CN103845233A - Sea buckthorn oil whitening cream - Google Patents
Sea buckthorn oil whitening cream Download PDFInfo
- Publication number
- CN103845233A CN103845233A CN201410049232.6A CN201410049232A CN103845233A CN 103845233 A CN103845233 A CN 103845233A CN 201410049232 A CN201410049232 A CN 201410049232A CN 103845233 A CN103845233 A CN 103845233A
- Authority
- CN
- China
- Prior art keywords
- skin
- percent
- oleum hippophae
- sea buckthorn
- licochalcone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a sea buckthorn oil whitening cream. The cream is prepared from the following raw materials in percentage by weight by a conventional method: 0.05-0.15 percent of sea buckthorn oil, 2-4 percent of maize germ oil, 4-8 percent of squalane, 6-10 percent of isooctyl stearate, 4-8 percent of sorbitol, 1-3 percent of sodium bis-(2-ethylhexyl) sulfosuccinate, 0.05-0.15 percent of skin lightening agent, and the balance of water. The sea buckthorn oil whitening cream can be used for effectively eliminating melanin on skin and lightening skin.
Description
Technical field:
The present invention relates to a kind of Oleum Hippophae skin whitener.
Background technology:
Along with there is chromogenesis imbalance on the aging of population, environmental pollution, the increasing people's skin of global warning, the brown patch of skin, freckle have become serious skin puzzlement in recent years.Particularly after brown patch, freckle and Exposure to Sunlight, the black pigment on skin is calm can increase and produce, increase with the age, was more and more difficult to eliminate, thereby became the unavoidable worry of people simultaneously.Black pigment calm on skin is almost melanin entirely, in the melanosome in its melanocyte between epidermis and corium, produces, and the melanocyte of generation spreads to flanking cell by osmosis.
As everyone knows, skin color is mainly determined by melanic content in skin, and melanin can protect body to avoid ultraviolet injury, and melanin is synthesized by melanocyte.The biochemical reaction process occurring in melanocyte: fatty acid tyrosine, under the effect of tryrosinase, generates DOPA quinone, and it changes melanin into through red pigment and colourless pigment under the Oxidation of enzyme or non-enzyme, and this process is melanic main reason.Therefore, hinder or suppress the effect of tryrosinase in this reaction first stage, can suppress melanogenesis, so, seek and can hinder or the medicine of restraint of tyrosinase effect, to stoping or to suppress the melanocyte that generates because of tryrosinase effect very important.
Expect to occur a kind of skin whitener, can hinder tyrosinase activity, or act on each stage of melanin metabolic pathway, the generation of control, check melanin.
Summary of the invention:
For prior art above shortcomings, technical problem to be solved by this invention is to provide a kind of Oleum Hippophae skin whitener.
A kind of Oleum Hippophae skin whitener, adopts conventional method to be prepared from by following materials by weight percentage: Oleum Hippophae 0.05-0.15%, Fructus Maydis oil 2-4%, squalane 4-8%, Ethylhexyl stearate 6-10%, sorbitol 4-8%, succinate sodium 2-ethylhexyl 1-3%, skin-whitening agents 0.05-0.15%, surplus are water.
Described skin-whitening agents is Licochalcone A and/or verbascoside.
Described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Licochalcone A, English name: Licochalcone A, CAS accession number: 58749-22-7, can restraint of tyrosinase, can suppress again the oxidasic activity of dopachrome interconvertible enzyme and DHICA, having obvious removing free radical and antioxidation, is one whitening cosmetics additive fast and efficiently.
Verbascoside, English name: Acteoside, No. CAS: 61276-17-3, extract the fleshy stem of source for the dry zone scale leaf of orobanchaceae plant cistanche Cistanche deserticola Y.C.Ma, there is antioxidation, whitening, antidotal effect.
Obviously can also add in the present invention other raw materials, as chelating agen, antibacterial, antiseptic, pigment and essence etc.
Oleum Hippophae skin whitener of the present invention can adopt industry universal method to be prepared from, for example, can adopt following method: the oil phase that Oleum Hippophae, Fructus Maydis oil, squalane and Ethylhexyl stearate are mixed is heated to 70 DEG C; The water that sorbitol, succinate sodium 2-ethylhexyl and water are mixed is heated to 70 DEG C; Under agitation water is added in oil phase, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature, can make this Oleum Hippophae skin whitener.Obviously, preparation method adopts known technology, is not innovation of the present invention.
Oleum Hippophae skin whitener of the present invention can effectively be eliminated the melanin on skin, skin whitening.
Detailed description of the invention:
In the present invention, if no special instructions, each raw material is all taking working substance content as 100%.
Embodiment 1
Composition of raw materials (percentage by weight): Oleum Hippophae 0.1%, Fructus Maydis oil 3%, squalane 6%, Ethylhexyl stearate 8%, sorbitol 6%, succinate sodium 2-ethylhexyl 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is Licochalcone A.
The oil phase that Oleum Hippophae, Fructus Maydis oil, squalane and Ethylhexyl stearate are mixed is heated to 70 DEG C; The water that sorbitol, succinate sodium 2-ethylhexyl and water are mixed is heated to 70 DEG C; Under agitation water is added in oil phase, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature, can make this Oleum Hippophae skin whitener.
Embodiment 2
Composition of raw materials (percentage by weight): Oleum Hippophae 0.1%, Fructus Maydis oil 3%, squalane 6%, Ethylhexyl stearate 8%, sorbitol 6%, succinate sodium 2-ethylhexyl 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is verbascoside.
The oil phase that Oleum Hippophae, Fructus Maydis oil, squalane and Ethylhexyl stearate are mixed is heated to 70 DEG C; The water that sorbitol, succinate sodium 2-ethylhexyl and water are mixed is heated to 70 DEG C; Under agitation water is added in oil phase, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature.
Embodiment 3
Composition of raw materials (percentage by weight): Oleum Hippophae 0.1%, Fructus Maydis oil 3%, squalane 6%, Ethylhexyl stearate 8%, sorbitol 6%, succinate sodium 2-ethylhexyl 2%, skin-whitening agents 0.1%, surplus are water.Described skin-whitening agents is the mixture of 80% Licochalcone A and 20% verbascoside.
The oil phase that Oleum Hippophae, Fructus Maydis oil, squalane and Ethylhexyl stearate are mixed is heated to 70 DEG C; The water that sorbitol, succinate sodium 2-ethylhexyl and water are mixed is heated to 70 DEG C; Under agitation water is added in oil phase, be cooled to 50 DEG C, add skin-whitening agents, stir and be cooled to room temperature.
Comparative example 1
Composition of raw materials and preparation method are substantially the same manner as Example 1, and difference is only: in composition of raw materials, do not add any skin-whitening agents.
Test case 1
Phosphate buffer (PBS) with 0.2mol/L pH=6.8 is prepared respectively:
Sample solution 1: the solution that Licochalcone A concentration is 0.2mg/ml;
Sample solution 2: the solution that verbascoside concentration is 0.2mg/ml;
Sample solution 3: Licochalcone A concentration is the mixed solution that 0.16mg/ml and verbascoside concentration are 0.04mg/ml;
In the sample solution of 0.9ml, add the phosphate buffer (PBS) of 1mlL-tyrosine (0.3mol) and 1ml pH=6.8, preheating 10 minutes in 37 DEG C of thermostatic water bath, add again 0.1ml tryrosinase aqueous solution (1.0mg/ml, mcllvains buffer), fully stir, after 15 minutes, measure 475nm absorbance (D1) 37 DEG C of reactions.In addition, replace style solution to carry out same reaction with above-mentioned phosphate buffer, record absorbance (D2).In order to contrast, do not adding under the condition of sample solution and tryrosinase, record absorbance (D3).Calculate tyrosinase activity suppression ratio with following formula.
Tyrosinase activity suppression ratio (%)=(D2-D1)/(D2-D3) × 100
Table 1: tyrosinase activity suppression ratio test chart
| ? | Tyrosinase activity suppression ratio, % |
| Sample solution 1 (Licochalcone A) | 60.2 |
| Sample solution 2 (verbascoside) | 32.5 |
| Sample solution 3 (80% Licochalcone A+20% verbascoside) | 64.8 |
As seen from the above table, all effective restraint of tyrosinase activity of Licochalcone A and verbascoside, play whitening effect.By composite to Licochalcone A and verbascoside, tyrosinase activity suppression ratio surprisingly improves, whitening effect Synergistic.
Test case 2:
Experimental selection female volunteers, measures melanin content in human body skin, and the white-skinned face function of skin whitener product is evaluated.
Adopt MEXAMETER MX18 skin pigment instrument using first 1 day of skin whitener and using continuously skin whitener within 14 days, to measure afterwards the melanin content of its hand skin.Measure environment: test environment temperature (22 ± 1) DEG C, humidity (50 ± 5) %, averages.Study subject uses skin whitener product one time every day, and using method is: after clean hand skin, dry, skin whitener is spread upon on hand skin with hands.Study subject does not use other whitening products at test period.Measure numerical value higher, illustrate that in skin, melanin content is higher.
Melanin reduction rate=(use the skin whitener melanin content of first 1 day-use continuously skin whitener after 14 days melanin content) ÷ uses skin whitener melanin content × 100% of first 1 day.
Melanin reduction rate is higher, illustrates that whitening effect is more obvious.
Table 2: test data table
| ? | Melanin reduction rate, % |
| Embodiment 1 | 12.2 |
| Embodiment 2 | 6.9 |
| Embodiment 3 | 12.9 |
| Comparative example 1 | 2.2 |
As seen from the above table, in skin whitener, add Licochalcone A and verbascoside and all have good whitening effect.By Licochalcone A with verbascoside is composite is added in skin whitener, whitening effect Synergistic, its mechanism needs the further Exploration and Research of inventor.
Claims (3)
1. an Oleum Hippophae skin whitener, adopts conventional method to be prepared from by following materials by weight percentage: Oleum Hippophae 0.05-0.15%, Fructus Maydis oil 2-4%, squalane 4-8%, Ethylhexyl stearate 6-10%, sorbitol 4-8%, succinate sodium 2-ethylhexyl 1-3%, skin-whitening agents 0.05-0.15%, surplus are water.
2. Oleum Hippophae skin whitener claimed in claim 1, is characterized in that, described skin-whitening agents is Licochalcone A and/or verbascoside.
3. Oleum Hippophae skin whitener as claimed in claim 2, is characterized in that, described skin-whitening agents is made up of following compositions in weight percentage: 70-90% Licochalcone A and 10-30% verbascoside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049232.6A CN103845233A (en) | 2014-02-13 | 2014-02-13 | Sea buckthorn oil whitening cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410049232.6A CN103845233A (en) | 2014-02-13 | 2014-02-13 | Sea buckthorn oil whitening cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103845233A true CN103845233A (en) | 2014-06-11 |
Family
ID=50853643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410049232.6A Withdrawn CN103845233A (en) | 2014-02-13 | 2014-02-13 | Sea buckthorn oil whitening cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103845233A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870541A (en) * | 2020-09-01 | 2020-11-03 | 江西建昌帮药业有限公司 | Herbal whitening compound composition, mask and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103284917A (en) * | 2013-06-08 | 2013-09-11 | 上海巴方精细化工有限公司 | Rose essential oil bath salt |
| CN103565675A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Nutritional sea-buckthorn vanishing cream |
-
2014
- 2014-02-13 CN CN201410049232.6A patent/CN103845233A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101394900A (en) * | 2006-02-28 | 2009-03-25 | 拜耳消费者保健股份公司 | Combination or plant extract comprising verbascoside and luteolin and their use in a cosmetically or pharmaceutical composition for pigmentation modulation |
| CN103284917A (en) * | 2013-06-08 | 2013-09-11 | 上海巴方精细化工有限公司 | Rose essential oil bath salt |
| CN103565675A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Nutritional sea-buckthorn vanishing cream |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870541A (en) * | 2020-09-01 | 2020-11-03 | 江西建昌帮药业有限公司 | Herbal whitening compound composition, mask and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103845235A (en) | Whitening cosmetic | |
| KR20180005162A (en) | Cosmetic composition for skin whitening and method for producing the same | |
| CN104146897A (en) | Cosmetic having effect of whitening | |
| JP5921056B2 (en) | Cosmetic composition | |
| EP2200574B1 (en) | Novel use of panduratin derivatives or extract of kaempferia pandurata comprising the same | |
| CN103845237A (en) | Whitening body lotion | |
| TW577748B (en) | External preparations for skin whitening | |
| KR101551243B1 (en) | Cosmetic Composition for Skin Whitening Having Fomes Fomentarius | |
| CN1794967B (en) | Whitening and antioxidative cosmetic composition containing resveratrol and method for preparing the same | |
| CN104666146A (en) | Application of noble dendrobium compound extract in cosmetic with whitening effect | |
| CN103845234A (en) | Hyaluronic acid whitening cream | |
| CN103860400A (en) | Vitamin e whitening cream | |
| CN104188887A (en) | Whitening composition and application thereof | |
| CN103845233A (en) | Sea buckthorn oil whitening cream | |
| CN106413687B (en) | Product and its preparation method and application containing gadol extract and ginkgo biloba extract | |
| CN103860413A (en) | Rose whitening cream | |
| CN103860424A (en) | Tea tree essential oil whitening cream | |
| CN108030711A (en) | Skin whitening care cosmetics | |
| CN103845236A (en) | Aloe whitening cream | |
| CN103860412A (en) | Skin-whitening hand cream | |
| KR101525090B1 (en) | Cosmetic Composition for skin Whitening | |
| CN103845271A (en) | Whitening skin care product | |
| KR101551240B1 (en) | Cosmetic Composition for Skin Whitening Having Kaempferia Parviflora | |
| CN103655351B (en) | Cinnamon essential oil bath salt | |
| JP2000191504A (en) | Cosmetic composition for whitening skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20140611 |
|
| WW01 | Invention patent application withdrawn after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140611 |
|
| RJ01 | Rejection of invention patent application after publication |