/v ethanol extraction 2 times, merge alcohol extract, medicinal residues boil 2 times with decocting again, merge decocting liquid.After respectively alcohol extract, decocting liquid being concentrated, mix, then add suitable dextrin, soluble starch, granulate, obtain granule.
The preparation of embodiment 3 pharmaceutical compositions of the present invention
Get Herba Pogostemonis stalk 10g, Fructus Aurantii 10g, Cortex Magnoliae Officinalis 10g, Pericarpium Citri Reticulatae 10g, Fructus Tsaoko 8g, Poria 10g, Semen Armeniacae Amarum 10g, Massa Medicata Fermentata 12g, Fructus Setariae Germinatus (parched) 10g, Fructus Hordei Germinatus (parched) 10g, Fructus Crataegi (parched) 10g, Semen Raphani (parched) 15g, Pericarpium Arecae 10g.First, with after 60～65%v/v ethanol extraction 3 times, merge alcohol extract, reclaim ethanol, then add suitable dextrin, soluble starch, granulate, tabletting, obtains tablet.
The preparation of embodiment 4 pharmaceutical compositions of the present invention
Get granule prepared by embodiment 2, after filled capsules, obtain capsule.
The preparation of embodiment 5 pharmaceutical compositions of the present invention
Get decoction prepared by embodiment 1, leave standstill, get supernatant, after concentrating, dry, pulverize, for subsequent use; Get appropriate Macrogol 4000, after melting, above-mentioned medicated powder is added in melting substrate, insulation at 75-85 DEG C; Adopt various pill dripping machine, drip inside/outside footpath and a speed appropriateness, splashed in dimethicone, collects drop pill, obtains drop pill.
Illustrate beneficial effect of the present invention by test example below.
Clinical (outpatient service) treatment situation of test example 1 pharmaceutical composition of the present invention
(1) accept patient's situation for medical treatment
Patient age and sex scope: old children all has, teenager and child are in the majority, and there are men and women, possesses following symptom feature, accepts altogether 291 examples for medical treatment.
Symptom feature: food stagnation damp-stagnancy, ascending or descending movement of vital Qi mistake department, gastral cavity abdomen feeling of fullness distending pain, belching and acid regurgitation, food is disliked in vomiting, or loose stool and diarrhea is smelly dirty, greasy fur on tongue or rotten greasy, forceful pulse or sliding etc.Above symptom feature only need possess part, needn't all possess.
(2) treatment standard
Recovery from illness: above-mentioned symptom feature disappears completely, recovers normal study or work.
Evident in efficacy: above-mentioned symptom obviously alleviates, or comparatively fast can recover study/ability to work.
Have certain effect: patient's symptom alleviates to some extent, or remission time is slower, or can not recovers normal activity for a long time.
Invalid: symptom still, is not improved completely.
(3) Therapeutic Method
1, the made decoction of embodiment 1, every bu take for 3 times (9 years old following child take the circumstances into consideration to increase every day medicining times or dosage), generally take 1 to 5.
2, note also science conditioning daily life, observe some necessary points for attention, as eating and drinking too much at one meal not, do not eat raw wet (comprising the product of YIN nourishing), raw food, frying, hard, the thing of growing the unfavorable digestion such as greasy (glutinous rice cake, the ball of glutinous rice one class), smelly corruption (fermented bean curd, bean curd with odor, Fermented Bean Drink, addled egg one class) and the stale thing such as overnight, do not have a drink etc. containing sugar beverage (drinking boiled water or weak tea instead), avoid tobacco and wine, not affection of dampness is drenched with rain or in moist environment.
(4) therapeutic outcome
In medicine composite for curing primary disease men and women patient of the present invention 291 examples, obtain good curative effect.Treatment time, according to the difference of the concrete conditions such as each conditions of patients weight, age size, physical strength and slightly institute's difference, within general 1 day to 2 days, left and right symptom can alleviate, within 2 days to 5 days, the various symptoms in left and right can disappear completely or substantially disappear, by above-mentioned science conditioning daily life, sincerely abide by points for attention, can receive merit.
By above-mentioned treatment standard, in 291 routine patients, there are 269 example recoveries from illness, cure rate reaches 92.44%; 21 examples are evident in efficacy, are 7.22%; 1 example has certain effect, accounts for 0.34%; 0 routine DeGrain (invalid), accounts for 0%.Total effective rate reaches 100%.
Model case
Patient, female, 7 years old, student, to certain hospital therapy, gave lenitive pill and JIANWEI XIAOSHI PIAN with " getting ill from overeating ", does not imitate, then diagnosis and treatment again after clothes.Through inquiry, infant is drenched with rain, and hair, clothes drench, the dinner of taking food immediately after changing one's clothes, and food does not stop mouth, and tripe belly stay is swollen very just stops eating, and fall ill next day.Infant and head of a family's readme thereof: main manifestations is anorexia nausea, belching and acid regurgitation, implication is smelly dirty, distension and fullness in the abdomen painful abdominal mass pain, the smelly dirty and thing that folder is not changed of defecating.Hope its tongue, light red and tongue corruption is greasy, pile up as white lead grain.Cut its arteries and veins, sliding real and time have and moistening meaning and show slightly.Analyze: how wet south is, therefore southerner is suffered from damp disease or hygropyrexia is very general.And the border in basin in river, dampness is difficult to wind and falls apart, and reverberates in " basin ", as vexed as steaming, so damp bridle volt is more general in the person of another name for Sichuan Province.Though modern infant primary symptom shows as food stagnation, before having ignored patient and eat, front doctor once had this many damps in drench with rain a joint and another name for Sichuan Province human body to stay the body constitution of volt, and only to know food stagnation removing, and do not execute damp eliminating, result curative effect is barely satisfactory, is difficult to receive merit.
Modern infant is damp-stagnancy food stagnation in fact, cause the card of ascending or descending movement of vital Qi mistake department, Fa Dangfangization is strongly fragrant wet, food stagnation removing food stagnation, work along both lines, so give pharmaceutical composition of the present invention (prepared by embodiment 1), and exhort that it observes the method for administration of above-mentioned " Therapeutic Method " it " 1 " and the science of " 2 " is nursed one's health daily life and points for attention.Patient takes medicine only 1 day, and symptom becomes better, and takes 2,3, good greatly, recover to go to school, and the consolidation that continues to take medicine, to 5 days, recover normal completely.Follow up a case by regular visits to and have no recurrence.
Brief summary: inventor is once repeatedly by pharmaceutical composition of the present invention and classic prescriptions lenitive pill or other commercially available Chinese patent medicine efficacies that helps digestion, and prescription curative effect of the present invention is all better than lenitive pill and other commercially available Chinese patent medicines that help digestion.
In sum, drug regimen composition formula of the present invention is precise and appropriate, can effectively treat ascending or descending movement of vital Qi mistake department due to food stagnation damp-stagnancy, gastral cavity abdomen feeling of fullness distending pain, and belching and acid regurgitation, food is disliked in vomiting, and the smelly dirty card that waits of loose stool and diarrhea, for clinical application provides a kind of new selection.
Claims (9)
1. a pharmaceutical composition for the treatment of food stagnation damp-stagnancy, is characterized in that: it is the preparation being prepared from by the crude drug of following weight proportion:
8～10 parts, Herba Pogostemonis stalk, 8～10 parts of Fructus Aurantiis, 8～10 parts of Cortex Magnoliae Officinalis, 8～10 parts of Pericarpium Citri Reticulataes, 6～8 parts of Fructus Tsaokos, 8～10 parts, Poria, 8～10 parts, Semen Armeniacae Amarum, 12～15 parts of Massa Medicata Fermentata, 8～10 parts of Fructus Setariae Germinatuss, 8～10 parts, Fructus Hordei Germinatus, 8～10 parts of Fructus Crataegis, 15～18 parts of Semen Raphanis, 8～10 parts of Pericarpium Arecae.
2. pharmaceutical composition according to claim 1, is characterized in that: it is the preparation being prepared from by the crude drug of following weight proportion:
10 parts, Herba Pogostemonis stalk, 10 parts of Fructus Aurantiis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Fructus Tsaokos, 10 parts, Poria, 10 parts, Semen Armeniacae Amarum, 12 parts of Massa Medicata Fermentata, 10 parts of Fructus Setariae Germinatuss, 10 parts, Fructus Hordei Germinatus, 10 parts of Fructus Crataegis, 18 parts of Semen Raphanis, 10 parts of Pericarpium Arecae.
3. pharmaceutical composition according to claim 1 and 2, is characterized in that: described Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Crataegi, Semen Raphani are parched medicinal material.
4. according to the pharmaceutical composition described in claim 1～3 any one, it is characterized in that: described pharmaceutical composition be by the medicated powder of the crude drug of described weight proportion or the water of crude drug or/and ethanol extraction is active component, add the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from.
5. pharmaceutical composition according to claim 4, is characterized in that: described preparation is oral formulations.
6. pharmaceutical composition according to claim 5, is characterized in that: described oral agents is granule, powder, pill, drop pill, capsule, soft capsule, tablet or oral liquid.
7. the preparation method of pharmaceutical composition described in claim 1～6 any one, is characterized in that: it comprises the steps:
(1) by described weight proportion weighting raw materials;
(2) by the water of the medicated powder of crude drug or crude drug or/and ethanol extraction, add pharmaceutically can with adjuvant or complementary composition be prepared into conventional formulation.
8. the purposes of the pharmaceutical composition described in claim 1～6 any one in the medicine of preparation treatment food stagnation damp-stagnancy.
9. purposes according to claim 8, is characterized in that: described medicine is ascending or descending movement of vital Qi mistake department due to treatment food stagnation damp-stagnancy, gastral cavity abdomen feeling of fullness distending pain, and belching and acid regurgitation, food is disliked in vomiting, or loose stool and diarrhea is smelly dirty, greasy fur on tongue or rotten greasy, forceful pulse or the medicine of sliding.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104286839A (en) * | 2014-08-01 | 2015-01-21 | 贵阳医学院 | Chewable tablets capable of reinforcing earth to generate metal and preparation method thereof |
| CN105012840A (en) * | 2015-07-24 | 2015-11-04 | 闫花英 | Traditional Chinese medicine composition for treatment of food retention gastrointestinal type diarrhea |
| CN105106902A (en) * | 2015-09-22 | 2015-12-02 | 麻翠秋 | Foot bath liquid for treating infantile vomiting |
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| CN101474386A (en) * | 2009-01-20 | 2009-07-08 | 新乡佐今明制药股份有限公司 | Chinese medicine for promoting digestion and nourishing stomach and preparation method |
| CN102078580A (en) * | 2009-12-01 | 2011-06-01 | 杜明余 | Traditional Chinese medicine composition for indigestion diarrhea |
| CN102485268A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司达仁堂制药厂 | Pharmaceutical composition with dispersing food and fortifying spleen as well as its preparation method |
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| CN101474386A (en) * | 2009-01-20 | 2009-07-08 | 新乡佐今明制药股份有限公司 | Chinese medicine for promoting digestion and nourishing stomach and preparation method |
| CN102078580A (en) * | 2009-12-01 | 2011-06-01 | 杜明余 | Traditional Chinese medicine composition for indigestion diarrhea |
| CN102485268A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司达仁堂制药厂 | Pharmaceutical composition with dispersing food and fortifying spleen as well as its preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104286839A (en) * | 2014-08-01 | 2015-01-21 | 贵阳医学院 | Chewable tablets capable of reinforcing earth to generate metal and preparation method thereof |
| CN105012840A (en) * | 2015-07-24 | 2015-11-04 | 闫花英 | Traditional Chinese medicine composition for treatment of food retention gastrointestinal type diarrhea |
| CN105106902A (en) * | 2015-09-22 | 2015-12-02 | 麻翠秋 | Foot bath liquid for treating infantile vomiting |
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| CN103933453B (en) | 2016-09-21 |
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