CN103933408A

CN103933408A - Traditional Chinese medicinal decoction for treating acute gouty arthritis

Info

Publication number: CN103933408A
Application number: CN201410203074.5A
Authority: CN
Inventors: 肖贻泰; 李守英; 宋海平; 薛童; 于晓燕; 薛文婷; 顾国岳
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-15
Filing date: 2014-05-15
Publication date: 2014-07-23

Abstract

The invention discloses a traditional Chinese medicinal decoction for treating acute gouty arthritis. The decoction is prepared from the following raw medicinal materials in parts by weight: 30 parts of felwort, 30 parts of purslane, 20 parts of ash bark, 15 parts of stramonium, 25 parts of calamus, 20 parts of honeysuckle, 20 parts of cortex erythrinae, 15 parts of rhizoma arisaematis, 10 parts of bamboo leaf, 15 parts of radix berberidis, 20 parts of tinospora sinensis merr, 25 parts of gallnut, 10 parts of coptis chinensis, 25 parts of erycibe obtusifolia benth, 20 parts of herba houttuyniae, 8 parts of polygonatum kingianum, 22 parts of salviae miltiorrhizae, 10 parts of fructus psoraleae, 15 parts of ligusticum wallichii, 5 parts of cinnamon, 12 parts of rhizoma atractylodis macrocephalae, 16 parts of frankincense, 20 parts of unpleasant swallowwort herb, 15 parts of couch grass root and 10 parts of liquorice. The raw medicinal materials are compatible by syndrome differentiation to play the roles in dispelling wind and eliminating humidity, clearing heat and removing toxicity, eliminating cold to stop pain, tonifying spleen and kidney, can be used for effectively relieving the symptom of a patient with acute gouty arthritis and reducing the content of blood uric acid in a human body, has a remarkable curative effect on the acute gouty arthritis, is safe, and does not have toxic or side effect.

Description

A kind of Chinese medicine decoction for the treatment of acute gouty arthritis

Technical field

The present invention relates to a kind of Chinese medicine decoction for the treatment of acute gouty arthritis, belong to the field of Chinese medicines.

Background technology

Acute gouty arthritis is a kind of commonly encountered diseases, frequently-occurring disease of serious harm human health.It is purine metabolic disturbance and (or) the caused one group of disease of underexcretion.Clinical characters is that acute single arthritis, the uric acid sodium salt of hyperuricemia, outbreak repeatedly forms tophus deposition, tophus etc., and along with growth in the living standard, its sickness rate has the trend increasing gradually, and this disease complication is serious, medical history is long, and medical expense is high.

At present, treatment acute gouty arthritis, general colchicine, nonsteroidal antiinflammatory drug and the glucocorticoid etc. of adopting, but there is following defect: 1. apply colchicine, although there is good analgesic effect, but this poison of drug is very large, such as nausea and vomiting, abdominal pain diarrhea, hepatocellular damage, bone marrow depression, alopecia, respiration inhibition etc.2. apply nonsteroidal antiinflammatory drug, as indomethacin, easily cause gastrointestinal upset, headache, dizziness, anxiety, erythra and renal function injury.3. apply glucocorticoid, easily affect patient's blood pressure, blood glucose, blood fat and bone metabolism, bring out or increase the weight of peptic ulcer.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine decoction for the treatment of acute gouty arthritis.

The technology used in the present invention solution is:

Treat a Chinese medicine decoction for acute gouty arthritis, it is to be made by the crude drug of following weight parts proportioning: 30 parts of Radix Gentianaes, 30 parts of Herba Portulacaes, 20 parts of Cortex Fraxinis, 15 parts of Flos Daturae, 25 parts of Rhizoma Acori Gramineis, 20 parts of Flos Loniceraes, 20 parts of Cortex erythrinaes, 15 parts of Rhizoma Arisaematiss, 10 parts, Folium Bambusae, 15 parts of Radix Berberidis, 20 parts of Herba Lycopodii, 25 parts of Galla Chinensiss, 10 parts of Rhizoma Coptidis, 25 parts of Caulis Erycibess, 20 parts of Herba Houttuyniae, 8 parts of Rhizoma Polygonatis, 22 parts of Radix Salviae Miltiorrhizaes, 10 parts of Fructus Psoraleaes, 15 parts of Rhizoma Chuanxiongs, 5 parts of Cortex Cinnamomis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Olibanums, 20 parts of Radix Tylophorae arenicolaes, 15 parts of Rhizoma Imperataes, 10 parts, Radix Glycyrrhizae.

Above-mentioned Chinese medicine decoction can be prepared as follows: the raw material of Chinese medicine of above-mentioned weight portion is put into drug-decocting appliance, add the clean water that meets drinking water standard, amount of water is advisable to surpass liquid level 2～3cm; Enter to decoct and front above-mentioned raw material of Chinese medicine is soaked to half an hour, make it fully moistening, fully fried in order to medicine juice; Then (suddenly) fire of useing force boils, then uses literary composition (micro-) fire instead and decoct.When decocting about 15 minutes, stop, removing medicinal residues, get decoction.

Pharmacology of the present invention and effect are as follows:

The present invention is with expelling wind and removing dampness, heat-clearing and toxic substances removing, and dispersing cold for relieving pain, reinforcing spleen and kidney is starting point, and Rational choice 25 taste crude drug are brewed into Chinese medicine decoction, and in side, Radix Gentianae and Herba Portulacae are monarch drug altogether, and wherein Radix Gentianae mainly plays the effect of heat clearing and damp drying; Herba Portulacae is in order to heat-clearing and toxic substances removing, and diuretic dries, loose blood detumescence, anti-inflammatory analgetic, hemostasis removing heat from blood; The two compatibility can reach heat clearing and damp drying, the effect of removing toxic substances and promoting subsidence of swelling; Cortex Fraxini, Flos Daturae, Rhizoma Acori Graminei, Flos Lonicerae, Cortex erythrinae, Rhizoma Arisaematis, Folium Bambusae, Radix Berberidis, Herba Lycopodii, Galla Chinensis, Rhizoma Coptidis are ministerial drug altogether, with the merit of row expelling wind and removing dampness, heat-clearing and toxic substances removing; Cortex Fraxini heat clearing and damp drying wherein; Flos Daturae, the removing toxic substances of Rhizoma Acori Graminei compatibility monarch drug; Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome; Cortex erythrinae wind-damp dispelling, the meridian dredging; Rhizoma Arisaematis drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating; Folium Bambusae clearing heat and relieving fidgetness; Radix Berberidis detoxicating, relieving inflammation; Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral; Galla Chinensis hemostasis; Removing toxic substances; Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication; And assistant is with dispersing cold for relieving pain, subsides a swelling, the crude drug such as reinforcing spleen and kidney; Caulis Erycibes expelling wind and removing dampness wherein, reducing swelling and alleviating pain; Herba Houttuyniae heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; Rhizoma Polygonati boosting qi and nourishing yin, spleen invigorating, kidney tonifying; Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, the relieving restlessness of invigorating blood circulation, clear away heart-fire; Fructus Psoraleae reinforcing the kidney and supporting YANG; Rhizoma Chuanxiong blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression; , wind-expelling pain-stopping; It is supporing yang that Cortex Cinnamomi is mended fire, dispersing cold for relieving pain; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic; Olibanum regulating qi and activating blood; Radix Tylophorae arenicolae clearing away heat and cooling blood; Removing toxic substances; Rhizoma Imperatae cooling blood for hemostasis, heat-clearing and toxic substances removing; Make, with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, to have the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing concurrently.Full side's compatibility is played expelling wind and removing dampness, heat-clearing and toxic substances removing, dispersing cold for relieving pain altogether, the effect of reinforcing spleen and kidney, can effectively alleviate acute gouty arthritis patient's symptom, reduces blood in human body in uric acid content, acute gouty arthritis is had to significant curative effect, and safety, have no side effect.

Clinical trial

1, clinical data

Accept out-patient's 200 examples for medical treatment, patient is divided into two groups at random, treatment group 100 examples, give decoction treatment of the present invention, and matched group 100 examples give existing medicine allopurinol treatment.40 years old following 20 example in treatment group, 40-49 year 36 examples, 50-59 year 25 examples, 60 years old above 19 example; Wherein invade metatarsophalangeal joints 49 examples, ankle joint 33 examples, other joint 18 examples, blood uric acid 408.5～658.0 μ mol/L, average 530 μ mol/L.40 years old following 19 example in matched group, 40-49 year 42 examples, 50-59 year 20 examples, 60 years old above 19 example; Wherein invade metatarsophalangeal joints 50 examples, ankle joint 33 examples, other joint 17 examples, blood uric acid 410.0～680.7 μ mol/L, average 528 μ mol/L, blood uric acid normal value is 150～430 μ mol/L.Two groups of patient age distributions, the course of disease, Level of Serum Uric Acid etc., without significant difference, have comparability.

2, diagnostic criteria

The 2.1 diagnostic criteria diagnosis of formulating for 1977 with reference to rheumatoid disease association;

2.2 Chinese medical discriminations belong to pyretic arthralgia person; Disease is seen: joint is red, swollen, burning pain, joint stuffiness; Heat aggravation, obtains cold slightly easypro; Many night-time attacks, pain is acute; Severe patient involves ankle and other little joints, the heat that occurs together, xerostomia, dark coloured urine Huang, yellow and greasy fur, slippery and rapid pulse.

All cases is all determined diagnosis by above-mentioned diagnostic criteria.

3, Therapeutic Method

Therapeutic Method is under the voluntary prerequisite of patient, and treatment group patient takes medicine decoction of the present invention, and two doses of every days, dosage is 300 milliliters; Matched group patient takes allopurinol 0.1g, and every day 3 times is oral; Vit B120mg, every day 3 times is oral, heating and urinary system calculus person anti symptom treatment.

All take for two groups and treat 7 days as 1 course for the treatment of, after 2 courses for the treatment of, add up therapeutic outcome.

4, efficacy assessment standard

Recovery from illness: clinical symptoms all disappears, and joint motion freely, be down to normally by blood uric acid;

Effective: clinical symptoms takes a turn for the better, and joint motion is flexible, and blood uric acid is treated front reduction more than 10%;

Invalid: clinical symptom remission is not obvious, blood uric acid is front without significant change with treatment.

5, results and analysis

Table 1

Group	Number of cases	Recovery from illness	Effective	Invalid	Total effective rate
						Treatment group	100	91	6	3	97％
Matched group	100	50	21	29	71％

As can be seen from Table 1, treatment group curative effect is obviously better than matched group.

The specific embodiment

By following proportioning, take each raw material of Chinese medicine:

Radix Gentianae 30g, Herba Portulacae 30g, Cortex Fraxini 20g, Flos Daturae 15g, Rhizoma Acori Graminei 25g, Flos Lonicerae 20g, Cortex erythrinae 20g, Rhizoma Arisaematis 15g, Folium Bambusae 10g, Radix Berberidis 15g, Herba Lycopodii 20g, Galla Chinensis 25g, Rhizoma Coptidis 10g, Caulis Erycibes 25g, Herba Houttuyniae 20g, Rhizoma Polygonati 8g, Radix Salviae Miltiorrhizae 22g, Fructus Psoraleae 10g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 5g, Rhizoma Atractylodis Macrocephalae 12g, Olibanum 16g, Radix Tylophorae arenicolae 20g, Rhizoma Imperatae 15g, Radix Glycyrrhizae 10g.

Preparation method is as follows:

The raw material of Chinese medicine of above-mentioned weight portion is put into drug-decocting appliance, add the clean water that meets drinking water standard, amount of water is advisable to surpass liquid level 2～3cm; Enter to decoct and front above-mentioned raw material of Chinese medicine is soaked to half an hour, make it fully moistening, fully fried in order to medicine juice; Then (suddenly) fire of useing force boils, then uses literary composition (micro-) fire instead and decoct.When decocting about 15 minutes, stop, removing medicinal residues, get decoction.

Claims

1. a Chinese medicine decoction for the treatment of acute gouty arthritis, it is characterized in that it is to be made by the crude drug of following weight parts proportioning: 30 parts of Radix Gentianaes, 30 parts of Herba Portulacaes, 20 parts of Cortex Fraxinis, 15 parts of Flos Daturae, 25 parts of Rhizoma Acori Gramineis, 20 parts of Flos Loniceraes, 20 parts of Cortex erythrinaes, 15 parts of Rhizoma Arisaematiss, 10 parts, Folium Bambusae, 15 parts of Radix Berberidis, 20 parts of Herba Lycopodii, 25 parts of Galla Chinensiss, 10 parts of Rhizoma Coptidis, 25 parts of Caulis Erycibess, 20 parts of Herba Houttuyniae, 8 parts of Rhizoma Polygonatis, 22 parts of Radix Salviae Miltiorrhizaes, 10 parts of Fructus Psoraleaes, 15 parts of Rhizoma Chuanxiongs, 5 parts of Cortex Cinnamomis, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Olibanums, 20 parts of Radix Tylophorae arenicolaes, 15 parts of Rhizoma Imperataes, 10 parts, Radix Glycyrrhizae.