CN1039278C - Processing method for aqueous raticide - Google Patents
Processing method for aqueous raticide Download PDFInfo
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- CN1039278C CN1039278C CN93105049A CN93105049A CN1039278C CN 1039278 C CN1039278 C CN 1039278C CN 93105049 A CN93105049 A CN 93105049A CN 93105049 A CN93105049 A CN 93105049A CN 1039278 C CN1039278 C CN 1039278C
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- coumatetralyl
- aqueous
- aqua
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Abstract
The present invention discloses a preparation method for aqueous coumatetralyl which is prepared by chemically treating the existing raw coumatetralyl by an alkali cosolvent. Raw powdery coumatetralyl is chemically treated into soluble coumatetralyl sodium salt (a coumatetralyl mother liquid) by sodium carbonate first, and a proper amount of sodium benzoate stabilizers and sugar attractants are added after the soluble coumatetralyl sodium salt is filtered and deslagged; different types (different contents of raw coumatetralyl) of aqueous coumatetralyl are prepared by softened water, such as 3.75% of aqueous coumatetralyl, 7.5% of aqueous coumatetralyl, etc. Aqueous coumatetralyl prepared by the present invention overcomes the water insoluble disadvantage of original powdery coumatetralyl, and different kinds of convenient coumatetralyl poison bait can be prepared after grains are immersed; the present invention is surface for the deratization in different kinds of environment.
Description
The present invention relates to chemical medicine field, specifically, be a kind of preparation method of coumatetralyl aqua, be applicable to that the rodent poison bait as various muroids uses.
Coumatetralyl belongs to typical anti-coagulant rodenticide as a kind of mouse medicine, and is strong with its lethality, and killing mouse property is good and obtain general application.The coumatetralyl of existing domestic use mostly is a kind of powder or granular medicament, be earlier the former medicine of coumatetralyl to be added the female powder of starch preparation or coumatetralyl, again female powder is added that graininess poison bait or Powdered poison bait are mixed with the adhesive type poison bait or the mixed type poison bait goes to kill mouse, this coumatetralyl is easy to use, and killing mouse property is also better.But this particle powder shape mouse medicine is difficult for stirring when processing is produced, and particularly this mouse medicine is water insoluble.After making moist or drenching with rain, the coumatetralyl medicine on the poison bait very easily comes off, and influences deratization effect, uses also to be restricted.
The objective of the invention is to disclose a kind of water-soluble, poison bait and prepare coumatetralyl new drug easily--the preparation method of coumatetralyl aqua,, enlarge the range of application of coumatetralyl to improve the deratization effect of this mouse medicine of coumatetralyl.
Basic design of the present invention is by adding a kind of cosolvent, making the former medicine of water-fast Powdered coumatetralyl become the coumatetralyl salt (mother liquor) of solubility, and obtain a kind of coumatetralyl aqua.
The coumatetralyl aqua that provides among the present invention is a kind of 3-(2-tetralin base)-4 Hydroxycoumarin sodium salts.
Its molecular formula is: C
19H
15O
3N
a
Molecular weight is: 314.3 structural formulas are:
Be to generate by former medicine of coumatetralyl and the reaction of a kind of alkalescent cosolvent.Its reaction mechanism is
Coumatetralyl aqua outward appearance is sepia not to be had and smells tasteless transparency liquid, and pH value is 9-10, can with the miscible coumatetralyl aqua that becomes different dosage form (content) of the water of any ratio.Main formulation commonly used has 3.75% coumatetralyl aqua, 5% coumatetralyl aqua and 7.5% coumatetralyl aqua etc.
The coumatetralyl aqua is formulated with the former medicine of coumatetralyl, and the former medicine of coumatetralyl is water-fast, prepare and can prepare after the aqua coumatetralyl need manage to make the middle chemical treatment of the former medicine of coumatetralyl by a kind of cosolvent to become soluble substance.Among the present invention, the acquisition of coumatetralyl aqua is by with the alkalescent cosolvent the former medicine of coumatetralyl being processed into solubility salt (coumatetralyl mother liquor), adding an amount of stabilizing agent (preservative) and attractant again, forming with the soft water allotment.Among the present invention, coumatetralyl former medicinal be the former medicine of the Powdered coumatetralyl of white yellow crystal of effective ingredient resultant 〉=95%, what the alkalescent cosolvent was used is the sodium carbonate of technical grade, what stabilizing agent was used is Sodium Benzoate, what attractant was used is sugar, is deployed into the aqua coumatetralyl-coumatetralyl sodium salt of different former medicine content at last with soft water.Adding stabilizing agent and attractant are stability and the palatabilities in order to improve the coumatetralyl aqua in the coumatetralyl sodium salt.Preparation process of the present invention is:
Former medicine of coumatetralyl and sodium carbonate cosolvent are inserted in the reactor, after the heating for dissolving, filter, remove mechanical dregs, add stabilizing agent and attractant in solution, mix and stir, analytical control gets final product with the soft water allotment.For the ease of grasping the content of the former medicine effective ingredient in technology and the control coumatetralyl aqua, generally be to make certain coumatetralyl aqua (as the coumatetralyl aqua of 25% formulation) earlier when preparation, and then allocate to the coumatetralyl aqua of the formulation that needs with demineralized water than plateau medicine content
The coumatetralyl aqua of the present invention's preparation is owing to overcome the water-fast shortcoming of former powdery coumatetralyl, make the various poison baits of coumatetralyl easily after can be made into coumatetralyl poison water or steeping corn, have the preparation poison bait convenient, be not afraid of humidity, high-efficiency low-toxicity, to the muroid good palatability, be applicable to advantages such as various environment kill mouse.And preparing process simply, efficiently, does not produce three-waste pollution.
The following examples can further describe the present invention:
The high formulation coumatetralyl aqua of a, preparation 25% former medicine effective ingredient
The sodium carbonate of 52.5 parts distilled water and 7.5 parts is packed in the reactor, open the reactor cap relief valve and slowly rise to 90 ℃, the former medicine of coumatetralyl that adds 25 parts again, build the reactor hole cover, start agitator, under 90 ℃ temperature, kept 1 hour, temperature in the kettle slowly is warming up to 100 ℃, keep reaction (1-1.5) hour again, blowing when treating that temperature in the kettle is reduced to 50 ℃, filter, remove mechanical dregs, filtrate is sent in the mixing kettle, add 5 parts of Sodium Benzoates and 10 portions of sugar, stirred 10 minutes, sample analysis can obtain the high formulation coumatetralyl aqua of 25% effective ingredient
B, preparation 3.75% formulation coumatetralyl aqua
Get the coumatetralyl aqua of above-mentioned 25% high formulation: in the 15 one's share of expenses for a joint undertaking mixing kettles, add 85 parts of demineralized waters, evenly stir, sample analysis is allocated until qualified with soft water again.
C, preparation 7.5% formulation coumatetralyl aqua
Get 30 parts in 25% high formulation coumatetralyl aqua of fan in mixing kettle, add 70 parts of demineralized waters, evenly stir, sample analysis, again with the soft water allotment until qualified.
Accompanying drawing has provided preparation process figure of the present invention
Claims (3)
1, a kind of preparation method of coumatetralyl aqua is characterized in that
A, under (90-100) ℃ temperature, add 52.5 parts of demineralized waters with 7.5 parts sodium carbonate cosolvents the former medicine chemical treatment of 25 parts powdery coumatetralyl become coumatetralyl sodium salt (coumatetralyl mother liquor)
B, remove by filter behind the mechanical dregs at 50 ℃ and add 5 parts Sodium Benzoate stabilizing agent and 10 parts of sugar attractants down in the coumatetralyl mother liquor, mixing and stirring
C, sample analysis are allocated the coumatetralyl aqua of making different dosage form with demineralized water.
2, preparation method as claimed in claim 1 is characterized in that it is 2-2.5 hour that the sodium carbonate cosolvent is handled the time of the former medicine of coumatetralyl.
3, preparation method as claimed in claim 1, the mixing time that it is characterized in that adding behind stabilizing agent and the attractant is 10 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93105049A CN1039278C (en) | 1993-05-18 | 1993-05-18 | Processing method for aqueous raticide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93105049A CN1039278C (en) | 1993-05-18 | 1993-05-18 | Processing method for aqueous raticide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1085385A CN1085385A (en) | 1994-04-20 |
| CN1039278C true CN1039278C (en) | 1998-07-29 |
Family
ID=4985508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93105049A Expired - Fee Related CN1039278C (en) | 1993-05-18 | 1993-05-18 | Processing method for aqueous raticide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1039278C (en) |
-
1993
- 1993-05-18 CN CN93105049A patent/CN1039278C/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 新编农药手册 1989.10.1 农业部药检所;农业出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1085385A (en) | 1994-04-20 |
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