CN103764664A - 一种硫氰酸红霉素的制备方法 - Google Patents

一种硫氰酸红霉素的制备方法 Download PDF

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Publication number
CN103764664A
CN103764664A CN201280035956.4A CN201280035956A CN103764664A CN 103764664 A CN103764664 A CN 103764664A CN 201280035956 A CN201280035956 A CN 201280035956A CN 103764664 A CN103764664 A CN 103764664A
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China
Prior art keywords
erythromycin
thiocyanate
solvent
acetone
combination
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CN201280035956.4A
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CN103764664B (zh
Inventor
熊辉
赵科义
邓肇政
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Yichang dongyangguang Biochemical Pharmaceutical Co., Ltd
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Yichang Changjiang Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

本发明属于制药领域，具体公开了一种硫氰酸红霉素的制备方法。本发明提供的制备方法采用红霉素或红霉素盐类化合物作为原料，溶解于丙酮或含有丙酮的混合溶剂，可获得主组分硫氰酸红霉素A含量更高，杂质更少的硫氰酸红霉素，能作为合成阿奇霉素、克拉霉素并满足欧洲标准和美国标准的起始原料。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201280035956.4A 2011-08-26 2012-08-24 一种硫氰酸红霉素的制备方法 Active CN103764664B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280035956.4A CN103764664B (zh) 2011-08-26 2012-08-24 一种硫氰酸红霉素的制备方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201110248968.2 2011-08-26
CN201110248968 2011-08-26
CN2011102489682 2011-08-26
CN201280035956.4A CN103764664B (zh) 2011-08-26 2012-08-24 一种硫氰酸红霉素的制备方法
PCT/CN2012/080554 WO2013029497A1 (zh) 2011-08-26 2012-08-24 一种硫氰酸红霉素的制备方法

Publications (2)

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CN103764664A true CN103764664A (zh) 2014-04-30
CN103764664B CN103764664B (zh) 2016-03-02

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Country Status (8)

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US (1) US9409940B2 (zh)
EP (1) EP2749564B1 (zh)
CN (1) CN103764664B (zh)
ES (1) ES2602171T3 (zh)
HR (1) HRP20161370T1 (zh)
PL (1) PL2749564T3 (zh)
SI (1) SI2749564T1 (zh)
WO (1) WO2013029497A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105601687B (zh) * 2016-03-28 2019-05-24 四川新迪医药化工有限公司 一种硫氰酸红霉素的精制方法
CN109912671B (zh) * 2019-04-12 2022-04-26 宁夏泰益欣生物科技有限公司 一种利用阿维菌素结晶母液提取阿维菌素B2a的方法
CN110003295B (zh) * 2019-04-29 2020-05-12 宜昌东阳光药业股份有限公司 一种硫氰酸红霉素的制备方法
CN113201038B (zh) * 2021-04-13 2022-07-26 宜昌东阳光生化制药有限公司 一种降低硫氰酸红霉素溶剂残留的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1367842A (fr) * 1963-07-24 1964-07-24 Pierrel Spa Procédé de fabrication d'un nouveau sel d'érythromycine soluble dans l'eau
CN101624412A (zh) * 2008-07-10 2010-01-13 刘力 大环内酯类衍生物及其制备和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2791531A (en) * 1953-10-22 1957-05-07 Lilly Co Eli Erythromycin thiocyanate and compositions containing same
GB1013837A (en) 1962-12-07 1965-12-22 Pierrel Spa Erythromycin salts and esters
CN1099039A (zh) * 1994-05-17 1995-02-22 陕西省六星科工贸有限公司 一种提取红霉素碱的生产工艺
CN101407533B (zh) 2008-11-28 2011-06-08 宁夏启元药业有限公司 一种红霉素硫氰酸盐的生产方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1367842A (fr) * 1963-07-24 1964-07-24 Pierrel Spa Procédé de fabrication d'un nouveau sel d'érythromycine soluble dans l'eau
CN101624412A (zh) * 2008-07-10 2010-01-13 刘力 大环内酯类衍生物及其制备和用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
李平，等: "硫氰酸红霉素合成方法研究", 《中国兽药杂志》 *
赵茜，等: "红霉素溶析结晶过程中原溶剂对其晶习及纯度的影响研究", 《中国抗生素杂志》 *
黄阿根，等: "红霉素在丙酮-水***中的溶解度", 《中国抗生素杂志》 *

Also Published As

Publication number Publication date
US9409940B2 (en) 2016-08-09
PL2749564T3 (pl) 2017-07-31
EP2749564A1 (en) 2014-07-02
WO2013029497A1 (zh) 2013-03-07
CN103764664B (zh) 2016-03-02
EP2749564A4 (en) 2015-01-14
HRP20161370T1 (hr) 2016-12-02
SI2749564T1 (sl) 2016-11-30
US20140228555A1 (en) 2014-08-14
ES2602171T3 (es) 2017-02-17
EP2749564B1 (en) 2016-10-12

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Denomination of invention: Preparation method of erythromycin thiocyanate

Effective date of registration: 20191223

Granted publication date: 20160302

Pledgee: Agricultural Bank of China Limited Dongguan Chang'an sub branch

Pledgor: HEC Pharm Co., Ltd.

Registration number: Y2019440020036

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Address after: 443300 No.62 Binjiang Road, Lucheng, Yidu, Yichang, Hubei Province

Patentee after: Yichang dongyangguang Biochemical Pharmaceutical Co., Ltd

Address before: No.62 Binjiang Road, Yidu City, Yichang City, Hubei Province 443300

Patentee before: HEC PHARM Co.,Ltd.

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Denomination of invention: A preparation method of erythromycin thiocyanate

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Granted publication date: 20160302

Pledgee: Agricultural Bank of China Limited Dongguan Chang'an sub branch

Pledgor: Yichang dongyangguang Biochemical Pharmaceutical Co., Ltd

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