CN102246760A - Bactericidal composition containing fluopicolide and metalaxyl - Google Patents
Bactericidal composition containing fluopicolide and metalaxyl Download PDFInfo
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- CN102246760A CN102246760A CN2011102481178A CN201110248117A CN102246760A CN 102246760 A CN102246760 A CN 102246760A CN 2011102481178 A CN2011102481178 A CN 2011102481178A CN 201110248117 A CN201110248117 A CN 201110248117A CN 102246760 A CN102246760 A CN 102246760A
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- metalaxyl
- bactericidal composition
- bacterium amine
- fluorine pyrrole
- pyrrole bacterium
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Abstract
The invention relates to a complex bactericide, which comprises the following active ingredients in percentage by mass: 1 to 80 percent of fluopicolide and 80 to 1 percent of metalaxyl, wherein the content of the fluopicolide and the metalaxyl in the complex preparation is between 1 and 80 percent. The complex bactericide can be prepared into formulations such as a suspending agent, wettable powder, water dispersible granules, aqueous emulsion, microemulsion and the like by a method known by technical personnel in the field. The bactericidal composition can be used for preventing and controlling various diseases such as downy mildew, epidemic diseases, late blight, cataplexy and the like which are caused by oomycete fungi.
Description
Technical field:
The present invention relates to the composite bactericide that a kind of pesticide field has synergistic effect, its active ingredient is fluorine pyrrole bacterium amine and Metalaxyl-M.
Background technology:
Fluorine pyrrole bacterium amine, a kind of benzamide series bactericidal agent of Bayer crop science company development, its English Fluopicolide by name, chemical name is: 2,6-two chloro-N-[(3-chloro-5-trifluoromethyl-2-pyridine radicals) methyl] benzamide.Common Oomycete diseases such as downy mildew, eqpidemic disease, late blight, damping off are had outstanding preventive effect,, be specially adapted to high-quality, green vegetables production crop and Environmental security.This product has good system's conductivity and stronger thin layer penetration power, and each main form of pathogen is all had good inhibitory effect, can provide comprehensively and lasting protection for young leaves, stem, stem tuber, young fruit.Because medicament can be through the blade face fast Absorption, thus resistance of rainwater washing against, for vegetables diseases prevention in rainy season provides reliable guarantee.Its structural formula is:
Metalaxyl-M, chemical name is: (R)-N-(2-methoxyl group acetyl group)-N-(2, the 6-xylyl)-2-methyl lactamine.Structural formula is as follows:
Metalaxyl-M is the R isomer of common metalaxyl, is a kind of efficient systemic fungicide.This product has protection and therapeutic action, and drug effect height, residual low has good Environmental compatibility, is a kind of systematic, has the bactericide of prevention and therapeutic efficiency.Metalaxyl-M has efficiently crop pests such as the vegetables due to Pseudoperonospora cubensis, phytophthora root rot bacterium, the rotten mildew fungus, fruit tree, tobacco, oil plant, cotton, grains.Higher 2～10 times than the drug effect of racemic metalaxyl, fast 2 times in degraded in soil, help to reduce dose and spraying times, increase spraying cycle, and increased to user's safety and with the compatibility of environment.Can make cauline leaf, seed and soil treatment.
Summary of the invention:
Because weather is comparatively unusual in recent years, Changes in weather is too fast, causes corps diseases serious, and too much dispenser is that the various sterilization agent produces resistance, and in view of the situation, the present invention proposes a kind of microbicide compositions with synergistic effect and delaying drug resistance appearance.
Bactericidal composition active ingredient of the present invention is fluorine pyrrole bacterium amine and Metalaxyl-M, is used to prevent and treat the fungus-caused various diseases of Oomycete, as downy mildew, eqpidemic disease, late blight, damping off etc.
Bactericidal composition of the present invention is characterised in that the mass ratio of its active ingredient fluorine pyrrole bacterium amine and Metalaxyl-M is 1～50: 50～1.
Bactericidal composition of the present invention is characterised in that an active ingredient fluorine pyrrole bacterium amine is 1～30: 30～1 with the preferred mass ratio of Metalaxyl-M.
The gross mass content of fluorine pyrrole bacterium amine and Metalaxyl-M is 1～80% in the bactericidal composition of the present invention.
Bactericidal composition of the present invention adopts method known in those skilled in the art, can be prepared into formulations such as suspending agent, wetting powder, water dispersible granules, aqueous emulsion.
Technical solution of the present invention is as follows:
Technical scheme one under the present invention, affiliated bactericidal composition is a wetting powder:
The concrete procedure of processing of this bactericidal composition wetting powder is: press above-mentioned prescription with fluorine pyrrole bacterium amine and Metalaxyl-M and dispersant, wetting agent and filler mixing, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder of the present composition.
Two of technical scheme of the present invention, described bactericidal composition are suspending agent, and the percentage by weight of component is:
The concrete production stage of this suspending agent is earlier other auxiliary agents to be mixed, mix through high speed shear, add fluorine pyrrole bacterium amine and Metalaxyl-M, abrading-ball is 2～3 hours in ball crusher, make a diameter all below 5 μ m, make the suspending agent preparation that contains the bactericidal composition of fluorine pyrrole bacterium amine and Metalaxyl-M of the present invention.
Three of technical scheme of the present invention, described bactericidal composition are aqueous emulsion, and the percentage by weight of component is:
The concrete production stage of this aqueous emulsion is: at first former medicine fluorine pyrrole bacterium amine is added with Metalaxyl-M, solvent and emulsifier, cosolvent and be in the same place, make and be dissolved into uniform oil phase; With part water, antifreeze, other insecticides adjuvant such as antimicrobial mixes into uniform water; When the reactor high speed stirs, oil phase is added water, slowly add water, open clipper and carry out high speed shear, and add remaining water, shear half an hour approximately, form the aqueous emulsion of oil-in-water type until reaching the phase inversion point.Promptly make the aqueous emulsion of the bactericidal composition that contains fluorine pyrrole bacterium amine and Metalaxyl-M.
Four of technical scheme of the present invention, described bactericidal composition are water dispersible granules, and the percentage by weight of component is:
The concrete procedure of processing of this bactericidal composition water dispersible granules is: by above-mentioned prescription fluorine pyrrole bacterium amine, Metalaxyl-M and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis makes the water dispersible granules that contains the bactericidal composition of fluorine pyrrole bacterium amine and Metalaxyl-M of the present invention.
Described emulsifier is selected from any one or more mixtures formed with arbitrary proportion in calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styryl phenol APEO, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, the polyoxyethylene aliphatic alcohol ether.
Described solvent is any one or more mixed solvents formed with arbitrary proportion in dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), the water equal solvent.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
Described wetting agent is selected from: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., among the wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described stabilizing agent is selected from: a kind of in sodium citrate, the resorcinol.
Described antifreezing agent is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20Saturated fat acid compounds, C
8-10In the aliphatic alcohols compound one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for the bactericide resistance.Have prevention and protective effect simultaneously concurrently,, therefore can produce good protective action crops because medicament has good system's conductivity.
Bactericidal composition of the present invention is applicable to by the germ various diseases of Oomycete, as: late blight morning, damping off and the black shank etc. of the downy mildew of melon and fruit, vegetables, eqpidemic disease, potato.
Embodiment:
For making technical solutions according to the invention more clear, be illustrated with specific embodiment, but the present invention is not limited only to these examples.
Different farm chemical ingredients being carried out composite, is to solve some single agent some in using modes comparatively effectively and efficiently at present.The agricultural of different types of structure is carried out composite can occur usually afterwards three kinds of type of action, i.e. antagonism, summation action and synergistic effect.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for the bactericide resistance.Have prevention and protective effect simultaneously concurrently, after dispenser, can produce tangible production-increasing function.
Test 1: fluorine pyrrole bacterium amine and Metalaxyl-M are composite to be tested the cucumber downy mildew control efficiency
Indoor inhibitory effect assay method: adopt growth rate method to measure the inhibitory action of bactericidal composition to bacterium of downy mildew of cucumber.The cucumber cream mold of cultivating 4d from the PDA medium edge cut-off that falls directly is inoculated into respectively on the PDA culture medium flat plate that contains the variable concentrations bactericide for the mycelia piece of 5mm, 28 ℃ of following constant temperature culture, not contain the medicament flat board is blank, measure the colony diameter that each is handled behind the 4d, calculate the inhibition percentage of medicament mycelial growth.Carry out regression analysis by the logarithm of each treatment dosage and the probability value of mycelial growth inhibition rate, calculate various bactericide, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again concentration (EC50) in the inhibition of cucumber downy mildew.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Each processing of table 1 is to the Toxicity Determination result of bacterium of downy mildew of cucumber
Measurement result shows that fluorine pyrrole bacterium amine and Metalaxyl-M are 1～15 in proportioning: in the time of between 10～1, have obvious synergistic effect, especially at fluorine pyrrole bacterium amine and Metalaxyl-M at 1: 10th,, synergistic effect is especially obvious, co-toxicity coefficient reaches 273.2.
Test that 2 fluorine pyrrole bacterium amine and Metalaxyl-M are composite to be tested the tomato late blight control efficiency
The percentage mycelial inhibition assay method is adopted in test, measures fluorine pyrrole bacterium amine and the composite and single agent of the Metalaxyl-M control efficiency for tomato late blight.The medicine of different disposal is made into 5 variable concentrations gradients with sterile water, drawing 1ml soup (is contrast with the clear water) with suction pipe on aseptic workbench joins in the 8cm culture dish, add the about 50-60PDA medium in 9ml fusing back with syringe again, soup is evenly mixed with medium, be cooled to room temperature, the tomato late blight germ piece of inoculation diameter 5mm in culture dish is cultivated 5～7d in 25 ℃ of incubators then, after treating that culture dish is covered with in contrast, measure colony diameter with the right-angled intersection method.Triplicate is averaged, and calculates the percentage mycelial inhibition of medicament.
Percentage mycelial inhibition (%)=[(contrast colony diameter-processing colony diameter)/contrast colony diameter] * 100
Calculate concentration EC in the inhibition according to above publicity
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Table 2 different disposal is to tomato late blight Toxicity Determination result
Measurement result shows that measurement result shows that fluorine pyrrole bacterium amine and Metalaxyl-M are 1～15 in proportioning: in the time of between 10～1, has obvious synergistic effect for tomato late blight, especially at fluorine pyrrole bacterium amine and Metalaxyl-M at 1: 5 o'clock, synergistic effect is especially obvious, co-toxicity coefficient reaches 437.1.
In sum, the bactericidal composition that contains fluorine pyrrole bacterium amine and Metalaxyl-M of the present invention has obvious synergistic effect for the fungus-caused disease of Oomycete, has bigger dissemination.
Claims (4)
1. pesticide sterilizing composite preparation, it is characterized in that: this bactericidal composition preparation is to be that two yuan of carrying out of active ingredient are composite with fluorine pyrrole bacterium amine and Metalaxyl-M, all the other are auxiliary agent and complementary component, and wherein the mass ratio of active ingredient fluorine pyrrole bacterium amine and Metalaxyl-M is 1 ~ 50:50 ~ 1 in this bactericidal composition preparation.
2. bactericidal composition preparation according to claim 1 is characterized in that: the mass ratio of active ingredient fluorine pyrrole bacterium amine and Metalaxyl-M 1 ~ 30:30 ~ 1 more preferably in this Pesticidal combination preparation.
3. bactericidal composition preparation according to claim 1 and 2 is characterized in that: this Pesticidal combination preparation active ingredient fluorine pyrrole bacterium amine and the total mass ratio of Metalaxyl-M in composition are 1 ~ 80%.
4. bactericidal composition preparation according to claim 3 is characterized in that: the preparation formulation that this Pesticidal combination preparation can be prepared into is wetting powder, suspending agent, soluble liquid, aqueous emulsion and water dispersible granules.
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| CN2011102481178A CN102246760A (en) | 2011-04-30 | 2011-08-26 | Bactericidal composition containing fluopicolide and metalaxyl |
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| CN201110120626.2 | 2011-04-30 | ||
| CN2011102481178A CN102246760A (en) | 2011-04-30 | 2011-08-26 | Bactericidal composition containing fluopicolide and metalaxyl |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102763646A (en) * | 2012-06-30 | 2012-11-07 | 广东中迅农科股份有限公司 | Metalaxyl emulsion in water and preparation method of metalaxyl emulsion in water |
| CN104381266A (en) * | 2014-09-25 | 2015-03-04 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
| CN104472497A (en) * | 2014-11-27 | 2015-04-01 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericide composition for preventing and treating soybean root rot disease |
| CN106035379A (en) * | 2016-06-27 | 2016-10-26 | 中国烟草总公司郑州烟草研究院 | Bactericide composition containing phenylamide and benzamide bactericides and biocontrol bacterium, preparation and applications |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291187A (en) * | 1998-02-19 | 2001-04-11 | 阿方蒂农科英国有限公司 | 2-pyridylmethylamine derivatives useful as fungicides |
| CN101448396A (en) * | 2006-05-18 | 2009-06-03 | 拜尔农作物科学股份公司 | Synergistic active ingredient combinations |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
-
2011
- 2011-08-26 CN CN2011102481178A patent/CN102246760A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291187A (en) * | 1998-02-19 | 2001-04-11 | 阿方蒂农科英国有限公司 | 2-pyridylmethylamine derivatives useful as fungicides |
| CN101448396A (en) * | 2006-05-18 | 2009-06-03 | 拜尔农作物科学股份公司 | Synergistic active ingredient combinations |
| CN101999356A (en) * | 2010-11-26 | 2011-04-06 | 惠州市中迅化工有限公司 | Sterilization composition containing fluopicolide and metalaxyl and application thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102763646A (en) * | 2012-06-30 | 2012-11-07 | 广东中迅农科股份有限公司 | Metalaxyl emulsion in water and preparation method of metalaxyl emulsion in water |
| CN104381266A (en) * | 2014-09-25 | 2015-03-04 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
| CN104472497A (en) * | 2014-11-27 | 2015-04-01 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericide composition for preventing and treating soybean root rot disease |
| CN106035379A (en) * | 2016-06-27 | 2016-10-26 | 中国烟草总公司郑州烟草研究院 | Bactericide composition containing phenylamide and benzamide bactericides and biocontrol bacterium, preparation and applications |
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Application publication date: 20111123 |