CN103933176B - A kind of Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof Download PDFInfo
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- CN103933176B CN103933176B CN201410192258.6A CN201410192258A CN103933176B CN 103933176 B CN103933176 B CN 103933176B CN 201410192258 A CN201410192258 A CN 201410192258A CN 103933176 B CN103933176 B CN 103933176B
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof, comprise the crude drug of following weight portion: Radix Astragali 280-350 part;? Flos Magnoliae 280-350 part, Semen Citri Reticulatae 280-350 part, Caulis Spatholobi 280-350 part, Fructus Mori 150-200 part, Radix Salviae Miltiorrhizae 150-200 part, Radix Angelicae Sinensis 140-180 part, Radix Polygalae 80-120 part, stir-baked HIRUDO 80-120 part, Folium Artemisiae Argyi 30-100 part.Formula of the present invention is unique, preparation is simple, with the Radix Astragali, Flos Magnoliae, Semen Citri Reticulatae, Caulis Spatholobi for monarch drug, other crude drug are ministerial drug and adjuvant, by collocation and the collaborative onset of each medicine, play effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, eliminating stagnation of dispeling cold, have good curative effect to apoplexy sequela, especially to the sequela Be very effective such as hemiplegia, hemiplegia, limbs are dumb.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to Chinese medicine composition for the treatment of apoplexy sequela and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Cerebral hemorrhage refers to non-traumatic cerebral intraparenchymal hemorrhage, accounts for 20% ~ 30% of whole apoplexy, and the reason of generation is main relevant with cerebrovascular pathological changes, namely closely related with aging, the smoking of hyperlipidemia, diabetes, hypertension, blood vessel etc.The patient of cerebral hemorrhage is often due to sudden onset during excited, hard exerting oneself, and Infant Mortality is very high, about has half patient dead within the morbidity a few days, even if survivor majority also can leave sequela in various degree.
Apoplexy sequela has following several performance clinically: 1, limbs disturbance: main manifestations hemiplegia side sensation and dyskinesia; 2, spirit and cognitive disorder: as personality changes, remain passive and pessimistic, depressed joyless, lethargy, emotional etc.; 3, laloplegia; 4, dysphagia; 5, unstable, the neck of headache, dizzy, nauseating, insomnia, dreaminess, absent minded, tinnitus, dim eyesight, hyperhidrosis, cardiopalmus, paces is ached the symptoms such as tired, unable, inappetence, hypomnesis, dementia, depression.
The body and mind of apoplexy sequela to patient brings very large injury, could rehabilitation as early as possible even if want to coordinate the recovery function such as Drug therapy and physical therapy to take exercise.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of apoplexy sequela, said composition formula is unique, to the limbs disturbance that apoplexy sequela causes, and the particular significant effect such as dumb in hemiplegia, hemiplegia, limb activity.
Another object of the present invention is to provide the preparation method of said composition.
The concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of apoplexy sequela, it is characterized in that the crude drug comprising following weight portion: Radix Astragali 280-350 part, Magnolia denudata 280-350 part, Semen Citri Reticulatae 280-350 part, Caulis Spatholobi 280-350 part, Fructus Mori 150-200 part, Radix Salviae Miltiorrhizae 150-200 part, Radix Angelicae Sinensis 140-180 part, Radix Polygalae 80-120 part, stir-baked HIRUDO 80-120 part, Folium Artemisiae Argyi 30-100 part.
In above-mentioned Chinese medicine composition, preferably include the crude drug of following weight portion: the Radix Astragali 300 parts, Magnolia denudata 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts.
The present composition is reasonably combined according to the principle of monarch, and each crude drug works in coordination with onset, has effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, eliminating stagnation of dispeling cold, has significant curative effect to apoplexy sequela.
The present invention's each crude drug effect is as follows:
The Radix Astragali, nature and flavor are sweet, and temperature, has effect of invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst.
Magnolia denudata, nature and flavor are pungent, warm, have that expelling wind and cold is sensible, effect that lung qi dispersing stuffy nose relieving, expectorant, lung benefiting are gentle, can be used for the disease such as headache, blood stasis type dysmenorrhea, nasal obstruction, acute and chronic nasal sinusitis, allergic rhinitis.
Semen Citri Reticulatae, nature and flavor are bitter, and flat, have and regulate the flow of vital energy, eliminating stagnation, effect of pain relieving, for inguinal hernia, painful and swollen testis, acute mastitis swells and ache.
Caulis Spatholobi, nature and flavor are bitter, sweet, and temperature, has and enrich blood, invigorate blood circulation, effect of dredging collateral, for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.
Fructus Mori, nature and flavor are sweet, sour, cold in nature, have nourishing YIN and supplementing blood, effect of moisturizing of promoting the production of body fluid, thirsty for the having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence, soreness of waist tinnitus, early whitening of beard and hair, insomnia and dreamful sleep, Tianjin wound, quench one's thirst, dryness of the intestine constipation.
Radix Salviae Miltiorrhizae, nature and flavor are bitter, are slightly cold, have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire, for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Angelicae Sinensis, nature and flavor are sweet, pungent, warm, and having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Polygalae, nature and flavor are bitter, pungent, warm, have Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminate the phlegm, effect of detumescence, and the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Hirudo, nature and flavor are salty, bitter, flat, have removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow, Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
Folium Artemisiae Argyi, nature and flavor are pungent, bitter, temperature, there is dispersing cold for relieving pain, effect of warming the meridian for stopping bleeding, for few abdomen cold type of pain, coldness and unbalance in meridians, official is cold infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage.
Further, in order to increase curative effect, the basis of above-mentioned formula can add parthenocissus, Fructus Xanthii, Semen Trichosanthis composition form new sub-side.New sub-side is made up of the crude drug of following weight portion: Radix Astragali 280-350 part, Magnolia denudata 280-350 part, Semen Citri Reticulatae 280-350 part, Caulis Spatholobi 280-350 part, Fructus Mori 150-200 part, Radix Salviae Miltiorrhizae 150-200 part, Radix Angelicae Sinensis 140-180 part, Radix Polygalae 80-120 part, stir-baked HIRUDO 80-120 part, Folium Artemisiae Argyi 30-100 part, parthenocissus 80-120 part, Fructus Xanthii 30-70 part, Semen Trichosanthis 30-70 part.Preferably be made up of the crude drug of following weight portion: the Radix Astragali 300 parts, Magnolia denudata 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts, parthenocissus 100 parts, Fructus Xanthii 50 parts, Semen Trichosanthis 50 parts.
The present composition directly makes powder after can pulverizing, and also can make the watered pill, and the preparation method of the watered pill is: each crude drug is ground into fine powder, then sieves, mix, and take water as binding agent, makes the watered pill by general method for making.Every regulation (Chinese Pharmacopoeia version in 2000 annex IA) that the watered pill obtained by the present invention is relevant under meeting pill item.
When preparing the watered pill, water used is purified water, meets " Chinese Pharmacopoeia " version prescription in 2000.
The consumption of medicine of the present invention is: a 5g, three times on the one, 10 days courses for the treatment of, onset in general 20 days, severe patient onset in about 35 days.
Formula of the present invention is unique, preparation is simple, with the Radix Astragali, Magnolia denudata, Semen Citri Reticulatae, Caulis Spatholobi, Fructus Mori, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Polygalae, stir-baked HIRUDO, Folium Artemisiae Argyi for key agents effective ingredient, wherein the Radix Astragali, Magnolia denudata, Semen Citri Reticulatae, Caulis Spatholobi are monarch drug, other crude drug are ministerial drug and adjuvant, by collocation and the collaborative onset of each medicine, play effect of blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, eliminating stagnation of dispeling cold, good curative effect is had, especially to the sequela Be very effective such as hemiplegia, hemiplegia, limbs are dumb to apoplexy sequela.
Detailed description of the invention
Below by specific embodiment, the present invention being further detailed, it is to be understood that following explanation is only to explain the present invention, its content not being limited.If no special instructions, following embodiment Raw survival dose is weight portion.
embodiment 1
Pharmaceutical formulation of the present invention is: the Radix Astragali 300 parts, Magnolia denudata 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts.
Preparation method is: each crude drug is ground into fine powder, then sieves, mix, and take water as binding agent, makes the watered pill by general method for making.Or each crude drug is ground into fine powder, makes powder.
embodiment 2
Pharmaceutical formulation of the present invention is: the Radix Astragali 280 parts, Magnolia denudata 350 parts, Semen Citri Reticulatae 280 parts, Caulis Spatholobi 350 parts, Fructus Mori 150 parts, Radix Salviae Miltiorrhizae 200 parts, Radix Angelicae Sinensis 140 parts, Radix Polygalae 120 parts, stir-baked HIRUDO 80 parts, Folium Artemisiae Argyi 100 parts.Preparation method is with embodiment 1.
embodiment 3
Pharmaceutical formulation of the present invention is: the Radix Astragali 350 parts, Magnolia denudata 280 parts, Semen Citri Reticulatae 350 parts, Caulis Spatholobi 280 parts, Fructus Mori 200 parts, Radix Salviae Miltiorrhizae 150 parts, Radix Angelicae Sinensis 180 parts, Radix Polygalae 80 parts, stir-baked HIRUDO 120 parts, Folium Artemisiae Argyi 30 parts.Preparation method is with embodiment 1.
embodiment 4
Pharmaceutical formulation of the present invention is: the Radix Astragali 300 parts, Magnolia denudata 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts, parthenocissus 100 parts, Fructus Xanthii 50 parts, Semen Trichosanthis 50 parts.Preparation method is with embodiment 1.
embodiment 5
Pharmaceutical formulation of the present invention is: the Radix Astragali 280 parts, Magnolia denudata 350 parts, Semen Citri Reticulatae 280 parts, Caulis Spatholobi 350 parts, Fructus Mori 150 parts, Radix Salviae Miltiorrhizae 200 parts, Radix Angelicae Sinensis 140 parts, Radix Polygalae 120 parts, stir-baked HIRUDO 80 parts, Folium Artemisiae Argyi 100 parts, parthenocissus 80 parts, Fructus Xanthii 70 parts, Semen Trichosanthis 30 parts.Preparation method is with embodiment 1.
embodiment 6
Pharmaceutical formulation of the present invention is: the Radix Astragali 350 parts, Magnolia denudata 280 parts, Semen Citri Reticulatae 350 parts, Caulis Spatholobi 280 parts, Fructus Mori 200 parts, Radix Salviae Miltiorrhizae 150 parts, Radix Angelicae Sinensis 180 parts, Radix Polygalae 80 parts, stir-baked HIRUDO 120 parts, Folium Artemisiae Argyi 30 parts, parthenocissus 120 parts, Fructus Xanthii 30 parts, Semen Trichosanthis 70 parts.Preparation method is with embodiment 1.
Medicine of the present invention has effect of good blood circulation promoting and blood stasis dispelling, coronary circulation-promoting pain-relieving, eliminating stagnation of dispeling cold, and the some cases below by inventor's treatment proves good result of the present invention.
clinical trial
1, patient profiles
Patient is 2010-2013 years patients with cerebral hemorrhage of accepting for medical treatment, has apoplexy sequela in various degree after treatment.Patient is totally 292 people, wherein male 185 people, female 107 people, patient age 45-80 year, 62.8 years old mean age, patients used goes out one or more clinical symptoms following: hemiplegia, paresis or hemiplegia, general paralysis, extremity are dumb, facial hemiparalysis, consciousness and language performance obstacle.
, Therapeutic Method
Patient is equally divided into 4 groups according to age and the course of disease, the watered pill that each group uses the embodiment of the present invention 1,2,4,5 to prepare respectively, every day 3 times, each 5g.Taking medicine, each group patient simultaneously carries out physics and exercise therapy according to doctor advised simultaneously.
, criterion of therapeutical effect
Effective: the clinical symptoms such as hemiplegia, paralysis, extremity are dumb, facial hemiparalysis all disappears or takes a turn for the better more than 70%;
Effective: sanity, language performance are normal, and each function of limbs makes progress before comparatively treating, clinical symptoms improvement 40-70%;
Invalid: above standard cannot be reached.
, therapeutic outcome
Each group of patient consumes is after 10 days, and patients with mild symptom takes an evident turn for the better, and continues to take the improvement that each group of patient all shows different situations, and treatment is after 40 days continuously, and each group patient treatment outcome sees the following form 1.
As can be seen from upper table data, medicine of the present invention has good therapeutic effect to apoplexy sequela, and effective percentage is more than 91%, and wherein, the therapeutical effect of the medicine of embodiment 4 is the most obvious, and effect is best.
Claims (7)
1. treat the Chinese medicine composition of apoplexy sequela for one kind, it is characterized in that being made up of the crude drug of following weight portion: Radix Astragali 280-350 part, Flos Magnoliae 280-350 part, Semen Citri Reticulatae 280-350 part, Caulis Spatholobi 280-350 part, Fructus Mori 150-200 part, Radix Salviae Miltiorrhizae 150-200 part, Radix Angelicae Sinensis 140-180 part, Radix Polygalae 80-120 part, stir-baked HIRUDO 80-120 part, Folium Artemisiae Argyi 30-100 part.
2. Chinese medicine composition according to claim 1, is characterized in that being made up of the crude drug of following weight portion: the Radix Astragali 300 parts, Flos Magnoliae 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that: dosage form is the watered pill.
4. treat a Chinese medicine composition for apoplexy sequela, it is characterized in that being made up of the crude drug of following weight portion: Radix Astragali 280-350 part, Flos Magnoliae 280-350 part, Semen Citri Reticulatae 280-350 part, Caulis Spatholobi 280-350 part, Fructus Mori 150-200 part, Radix Salviae Miltiorrhizae 150-200 part, Radix Angelicae Sinensis 140-180 part, Radix Polygalae 80-120 part, stir-baked HIRUDO 80-120 part, Folium Artemisiae Argyi 30-100 part, parthenocissus 80-120 part, Fructus Xanthii 30-70 part, Semen Trichosanthis 30-70 part.
5. Chinese medicine composition according to claim 4, is characterized in that being made up of the crude drug of following weight portion: the Radix Astragali 300 parts, Flos Magnoliae 300 parts, Semen Citri Reticulatae 300 parts, Caulis Spatholobi 300 parts, Fructus Mori 180 parts, Radix Salviae Miltiorrhizae 180 parts, Radix Angelicae Sinensis 150 parts, Radix Polygalae 100 parts, stir-baked HIRUDO 100 parts, Folium Artemisiae Argyi 50 parts, parthenocissus 100 parts, Fructus Xanthii 50 parts, Semen Trichosanthis 50 parts.
6. the Chinese medicine composition according to claim 4 or 5, is characterized in that: dosage form is the watered pill.
7. a preparation method for the Chinese medicine composition for the treatment of apoplexy sequela according to claim 3, is characterized in that: each crude drug is ground into fine powder, then sieves, mix, and take water as binding agent, makes the watered pill by general method for making.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249221A (en) * | 2008-03-31 | 2008-08-27 | 刘玉安 | Chinese medicine for curing cerebral hemorrhage sequelae, cerebral infarction and cerebral thrombus |
| CN101357162A (en) * | 2008-09-10 | 2009-02-04 | 吴春荣 | Traditional Chinese medicine capable of inducing menstruation and removing bloodstasis |
| CN102614270A (en) * | 2012-05-05 | 2012-08-01 | 钱家美 | Chinese medicine for treating cerebral hemorrhage and cerebral infarction diseases and sequelae thereof |
| CN102784214A (en) * | 2012-08-23 | 2012-11-21 | 李尚晏 | Dropping pills for treating cerebral arteriosclerosis and cerebral hemorrhage sequela and preparation method thereof |
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2014
- 2014-05-08 CN CN201410192258.6A patent/CN103933176B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249221A (en) * | 2008-03-31 | 2008-08-27 | 刘玉安 | Chinese medicine for curing cerebral hemorrhage sequelae, cerebral infarction and cerebral thrombus |
| CN101357162A (en) * | 2008-09-10 | 2009-02-04 | 吴春荣 | Traditional Chinese medicine capable of inducing menstruation and removing bloodstasis |
| CN102614270A (en) * | 2012-05-05 | 2012-08-01 | 钱家美 | Chinese medicine for treating cerebral hemorrhage and cerebral infarction diseases and sequelae thereof |
| CN102784214A (en) * | 2012-08-23 | 2012-11-21 | 李尚晏 | Dropping pills for treating cerebral arteriosclerosis and cerebral hemorrhage sequela and preparation method thereof |
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