CN103860424A - Tea tree essential oil whitening cream - Google Patents
Tea tree essential oil whitening cream Download PDFInfo
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- CN103860424A CN103860424A CN201410049285.8A CN201410049285A CN103860424A CN 103860424 A CN103860424 A CN 103860424A CN 201410049285 A CN201410049285 A CN 201410049285A CN 103860424 A CN103860424 A CN 103860424A
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Abstract
The invention discloses a tea tree essential oil whitening cream which is prepared from the following raw materials in percentage by weight according to a conventional method: 0.05-0.15 percent of tea tree essential oil, 2-4 percent of spermaceti wax, 4-8 percent of squalane, 6-10 percent of polyoxyethylene sorbitan laurate, 4-8 percent of sorbitol, 1-3 percent of dodecyl polyglucoside, 0.05-0.15 percent of skin whitening agent and the balance of water. The tea tree essential oil whitening cream can be used for effectively eliminating melanin of the skin and whitening the skin.
Description
Technical field:
The present invention relates to a kind of tea tree ethereal oil skin whitener.
Background technology:
Along with there is chromogenesis imbalance on the aging of population, environmental pollution, the increasing people's skin of global warning, the brown patch of skin, freckle have become serious skin puzzlement in recent years.Particularly after brown patch, freckle and Exposure to Sunlight, the black pigment on skin is calm can increase and produce, increase with the age, was more and more difficult to eliminate, thereby became the unavoidable worry of people simultaneously.Black pigment calm on skin is almost melanin entirely, in the melanosome in its melanocyte between epidermis and corium, produces, and the melanocyte of generation spreads to flanking cell by osmosis.
As everyone knows, skin color is mainly determined by melanic content in skin, and melanin can protect body to avoid ultraviolet injury, and melanin is synthesized by melanocyte.The biochemical reaction process occurring in melanocyte: fatty acid tyrosine, under the effect of tryrosinase, generates DOPA quinone, and it changes melanin into through red pigment and colourless pigment under the Oxidation of enzyme or non-enzyme, and this process is melanic main reason.Therefore, hinder or suppress the effect of tryrosinase in this reaction first stage, can suppress melanogenesis, so, seek and can hinder or the medicine of restraint of tyrosinase effect, to stoping or to suppress the melanocyte that generates because of tryrosinase effect very important.
Expect to occur a kind of skin whitener, can hinder tyrosinase activity, or act on each stage of melanin metabolic pathway, the generation of control, check melanin.
Summary of the invention:
For prior art above shortcomings, technical problem to be solved by this invention is to provide a kind of tea tree ethereal oil skin whitener.
A kind of tea tree ethereal oil skin whitener, adopts conventional method to be prepared from by following materials by weight percentage: tea tree ethereal oil 0.05-0.15%, spermaceti 2-4%, squalane 4-8%, polyoxyethylene sorbitan laurate 6-10%, sorbitol 4-8%, Dodecyl Polyglucosides 1-3%, skin-whitening agents 0.05-0.15%, surplus are water.
Described skin-whitening agents is Licochalcone A and/or verbascoside.
Described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Licochalcone A, English name: Licochalcone A, CAS accession number: 58749-22-7, can restraint of tyrosinase, can suppress again the oxidasic activity of dopachrome interconvertible enzyme and DHICA, having obvious removing free radical and antioxidation, is one whitening cosmetics additive fast and efficiently.
Verbascoside, English name: Acteoside, No. CAS: 61276-17-3, extract the fleshy stem of source for the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma, there is antioxidation, whitening, antidotal effect.
Obviously can also add in the present invention other raw materials, as chelating agen, antibacterial, antiseptic, pigment and essence etc.
Tea tree ethereal oil skin whitener of the present invention can adopt industry universal method to be prepared from, for example, can adopt following method: the oil phase that tea tree ethereal oil, spermaceti, squalane and polyoxyethylene sorbitan laurate are mixed is heated to 70 ℃; The water that sorbitol, Dodecyl Polyglucosides and water are mixed is heated to 70 ℃; Under agitation water is added in oil phase, be cooled to 50 ℃, add skin-whitening agents, stir and be cooled to room temperature, can make this tea tree ethereal oil skin whitener.Obviously, preparation method adopts known technology, is not innovation of the present invention.
Tea tree ethereal oil skin whitener of the present invention can effectively be eliminated the melanin on skin, skin whitening.
The specific embodiment:
In the present invention, if no special instructions, each raw material is all take working substance content as 100%.
Embodiment 1
Composition of raw materials (percentage by weight): tea tree ethereal oil 0.1%, spermaceti 3%, squalane 6%, polyoxyethylene sorbitan laurate 8%, sorbitol 6%, Dodecyl Polyglucosides 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is Licochalcone A.
The oil phase that tea tree ethereal oil, spermaceti, squalane and polyoxyethylene sorbitan laurate are mixed is heated to 70 ℃; The water that sorbitol, Dodecyl Polyglucosides and water are mixed is heated to 70 ℃; Under agitation water is added in oil phase, be cooled to 50 ℃, add skin-whitening agents, stir and be cooled to room temperature, can make this tea tree ethereal oil skin whitener.
Embodiment 2
Composition of raw materials (percentage by weight): tea tree ethereal oil 0.1%, spermaceti 3%, squalane 6%, polyoxyethylene sorbitan laurate 8%, sorbitol 6%, Dodecyl Polyglucosides 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is verbascoside.
The oil phase that tea tree ethereal oil, spermaceti, squalane and polyoxyethylene sorbitan laurate are mixed is heated to 70 ℃; The water that sorbitol, Dodecyl Polyglucosides and water are mixed is heated to 70 ℃; Under agitation water is added in oil phase, be cooled to 50 ℃, add skin-whitening agents, stir and be cooled to room temperature.
Embodiment 3
Composition of raw materials (percentage by weight): tea tree ethereal oil 0.1%, spermaceti 3%, squalane 6%, polyoxyethylene sorbitan laurate 8%, sorbitol 6%, Dodecyl Polyglucosides 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is the mixture of 80% Licochalcone A and 20% verbascoside.
The oil phase that tea tree ethereal oil, spermaceti, squalane and polyoxyethylene sorbitan laurate are mixed is heated to 70 ℃; The water that sorbitol, Dodecyl Polyglucosides and water are mixed is heated to 70 ℃; Under agitation water is added in oil phase, be cooled to 50 ℃, add skin-whitening agents, stir and be cooled to room temperature.
Comparative example 1
Composition of raw materials and preparation method are substantially the same manner as Example 1, and difference is only: in composition of raw materials, do not add any skin-whitening agents.
Test case 1
Phosphate buffer (PBS) with 0.2mol/L pH=6.8 is prepared respectively:
Sample solution 1: the solution that Licochalcone A concentration is 0.2mg/ml;
Sample solution 2: the solution that verbascoside concentration is 0.2mg/ml;
Sample solution 3: Licochalcone A concentration is the mixed solution that 0.16mg/ml and verbascoside concentration are 0.04mg/ml;
In the sample solution of 0.9ml, add the phosphate buffer (PBS) of 1mlL-tyrosine (0.3mol) and 1ml pH=6.8, preheating 10 minutes in 37 ℃ of thermostatic water bath, add again 0.1ml tryrosinase aqueous solution (1.0mg/ml, mcllvains buffer), fully stir, after 15 minutes, measure 475nm absorbance (D1) 37 ℃ of reactions.In addition, replace style solution to carry out same reaction with above-mentioned phosphate buffer, record absorbance (D2).In order to contrast, do not adding under the condition of sample solution and tryrosinase, record absorbance (D3).Calculate tyrosinase activity suppression ratio with following formula.
Tyrosinase activity suppression ratio (%)=(D2-D1)/(D2-D3) × 100
Table 1: tyrosinase activity suppression ratio test chart
| ? | Tyrosinase activity suppression ratio, % |
| Sample solution 1 (Licochalcone A) | 60.2 |
| Sample solution 2 (verbascoside) | 32.5 |
| Sample solution 3 (80% Licochalcone A+20% verbascoside) | 64.8 |
As seen from the above table, all effective restraint of tyrosinase activity of Licochalcone A and verbascoside, play whitening effect.By composite to Licochalcone A and verbascoside, tyrosinase activity suppression ratio surprisingly improves, whitening effect Synergistic.
Test case 2:
Experimental selection female volunteers, measures melanin content in human body skin, and the white-skinned face function of skin whitener product is evaluated.
Adopt MEXAMETER MX18 skin pigment instrument using first 1 day of skin whitener and using continuously skin whitener within 14 days, to measure afterwards the melanin content of its hand skin.Measure environment: test environment temperature (22 ± 1) ℃, humidity (50 ± 5) %, averages.Study subject uses skin whitener product one time every day, and using method is: after clean hand skin, dry, skin whitener is spread upon on hand skin with hands.Study subject does not use other whitening products at test period.Measure numerical value higher, illustrate that in skin, melanin content is higher.
Melanin reduction rate=(use the skin whitener melanin content of first 1 day-use continuously skin whitener after 14 days melanin content) ÷ uses skin whitener melanin content × 100% of first 1 day.
Melanin reduction rate is higher, illustrates that whitening effect is more obvious.
Table 2: test data table
| ? | Melanin reduction rate, % |
| Embodiment 1 | 11.1 |
| Embodiment 2 | 6.3 |
| Embodiment 3 | 11.8 |
| Comparative example 1 | 1.8 |
As seen from the above table, in skin whitener, add Licochalcone A and verbascoside and all have good whitening effect.By Licochalcone A with verbascoside is composite is added in skin whitener, whitening effect Synergistic, its mechanism needs the further Exploration and Research of inventor.
Claims (3)
1. a tea tree ethereal oil skin whitener, adopts conventional method to be prepared from by following materials by weight percentage: tea tree ethereal oil 0.05-0.15%, spermaceti 2-4%, squalane 4-8%, polyoxyethylene sorbitan laurate 6-10%, sorbitol 4-8%, Dodecyl Polyglucosides 1-3%, skin-whitening agents 0.05-0.15%, surplus are water.
2. tea tree ethereal oil skin whitener claimed in claim 1, is characterized in that, described skin-whitening agents is Licochalcone A and/or verbascoside.
3. tea tree ethereal oil skin whitener as claimed in claim 2, is characterized in that, described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049285.8A CN103860424A (en) | 2014-02-13 | 2014-02-13 | Tea tree essential oil whitening cream |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049285.8A CN103860424A (en) | 2014-02-13 | 2014-02-13 | Tea tree essential oil whitening cream |
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| CN103860424A true CN103860424A (en) | 2014-06-18 |
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| CN201410049285.8A Withdrawn CN103860424A (en) | 2014-02-13 | 2014-02-13 | Tea tree essential oil whitening cream |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107890440A (en) * | 2017-11-20 | 2018-04-10 | 南宁科城汇信息科技有限公司 | A kind of skin whitener containing Chinese juniper wood polyphenol powde and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103099756A (en) * | 2013-02-01 | 2013-05-15 | 深圳市瓜芬生物科技有限公司 | Acne-removing and anti-allergic cosmetic cream and preparation method thereof |
| CN103284917A (en) * | 2013-06-08 | 2013-09-11 | 上海巴方精细化工有限公司 | Rose essential oil bath salt |
-
2014
- 2014-02-13 CN CN201410049285.8A patent/CN103860424A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103099756A (en) * | 2013-02-01 | 2013-05-15 | 深圳市瓜芬生物科技有限公司 | Acne-removing and anti-allergic cosmetic cream and preparation method thereof |
| CN103284917A (en) * | 2013-06-08 | 2013-09-11 | 上海巴方精细化工有限公司 | Rose essential oil bath salt |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107890440A (en) * | 2017-11-20 | 2018-04-10 | 南宁科城汇信息科技有限公司 | A kind of skin whitener containing Chinese juniper wood polyphenol powde and preparation method thereof |
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Application publication date: 20140618 |