CN103911305B - 卷曲乳杆菌菌株及其用途 - Google Patents
卷曲乳杆菌菌株及其用途 Download PDFInfo
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- CN103911305B CN103911305B CN201310002837.5A CN201310002837A CN103911305B CN 103911305 B CN103911305 B CN 103911305B CN 201310002837 A CN201310002837 A CN 201310002837A CN 103911305 B CN103911305 B CN 103911305B
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- vaginitis
- bacterial strain
- present
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- lactobacillus crispatus
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- 230000001580 bacterial effect Effects 0.000 title claims abstract description 63
- 241000218492 Lactobacillus crispatus Species 0.000 title claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 210000004392 genitalia Anatomy 0.000 claims abstract description 4
- 206010046914 Vaginal infection Diseases 0.000 claims description 23
- 201000008100 Vaginitis Diseases 0.000 claims description 22
- 241000222122 Candida albicans Species 0.000 claims description 21
- 241000191967 Staphylococcus aureus Species 0.000 claims description 21
- 229940095731 candida albicans Drugs 0.000 claims description 21
- 241000894006 Bacteria Species 0.000 claims description 14
- 230000000968 intestinal effect Effects 0.000 claims description 9
- 241000588724 Escherichia coli Species 0.000 claims description 8
- 229940023064 escherichia coli Drugs 0.000 claims description 7
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims description 5
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims description 5
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 claims description 5
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 claims description 5
- 208000011833 infective vaginitis Diseases 0.000 claims description 5
- 230000005906 menstruation Effects 0.000 claims description 5
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 12
- 230000003042 antagnostic effect Effects 0.000 abstract description 9
- 210000002919 epithelial cell Anatomy 0.000 abstract description 6
- 239000000853 adhesive Substances 0.000 abstract description 4
- 230000001070 adhesive effect Effects 0.000 abstract description 4
- 244000052769 pathogen Species 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 description 51
- 210000004027 cell Anatomy 0.000 description 17
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 16
- 239000002609 medium Substances 0.000 description 16
- 239000007788 liquid Substances 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 8
- 239000004310 lactic acid Substances 0.000 description 8
- 235000014655 lactic acid Nutrition 0.000 description 8
- 210000001215 vagina Anatomy 0.000 description 8
- 244000052616 bacterial pathogen Species 0.000 description 6
- 230000009977 dual effect Effects 0.000 description 6
- 244000005706 microflora Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 230000000392 somatic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 240000001624 Espostoa lanata Species 0.000 description 2
- 235000009161 Espostoa lanata Nutrition 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000006916 nutrient agar Substances 0.000 description 2
- 235000019319 peptone Nutrition 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000006152 selective media Substances 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 235000017281 sodium acetate Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 241000186783 Lactobacillus vaginalis Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 240000005384 Rhizopus oryzae Species 0.000 description 1
- 235000013752 Rhizopus oryzae Nutrition 0.000 description 1
- 108010021006 Tyrothricin Proteins 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000006153 eosin methylene blue Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- GSXRBRIWJGAPDU-BBVRJQLQSA-N tyrocidine A Chemical compound C([C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N[C@H](CC=2C=CC=CC=2)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 GSXRBRIWJGAPDU-BBVRJQLQSA-N 0.000 description 1
- 229960003281 tyrothricin Drugs 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
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CN201310002837.5A CN103911305B (zh) | 2013-01-05 | 2013-01-05 | 卷曲乳杆菌菌株及其用途 |
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CN201310002837.5A CN103911305B (zh) | 2013-01-05 | 2013-01-05 | 卷曲乳杆菌菌株及其用途 |
Publications (2)
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CN103911305A CN103911305A (zh) | 2014-07-09 |
CN103911305B true CN103911305B (zh) | 2016-04-13 |
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104546947B (zh) * | 2014-09-30 | 2019-01-08 | 深圳华大基因科技有限公司 | 卷曲乳杆菌在治疗或预防类风湿性关节炎中的应用 |
CN104694413B (zh) * | 2014-11-21 | 2018-04-17 | 北京百益恒源科技有限公司 | 一株弯曲乳酸杆菌(Lactobacillus crispatus)及其制药用途 |
CN107794236B (zh) * | 2017-10-10 | 2022-10-18 | 内蒙古双奇药业股份有限公司 | 一种卷曲乳杆菌及其应用 |
CN107937324B (zh) * | 2018-01-10 | 2020-01-21 | 中国科学院微生物研究所 | 一株卷曲乳杆菌及其应用 |
CN108546663B (zh) * | 2018-05-10 | 2020-06-16 | 北京市农林科学院 | 一种猪源卷曲乳杆菌及其应用 |
CN109394796A (zh) * | 2018-12-06 | 2019-03-01 | 青岛东海药业有限公司 | 卷曲乳杆菌制剂及其应用 |
CN114480198A (zh) * | 2022-02-11 | 2022-05-13 | 西南大学 | 一株***卷曲乳杆菌及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556852A (zh) * | 2001-09-20 | 2004-12-22 | �����ɷ� | 作为人体***中的益生微生物的乳酸产生细菌 |
CN101048168A (zh) * | 2004-10-05 | 2007-10-03 | 普罗比公司 | 用于改善的***健康的益生菌乳杆菌属菌株 |
CN102727531A (zh) * | 2012-07-23 | 2012-10-17 | 郑州金森生物科技工程有限公司 | 一种对***炎具有治疗和预防作用的活性乳酸菌胶囊 |
-
2013
- 2013-01-05 CN CN201310002837.5A patent/CN103911305B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1556852A (zh) * | 2001-09-20 | 2004-12-22 | �����ɷ� | 作为人体***中的益生微生物的乳酸产生细菌 |
CN101048168A (zh) * | 2004-10-05 | 2007-10-03 | 普罗比公司 | 用于改善的***健康的益生菌乳杆菌属菌株 |
CN102727531A (zh) * | 2012-07-23 | 2012-10-17 | 郑州金森生物科技工程有限公司 | 一种对***炎具有治疗和预防作用的活性乳酸菌胶囊 |
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CN103911305A (zh) | 2014-07-09 |
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Effective date of registration: 20210908 Address after: 300451 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, Tianjin Development Zone, Binhai New Area, Tianjin Patentee after: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) Co.,Ltd. Patentee after: Zhejiang xinlifei Biotechnology Co.,Ltd. Address before: 300457 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, development zone, Binhai New Area, Tianjin Patentee before: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) Co.,Ltd. |
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Effective date of registration: 20231103 Address after: Room 707, 7th Floor, No. 48 Zijinghua Road (East Building), Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee after: Zhejiang xinlifei Biotechnology Co.,Ltd. Address before: 300451 s1316, 13th floor, experimental building, Tianjin International Biological Research Institute, No. 220, Dongting Road, Tianjin Development Zone, Binhai New Area, Tianjin Patentee before: XINLIFEI BIOMEDICAL TECHNOLOGY (TIANJIN) CO.,LTD. Patentee before: Zhejiang xinlifei Biotechnology Co.,Ltd. |
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Effective date of registration: 20231214 Address after: Room 206, 2nd Floor, Building 5, No. 368 Jinpeng Street, Sandun Town, Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee after: HANGZHOU HELI XINJIAN INDUSTRIAL Co.,Ltd. Address before: Room 707, 7th Floor, No. 48 Zijinghua Road (East Building), Xihu District, Hangzhou City, Zhejiang Province, 310000 Patentee before: Zhejiang xinlifei Biotechnology Co.,Ltd. |