CN103843769A - Bactericidal composition containing fluopicolide and metalaxyl-m - Google Patents
Bactericidal composition containing fluopicolide and metalaxyl-m Download PDFInfo
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- CN103843769A CN103843769A CN201210516138.8A CN201210516138A CN103843769A CN 103843769 A CN103843769 A CN 103843769A CN 201210516138 A CN201210516138 A CN 201210516138A CN 103843769 A CN103843769 A CN 103843769A
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- metalaxyl
- fluopicolide
- bactericidal composition
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- composite bactericide
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Abstract
The invention relates to a compound bactericide. The effective components of the compound bactericide are fluopicolide and metalaxyl-m, wherein the mass percent ratio of fluopicolide to metalaxyl-m is (1-80): (80-1), and the content of fluopicolide and metalaxyl-m in the compound preparation is 1-80%. The compound bactericide provided by the invention can be prepared into such dosage forms as missible oil, wettable powder, water dispersible granules, emulsion in water, microemulsion or the like by a method known to those skilled in the art. The bactericidal composition provided by the invention is suitable for preventing and controlling a variety of diseases caused by oomycete fungi, such as downy mildew, loimia, phytophthora infestans, cataplexy, etc.
Description
Technical field
The present invention relates to the composite bactericide that a kind of pesticide field has synergistic effect, its active ingredient is fluopicolide and Metalaxyl-M.
Background technology
Fluopicolide, a kind of benzamide series bactericidal agent of Bayer Bitterfeld GmbH crop science company development, its English Fluopicolide by name, chemical name is: the chloro-5-trifluoromethyl-2-of the chloro-N-[(3-of 2,6-bis-pyridine radicals) methyl] benzamide.The common Oomycete diseases such as downy mildew, epidemic disease, late blight, damping off are had to outstanding preventive effect, to crop and Environmental security, be specially adapted to high-quality, green vegetables production.This product has good system conductivity and stronger thin layer penetration power, and the each Main Morphology of pathogen is all had to good inhibitory action, can provide comprehensively and protection lastingly for young leaves, stem, stem tuber, young fruit.Because medicament can absorb fast through blade face, thus resistance of rainwater washing against, for vegetables diseases prevention in rainy season provides reliable guarantee.
Metalaxyl-M, chemical name is: (R)-N-(2-methoxyl group acetyl group)-N-(2,6-xylyl)-2-methyl lactamine.
Metalaxyl-M is the R isomer of common metalaxyl, is a kind of efficient systemic fungicide.This product has protection and therapeutic action, and drug effect is high, residual low, has good Environmental compatibility, is a kind of systematic, has the bactericide of prevention and therapeutic efficiency.Metalaxyl-M has efficiently crop pests such as the vegetables due to Pseudoperonospora cubensis, phytophthora root rot bacterium, rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, grains.Higher 2 ~ 10 times than the drug effect of racemic metalaxyl, fast 2 times in degraded in soil, contribute to reduce dose and spraying times, increase spraying cycle, and increased safety to user and the compatibility with environment.Can make cauline leaf, seed and soil treatment.
Summary of the invention
Because weather is comparatively unusual in recent years, Changes in weather is too fast, causes corps diseases serious, and too much dispenser is that various sterilization agent produces resistance, and in view of the situation, the present invention proposes a kind of microbicide compositions with synergistic effect and delaying drug resistance appearance.
Bactericidal composition active ingredient of the present invention is fluopicolide and Metalaxyl-M, for preventing and treating the fungus-caused various diseases of Oomycete, as downy mildew, epidemic disease, late blight, damping off etc.
Bactericidal composition of the present invention is characterised in that, the mass ratio of its active ingredient fluopicolide and Metalaxyl-M is 1 ~ 50:50 ~ 1.
Bactericidal composition of the present invention is characterised in that, playing an active ingredient fluopicolide is 1 ~ 30:30 ~ 1 with the preferred mass ratio of Metalaxyl-M.
In bactericidal composition of the present invention, the gross mass content of fluopicolide and Metalaxyl-M is 1 ~ 80%.
Bactericidal composition of the present invention adopts method known in those skilled in the art, can be prepared into the formulations such as suspending agent, wetting powder, water dispersible granules, aqueous emulsion.
Technical solution of the present invention is as follows:
Technical scheme one under the present invention, affiliated bactericidal composition is wetting powder:
Fluopicolide 1 ~ 50%
Metalaxyl-M 1 ~ 50%
Dispersant 3 ~ 20%
Wetting agent 3 ~ 10%
Filler surplus
The concrete procedure of processing of this bactericidal composition wetting powder is: by above-mentioned formula, fluopicolide and Metalaxyl-M and dispersant, wetting agent and filler are mixed, uniform stirring in stirred tank, after airslide disintegrating mill, mixing, can be made into the wetting powder of the present composition.
Two of technical scheme of the present invention, described bactericidal composition is suspending agent, the percentage by weight of component is:
Fluopicolide 1 ~ 50%
Metalaxyl-M 1 ~ 50%
Dispersant 5～20%
Antifreezing agent 1～5%
Thickener 0.1～2%
Defoamer 0.1～0.8%
Water surplus
The concrete production stage of this suspending agent is for first mixing other auxiliary agents, mix through high speed shear, add fluopicolide and Metalaxyl-M, abrading-ball 2 ~ 3 hours in ball crusher, make a diameter all below 5 μ m, make the suspending agent preparation of the bactericidal composition that contains fluopicolide and Metalaxyl-M of the present invention.
Three of technical scheme of the present invention, described bactericidal composition is aqueous emulsion, the percentage by weight of component is:
Fluopicolide 1 ~ 50%
Metalaxyl-M 1 ~ 50%
Emulsifier 3～30%
Solvent 5～15%
Stabilizing agent 2～15%
Antifreezing agent 1～5%
Defoamer 0.1～8%
Thickener 0.2～2%
Water surplus
The concrete production stage of this aqueous emulsion is: first former medicine fluopicolide and Metalaxyl-M, solvent and emulsifier, cosolvent are added together, make to be dissolved into uniform oil phase; By part water, antifreeze, other the insecticides adjuvant such as antimicrobial mixes into uniform water; When reactor high speed stirs, oil phase is added to water, slowly add water until reach phase inversion point, open clipper and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type.Make the aqueous emulsion of the bactericidal composition that contains fluopicolide and Metalaxyl-M.
Four of technical scheme of the present invention, described bactericidal composition is water dispersible granules, the percentage by weight of component is:
Fluopicolide 1 ~ 50%
Metalaxyl-M 1 ~ 50%
Dispersant 3 ~ 20%
Wetting agent 3 ~ 10%
Disintegrant 2 ~ 5%
Filler surplus
The concrete procedure of processing of this bactericidal composition water dispersible granules is: by above-mentioned formula, fluopicolide, Metalaxyl-M and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, then add and in fluidized bed prilling dryer, carry out after granulation, dry, screening, through sample analysis, making the water dispersible granules of the bactericidal composition that contains fluopicolide and Metalaxyl-M of the present invention.
Described emulsifier is selected from any one or more mixtures with arbitrary proportion composition in calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether.
Described solvent is any one or more mixed solvents with arbitrary proportion composition in dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), water equal solvent.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Described wetting agent is selected from: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., one or more in wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol.
Described stabilizing agent is selected from: the one in sodium citrate, resorcinol.
Described antifreezing agent is selected from: one or more in ethylene glycol, propane diols, glycerine.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more in aliphatic alcohols compound.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for bactericide resistance.Have prevention and protective effect simultaneously concurrently, because medicament has good system conductivity, therefore can produce good protective effect to crops.
Bactericidal composition of the present invention is applicable to by the germ various diseases of Oomycete, as: late blight morning, damping off and the black shank etc. of the downy mildew of melon and fruit, vegetables, epidemic disease, potato.
Embodiment
For making technical solutions according to the invention more clear, be illustrated with specific embodiment, but the present invention is not limited only to these examples.
Different farm chemical ingredients being carried out composite, is to solve at present some in using of some single doses comparatively effectively and mode efficiently.The agricultural of different types of structure is carried out composite conventionally there will be afterwards three kinds of type of action, i.e. antagonism, summation action and synergistic effect.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for bactericide resistance.Have prevention and protective effect simultaneously concurrently, after dispenser, can produce obvious production-increasing function.
Test 1: fluopicolide and Metalaxyl-M are composite to be tested cucumber downy mildew control efficiency
Indoor inhibitory effect assay method: adopt growth rate method to measure the inhibitory action of bactericidal composition to bacterium of downy mildew of cucumber.The cucumber cream mold of cultivating 4d from the PDA medium mycelia piece that cut-off footpath, edge is 5mm that falls is inoculated into respectively on the PDA culture medium flat plate containing variable concentrations bactericide, constant temperature culture at 28 DEG C, not contain medicament flat board as blank, after 4d, measure the colony diameter of each processing, calculate the inhibition percentage of medicament to mycelial growth.Carry out regression analysis by the logarithm of each treatment dosage and the probability value of mycelial growth inhibition rate, calculate various bactericide to concentration (EC50) in the inhibition of cucumber downy mildew, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
When CTC≤80, composition performance is for antagonism, and as 80 < CTC < 120, composition performance is for summation action, and when CTC >=120, composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) × 100
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100
Table 1 is respectively processed the Toxicity Determination result to bacterium of downy mildew of cucumber
| Process | EC 50（μg/ML） | ATI | TTI | Poison system (CTC) altogether |
| Fluopicolide (A) | 2.17 | 100.0 | —— | —— |
| Metalaxyl-M (B) | 5.91 | 36.27 | —— | —— |
| A:B(1:15) | 2.58 | 84.11 | 40.67 | 206.8 |
| A:B(1:10) | 1.87 | 116.0 | 42.47 | 273.2 |
| A:B(1:5) | 1.69 | 128.4 | 47.26 | 271.7 |
| A:B(5:1) | 1.18 | 183.9 | 89.45 | 205.6 |
| A:B(10:1) | 1.08 | 200.9 | 94.25 | 213.2 |
Measurement result shows, fluopicolide and Metalaxyl-M are between 1 ~ 15:10 ~ 1 time in proportioning, have obvious synergistic effect, at fluopicolide and Metalaxyl-M at 1:10 are especially, and synergistic effect is especially obvious, and co-toxicity coefficient reaches 273.2.
Test that 2 fluopicolides and Metalaxyl-M are composite to be tested tomato late blight control efficiency
Test adopts percentage mycelial inhibition assay method, measure fluopicolide and Metalaxyl-M is composite and single dose for the control efficiency of tomato late blight.The medicine of different disposal is made into 5 variable concentrations gradients with sterile water, on aseptic working platform, drawing 1ml liquid (taking clear water as contrast) with suction pipe joins in 8cm culture dish, add the rear about 50-60PDA medium of 9ml fusing with syringe again, liquid is evenly mixed with medium, be cooled to room temperature, then, to the tomato late blight germ piece of inoculating diameter 5mm in culture dish, in 25 DEG C of incubators, cultivate 5 ~ 7d, cover with after culture dish until contrast, with right-angled intersection method measurement colony diameter.In triplicate, average, calculate the percentage mycelial inhibition of medicament.
Percentage mycelial inhibition (%)=[(contrast colony diameter-processing colony diameter)/contrast colony diameter] × 100
Calculate concentration EC in inhibition according to above publicity
50, then calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun.
When CTC≤80, composition performance is for antagonism, and as 80 < CTC < 120, composition performance is for summation action, and when CTC >=120, composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) × 100
The percentage composition of B in percentage composition+B medicament toxicity index × mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
Co-toxicity coefficient (CTC)=[the theoretical toxicity index of mixture actual measurement toxicity index (ATI)/mixture (TTI)] × 100
Table 2 different disposal is to tomato late blight Toxicity Determination result
| Process | EC 50（μg/ML） | ATI | TTI | Poison system (CTC) altogether |
| Fluopicolide (A) | 0.25 | 100.0 | —— | —— |
| Metalaxyl-M (B) | 0.38 | 65.79 | —— | —— |
| A:B(1:15) | 0.13 | 192.3 | 67.93 | 283.1 |
| A:B(1:10) | 0.11 | 227.3 | 68.90 | 329.9 |
| A:B(1:5) | 0.08 | 312.5 | 71.49 | 437.1 |
| A:B(5:1) | 0.12 | 208.3 | 94.30 | 220.9 |
| A:B(10:1) | 0.14 | 178.9 | 96.89 | 184.3 |
Measurement result shows, measurement result shows, fluopicolide and Metalaxyl-M are between 1 ~ 15:10 ~ 1 time in proportioning, there is obvious synergistic effect for tomato late blight, especially at fluopicolide and Metalaxyl-M during at 1:5, synergistic effect is especially obvious, and co-toxicity coefficient reaches 437.1.
In sum, the bactericidal composition that contains fluopicolide and Metalaxyl-M of the present invention has obvious synergistic effect for the fungus-caused disease of Oomycete, has larger dissemination.
Claims (6)
1. a bactericidal composition that contains fluopicolide and Metalaxyl-M.
2. composite bactericide according to claim 1, is characterized in that: the mass ratio of fluopicolide and Metalaxyl-M is 1 ~ 50:50 ~ 1.
3. composite bactericide according to claim 1, is characterized in that: fluopicolide is 1 ~ 30:30 ~ 1 with the quality optimization ratio of Metalaxyl-M.
4. composite bactericide according to claim 1, is characterized in that: active ingredient fluopicolide and the Metalaxyl-M total mass ratio in composition is 1 ~ 80%.
5. according to the composite bactericide of claim 1 majority, it is characterized in that: adopt the known technical scheme of those skilled in the art can be prepared into the formulations such as suspending agent, wetting powder, water dispersible granules, aqueous emulsion.
6. composite bactericide according to claim 1, is characterized in that: bactericidal composition of the present invention can be for control by the fungus-caused various diseases of Oomycete, as downy mildew, epidemic disease, late blight, damping off etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210516138.8A CN103843769A (en) | 2012-12-06 | 2012-12-06 | Bactericidal composition containing fluopicolide and metalaxyl-m |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210516138.8A CN103843769A (en) | 2012-12-06 | 2012-12-06 | Bactericidal composition containing fluopicolide and metalaxyl-m |
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|---|---|
| CN103843769A true CN103843769A (en) | 2014-06-11 |
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|---|---|---|---|
| CN201210516138.8A Pending CN103843769A (en) | 2012-12-06 | 2012-12-06 | Bactericidal composition containing fluopicolide and metalaxyl-m |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104472494A (en) * | 2014-11-24 | 2015-04-01 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
| CN114931139A (en) * | 2022-07-27 | 2022-08-23 | 北京金泰毅农作物科技有限公司 | Plant disease control composition containing fluopicolide and metalaxyl-M and application thereof |
-
2012
- 2012-12-06 CN CN201210516138.8A patent/CN103843769A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104472494A (en) * | 2014-11-24 | 2015-04-01 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
| CN114931139A (en) * | 2022-07-27 | 2022-08-23 | 北京金泰毅农作物科技有限公司 | Plant disease control composition containing fluopicolide and metalaxyl-M and application thereof |
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Application publication date: 20140611 |